Click here to switch to the map view.

The map label for this gene is ccmB

Identifier: 16273018

GI number: 16273018

Start: 1154386

End: 1155051

Strand: Direct

Name: ccmB

Synonym: HI1090

Alternate gene names: 16273018

Gene position: 1154386-1155051 (Clockwise)

Preceding gene: 16273017

Following gene: 16273019

Centisome position: 63.08

GC content: 42.19

Gene sequence:

>666_bases
ATGATTTTTTTAGAGATAATTAAACGAGAACTTCAAATTGCGATGCGTAAAAATGCGGAAATTTTAAATCCGCTATGGTT
CTTTTTGCTTGTGATTACTTTGTTTCCGCTTGTTATTGGGCCAGATCCTAAATTACTTTCCCGTATCGCACCGGGTATCG
CATGGGTAGCTGCATTACTTTCAGCATTGCTTTCTTTTGAACGTTTATTCCGTGATGATTTTATTGATGGCTCTCTTGAA
CAATTAATGTTAACCGCACAGCCTTTGCCAATGACAGCTTTGGCTAAAGTGGTTGCACATTGGTTGCTCACTGGTTTGCC
GCTTATTTTGCTATCACCTATTGCGGCTTTGTTGCTTTCTCTTGAAGTGAATATTTGGTGGGCATTAGTTTTGACATTGT
TACTGGGCACCCCTGTATTGAGCTGTATCGGTGCTATTGGCGTGGCTTTAACGGTGGGATTGCGAAAAGGTGGCGTGTTG
TTGAGTTTGCTTGTTGTTCCGTTGTTTATTCCTGTTTTAATTTTTGCTTCATCGGTATTGGAGGCAGCAGGATTAAATGT
GCCTTATGGGGGGCAACTGGCGATTTTAGGTGCCATGATGGTTGGCGCTGTAACGCTTTCGCCTTTTGCCATCGCGGCAG
CGTTGCGAATTAGTTTAGATAATTAA

Upstream 100 bases:

>100_bases
GCTCAACGAGGTGGTATTGTGTTGTTAACCAGCCACCAAGAAGTGCCAAGTTCTCATCTGCAAAAATTGAATTTAGCGGC
TTATAAAGCGGAATAACTTA

Downstream 100 bases:

>100_bases
TTTTATTCATCGTATAAAAGTGCGGTGGTTTTTCTCTTTAATTTTTAAGGATTTTTTATGTGGAAGTGGCTACATCCTTA
TGCAAAACCCGAAACTCAAT

Product: heme exporter protein B

Products: NA

Alternate protein names: Cytochrome c-type biogenesis protein CcmB

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MIFLEIIKRELQIAMRKNAEILNPLWFFLLVITLFPLVIGPDPKLLSRIAPGIAWVAALLSALLSFERLFRDDFIDGSLE
QLMLTAQPLPMTALAKVVAHWLLTGLPLILLSPIAALLLSLEVNIWWALVLTLLLGTPVLSCIGAIGVALTVGLRKGGVL
LSLLVVPLFIPVLIFASSVLEAAGLNVPYGGQLAILGAMMVGAVTLSPFAIAAALRISLDN

Sequences:

>Translated_221_residues
MIFLEIIKRELQIAMRKNAEILNPLWFFLLVITLFPLVIGPDPKLLSRIAPGIAWVAALLSALLSFERLFRDDFIDGSLE
QLMLTAQPLPMTALAKVVAHWLLTGLPLILLSPIAALLLSLEVNIWWALVLTLLLGTPVLSCIGAIGVALTVGLRKGGVL
LSLLVVPLFIPVLIFASSVLEAAGLNVPYGGQLAILGAMMVGAVTLSPFAIAAALRISLDN
>Mature_221_residues
MIFLEIIKRELQIAMRKNAEILNPLWFFLLVITLFPLVIGPDPKLLSRIAPGIAWVAALLSALLSFERLFRDDFIDGSLE
QLMLTAQPLPMTALAKVVAHWLLTGLPLILLSPIAALLLSLEVNIWWALVLTLLLGTPVLSCIGAIGVALTVGLRKGGVL
LSLLVVPLFIPVLIFASSVLEAAGLNVPYGGQLAILGAMMVGAVTLSPFAIAAALRISLDN

Specific function: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

COG id: COG2386

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmB/CycW/HelB family

Homologues:

Organism=Escherichia coli, GI1788528, Length=220, Percent_Identity=65, Blast_Score=231, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMB_HAEIN (P45033)

Other databases:

- EMBL:   L42023
- PIR:   F64166
- RefSeq:   NP_439247.1
- GeneID:   950092
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1090
- NMPDR:   fig|71421.1.peg.1047
- TIGR:   HI_1090
- HOGENOM:   HBG656580
- OMA:   AKVVAHW
- ProtClustDB:   CLSK869927
- BioCyc:   HINF71421:HI_1090-MONOMER
- InterPro:   IPR003544
- PRINTS:   PR01414
- TIGRFAMs:   TIGR01190

Pfam domain/function: PF03379 CcmB

EC number: NA

Molecular weight: Translated: 23644; Mature: 23644

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd1d0508)-; HASH(0xb8ea098)-; HASH(0xcc0f134)-; HASH(0xdf2b49c)-; HASH(0xd443afc)-; HASH(0xd1af27c)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFLEIIKRELQIAMRKNAEILNPLWFFLLVITLFPLVIGPDPKLLSRIAPGIAWVAALL
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHH
SALLSFERLFRDDFIDGSLEQLMLTAQPLPMTALAKVVAHWLLTGLPLILLSPIAALLLS
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEVNIWWALVLTLLLGTPVLSCIGAIGVALTVGLRKGGVLLSLLVVPLFIPVLIFASSVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
EAAGLNVPYGGQLAILGAMMVGAVTLSPFAIAAALRISLDN
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MIFLEIIKRELQIAMRKNAEILNPLWFFLLVITLFPLVIGPDPKLLSRIAPGIAWVAALL
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHH
SALLSFERLFRDDFIDGSLEQLMLTAQPLPMTALAKVVAHWLLTGLPLILLSPIAALLLS
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEVNIWWALVLTLLLGTPVLSCIGAIGVALTVGLRKGGVLLSLLVVPLFIPVLIFASSVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
EAAGLNVPYGGQLAILGAMMVGAVTLSPFAIAAALRISLDN
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800