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The map label for this gene is dlgD [H]

Identifier: 16272965

GI number: 16272965

Start: 1096042

End: 1097040

Strand: Reverse

Name: dlgD [H]

Synonym: HI1031

Alternate gene names: 16272965

Gene position: 1097040-1096042 (Counterclockwise)

Preceding gene: 16272971

Following gene: 16272964

Centisome position: 59.94

GC content: 39.24

Gene sequence:

>999_bases
ATGAGAGTTTCTTATGATGAATTAAAAAATGAGTTTAAGCGTGTTTTATTAGATCGTCAGCTTACTGAGGAACTAGCAGA
AGAATGCGCTACTGCATTTACAGACACAACACAAGCGGGTGCTTATTCACACGGTATAAATCGTTTTCCTCGTTTTATTC
AACAACTTGAACAGGGAGATATTGTACCCAATGCAATCCCTACAAAAGTATTAAGTTTAGGTTCTATAGAACAGTGGGAT
GCACATCAAGCAATAGGCAATTTGACTGCCAAAAAAATGATGGATAGAGCAATAGAGTTAGCTTCACAACATGGTGTCGG
TGTAATAGCACTTCGTAATGCTAATCACTGGATGCGAGGAGGATCTTACGGTTGGCAAGCGGCTGAAAAAGGTTATATCG
GGATCTGTTGGACAAATGCATTAGCGGTAATGCCCCCTTGGGGAGCTAAAGAATGCCGTATAGGGACGAATCCATTAATT
ATTGCAGTTCCTACCACACCAATCACTATGGTGGATATGTCTTGCTCAATGTATTCCTATGGAATGTTAGAAGTCCATCG
TTTAGCTGGTCGTCAAACCTTTGTTGATGCAGGTTTTGATGATGAAGGAAATTTAACTCGTGATCCCTCTATTGTAGAAA
AAAACCGTCGTTTGCTGCCAATGGGATTTTGGAAAGGTTCTGGTTTATCTATCGTGCTGGATATGATTGCAACCTTACTA
TCGAATGGTGAATCGACAGTTGCTGTAACTGAAGATAAAAACGATGAATACTGTGTTTCTCAAGTGTTTATCGCCATTGA
AGTAGATCGCTTAATTGATGGTAAAAGCAAAGATGAAAAATTAAACCGCATTATGGATTATGTAAAAACAGCAGAACGAT
CTGATCCAACTCAAGCTGTTCGCCTACCTGGTCATGAATTTACCACTATTCTTTCGGATAACCAAACTAATGGTATTCCA
GTGGATGAACGAGTTTGGGCAAAATTAAAGACGTTATAA

Upstream 100 bases:

>100_bases
TTTATAAATAATTTATTTATTTTACATTTATTGACTGAGCTTTCTTATTTTTGTAAATTATGAAACGTAATTTTACTATA
TAAAATTAAGAGAGGAAAAA

Downstream 100 bases:

>100_bases
CAGCAATATGTTTCCAGTAAAACGCCATAATATAAAACGAATCACATTTGTGATAATCAATTGGAGGTGTAATGATGAGA
TCTCTCGCCCACTTTATTAA

Product: 2,3-diketo-L-gulonate reductase

Products: NA

Alternate protein names: 2,3-DKG reductase; 3-dehydro-L-gulonate 2-dehydrogenase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRVSYDELKNEFKRVLLDRQLTEELAEECATAFTDTTQAGAYSHGINRFPRFIQQLEQGDIVPNAIPTKVLSLGSIEQWD
AHQAIGNLTAKKMMDRAIELASQHGVGVIALRNANHWMRGGSYGWQAAEKGYIGICWTNALAVMPPWGAKECRIGTNPLI
IAVPTTPITMVDMSCSMYSYGMLEVHRLAGRQTFVDAGFDDEGNLTRDPSIVEKNRRLLPMGFWKGSGLSIVLDMIATLL
SNGESTVAVTEDKNDEYCVSQVFIAIEVDRLIDGKSKDEKLNRIMDYVKTAERSDPTQAVRLPGHEFTTILSDNQTNGIP
VDERVWAKLKTL

Sequences:

>Translated_332_residues
MRVSYDELKNEFKRVLLDRQLTEELAEECATAFTDTTQAGAYSHGINRFPRFIQQLEQGDIVPNAIPTKVLSLGSIEQWD
AHQAIGNLTAKKMMDRAIELASQHGVGVIALRNANHWMRGGSYGWQAAEKGYIGICWTNALAVMPPWGAKECRIGTNPLI
IAVPTTPITMVDMSCSMYSYGMLEVHRLAGRQTFVDAGFDDEGNLTRDPSIVEKNRRLLPMGFWKGSGLSIVLDMIATLL
SNGESTVAVTEDKNDEYCVSQVFIAIEVDRLIDGKSKDEKLNRIMDYVKTAERSDPTQAVRLPGHEFTTILSDNQTNGIP
VDERVWAKLKTL
>Mature_332_residues
MRVSYDELKNEFKRVLLDRQLTEELAEECATAFTDTTQAGAYSHGINRFPRFIQQLEQGDIVPNAIPTKVLSLGSIEQWD
AHQAIGNLTAKKMMDRAIELASQHGVGVIALRNANHWMRGGSYGWQAAEKGYIGICWTNALAVMPPWGAKECRIGTNPLI
IAVPTTPITMVDMSCSMYSYGMLEVHRLAGRQTFVDAGFDDEGNLTRDPSIVEKNRRLLPMGFWKGSGLSIVLDMIATLL
SNGESTVAVTEDKNDEYCVSQVFIAIEVDRLIDGKSKDEKLNRIMDYVKTAERSDPTQAVRLPGHEFTTILSDNQTNGIP
VDERVWAKLKTL

Specific function: Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate [H]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790000, Length=332, Percent_Identity=71.3855421686747, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1787020, Length=335, Percent_Identity=24.7761194029851, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786727, Length=336, Percent_Identity=24.1071428571429, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17507179, Length=320, Percent_Identity=25.3125, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17536633, Length=333, Percent_Identity=25.5255255255255, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45553211, Length=325, Percent_Identity=26.1538461538462, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667912, Length=325, Percent_Identity=26.1538461538462, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667908, Length=325, Percent_Identity=26.1538461538462, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667904, Length=325, Percent_Identity=26.1538461538462, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24658010, Length=267, Percent_Identity=25.8426966292135, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24648360, Length=306, Percent_Identity=24.5098039215686, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.130 [H]

Molecular weight: Translated: 36971; Mature: 36971

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVSYDELKNEFKRVLLDRQLTEELAEECATAFTDTTQAGAYSHGINRFPRFIQQLEQGD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHCC
IVPNAIPTKVLSLGSIEQWDAHQAIGNLTAKKMMDRAIELASQHGVGVIALRNANHWMRG
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHCC
GSYGWQAAEKGYIGICWTNALAVMPPWGAKECRIGTNPLIIAVPTTPITMVDMSCSMYSY
CCCCCHHHCCCEEEEEECCCEEEECCCCCCCCEECCCCEEEEECCCCEEEEECCCCHHHH
GMLEVHRLAGRQTFVDAGFDDEGNLTRDPSIVEKNRRLLPMGFWKGSGLSIVLDMIATLL
HHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHCCCCEEEEEEECCCCHHHHHHHHHHHH
SNGESTVAVTEDKNDEYCVSQVFIAIEVDRLIDGKSKDEKLNRIMDYVKTAERSDPTQAV
CCCCCEEEEECCCCCCHHHHHEEEEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEE
RLPGHEFTTILSDNQTNGIPVDERVWAKLKTL
ECCCCCEEEEECCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MRVSYDELKNEFKRVLLDRQLTEELAEECATAFTDTTQAGAYSHGINRFPRFIQQLEQGD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHCC
IVPNAIPTKVLSLGSIEQWDAHQAIGNLTAKKMMDRAIELASQHGVGVIALRNANHWMRG
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHCC
GSYGWQAAEKGYIGICWTNALAVMPPWGAKECRIGTNPLIIAVPTTPITMVDMSCSMYSY
CCCCCHHHCCCEEEEEECCCEEEECCCCCCCCEECCCCEEEEECCCCEEEEECCCCHHHH
GMLEVHRLAGRQTFVDAGFDDEGNLTRDPSIVEKNRRLLPMGFWKGSGLSIVLDMIATLL
HHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHCCCCEEEEEEECCCCHHHHHHHHHHHH
SNGESTVAVTEDKNDEYCVSQVFIAIEVDRLIDGKSKDEKLNRIMDYVKTAERSDPTQAV
CCCCCEEEEECCCCCCHHHHHEEEEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEE
RLPGHEFTTILSDNQTNGIPVDERVWAKLKTL
ECCCCCEEEEECCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA