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The map label for this gene is tktA

Identifier: 16272957

GI number: 16272957

Start: 1087262

End: 1089259

Strand: Reverse

Name: tktA

Synonym: HI1023

Alternate gene names: 16272957

Gene position: 1089259-1087262 (Counterclockwise)

Preceding gene: 16272958

Following gene: 16272944

Centisome position: 59.52

GC content: 42.99

Gene sequence:

>1998_bases
ATGGCAACTCGTAGACAATTAGCCAATGCAATTCGTGTCTTAGCAATGGATTCTGTACAAAAAGCGAAATCTGGTCACCC
TGGTGCACCAATGGGGATGGCGGATATTGCTGAAGTATTATGGCGCGACTTTTTAAAACACAATCCAACCAATCCTAAAT
GGGCTGATCGAGATCGTTTTGTACTTTCTAACGGCCATGGTTCTATGTTGATTTATAGTCTTTTACATTTAACTGGCTAT
GATCTTTCTATCGAAGATTTAAAACAATTCCGTCAATTACATTCTAAAACCCCAGGTCACCCAGAATATGGTTATGCCCC
TGGTGTTGAAACCACGACTGGCCCGTTAGGTCAAGGTATCACTAATGCGGTGGGTATGGCAATTGCTGAGAAAACCTTAG
CTGGACAATTTAACCGTGAAGGCCATGAAATTGTCGATCACCACACTTATGTGTTCTTAGGCGATGGTTGTTTAATGGAA
GGGATTTCTCACGAGGCTTGCTCTTTAGCAGGAACCTTAGGTCTGGGTAAATTAATCGCATTCTACGATGACAACAATAT
TTCCATTGATGGTCATGTTGATGGCTGGTTCAGTGATGACACTGCCGAGCGTTTTGAAGCTTATGGCTGGCAAGTAATCC
GTAATGTAGATGGTCACGATGCAGAGCAAATTCGTGCTGCTACCATTCTTGCTCAAGCAGAAAAAGGAAAACCAACGTTA
ATTATTTGTAAAACCATCATCGGCTTTGGTTCACCAAATAAATCAGGTTCTCATGATTCCCATGGCGCACCATTAGGCGA
TGAAGAAATCGATTTAACCCGTAAAGCACTTGGTTGGGAATATGCGCCATTTGAAATTCCAGCTGAATACTATGCTGAAT
GGTCGGCAAAAGAGAAAGGTGCTGCAGCAGAAAAATCTTGGGAAGAAAAATTTGCCGCTTATGCAAAAGCCTATCCTGAA
TTAGCAGCAGAATTTAAACGTCGTGTTTCTGGCGAATTACCAACAAACTGGGCGGCAGAATCTAAAGCGTTCATCGAAAA
ATTACAAGCAAATCCAGCGAGTATTGCAAGCCGTAAAGCATCACAAAATGCTATCGAAGCTTATGCGCACGTATTACCTG
AATTCTTAGGTGGCTCTGCAGACTTAGCAAGCTCTAACTTAACGTTATGGAGTGGTTCTAAACCAATTCGTGCCCACGAA
AACGTAGGTGGTAACTACATTAACTACGGCGTTCGTGAATTTGGTATGTCTGCCATTATGAACGGTATTGCTTTACACGG
CGGTTTCATTCCTTACGGCGCAACCTTCTTAATGTTCTACGAATATGCTCACAATGCGGTGCGTATGGCAGCATTAATGA
AACAACGCACATTATTCGTTTATACCCACGATTCCATTGGTTTAGGCGAAGATGGGCCTACACACCAACCAGTAGAACAA
ACGGCTTCACTACGCTTAATTCCAAACCTTGAAACATGGCGTCCATGTGACCAAGTTGAATCAGCCATCGCATGGCAACA
AGCGGTTGAACGTCAAGATGGCCCAAGTGCGTTGATCTTTACCCGTCAAAACTTAGCCCAAATGGACCGCACTTCTGCAC
AATTAGATGCGGTTAAACGTGGTGCTTATGTGTTAAAAGACTGTGATGGCACACCTGAGTTAATCTTCATTGCGACAGGT
TCTGAAGTGGAATTAGCAGTGCAAGCAGCCGAAGCATTAAGTGCTGAAGGTAAAAAAGTACGCGTTGTTTCTATGCCAAG
TACTAACCGTTTCGATAAACAAGATGCAGCGTACCGTGAAAGTGTATTACCTGCAGCGGTAACCAAACGTGTTGCGATTG
AAGCGGGTATTGCTGACTTCTGGTATAAATACGTTGGATTCAATGGTCGTGTTATCGGTATGAATAGCTTTGGCGAATCC
GCACCAGCAGATCAATTATTCAAACTCTTTGGTTTCACTGTTGAAAACGTGGTAGCAAAAGCGAAAGAAATTCTTTAA

Upstream 100 bases:

>100_bases
CTAATTTTCACATAGTAACCTTGCAAGATATTGTTACAAGTATTTGCACTCACTTTCGGTCAAGATTAGGAAAATAACAA
AATATTCACAGGAGAACAAA

Downstream 100 bases:

>100_bases
GATTAAACTAAACTAGCTCCTTGATATTCAAGGAGCTTTATTATTGGCTATTGAAAATTATTGTGAGATATGAAATAAAG
AAAGGAATAGATTTATACTT

Product: transketolase

Products: NA

Alternate protein names: TK

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKGKPTL
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKGAAAEKSWEEKFAAYAKAYPE
LAAEFKRRVSGELPTNWAAESKAFIEKLQANPASIASRKASQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHE
NVGGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMDRTSAQLDAVKRGAYVLKDCDGTPELIFIATG
SEVELAVQAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRESVLPAAVTKRVAIEAGIADFWYKYVGFNGRVIGMNSFGES
APADQLFKLFGFTVENVVAKAKEIL

Sequences:

>Translated_665_residues
MATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGY
DLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLME
GISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKGKPTL
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKGAAAEKSWEEKFAAYAKAYPE
LAAEFKRRVSGELPTNWAAESKAFIEKLQANPASIASRKASQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHE
NVGGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMDRTSAQLDAVKRGAYVLKDCDGTPELIFIATG
SEVELAVQAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRESVLPAAVTKRVAIEAGIADFWYKYVGFNGRVIGMNSFGES
APADQLFKLFGFTVENVVAKAKEIL
>Mature_664_residues
ATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRFVLSNGHGSMLIYSLLHLTGYD
LSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGITNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLMEG
ISHEACSLAGTLGLGKLIAFYDDNNISIDGHVDGWFSDDTAERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKGKPTLI
ICKTIIGFGSPNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKGAAAEKSWEEKFAAYAKAYPEL
AAEFKRRVSGELPTNWAAESKAFIEKLQANPASIASRKASQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHEN
VGGNYINYGVREFGMSAIMNGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQT
ASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMDRTSAQLDAVKRGAYVLKDCDGTPELIFIATGS
EVELAVQAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRESVLPAAVTKRVAIEAGIADFWYKYVGFNGRVIGMNSFGESA
PADQLFKLFGFTVENVVAKAKEIL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family

Homologues:

Organism=Homo sapiens, GI205277463, Length=671, Percent_Identity=26.2295081967213, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4507521, Length=671, Percent_Identity=26.2295081967213, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI133778974, Length=594, Percent_Identity=26.2626262626263, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI225637459, Length=673, Percent_Identity=21.3967310549777, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI225637463, Length=594, Percent_Identity=21.7171717171717, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI225637461, Length=594, Percent_Identity=21.7171717171717, Blast_Score=98, Evalue=3e-20,
Organism=Escherichia coli, GI48994911, Length=665, Percent_Identity=77.4436090225564, Blast_Score=1095, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=69.2307692307692, Blast_Score=997, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=672, Percent_Identity=24.702380952381, Blast_Score=166, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=49.2492492492492, Blast_Score=616, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6319593, Length=670, Percent_Identity=45.0746268656716, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI45551847, Length=694, Percent_Identity=25.3602305475504, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI45550715, Length=694, Percent_Identity=25.3602305475504, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24645119, Length=660, Percent_Identity=25, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24666278, Length=262, Percent_Identity=32.824427480916, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TKT_HAEIN (P43757)

Other databases:

- EMBL:   L42023
- PIR:   G64108
- RefSeq:   NP_439183.1
- ProteinModelPortal:   P43757
- SMR:   P43757
- GeneID:   949889
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1023
- NMPDR:   fig|71421.1.peg.985
- TIGR:   HI_1023
- HOGENOM:   HBG565885
- OMA:   MAVWRPC
- ProtClustDB:   PRK05899
- BioCyc:   HINF71421:HI_1023-MONOMER
- BRENDA:   2.2.1.1
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- PANTHER:   PTHR11624:SF1
- SMART:   SM00861
- TIGRFAMs:   TIGR00232

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.1

Molecular weight: Translated: 72719; Mature: 72588

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFSDDTAERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKGKPTL
EEECCCEEECCCCCCCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCCEE
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKG
EEEEHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCC
AAAEKSWEEKFAAYAKAYPELAAEFKRRVSGELPTNWAAESKAFIEKLQANPASIASRKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
SQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHENVGGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHH
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMDRTSAQLDAVKR
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHC
GAYVLKDCDGTPELIFIATGSEVELAVQAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRE
CCEEEECCCCCCCEEEEEECCCEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHH
SVLPAAVTKRVAIEAGIADFWYKYVGFNGRVIGMNSFGESAPADQLFKLFGFTVENVVAK
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
AKEIL
HHHCC
>Mature Secondary Structure 
ATRRQLANAIRVLAMDSVQKAKSGHPGAPMGMADIAEVLWRDFLKHNPTNPKWADRDRF
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCE
VLSNGHGSMLIYSLLHLTGYDLSIEDLKQFRQLHSKTPGHPEYGYAPGVETTTGPLGQGI
EEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
TNAVGMAIAEKTLAGQFNREGHEIVDHHTYVFLGDGCLMEGISHEACSLAGTLGLGKLIA
HHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCHHHHCCCHHHHHHHHHHCCCCEEE
FYDDNNISIDGHVDGWFSDDTAERFEAYGWQVIRNVDGHDAEQIRAATILAQAEKGKPTL
EEECCCEEECCCCCCCCCCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCCEE
IICKTIIGFGSPNKSGSHDSHGAPLGDEEIDLTRKALGWEYAPFEIPAEYYAEWSAKEKG
EEEEHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCC
AAAEKSWEEKFAAYAKAYPELAAEFKRRVSGELPTNWAAESKAFIEKLQANPASIASRKA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
SQNAIEAYAHVLPEFLGGSADLASSNLTLWSGSKPIRAHENVGGNYINYGVREFGMSAIM
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
NGIALHGGFIPYGATFLMFYEYAHNAVRMAALMKQRTLFVYTHDSIGLGEDGPTHQPVEQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHH
TASLRLIPNLETWRPCDQVESAIAWQQAVERQDGPSALIFTRQNLAQMDRTSAQLDAVKR
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHC
GAYVLKDCDGTPELIFIATGSEVELAVQAAEALSAEGKKVRVVSMPSTNRFDKQDAAYRE
CCEEEECCCCCCCEEEEEECCCEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHH
SVLPAAVTKRVAIEAGIADFWYKYVGFNGRVIGMNSFGESAPADQLFKLFGFTVENVVAK
HCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
AKEIL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800