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The map label for this gene is hktE

Identifier: 16272865

GI number: 16272865

Start: 985888

End: 987414

Strand: Direct

Name: hktE

Synonym: HI0928

Alternate gene names: 16272865

Gene position: 985888-987414 (Clockwise)

Preceding gene: 16272860

Following gene: 16272875

Centisome position: 53.87

GC content: 42.63

Gene sequence:

>1527_bases
ATGAGTTCTCAATGTCCTTTCTCGCACTTAGCTGCGACAAACTTAACAATGGGTAACGGTGCACCCGTTGCTGATAACCA
AAACAGCTTAACAGCTGGTCCGCGTGGTCCATTACTTGCACAAGATTTATGGCTTAACGAAAAATTAGCTGATTTCGTAC
GTGAAGTGATCCCAGAGCGTCGTATGCACGCTAAAGGTTCTGGCGCATTTGGTACTTTTACTGTGACACACGACATTACT
AAATATACTCGTGCAAAAATTTTTAGTGAAGTGGGTAAAAAAACGGAAATGTTCGCACGTTTTACCACCGTGGCAGGCGA
ACGTGGTGCAGCAGATGCTGAGCGTGATATTCGTGGTTTTGCATTAAAATTCTATACTGAAGAAGGTAACTGGGATTTAG
TAGGTAACAATACGCCAGTATTCTTCTTACGTGATCCACGTAAATTCCCAGATTTAAATAAAGCAGTAAAACGTGATCCT
CGCACTAATATGCGTTCAGCAACTAATAACTGGGATTTCTGGACATTATTACCAGAAGCATTACACCAAGTCACTGTTGT
AATGAGTGATCGTGGTATTCCAGCAAGTTATCGTCATATGCACGGTTTCGGTTCTCACACTTATAGTTTCTGGAACGAAG
CGGGCGAACGTTTTTGGGTAAAATTCCACTTCCGTACTCAACAAGGCATTAAAAATTTAACAGATGCTGAAGCAGCCGAA
ATTATTGCAAATGACCGTGAAAGCCATCAACGTGATTTATATGAAGCGATTGAACGTGGCGATTTCCCTAAATGGACATT
ATTTGTACAAATTATGCCGGAAGCAGATGCGGAAAAAGTGCCTTATCACCCATTCGACTTAACTAAAGTATGGTCGAAAA
AAGACTATCCATTAATTGAAGTCGGCGAGTTTGAATTAAACCGTAACCCAGAAAACTTCTTCGCTGATGTAGAACAATCT
GCGTTTGCACCAAGTAACTTGGTTCCGGGTATTGGCGCAAGCCCTGACAGAATGTTACAAGCCCGTTTATTTAACTATGC
GGATGCACAACGTTACCGTTTAGGTGTGAACTACCGTCAAATTCCAGTAAACCGTCCACGTTGCCCTGTTCATAGCAACC
AACGTGATGGTCAAGGTCGTGTAGATGGTAACTACGGTAGCTTGCCACACTACGAGCCAAACAGCTTCAGCCAATGGCAA
CAACAACCAGACTTTGCTGAACCACCACTTCGTATCAACGGAGATGCAGCACACTGGGATTATCGTAACGATGATAACGA
TTACTTCAGCCAACCTCGTGCATTATTTAACTTAATGAATGCAGAGCAAAAACAATCATTATTCAACAACACGGCAGCAG
CAATGGGCGATGCACCTGATTTCATCAAATATCGTCATATTCGTAACTGCCACTGGTGTGATGCCGCATACGGTGAAGGC
GTTGCGAAAGCATTAGGTTTAACCGTTGAAGATGCATTAAAAGCTCGTGATACTGATCCTGCATTAGGTCAAGGTGGATT
GTTATAA

Upstream 100 bases:

>100_bases
GATTAATTTAATAGATTTCGATTGTTTAAACCTTTCTATATGATACGCAAGAAATTCATTTCAACCTAACTAAATTTATT
AACTTTACAAGGAGTCTACA

Downstream 100 bases:

>100_bases
TCTTTCGAGTTAATTATTTTAAATAAATAATAGTAGTAATGAATCTGCACCTAAAAGTTAGGCTAAGGTTTAACTGATTA
GGGTGCAGATTTTTTTCAAT

Product: catalase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSSQCPFSHLAATNLTMGNGAPVADNQNSLTAGPRGPLLAQDLWLNEKLADFVREVIPERRMHAKGSGAFGTFTVTHDIT
KYTRAKIFSEVGKKTEMFARFTTVAGERGAADAERDIRGFALKFYTEEGNWDLVGNNTPVFFLRDPRKFPDLNKAVKRDP
RTNMRSATNNWDFWTLLPEALHQVTVVMSDRGIPASYRHMHGFGSHTYSFWNEAGERFWVKFHFRTQQGIKNLTDAEAAE
IIANDRESHQRDLYEAIERGDFPKWTLFVQIMPEADAEKVPYHPFDLTKVWSKKDYPLIEVGEFELNRNPENFFADVEQS
AFAPSNLVPGIGASPDRMLQARLFNYADAQRYRLGVNYRQIPVNRPRCPVHSNQRDGQGRVDGNYGSLPHYEPNSFSQWQ
QQPDFAEPPLRINGDAAHWDYRNDDNDYFSQPRALFNLMNAEQKQSLFNNTAAAMGDAPDFIKYRHIRNCHWCDAAYGEG
VAKALGLTVEDALKARDTDPALGQGGLL

Sequences:

>Translated_508_residues
MSSQCPFSHLAATNLTMGNGAPVADNQNSLTAGPRGPLLAQDLWLNEKLADFVREVIPERRMHAKGSGAFGTFTVTHDIT
KYTRAKIFSEVGKKTEMFARFTTVAGERGAADAERDIRGFALKFYTEEGNWDLVGNNTPVFFLRDPRKFPDLNKAVKRDP
RTNMRSATNNWDFWTLLPEALHQVTVVMSDRGIPASYRHMHGFGSHTYSFWNEAGERFWVKFHFRTQQGIKNLTDAEAAE
IIANDRESHQRDLYEAIERGDFPKWTLFVQIMPEADAEKVPYHPFDLTKVWSKKDYPLIEVGEFELNRNPENFFADVEQS
AFAPSNLVPGIGASPDRMLQARLFNYADAQRYRLGVNYRQIPVNRPRCPVHSNQRDGQGRVDGNYGSLPHYEPNSFSQWQ
QQPDFAEPPLRINGDAAHWDYRNDDNDYFSQPRALFNLMNAEQKQSLFNNTAAAMGDAPDFIKYRHIRNCHWCDAAYGEG
VAKALGLTVEDALKARDTDPALGQGGLL
>Mature_507_residues
SSQCPFSHLAATNLTMGNGAPVADNQNSLTAGPRGPLLAQDLWLNEKLADFVREVIPERRMHAKGSGAFGTFTVTHDITK
YTRAKIFSEVGKKTEMFARFTTVAGERGAADAERDIRGFALKFYTEEGNWDLVGNNTPVFFLRDPRKFPDLNKAVKRDPR
TNMRSATNNWDFWTLLPEALHQVTVVMSDRGIPASYRHMHGFGSHTYSFWNEAGERFWVKFHFRTQQGIKNLTDAEAAEI
IANDRESHQRDLYEAIERGDFPKWTLFVQIMPEADAEKVPYHPFDLTKVWSKKDYPLIEVGEFELNRNPENFFADVEQSA
FAPSNLVPGIGASPDRMLQARLFNYADAQRYRLGVNYRQIPVNRPRCPVHSNQRDGQGRVDGNYGSLPHYEPNSFSQWQQ
QPDFAEPPLRINGDAAHWDYRNDDNDYFSQPRALFNLMNAEQKQSLFNNTAAAMGDAPDFIKYRHIRNCHWCDAAYGEGV
AKALGLTVEDALKARDTDPALGQGGLL

Specific function: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide

COG id: COG0753

COG function: function code P; Catalase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the catalase family

Homologues:

Organism=Homo sapiens, GI4557014, Length=476, Percent_Identity=52.1008403361345, Blast_Score=499, Evalue=1e-141,
Organism=Escherichia coli, GI48994891, Length=496, Percent_Identity=41.7338709677419, Blast_Score=357, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71998444, Length=450, Percent_Identity=50.6666666666667, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI25151141, Length=451, Percent_Identity=48.780487804878, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI25147792, Length=451, Percent_Identity=48.5587583148559, Blast_Score=442, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6320462, Length=481, Percent_Identity=47.1933471933472, Blast_Score=400, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6321525, Length=362, Percent_Identity=43.3701657458564, Blast_Score=300, Evalue=3e-82,
Organism=Drosophila melanogaster, GI17981717, Length=477, Percent_Identity=47.5890985324948, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI19920968, Length=476, Percent_Identity=44.327731092437, Blast_Score=416, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CATA_HAEIN (P44390)

Other databases:

- EMBL:   U02682
- EMBL:   L42023
- PIR:   D64103
- RefSeq:   NP_439088.1
- ProteinModelPortal:   P44390
- SMR:   P44390
- GeneID:   949926
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0928
- NMPDR:   fig|71421.1.peg.894
- TIGR:   HI_0928
- HOGENOM:   HBG339355
- OMA:   HSYHRDG
- ProtClustDB:   CLSK877441
- BioCyc:   HINF71421:HI_0928-MONOMER
- BRENDA:   1.11.1.6
- GO:   GO:0005737
- InterPro:   IPR002226
- InterPro:   IPR020835
- InterPro:   IPR010582
- InterPro:   IPR018028
- InterPro:   IPR011614
- Gene3D:   G3DSA:2.40.180.10
- PANTHER:   PTHR11465
- PRINTS:   PR00067

Pfam domain/function: PF00199 Catalase; PF06628 Catalase-rel; SSF56634 Catalase_N

EC number: =1.11.1.6

Molecular weight: Translated: 57681; Mature: 57550

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00437 CATALASE_1; PS00438 CATALASE_2; PS51402 CATALASE_3

Important sites: ACT_SITE 63-63 ACT_SITE 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQCPFSHLAATNLTMGNGAPVADNQNSLTAGPRGPLLAQDLWLNEKLADFVREVIPER
CCCCCCCHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHH
RMHAKGSGAFGTFTVTHDITKYTRAKIFSEVGKKTEMFARFTTVAGERGAADAERDIRGF
HHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHCCCEE
ALKFYTEEGNWDLVGNNTPVFFLRDPRKFPDLNKAVKRDPRTNMRSATNNWDFWTLLPEA
EEEEEEECCCEEEECCCCCEEEEECCCCCCCHHHHHHCCCCCCHHHCCCCCCHHHHHHHH
LHQVTVVMSDRGIPASYRHMHGFGSHTYSFWNEAGERFWVKFHFRTQQGIKNLTDAEAAE
HHHEEEEEECCCCCHHHHHHCCCCCHHHHHHHHCCCEEEEEEEEECHHHHHHHHHHHHHH
IIANDRESHQRDLYEAIERGDFPKWTLFVQIMPEADAEKVPYHPFDLTKVWSKKDYPLIE
HHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCEEE
VGEFELNRNPENFFADVEQSAFAPSNLVPGIGASPDRMLQARLFNYADAQRYRLGVNYRQ
ECCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHEEECCCEEE
IPVNRPRCPVHSNQRDGQGRVDGNYGSLPHYEPNSFSQWQQQPDFAEPPLRINGDAAHWD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEECCCCCCCC
YRNDDNDYFSQPRALFNLMNAEQKQSLFNNTAAAMGDAPDFIKYRHIRNCHWCDAAYGEG
CCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHH
VAKALGLTVEDALKARDTDPALGQGGLL
HHHHHCCCHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSQCPFSHLAATNLTMGNGAPVADNQNSLTAGPRGPLLAQDLWLNEKLADFVREVIPER
CCCCCCHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHH
RMHAKGSGAFGTFTVTHDITKYTRAKIFSEVGKKTEMFARFTTVAGERGAADAERDIRGF
HHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHCCCEE
ALKFYTEEGNWDLVGNNTPVFFLRDPRKFPDLNKAVKRDPRTNMRSATNNWDFWTLLPEA
EEEEEEECCCEEEECCCCCEEEEECCCCCCCHHHHHHCCCCCCHHHCCCCCCHHHHHHHH
LHQVTVVMSDRGIPASYRHMHGFGSHTYSFWNEAGERFWVKFHFRTQQGIKNLTDAEAAE
HHHEEEEEECCCCCHHHHHHCCCCCHHHHHHHHCCCEEEEEEEEECHHHHHHHHHHHHHH
IIANDRESHQRDLYEAIERGDFPKWTLFVQIMPEADAEKVPYHPFDLTKVWSKKDYPLIE
HHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCEEE
VGEFELNRNPENFFADVEQSAFAPSNLVPGIGASPDRMLQARLFNYADAQRYRLGVNYRQ
ECCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHEEECCCEEE
IPVNRPRCPVHSNQRDGQGRVDGNYGSLPHYEPNSFSQWQQQPDFAEPPLRINGDAAHWD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEECCCCCCCC
YRNDDNDYFSQPRALFNLMNAEQKQSLFNNTAAAMGDAPDFIKYRHIRNCHWCDAAYGEG
CCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHH
VAKALGLTVEDALKARDTDPALGQGGLL
HHHHHCCCHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8188593; 7542800