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The map label for this gene is mutY

Identifier: 16272700

GI number: 16272700

Start: 822600

End: 823736

Strand: Direct

Name: mutY

Synonym: HI0759

Alternate gene names: 16272700

Gene position: 822600-823736 (Clockwise)

Preceding gene: 16272698

Following gene: 16272701

Centisome position: 44.95

GC content: 38.7

Gene sequence:

>1137_bases
ATGTTAGCAAAATCTTCCATCAATGCGCCATTTGCCAAATCTGTTTTAGCTTGGTACGACAAGTTTGGACGCAAGCATTT
ACCTTGGCAGCAAAATAAAACGCTTTATGGTGTATGGCTTTCTGAAGTGATGTTGCAACAAACGCAAGTTGCGACGGTAA
TTCCTTATTTTGAGCGGTTTATCAAAACATTTCCAAATATCACCGCACTTGCCAATGCTTCACAAGATGAAGTGTTACAT
TTATGGACGGGCTTAGGCTATTATGCACGAGCGCGTAATTTACATAAAGCCGCTCAAAAAGTGCGGGATGAATTTAATGG
AAATTTCCCAACAAATTTTGAGCAAGTTTGGGCATTATCTGGTGTGGGACGTTCAACTGCTGGTGCCATTTTATCTTCTG
TTTTAAATCAGCCTTATCCAATTTTAGATGGTAATGTGAAACGTGTGTTGGCACGTTATTTTGCTGTTGAGGGATGGAGT
GGCGAGAAAAAAGTAGAAAATCGCTTGTGGGCATTAACGGAGCAAGTTACACCTACGACGCGTGTGGCAGATTTTAATCA
AGCAATGATGGACATTGGTGCAATGGTTTGCATGCGAACTAAGCCCAAATGCGATCTTTGTCCGTTAAATATAGATTGTT
TGGCTTATAAAAATACAAACTGGGAAAAATTTCCAGCTAAAAAACCTAAAAAAGCGATGCCAGAAAAAACTACCTATTTT
TTAATTTTGTCGAAAAATGGCAAAGTATGTTTGGAACAGCGAGAAAACTCAGGATTATGGGGCGGATTATTTTGTTTTCC
ACAATTTGAAGATAAATCCTCGTTGCTTCATTTTTTAGCCCAAGAAAAAGTCACGCATTATCAAGAATGGCCGAGTTTTC
GACATACATTCAGCCATTTTCATTTAGATATTCATCCAATTTACGCCGAAATGGAGAGTACTTTATGCGTAGAGCAGGCT
AATTTAGACTGGCGAAAAGTGATGGAAAGCACAAAAGAATACCAATCAAACCTATCAAGTGCGGTCAAATATTGGTATGA
TCCACAAAATCCTGAACCGATCGGGCTGGCTCAGCCTGTGAAAAATCTTTTAATACAATTTGTAAGGAATCATTATGGCA
AGAACAGTATTTTGTGA

Upstream 100 bases:

>100_bases
TTGGCACCAAATAGGTTGCGAATTATACTGAAAAAATGCAGATAAACAAGCTCTATTTTCGTGTAAAATCATCAGCATTT
TTAACCGCACTTTTCTTTTT

Downstream 100 bases:

>100_bases
ATATCTCAAAAAAGAAGCGGAAGGCTTAGATTTTCAACTTTATCCTGGAGAGTTGGGCAAGCGTATTTTTGATTCAGTAA
GTAAACAGGCTTGGGGCGAA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MLAKSSINAPFAKSVLAWYDKFGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFERFIKTFPNITALANASQDEVLH
LWTGLGYYARARNLHKAAQKVRDEFNGNFPTNFEQVWALSGVGRSTAGAILSSVLNQPYPILDGNVKRVLARYFAVEGWS
GEKKVENRLWALTEQVTPTTRVADFNQAMMDIGAMVCMRTKPKCDLCPLNIDCLAYKNTNWEKFPAKKPKKAMPEKTTYF
LILSKNGKVCLEQRENSGLWGGLFCFPQFEDKSSLLHFLAQEKVTHYQEWPSFRHTFSHFHLDIHPIYAEMESTLCVEQA
NLDWRKVMESTKEYQSNLSSAVKYWYDPQNPEPIGLAQPVKNLLIQFVRNHYGKNSIL

Sequences:

>Translated_378_residues
MLAKSSINAPFAKSVLAWYDKFGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFERFIKTFPNITALANASQDEVLH
LWTGLGYYARARNLHKAAQKVRDEFNGNFPTNFEQVWALSGVGRSTAGAILSSVLNQPYPILDGNVKRVLARYFAVEGWS
GEKKVENRLWALTEQVTPTTRVADFNQAMMDIGAMVCMRTKPKCDLCPLNIDCLAYKNTNWEKFPAKKPKKAMPEKTTYF
LILSKNGKVCLEQRENSGLWGGLFCFPQFEDKSSLLHFLAQEKVTHYQEWPSFRHTFSHFHLDIHPIYAEMESTLCVEQA
NLDWRKVMESTKEYQSNLSSAVKYWYDPQNPEPIGLAQPVKNLLIQFVRNHYGKNSIL
>Mature_378_residues
MLAKSSINAPFAKSVLAWYDKFGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFERFIKTFPNITALANASQDEVLH
LWTGLGYYARARNLHKAAQKVRDEFNGNFPTNFEQVWALSGVGRSTAGAILSSVLNQPYPILDGNVKRVLARYFAVEGWS
GEKKVENRLWALTEQVTPTTRVADFNQAMMDIGAMVCMRTKPKCDLCPLNIDCLAYKNTNWEKFPAKKPKKAMPEKTTYF
LILSKNGKVCLEQRENSGLWGGLFCFPQFEDKSSLLHFLAQEKVTHYQEWPSFRHTFSHFHLDIHPIYAEMESTLCVEQA
NLDWRKVMESTKEYQSNLSSAVKYWYDPQNPEPIGLAQPVKNLLIQFVRNHYGKNSIL

Specific function: Adenine glycosylase active on G-A and C-A mispairs

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family

Homologues:

Organism=Homo sapiens, GI190358497, Length=357, Percent_Identity=34.733893557423, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI115298648, Length=357, Percent_Identity=34.733893557423, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI115298650, Length=357, Percent_Identity=34.733893557423, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI115298654, Length=357, Percent_Identity=34.733893557423, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI115298652, Length=357, Percent_Identity=34.733893557423, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI6912520, Length=357, Percent_Identity=34.733893557423, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI1789331, Length=360, Percent_Identity=58.3333333333333, Blast_Score=426, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTY_HAEIN (P44320)

Other databases:

- EMBL:   L42023
- PIR:   C64091
- RefSeq:   NP_438918.1
- ProteinModelPortal:   P44320
- SMR:   P44320
- GeneID:   950824
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0759
- NMPDR:   fig|71421.1.peg.727
- TIGR:   HI_0759
- HOGENOM:   HBG464473
- OMA:   FHLDIQP
- ProtClustDB:   CLSK870447
- BioCyc:   HINF71421:HI_0759-MONOMER
- GO:   GO:0005622
- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797
- Gene3D:   G3DSA:1.10.340.30
- Gene3D:   G3DSA:1.10.1670.10
- Gene3D:   G3DSA:3.90.79.10
- SMART:   SM00478
- SMART:   SM00525
- TIGRFAMs:   TIGR01084

Pfam domain/function: PF00730 HhH-GPD; SSF48150 DNA_glycsylse; SSF55811 NUDIX_hydrolase

EC number: 3.2.2.-

Molecular weight: Translated: 43505; Mature: 43505

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00764 ENDONUCLEASE_III_1; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAKSSINAPFAKSVLAWYDKFGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFERF
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
IKTFPNITALANASQDEVLHLWTGLGYYARARNLHKAAQKVRDEFNGNFPTNFEQVWALS
HHHCCCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
GVGRSTAGAILSSVLNQPYPILDGNVKRVLARYFAVEGWSGEKKVENRLWALTEQVTPTT
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCH
RVADFNQAMMDIGAMVCMRTKPKCDLCPLNIDCLAYKNTNWEKFPAKKPKKAMPEKTTYF
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHCCCCCCEEE
LILSKNGKVCLEQRENSGLWGGLFCFPQFEDKSSLLHFLAQEKVTHYQEWPSFRHTFSHF
EEECCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
HLDIHPIYAEMESTLCVEQANLDWRKVMESTKEYQSNLSSAVKYWYDPQNPEPIGLAQPV
EEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
KNLLIQFVRNHYGKNSIL
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLAKSSINAPFAKSVLAWYDKFGRKHLPWQQNKTLYGVWLSEVMLQQTQVATVIPYFERF
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
IKTFPNITALANASQDEVLHLWTGLGYYARARNLHKAAQKVRDEFNGNFPTNFEQVWALS
HHHCCCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
GVGRSTAGAILSSVLNQPYPILDGNVKRVLARYFAVEGWSGEKKVENRLWALTEQVTPTT
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCH
RVADFNQAMMDIGAMVCMRTKPKCDLCPLNIDCLAYKNTNWEKFPAKKPKKAMPEKTTYF
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHCCCCCCEEE
LILSKNGKVCLEQRENSGLWGGLFCFPQFEDKSSLLHFLAQEKVTHYQEWPSFRHTFSHF
EEECCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
HLDIHPIYAEMESTLCVEQANLDWRKVMESTKEYQSNLSSAVKYWYDPQNPEPIGLAQPV
EEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
KNLLIQFVRNHYGKNSIL
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800