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The map label for this gene is selB

Identifier: 16272649

GI number: 16272649

Start: 755334

End: 757193

Strand: Direct

Name: selB

Synonym: HI0709

Alternate gene names: 16272649

Gene position: 755334-757193 (Clockwise)

Preceding gene: 16272648

Following gene: 16272650

Centisome position: 41.27

GC content: 39.25

Gene sequence:

>1860_bases
ATGATTATTGTTACTTCAGGTCACGTTGATCACGGCAAAACAGCATTATTAAAAGCATTAACTGGCACAAGTACCGCACA
TTTACCAGAAGAAAAAAAACGCGGAATGACCATTGATTTGGGATATGCCTATCTGCCTTTAGAAAACAAAGTACTTGGCT
TTATTGATGTACCTGGGCACGAAAAATTCTTATCAAATATGCTGGCAGGTTTAGGTGGCGTGCATTATGCAATGTTAATT
GTGGCTGCGGATGAAGGCGTTGCGGTGCAAACAAAAGAACATTTAGCAATATTACGCCAACTTCAATTCCACGAAATTAT
TGTTGTCATCACAAAAGCAGATCGTACAAATTCAGCGCAAATAGAATCGTTAATCCAAACAATTAAACAAGATTATAGTT
TTTTACGCAATGCTAACTACTTCGTTACCTCAGCAGAAACGGGACAAGGAATTAGTGAATTACGTCATTACTTAGCTAAT
TTGGCAGAATTAGCTGATACTCAGAAACCTTTCCGCTATGCAATAGACCGAGTATTCAGCGTAAAAGGGGCGGGTACTGT
AGTAACAGGCACAGCCTTTTCAGGAACAGTGAAAGTAAACGATGAAATTTACCTTTCCACTGGACAGAAAATTCGTATAA
AAGCGATTCACGCACAAAATACATCAAGCGAACAAGGTATTGCAGGGCAACGTTTAGCGTTAAATTTAAATGCTGATTTA
GACCGCACGCCAATGAAACGAGGCGATTGGTTATTGCAGAATGAGCCACTTCCACCAACAGATCGCATCAGTGTACAAAT
TTTGGCTGAAGTACCATTAAATGAAAGCCAGCCTGTGCATATTTATCACGGAGCGAGTCGCACTACGGGTAAGCTCACCT
TATTACAGGGAAAAAATGCCGCTAAAAATGACCGCACTTTAGCTGAAATCATATTAGATTCACCATTATTCTTGGCTTTC
GGAGACAAACTTATTTTACGCAGTGGCGATACAAAAACCTTAATTGCCGGCGCACGAGTATTGGAAATTAACTCGCCAAA
ACGTCATAAACGAACTGAAGTGCGGTTAAATTTCTTAGCCAATTTAGCATTGGCAGAGAATGCTTCGCAACGTATTGCGC
TTACCCTTCAACATAATGCGACAACGGCACGCCAATTAATGTGGACGGAACAACTGACTTCCTTGCAATTAGATAAAGCA
CTCGCCGAGCGGGACGCTGTACGTTATCAAGATTGGTGTTTTAATCCTAATTACGTACAAGAAAAAACGCAGCAAATTTT
AACCGCACTTAATATCTATCACGAGCAACATAATGATCAACTTGGTGTAAGCAAAGCCAGATTATATCGAATGGCAACAT
TGAATCAGCCAGAAAATCTAATTCATCATTTTATCGATGAAATGCTTGATGATGGACGATTACAACAAACGCGTGGCTGG
ATTCATCTACCAGAGCACAAAATTCAGTTTAATACTGAAGAAAAATCACGTTGGACAGATGTATTAAACGAGTTTGAAAA
AGCAAACGGTCAAGCGATTTGGGTGCGCGATATGGCAAATGCACTCGCTATTGATGAATCAATTATGCGTAATTTTATGT
ATAAAGCAGGGAAACTTGGTTACCTCACGCCAATCGTAAAAGATAGATTTTTCTTAACTGAAACCCTCTATGCTTATGCA
AGACTCATCAAACAAATCGCAGAAGAAAAAGGAAAAGTTTCAGTAAATGAAGTACGTGATAAATTGAATTTCGGGCGCAA
ACTTACCGTTCAACTGATGGAATATTTCGACCGAATGGGTTTTTTACGTCGTAAAGGCAATGACCATATTCTACGCGATA
AGAATGTTTTTGATTTATGA

Upstream 100 bases:

>100_bases
TTTCCCAACCTATTATTGGGCGAATGGAAAACGGAAAAATTTGGCTAGATTTACGTAGCCTCGCGGATATTGAAACATTA
TTAAATACATTGGACGAACT

Downstream 100 bases:

>100_bases
TGTTTATGAAATCGCCCCTTACGCAGCAGGAGAGCAGGATTTGTTGCTCTATTTTGGGCAACTAGAAGAGTTATTTAAAC
CAGAATTTAGACAGGGTAAT

Product: selenocysteine-specific elongation factor

Products: NA

Alternate protein names: SelB translation factor

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGHEKFLSNMLAGLGGVHYAMLI
VAADEGVAVQTKEHLAILRQLQFHEIIVVITKADRTNSAQIESLIQTIKQDYSFLRNANYFVTSAETGQGISELRHYLAN
LAELADTQKPFRYAIDRVFSVKGAGTVVTGTAFSGTVKVNDEIYLSTGQKIRIKAIHAQNTSSEQGIAGQRLALNLNADL
DRTPMKRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGASRTTGKLTLLQGKNAAKNDRTLAEIILDSPLFLAF
GDKLILRSGDTKTLIAGARVLEINSPKRHKRTEVRLNFLANLALAENASQRIALTLQHNATTARQLMWTEQLTSLQLDKA
LAERDAVRYQDWCFNPNYVQEKTQQILTALNIYHEQHNDQLGVSKARLYRMATLNQPENLIHHFIDEMLDDGRLQQTRGW
IHLPEHKIQFNTEEKSRWTDVLNEFEKANGQAIWVRDMANALAIDESIMRNFMYKAGKLGYLTPIVKDRFFLTETLYAYA
RLIKQIAEEKGKVSVNEVRDKLNFGRKLTVQLMEYFDRMGFLRRKGNDHILRDKNVFDL

Sequences:

>Translated_619_residues
MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGHEKFLSNMLAGLGGVHYAMLI
VAADEGVAVQTKEHLAILRQLQFHEIIVVITKADRTNSAQIESLIQTIKQDYSFLRNANYFVTSAETGQGISELRHYLAN
LAELADTQKPFRYAIDRVFSVKGAGTVVTGTAFSGTVKVNDEIYLSTGQKIRIKAIHAQNTSSEQGIAGQRLALNLNADL
DRTPMKRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGASRTTGKLTLLQGKNAAKNDRTLAEIILDSPLFLAF
GDKLILRSGDTKTLIAGARVLEINSPKRHKRTEVRLNFLANLALAENASQRIALTLQHNATTARQLMWTEQLTSLQLDKA
LAERDAVRYQDWCFNPNYVQEKTQQILTALNIYHEQHNDQLGVSKARLYRMATLNQPENLIHHFIDEMLDDGRLQQTRGW
IHLPEHKIQFNTEEKSRWTDVLNEFEKANGQAIWVRDMANALAIDESIMRNFMYKAGKLGYLTPIVKDRFFLTETLYAYA
RLIKQIAEEKGKVSVNEVRDKLNFGRKLTVQLMEYFDRMGFLRRKGNDHILRDKNVFDL
>Mature_619_residues
MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGHEKFLSNMLAGLGGVHYAMLI
VAADEGVAVQTKEHLAILRQLQFHEIIVVITKADRTNSAQIESLIQTIKQDYSFLRNANYFVTSAETGQGISELRHYLAN
LAELADTQKPFRYAIDRVFSVKGAGTVVTGTAFSGTVKVNDEIYLSTGQKIRIKAIHAQNTSSEQGIAGQRLALNLNADL
DRTPMKRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGASRTTGKLTLLQGKNAAKNDRTLAEIILDSPLFLAF
GDKLILRSGDTKTLIAGARVLEINSPKRHKRTEVRLNFLANLALAENASQRIALTLQHNATTARQLMWTEQLTSLQLDKA
LAERDAVRYQDWCFNPNYVQEKTQQILTALNIYHEQHNDQLGVSKARLYRMATLNQPENLIHHFIDEMLDDGRLQQTRGW
IHLPEHKIQFNTEEKSRWTDVLNEFEKANGQAIWVRDMANALAIDESIMRNFMYKAGKLGYLTPIVKDRFFLTETLYAYA
RLIKQIAEEKGKVSVNEVRDKLNFGRKLTVQLMEYFDRMGFLRRKGNDHILRDKNVFDL

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily

Homologues:

Organism=Homo sapiens, GI34147630, Length=296, Percent_Identity=27.7027027027027, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI54607086, Length=290, Percent_Identity=25.8620689655172, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI223555963, Length=369, Percent_Identity=24.9322493224932, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI5729864, Length=369, Percent_Identity=24.9322493224932, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI82546879, Length=351, Percent_Identity=24.2165242165242, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI53729339, Length=252, Percent_Identity=29.7619047619048, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI53729337, Length=252, Percent_Identity=29.7619047619048, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI46094014, Length=240, Percent_Identity=25.8333333333333, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI194097354, Length=240, Percent_Identity=24.5833333333333, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI194018520, Length=240, Percent_Identity=24.5833333333333, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI194018522, Length=240, Percent_Identity=24.5833333333333, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI2367247, Length=623, Percent_Identity=43.0176565008026, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1789737, Length=379, Percent_Identity=27.7044854881267, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1790412, Length=379, Percent_Identity=27.7044854881267, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1789108, Length=327, Percent_Identity=25.9938837920489, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1789559, Length=94, Percent_Identity=37.2340425531915, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17556456, Length=389, Percent_Identity=27.2493573264781, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25141371, Length=367, Percent_Identity=27.5204359673025, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17506081, Length=254, Percent_Identity=27.9527559055118, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI115532067, Length=329, Percent_Identity=27.6595744680851, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115532065, Length=329, Percent_Identity=27.6595744680851, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565438, Length=325, Percent_Identity=26.1538461538462, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71994658, Length=227, Percent_Identity=25.9911894273128, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324761, Length=303, Percent_Identity=29.7029702970297, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19922690, Length=330, Percent_Identity=30.9090909090909, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19921738, Length=261, Percent_Identity=30.2681992337165, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281363316, Length=297, Percent_Identity=26.9360269360269, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17864358, Length=297, Percent_Identity=26.9360269360269, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550900, Length=395, Percent_Identity=21.7721518987342, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573213, Length=346, Percent_Identity=23.9884393063584, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221378008, Length=346, Percent_Identity=23.9884393063584, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644462, Length=346, Percent_Identity=23.9884393063584, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644464, Length=346, Percent_Identity=23.9884393063584, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644466, Length=346, Percent_Identity=23.9884393063584, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28572034, Length=118, Percent_Identity=34.7457627118644, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SELB_HAEIN (P43927)

Other databases:

- EMBL:   L42023
- PIR:   I64087
- RefSeq:   NP_438867.1
- ProteinModelPortal:   P43927
- GeneID:   950261
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0709
- NMPDR:   fig|71421.1.peg.677
- TIGR:   HI_0709
- HOGENOM:   HBG431466
- OMA:   SGFTRRK
- ProtClustDB:   CLSK870608
- BioCyc:   HINF71421:HI_0709-MONOMER
- GO:   GO:0005737
- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- TIGRFAMs:   TIGR00475
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 69976; Mature: 69976

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGH
CEEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEECEEEECCCCCEEEEEECCCH
EKFLSNMLAGLGGVHYAMLIVAADEGVAVQTKEHLAILRQLQFHEIIVVITKADRTNSAQ
HHHHHHHHHHCCHHEEEEEEEECCCCCEEECHHHHHHHHHHCCEEEEEEEEECCCCCHHH
IESLIQTIKQDYSFLRNANYFVTSAETGQGISELRHYLANLAELADTQKPFRYAIDRVFS
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHE
VKGAGTVVTGTAFSGTVKVNDEIYLSTGQKIRIKAIHAQNTSSEQGIAGQRLALNLNADL
ECCCCEEEEECEEECEEEECCEEEEECCCEEEEEEEECCCCCCCCCCCCCEEEEEECCCC
DRTPMKRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGASRTTGKLTLLQGKNA
CCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCCC
AKNDRTLAEIILDSPLFLAFGDKLILRSGDTKTLIAGARVLEINSPKRHKRTEVRLNFLA
CCCCHHHHHHHHCCCEEEEECCEEEEECCCCEEEEECEEEEEECCCCHHHHHHHHHHHHH
NLALAENASQRIALTLQHNATTARQLMWTEQLTSLQLDKALAERDAVRYQDWCFNPNYVQ
HHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHH
EKTQQILTALNIYHEQHNDQLGVSKARLYRMATLNQPENLIHHFIDEMLDDGRLQQTRGW
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEECCCCC
IHLPEHKIQFNTEEKSRWTDVLNEFEKANGQAIWVRDMANALAIDESIMRNFMYKAGKLG
EECCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCC
YLTPIVKDRFFLTETLYAYARLIKQIAEEKGKVSVNEVRDKLNFGRKLTVQLMEYFDRMG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHH
FLRRKGNDHILRDKNVFDL
HHHCCCCCCEECCCCCCCC
>Mature Secondary Structure
MIIVTSGHVDHGKTALLKALTGTSTAHLPEEKKRGMTIDLGYAYLPLENKVLGFIDVPGH
CEEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEECEEEECCCCCEEEEEECCCH
EKFLSNMLAGLGGVHYAMLIVAADEGVAVQTKEHLAILRQLQFHEIIVVITKADRTNSAQ
HHHHHHHHHHCCHHEEEEEEEECCCCCEEECHHHHHHHHHHCCEEEEEEEEECCCCCHHH
IESLIQTIKQDYSFLRNANYFVTSAETGQGISELRHYLANLAELADTQKPFRYAIDRVFS
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHE
VKGAGTVVTGTAFSGTVKVNDEIYLSTGQKIRIKAIHAQNTSSEQGIAGQRLALNLNADL
ECCCCEEEEECEEECEEEECCEEEEECCCEEEEEEEECCCCCCCCCCCCCEEEEEECCCC
DRTPMKRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGASRTTGKLTLLQGKNA
CCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCCC
AKNDRTLAEIILDSPLFLAFGDKLILRSGDTKTLIAGARVLEINSPKRHKRTEVRLNFLA
CCCCHHHHHHHHCCCEEEEECCEEEEECCCCEEEEECEEEEEECCCCHHHHHHHHHHHHH
NLALAENASQRIALTLQHNATTARQLMWTEQLTSLQLDKALAERDAVRYQDWCFNPNYVQ
HHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHH
EKTQQILTALNIYHEQHNDQLGVSKARLYRMATLNQPENLIHHFIDEMLDDGRLQQTRGW
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEECCCCC
IHLPEHKIQFNTEEKSRWTDVLNEFEKANGQAIWVRDMANALAIDESIMRNFMYKAGKLG
EECCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCC
YLTPIVKDRFFLTETLYAYARLIKQIAEEKGKVSVNEVRDKLNFGRKLTVQLMEYFDRMG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHH
FLRRKGNDHILRDKNVFDL
HHHCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800