Click here to switch to the map view.

The map label for this gene is selA [H]

Identifier: 16272648

GI number: 16272648

Start: 753952

End: 755337

Strand: Direct

Name: selA [H]

Synonym: HI0708

Alternate gene names: 16272648

Gene position: 753952-755337 (Clockwise)

Preceding gene: 16272647

Following gene: 16272649

Centisome position: 41.2

GC content: 39.25

Gene sequence:

>1386_bases
ATGACCGCACTTTTTCAACAACTTCCTTCCGTTGATAAAATTCTCAAAACACCTCAAGGCTTACAACTCATTACCGAATT
TGGTCACACTGCAGTCGTGGCAACATGTCGAGAATTATTAACCCAAGCTCGTCAATTTATAAAAAAAAACAATCAACTTC
CTGAATATTTTTCTAATTTTGACCGCACTTTTTTAGAAATTCATTCTCACTTACAAAAACAAAACCAAGTACAAATCAAA
GCGGTGCACAATCTGACTGGCACTGTGTTACACACAAATCTTGGGCGGGCACTTTGGTCTGAAGCAGCACAACAGGCAGC
GCTTTCTGCGATGCAAAAAAATGTTTCACTTGAATATGATTTAGATGAAGGTAAGCGTAGTCATCGCGATAATTACATCA
GTGAATTATTATGCAAACTCACAGGTGCGGAAGCAGCCTGTATTGTGAATAACAACGCCGCCGCAGTATTATTAATGTTA
GCGACCTTTGCTCAAGGTAAAGAAGTAATTATTTCTCGTGGCGAATTAATTGAAATTGGTGGTGCATTTCGTATTCCAGA
TATTATGGAACAAGCTGGATGCCATTTAGTGGAAGTGGGCACCACTAATCGCACTCACCTGAAAGATTATCGTAATGCTA
TCACTGAAAATACGGCTTTTTTAATGAAAGTGCATAGCAGCAATTATCAAATTTGTGGTTTTACCTCTTCAGTTTCAGAA
GAAGAACTCACCGAACTAGGTCAAGAAATGAATGTACCTGTAGTCACTGATTTAGGCAGCGGCGCATTAGTTGATTTAAG
CCAATATGGCTTACCAAAAGAACCAACCGTGCAAGAAAAAATCGCACAAGGTGTGGATTTGGTCTCTTTCTCTGGCGATA
AATTACTTGGTGGCGTGCAAGCAGGCATTATTGTGGGTAAAAAAGAATGGATCGAACAATTACAAGCCCATCCTCTCAAG
CGTGTATTACGTTGCGATAAAGTCATTTTAGCTGGCTTAGAAGCCACATTACGTTTGTATTTAAATCCTGAAAAACTAAC
CGAAAAGTTACCAACTTTGCGCTTACTCACGCAACCATTAAAACAACTCAAAATAAATGCTATGCGTCTCAAAGAGCGGT
TAGAATCTCGCTTAAATTCACAATTTGAGCTTCAAATTGAAGCTAGTCAAGCACAAATCGGTAGTGGCTCACAACCAATG
GAAAGAATCCCTTCCGTGGCTGTTACGATTGCAGAAAAAACAAACGCAAAACTTTCCGCACTTTCAGCTCGCTTTAAACA
ACTTTCCCAACCTATTATTGGGCGAATGGAAAACGGAAAAATTTGGCTAGATTTACGTAGCCTCGCGGATATTGAAACAT
TATTAAATACATTGGACGAACTATGA

Upstream 100 bases:

>100_bases
CTGCCACCTCACCGGAGATGACGCCCCTCCGTGGTTGAAATTGCGGTCACTTTAGCGTAAATTAATTGGCAATTCAACGT
TATTTTAAACGGATTCAAAA

Downstream 100 bases:

>100_bases
TTATTGTTACTTCAGGTCACGTTGATCACGGCAAAACAGCATTATTAAAAGCATTAACTGGCACAAGTACCGCACATTTA
CCAGAAGAAAAAAAACGCGG

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTALFQQLPSVDKILKTPQGLQLITEFGHTAVVATCRELLTQARQFIKKNNQLPEYFSNFDRTFLEIHSHLQKQNQVQIK
AVHNLTGTVLHTNLGRALWSEAAQQAALSAMQKNVSLEYDLDEGKRSHRDNYISELLCKLTGAEAACIVNNNAAAVLLML
ATFAQGKEVIISRGELIEIGGAFRIPDIMEQAGCHLVEVGTTNRTHLKDYRNAITENTAFLMKVHSSNYQICGFTSSVSE
EELTELGQEMNVPVVTDLGSGALVDLSQYGLPKEPTVQEKIAQGVDLVSFSGDKLLGGVQAGIIVGKKEWIEQLQAHPLK
RVLRCDKVILAGLEATLRLYLNPEKLTEKLPTLRLLTQPLKQLKINAMRLKERLESRLNSQFELQIEASQAQIGSGSQPM
ERIPSVAVTIAEKTNAKLSALSARFKQLSQPIIGRMENGKIWLDLRSLADIETLLNTLDEL

Sequences:

>Translated_461_residues
MTALFQQLPSVDKILKTPQGLQLITEFGHTAVVATCRELLTQARQFIKKNNQLPEYFSNFDRTFLEIHSHLQKQNQVQIK
AVHNLTGTVLHTNLGRALWSEAAQQAALSAMQKNVSLEYDLDEGKRSHRDNYISELLCKLTGAEAACIVNNNAAAVLLML
ATFAQGKEVIISRGELIEIGGAFRIPDIMEQAGCHLVEVGTTNRTHLKDYRNAITENTAFLMKVHSSNYQICGFTSSVSE
EELTELGQEMNVPVVTDLGSGALVDLSQYGLPKEPTVQEKIAQGVDLVSFSGDKLLGGVQAGIIVGKKEWIEQLQAHPLK
RVLRCDKVILAGLEATLRLYLNPEKLTEKLPTLRLLTQPLKQLKINAMRLKERLESRLNSQFELQIEASQAQIGSGSQPM
ERIPSVAVTIAEKTNAKLSALSARFKQLSQPIIGRMENGKIWLDLRSLADIETLLNTLDEL
>Mature_460_residues
TALFQQLPSVDKILKTPQGLQLITEFGHTAVVATCRELLTQARQFIKKNNQLPEYFSNFDRTFLEIHSHLQKQNQVQIKA
VHNLTGTVLHTNLGRALWSEAAQQAALSAMQKNVSLEYDLDEGKRSHRDNYISELLCKLTGAEAACIVNNNAAAVLLMLA
TFAQGKEVIISRGELIEIGGAFRIPDIMEQAGCHLVEVGTTNRTHLKDYRNAITENTAFLMKVHSSNYQICGFTSSVSEE
ELTELGQEMNVPVVTDLGSGALVDLSQYGLPKEPTVQEKIAQGVDLVSFSGDKLLGGVQAGIIVGKKEWIEQLQAHPLKR
VLRCDKVILAGLEATLRLYLNPEKLTEKLPTLRLLTQPLKQLKINAMRLKERLESRLNSQFELQIEASQAQIGSGSQPME
RIPSVAVTIAEKTNAKLSALSARFKQLSQPIIGRMENGKIWLDLRSLADIETLLNTLDEL

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis [H]

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family [H]

Homologues:

Organism=Escherichia coli, GI2367248, Length=458, Percent_Identity=58.296943231441, Blast_Score=513, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534 [H]

Pfam domain/function: PF03841 SelA [H]

EC number: =2.9.1.1 [H]

Molecular weight: Translated: 51128; Mature: 50997

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALFQQLPSVDKILKTPQGLQLITEFGHTAVVATCRELLTQARQFIKKNNQLPEYFSNF
CCCHHHHCCCHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
DRTFLEIHSHLQKQNQVQIKAVHNLTGTVLHTNLGRALWSEAAQQAALSAMQKNVSLEYD
HHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
LDEGKRSHRDNYISELLCKLTGAEAACIVNNNAAAVLLMLATFAQGKEVIISRGELIEIG
CCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCEEEEC
GAFRIPDIMEQAGCHLVEVGTTNRTHLKDYRNAITENTAFLMKVHSSNYQICGFTSSVSE
CCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCH
EELTELGQEMNVPVVTDLGSGALVDLSQYGLPKEPTVQEKIAQGVDLVSFSGDKLLGGVQ
HHHHHHHHHCCCCEEEECCCCCEEEHHHCCCCCCCCHHHHHHCCCCEEECCCCHHHCCHH
AGIIVGKKEWIEQLQAHPLKRVLRCDKVILAGLEATLRLYLNPEKLTEKLPTLRLLTQPL
HCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHCCHHHHHHHHH
KQLKINAMRLKERLESRLNSQFELQIEASQAQIGSGSQPMERIPSVAVTIAEKTNAKLSA
HHHHHHHHHHHHHHHHHCCCEEEEEEEECHHCCCCCCCHHHHCCCEEEEEEHHCCCHHHH
LSARFKQLSQPIIGRMENGKIWLDLRSLADIETLLNTLDEL
HHHHHHHHCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TALFQQLPSVDKILKTPQGLQLITEFGHTAVVATCRELLTQARQFIKKNNQLPEYFSNF
CCHHHHCCCHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
DRTFLEIHSHLQKQNQVQIKAVHNLTGTVLHTNLGRALWSEAAQQAALSAMQKNVSLEYD
HHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
LDEGKRSHRDNYISELLCKLTGAEAACIVNNNAAAVLLMLATFAQGKEVIISRGELIEIG
CCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCEEEEC
GAFRIPDIMEQAGCHLVEVGTTNRTHLKDYRNAITENTAFLMKVHSSNYQICGFTSSVSE
CCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCH
EELTELGQEMNVPVVTDLGSGALVDLSQYGLPKEPTVQEKIAQGVDLVSFSGDKLLGGVQ
HHHHHHHHHCCCCEEEECCCCCEEEHHHCCCCCCCCHHHHHHCCCCEEECCCCHHHCCHH
AGIIVGKKEWIEQLQAHPLKRVLRCDKVILAGLEATLRLYLNPEKLTEKLPTLRLLTQPL
HCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHCCHHHHHHHHH
KQLKINAMRLKERLESRLNSQFELQIEASQAQIGSGSQPMERIPSVAVTIAEKTNAKLSA
HHHHHHHHHHHHHHHHHCCCEEEEEEEECHHCCCCCCCHHHHCCCEEEEEEHHCCCHHHH
LSARFKQLSQPIIGRMENGKIWLDLRSLADIETLLNTLDEL
HHHHHHHHCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA