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The map label for this gene is ppx

Identifier: 16272637

GI number: 16272637

Start: 739234

End: 740205

Strand: Reverse

Name: ppx

Synonym: HI0695

Alternate gene names: 16272637

Gene position: 740205-739234 (Counterclockwise)

Preceding gene: 16272638

Following gene: 16272634

Centisome position: 40.45

GC content: 42.59

Gene sequence:

>972_bases
ATGAACGACTCTATTTTAGAACCCAAACATCGTGGCAATGTACGTGAAATTGCCGCAATTGATCTTGGCTCAAACAGCTT
TCATATGATTGTTGCGCGTATTGTAAACGGCTCAATCCAAGTGCTTTCGCGCTTAAAACAAAAAGTTAAACTCGCAGAAG
GCTTAGATGAAAATGCGGTGCTTAATCAAGAGGCCATCACACGTGGCGTGAATTGCTTAGCCTTATTTGCTGAACGTTTA
CAAGGTTTTCCTATGGAAAACGTCAATGTAGTTGGCACTTATACGTTACGAAGAGCGGTGAATAATGACGAATTTTTACG
TCAAGCAGCCAAAGTTTTCCCCTATCCCATTAATATTATTAGTGGGCAAACGGAAGCTAAAACCATCTACGCTGGTGTAT
GCCATACTCAGCCAGAAAAAGGCAGAAAGCTTGTTATAGATATTGGTGGTGGCTCGACAGAAATGATTATCGGCGATGAT
TTCACGCCGCTTATGGCTGAAAGCCGACATATGGGATGCGTGAGTTTTGCGACTCAATTTTTTACCGATGGCATCATTTC
CCCAGAAAACTTTCAACGCGCGCGCCAAAGTGCGGTCAATAAAATCGAAGATTTAGGCCTTGAATATCGCAAATTAGGTT
GGCAATCTGTGCTCGGCTCATCGGGGACGATTAAAACTGTTGCGCAAGTCATTGCGACTAATCTCGATCCAAATGGAACC
ATTACAGCCGAGCGATTAAATGCTCTAATTGAACAAACACTACAAGCCAAGCATTTTACCGAGCTAAATATTAACGGTTT
AAACCAAGACCGCGTGGATGTTTTTGTACCCGGTTTAGCGATTTTAAGTGCAGTGTTTGACGTTTTTCATATTCAACAAA
TGCGCTATTCTGACGGTGCATTGCGCGAAGGCGTCATTTATAGCCTAGAAAAAAATTTCCAAGTTGCAGATATTCGAGCG
AGCACCGCTTGA

Upstream 100 bases:

>100_bases
ACATTACGTTATCGCCTAATGCCACAGCTTTATTTTCAATCCGTTTCTAGCACAAACCAAGTGTTTGATTTGCTTTATAA
ATTTGAATTTTAGGAATGTT

Downstream 100 bases:

>100_bases
GGGTTAAGTGAGCAATTCAATATTGACCAAGCTCAAGCTCATCGCGTTGCGGATAGTGCTAATTTACTCAGTGCGCAATA
TTTATGGGAGAAAAATTTAG

Product: exopolyphosphatase

Products: NA

Alternate protein names: Metaphosphatase

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MNDSILEPKHRGNVREIAAIDLGSNSFHMIVARIVNGSIQVLSRLKQKVKLAEGLDENAVLNQEAITRGVNCLALFAERL
QGFPMENVNVVGTYTLRRAVNNDEFLRQAAKVFPYPINIISGQTEAKTIYAGVCHTQPEKGRKLVIDIGGGSTEMIIGDD
FTPLMAESRHMGCVSFATQFFTDGIISPENFQRARQSAVNKIEDLGLEYRKLGWQSVLGSSGTIKTVAQVIATNLDPNGT
ITAERLNALIEQTLQAKHFTELNINGLNQDRVDVFVPGLAILSAVFDVFHIQQMRYSDGALREGVIYSLEKNFQVADIRA
STA

Sequences:

>Translated_323_residues
MNDSILEPKHRGNVREIAAIDLGSNSFHMIVARIVNGSIQVLSRLKQKVKLAEGLDENAVLNQEAITRGVNCLALFAERL
QGFPMENVNVVGTYTLRRAVNNDEFLRQAAKVFPYPINIISGQTEAKTIYAGVCHTQPEKGRKLVIDIGGGSTEMIIGDD
FTPLMAESRHMGCVSFATQFFTDGIISPENFQRARQSAVNKIEDLGLEYRKLGWQSVLGSSGTIKTVAQVIATNLDPNGT
ITAERLNALIEQTLQAKHFTELNINGLNQDRVDVFVPGLAILSAVFDVFHIQQMRYSDGALREGVIYSLEKNFQVADIRA
STA
>Mature_323_residues
MNDSILEPKHRGNVREIAAIDLGSNSFHMIVARIVNGSIQVLSRLKQKVKLAEGLDENAVLNQEAITRGVNCLALFAERL
QGFPMENVNVVGTYTLRRAVNNDEFLRQAAKVFPYPINIISGQTEAKTIYAGVCHTQPEKGRKLVIDIGGGSTEMIIGDD
FTPLMAESRHMGCVSFATQFFTDGIISPENFQRARQSAVNKIEDLGLEYRKLGWQSVLGSSGTIKTVAQVIATNLDPNGT
ITAERLNALIEQTLQAKHFTELNINGLNQDRVDVFVPGLAILSAVFDVFHIQQMRYSDGALREGVIYSLEKNFQVADIRA
STA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family

Homologues:

Organism=Escherichia coli, GI1788848, Length=318, Percent_Identity=55.0314465408805, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI48994966, Length=306, Percent_Identity=43.1372549019608, Blast_Score=243, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPX_HAEIN (P44828)

Other databases:

- EMBL:   L42023
- PIR:   C64087
- RefSeq:   NP_438855.1
- ProteinModelPortal:   P44828
- SMR:   P44828
- GeneID:   950213
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0695
- NMPDR:   fig|71421.1.peg.665
- TIGR:   HI_0695
- HOGENOM:   HBG451789
- OMA:   LPILGHP
- ProtClustDB:   CLSK808440
- BioCyc:   HINF71421:HI_0695-MONOMER
- BRENDA:   3.6.1.11
- InterPro:   IPR022371
- InterPro:   IPR003695
- TIGRFAMs:   TIGR03706

Pfam domain/function: PF02541 Ppx-GppA

EC number: =3.6.1.11

Molecular weight: Translated: 35566; Mature: 35566

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSILEPKHRGNVREIAAIDLGSNSFHMIVARIVNGSIQVLSRLKQKVKLAEGLDENAV
CCCCCCCCHHCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHH
LNQEAITRGVNCLALFAERLQGFPMENVNVVGTYTLRRAVNNDEFLRQAAKVFPYPINII
CCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHCCCHHHHHHHHHHCCCCEEEE
SGQTEAKTIYAGVCHTQPEKGRKLVIDIGGGSTEMIIGDDFTPLMAESRHMGCVSFATQF
CCCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHCCCCCHHHHHHHHH
FTDGIISPENFQRARQSAVNKIEDLGLEYRKLGWQSVLGSSGTIKTVAQVIATNLDPNGT
HHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
ITAERLNALIEQTLQAKHFTELNINGLNQDRVDVFVPGLAILSAVFDVFHIQQMRYSDGA
EEHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHEEECHHHHHHHHHHHHHHHHHHCCCCC
LREGVIYSLEKNFQVADIRASTA
HHCCEEEEECCCCEEEEEEECCC
>Mature Secondary Structure
MNDSILEPKHRGNVREIAAIDLGSNSFHMIVARIVNGSIQVLSRLKQKVKLAEGLDENAV
CCCCCCCCHHCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHH
LNQEAITRGVNCLALFAERLQGFPMENVNVVGTYTLRRAVNNDEFLRQAAKVFPYPINII
CCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHCCCHHHHHHHHHHCCCCEEEE
SGQTEAKTIYAGVCHTQPEKGRKLVIDIGGGSTEMIIGDDFTPLMAESRHMGCVSFATQF
CCCCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCHHHHCCCCCHHHHHHHHH
FTDGIISPENFQRARQSAVNKIEDLGLEYRKLGWQSVLGSSGTIKTVAQVIATNLDPNGT
HHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
ITAERLNALIEQTLQAKHFTELNINGLNQDRVDVFVPGLAILSAVFDVFHIQQMRYSDGA
EEHHHHHHHHHHHHHHHHCCEEECCCCCCCCHHEEECHHHHHHHHHHHHHHHHHHCCCCC
LREGVIYSLEKNFQVADIRASTA
HHCCEEEEECCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800