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The map label for this gene is pepD

Identifier: 16272617

GI number: 16272617

Start: 717269

End: 718723

Strand: Direct

Name: pepD

Synonym: HI0675

Alternate gene names: 16272617

Gene position: 717269-718723 (Clockwise)

Preceding gene: 16272612

Following gene: 16272620

Centisome position: 39.19

GC content: 40.27

Gene sequence:

>1455_bases
ATGTCTGAAATTACAACACTTCAACCTTCACTGTTATGGAAATGGTTCGATCAAATTTGTGCAATCCCTCATCCTTCTCA
TTATGAAGATACGTTAGCTAACTTTATTGTAAATTGGGCAAAAGAAAAGCATTTTTTTGTTGAACGCGATGAAGTAGGTA
ATGTCCTCATTCGTAAACCTGCAACAAAAGGAATGGAAAATCACACGCCTGTTGTGCTACAAGCCCATCTAGATATGGTG
CCACAGGCTAATGAAGGCAATCCACATGATTTTACCAAAGATCCAATTCAACCTTATATCGATGGAGAATGGGTGAAAGC
ACGAGGTACCACACTAGGGTCTGACAATGGTATCGGTTTAGCCTCTACTTTAGCGGTGTTAGAAAGCAATGATTTAGCCC
ATCCACCTCTTGAAGTGCTTTTAACAATGACAGAAGAAACAGGCATGGATGGCGCAAAAGGCTTACGTCATAACTGGTTA
CAATCTGAAATTTTAATCAATACAGATACCGAAGAAATTGGCGAAATTTACATTGGTTGTGCGGGCGGGATTAACGCAAA
CTTTGAAATTCCCGTTCAATATGAAACTAATACGTTTGAGCACAGTGCACAAATCACCCTTAAAGGTTTACGTGGCGGCC
ACTCTGGCGGTGATATCCATACAGGGCGCGCAAATGCAATTAAAGTGTTAGCGCGAGTATTAGCAAAACTCTCTCAAAAT
CAACCGCACTTTGCTCTCTCTGAAATTCGTGGTGGCTCAATTCGTAATGCAATTCCTCGAGAAGCAGCAGCTGTGTTAGC
CTTTAATGGCGATGTAAAAACCATAGAAAGTGCGGTAGAAAATCTCGCGGTTGTGCTTAAAGAAGAATTAGCAATTGCAG
AACCTAATTTCACACTTTTTGTAGAATCCGCAGAAAAAGCCCCTACCGTATTCACCGCACAAAGTACTCAAACGGTTATT
AACGCACTCAACGTATTGCCAAACGGCGTAATCCGCAATAGTGATGTAGTTAAAAATGTCGTAGAAAGTTCATTAAGCGT
TGGCGTATTGAAAACAGAAGGTAATGTTGTAAAAAGCACCATTTTAGTTCGTTCATTAATTGAAAGCGGTAAATATTACG
TAACTGAAATGCTTAGCTCACTTGCAATCTTAGCAAATGCAAAAGTCGAGTTTTCTGCACCTTATCCAGGCTGGCAACCT
GTAAATGACTCTACTATCTTAGACGTTACTCGCAAACATTATGCTGAAGTGCTAGGCGAGCAACCTGTAGTGAAAGTCAT
TCACGCAGGATTAGAATGTGGTCTTTTAAAAGAACATTATCCAAACATTGAAATGATTTCTGTTGGGCCAACAATACGAA
ATGCTCACTCACCAGATGAAAAAGTGGAAATCGCAACAGTACAAACCTATTGGGATTTATTGACAAGAGTACTTGCCGAT
ATTCCTGCGAAGTAA

Upstream 100 bases:

>100_bases
TAGTTTAAATTTATCGAGAAATAAAAAATTGCGTAAGGATAACCCGAAATGGCGTTTTATGCTATTATTTCGTCAATATT
TTCAGTAAAAAGGAGCAATT

Downstream 100 bases:

>100_bases
TCTAATATTAATTAAAAGTGCGGTTAAAATTTCTTTTGTTTTAACCGCTCCTTTATTTTTTTCGTTTCGCTCTTGGGTGC
GCCTGATCGTACACTTCTGC

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSEITTLQPSLLWKWFDQICAIPHPSHYEDTLANFIVNWAKEKHFFVERDEVGNVLIRKPATKGMENHTPVVLQAHLDMV
PQANEGNPHDFTKDPIQPYIDGEWVKARGTTLGSDNGIGLASTLAVLESNDLAHPPLEVLLTMTEETGMDGAKGLRHNWL
QSEILINTDTEEIGEIYIGCAGGINANFEIPVQYETNTFEHSAQITLKGLRGGHSGGDIHTGRANAIKVLARVLAKLSQN
QPHFALSEIRGGSIRNAIPREAAAVLAFNGDVKTIESAVENLAVVLKEELAIAEPNFTLFVESAEKAPTVFTAQSTQTVI
NALNVLPNGVIRNSDVVKNVVESSLSVGVLKTEGNVVKSTILVRSLIESGKYYVTEMLSSLAILANAKVEFSAPYPGWQP
VNDSTILDVTRKHYAEVLGEQPVVKVIHAGLECGLLKEHYPNIEMISVGPTIRNAHSPDEKVEIATVQTYWDLLTRVLAD
IPAK

Sequences:

>Translated_484_residues
MSEITTLQPSLLWKWFDQICAIPHPSHYEDTLANFIVNWAKEKHFFVERDEVGNVLIRKPATKGMENHTPVVLQAHLDMV
PQANEGNPHDFTKDPIQPYIDGEWVKARGTTLGSDNGIGLASTLAVLESNDLAHPPLEVLLTMTEETGMDGAKGLRHNWL
QSEILINTDTEEIGEIYIGCAGGINANFEIPVQYETNTFEHSAQITLKGLRGGHSGGDIHTGRANAIKVLARVLAKLSQN
QPHFALSEIRGGSIRNAIPREAAAVLAFNGDVKTIESAVENLAVVLKEELAIAEPNFTLFVESAEKAPTVFTAQSTQTVI
NALNVLPNGVIRNSDVVKNVVESSLSVGVLKTEGNVVKSTILVRSLIESGKYYVTEMLSSLAILANAKVEFSAPYPGWQP
VNDSTILDVTRKHYAEVLGEQPVVKVIHAGLECGLLKEHYPNIEMISVGPTIRNAHSPDEKVEIATVQTYWDLLTRVLAD
IPAK
>Mature_483_residues
SEITTLQPSLLWKWFDQICAIPHPSHYEDTLANFIVNWAKEKHFFVERDEVGNVLIRKPATKGMENHTPVVLQAHLDMVP
QANEGNPHDFTKDPIQPYIDGEWVKARGTTLGSDNGIGLASTLAVLESNDLAHPPLEVLLTMTEETGMDGAKGLRHNWLQ
SEILINTDTEEIGEIYIGCAGGINANFEIPVQYETNTFEHSAQITLKGLRGGHSGGDIHTGRANAIKVLARVLAKLSQNQ
PHFALSEIRGGSIRNAIPREAAAVLAFNGDVKTIESAVENLAVVLKEELAIAEPNFTLFVESAEKAPTVFTAQSTQTVIN
ALNVLPNGVIRNSDVVKNVVESSLSVGVLKTEGNVVKSTILVRSLIESGKYYVTEMLSSLAILANAKVEFSAPYPGWQPV
NDSTILDVTRKHYAEVLGEQPVVKVIHAGLECGLLKEHYPNIEMISVGPTIRNAHSPDEKVEIATVQTYWDLLTRVLADI
PAK

Specific function: Dipeptidase with broad substrate specificity

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family

Homologues:

Organism=Escherichia coli, GI1786432, Length=487, Percent_Identity=56.8788501026694, Blast_Score=548, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPD_HAEIN (P44817)

Other databases:

- EMBL:   L42023
- PIR:   E64085
- RefSeq:   NP_438835.1
- ProteinModelPortal:   P44817
- SMR:   P44817
- MEROPS:   M20.007
- GeneID:   950737
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0675
- NMPDR:   fig|71421.1.peg.645
- TIGR:   HI_0675
- HOGENOM:   HBG354460
- OMA:   VERIWRF
- ProtClustDB:   CLSK870469
- BioCyc:   HINF71421:HI_0675-MONOMER
- BRENDA:   3.4.13.3
- GO:   GO:0006508
- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160
- PANTHER:   PTHR11014:SF2
- PIRSF:   PIRSF016599
- PRINTS:   PR00934
- TIGRFAMs:   TIGR01893

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20

EC number: =3.4.13.3

Molecular weight: Translated: 52889; Mature: 52758

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: ACT_SITE 78-78 ACT_SITE 145-145

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEITTLQPSLLWKWFDQICAIPHPSHYEDTLANFIVNWAKEKHFFVERDEVGNVLIRKP
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHCCEEEECC
ATKGMENHTPVVLQAHLDMVPQANEGNPHDFTKDPIQPYIDGEWVKARGTTLGSDNGIGL
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCH
ASTLAVLESNDLAHPPLEVLLTMTEETGMDGAKGLRHNWLQSEILINTDTEEIGEIYIGC
HHHHHHHCCCCCCCCCHHHEEEEHHHCCCCHHHHHHHHCCCCEEEEECCHHHHCCEEEEE
AGGINANFEIPVQYETNTFEHSAQITLKGLRGGHSGGDIHTGRANAIKVLARVLAKLSQN
CCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
QPHFALSEIRGGSIRNAIPREAAAVLAFNGDVKTIESAVENLAVVLKEELAIAEPNFTLF
CCCEEHHHCCCCCHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHEECCCEEEE
VESAEKAPTVFTAQSTQTVINALNVLPNGVIRNSDVVKNVVESSLSVGVLKTEGNVVKST
EECCCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHH
ILVRSLIESGKYYVTEMLSSLAILANAKVEFSAPYPGWQPVNDSTILDVTRKHYAEVLGE
HHHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
QPVVKVIHAGLECGLLKEHYPNIEMISVGPTIRNAHSPDEKVEIATVQTYWDLLTRVLAD
CHHHHHHHCCCCCCCHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
IPAK
CCCC
>Mature Secondary Structure 
SEITTLQPSLLWKWFDQICAIPHPSHYEDTLANFIVNWAKEKHFFVERDEVGNVLIRKP
CCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHCCEEEECC
ATKGMENHTPVVLQAHLDMVPQANEGNPHDFTKDPIQPYIDGEWVKARGTTLGSDNGIGL
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCH
ASTLAVLESNDLAHPPLEVLLTMTEETGMDGAKGLRHNWLQSEILINTDTEEIGEIYIGC
HHHHHHHCCCCCCCCCHHHEEEEHHHCCCCHHHHHHHHCCCCEEEEECCHHHHCCEEEEE
AGGINANFEIPVQYETNTFEHSAQITLKGLRGGHSGGDIHTGRANAIKVLARVLAKLSQN
CCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
QPHFALSEIRGGSIRNAIPREAAAVLAFNGDVKTIESAVENLAVVLKEELAIAEPNFTLF
CCCEEHHHCCCCCHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHEECCCEEEE
VESAEKAPTVFTAQSTQTVINALNVLPNGVIRNSDVVKNVVESSLSVGVLKTEGNVVKST
EECCCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHH
ILVRSLIESGKYYVTEMLSSLAILANAKVEFSAPYPGWQPVNDSTILDVTRKHYAEVLGE
HHHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
QPVVKVIHAGLECGLLKEHYPNIEMISVGPTIRNAHSPDEKVEIATVQTYWDLLTRVLAD
CHHHHHHHCCCCCCCHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHH
IPAK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800