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The map label for this gene is sun

Identifier: 16272567

GI number: 16272567

Start: 664167

End: 665522

Strand: Direct

Name: sun

Synonym: HI0624

Alternate gene names: 16272567

Gene position: 664167-665522 (Clockwise)

Preceding gene: 16272566

Following gene: 16272568

Centisome position: 36.29

GC content: 40.86

Gene sequence:

>1356_bases
ATGAAAAAATTCTCTTCTAAAACTATCAAAGCAAAAAATTCAGTAAAAATGACCGCACTTTCGACCAGGGCTATTGCTGC
AAACTTAATTTTGCAAGTATTGGATGAGGGCAAATCATTGTCAGCGTTAATTCCAGAAGTGCAACTTTCTGTAAAAGCTC
AAGATTTGCCTTTACTACAAGAAATTTGTTTTGGCGTGTGTCGAGTATTGCCTCGCTTAGAGCAAATTATCAAACGTCTT
GTGGATAAGCCGCTTAAAGGTAAAACTCGCATTGTTCATTGCCTGTTACTTGTAGGGTTATACCAATTGCTTTATATGCG
AGTGCCTGCTCATGCGGCAGTTGATGAGGTTGTGAACGCAACAAAATCATTAAAATCTGATAGTTTTAGAGGATTAGTGA
ATGCGGTTTTGCGTAGATTTTTACGTGAACAAGATGAAATTTTGGCAATTATCGATAAAAATTGGCAAACGCTTCACCCT
GAATGGTTCGTGAATAAATTAAAAAAAGCCTATCCGAATTGGCGTGAGATCATTGAGGCGAACAATCAGAAACCACCAAT
GTGGCTACGTGTGAATTCACAAAAAAACGCCCTCGAAACTTACCGCACTTTACTTGAAGAACAAGGTGTTTCTTCGAAAA
CAAGCCATCATCCTAATGCGCTATGTTTAGATATACCGATTGCGGTGCAAAAATTACCACACTTTGAAGAAGGGGCGGTT
ACGGTGCAAGATTTGAGTGCTCAATGGGCGGCAACGTTGCTTGAGCCAAAAAATGAGGAGTGGATCCTCGATGCTTGCGC
GGCACCAGGCGGTAAGACGACCCATATTTTAGAACTGGCACCTCAAGCTAATGTGATTGCATTAGATGTAGAATCTCATC
GCTTAAAACGAGTAGAAGAAAATCTTGAACGTTTAAATCAGCAAGCGATAGTGGTGTGTGGTGATGCGAGTAAACCTGAC
GAATGGTTAGCTGAAATCGGTAAAAGTGCGGCGAAATTTGACCGAATTTTACTTGATGCGCCTTGTTCTGCAACGGGGGT
GATTCGCCGCCACCCTGATATAAAATGGTTACGCAAAGAAACCGATATCGCTCAGCTCGTTGAATTACAGAAGAAAATTT
TGAGTGCACTTTGGGAAAAACTGAAGCCAAACGGTGTTTTGCTTTATGCGACTTGTTCTGTATTGCCAGAAGAAAATTGC
GAACAAATCCAAGCATTTTTAAATGCTCACGCAGATGCGGAGTTATTGTCATTGCCCTTTAGTGATGATAAAAGTGCGGT
GGGTTTTCAATTTATTCCGCAACCAAATAGTGGCGATGGGTTCTATTATGCGAAATTGCTTAAACGAGCATCATAA

Upstream 100 bases:

>100_bases
ACTTATTGCAATTACAATCTGCAGGTAAAAAGCCTATGTCTGCACAAGATTTATTAAATGGCCGTGCAGAATGGTTTACT
ATTGGTAAGGTGCTTGCATA

Downstream 100 bases:

>100_bases
AGGAGGGTGATAATGAAAATTATCATTTTGGGTGCAGGTCAGGTAGGAACGACGCTTGCAGAAAACTTAGTCAGTGAAGA
TAACGATATTACCTTAGTGG

Product: sun protein

Products: NA

Alternate protein names: 16S rRNA m5C967 methyltransferase; rRNA (cytosine-C(5)-)-methyltransferase rsmB

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKKFSSKTIKAKNSVKMTALSTRAIAANLILQVLDEGKSLSALIPEVQLSVKAQDLPLLQEICFGVCRVLPRLEQIIKRL
VDKPLKGKTRIVHCLLLVGLYQLLYMRVPAHAAVDEVVNATKSLKSDSFRGLVNAVLRRFLREQDEILAIIDKNWQTLHP
EWFVNKLKKAYPNWREIIEANNQKPPMWLRVNSQKNALETYRTLLEEQGVSSKTSHHPNALCLDIPIAVQKLPHFEEGAV
TVQDLSAQWAATLLEPKNEEWILDACAAPGGKTTHILELAPQANVIALDVESHRLKRVEENLERLNQQAIVVCGDASKPD
EWLAEIGKSAAKFDRILLDAPCSATGVIRRHPDIKWLRKETDIAQLVELQKKILSALWEKLKPNGVLLYATCSVLPEENC
EQIQAFLNAHADAELLSLPFSDDKSAVGFQFIPQPNSGDGFYYAKLLKRAS

Sequences:

>Translated_451_residues
MKKFSSKTIKAKNSVKMTALSTRAIAANLILQVLDEGKSLSALIPEVQLSVKAQDLPLLQEICFGVCRVLPRLEQIIKRL
VDKPLKGKTRIVHCLLLVGLYQLLYMRVPAHAAVDEVVNATKSLKSDSFRGLVNAVLRRFLREQDEILAIIDKNWQTLHP
EWFVNKLKKAYPNWREIIEANNQKPPMWLRVNSQKNALETYRTLLEEQGVSSKTSHHPNALCLDIPIAVQKLPHFEEGAV
TVQDLSAQWAATLLEPKNEEWILDACAAPGGKTTHILELAPQANVIALDVESHRLKRVEENLERLNQQAIVVCGDASKPD
EWLAEIGKSAAKFDRILLDAPCSATGVIRRHPDIKWLRKETDIAQLVELQKKILSALWEKLKPNGVLLYATCSVLPEENC
EQIQAFLNAHADAELLSLPFSDDKSAVGFQFIPQPNSGDGFYYAKLLKRAS
>Mature_451_residues
MKKFSSKTIKAKNSVKMTALSTRAIAANLILQVLDEGKSLSALIPEVQLSVKAQDLPLLQEICFGVCRVLPRLEQIIKRL
VDKPLKGKTRIVHCLLLVGLYQLLYMRVPAHAAVDEVVNATKSLKSDSFRGLVNAVLRRFLREQDEILAIIDKNWQTLHP
EWFVNKLKKAYPNWREIIEANNQKPPMWLRVNSQKNALETYRTLLEEQGVSSKTSHHPNALCLDIPIAVQKLPHFEEGAV
TVQDLSAQWAATLLEPKNEEWILDACAAPGGKTTHILELAPQANVIALDVESHRLKRVEENLERLNQQAIVVCGDASKPD
EWLAEIGKSAAKFDRILLDAPCSATGVIRRHPDIKWLRKETDIAQLVELQKKILSALWEKLKPNGVLLYATCSVLPEENC
EQIQAFLNAHADAELLSLPFSDDKSAVGFQFIPQPNSGDGFYYAKLLKRAS

Specific function: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA

COG id: COG0144

COG function: function code J; tRNA and rRNA cytosine-C5-methylases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmB/NOP family

Homologues:

Organism=Homo sapiens, GI76150625, Length=318, Percent_Identity=30.5031446540881, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI76150623, Length=318, Percent_Identity=30.5031446540881, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI32698918, Length=170, Percent_Identity=37.6470588235294, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI301336155, Length=190, Percent_Identity=32.6315789473684, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI39995082, Length=190, Percent_Identity=32.6315789473684, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI11545785, Length=220, Percent_Identity=29.0909090909091, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI2367212, Length=430, Percent_Identity=51.1627906976744, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI87081985, Length=224, Percent_Identity=28.125, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17536757, Length=321, Percent_Identity=30.8411214953271, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25143471, Length=174, Percent_Identity=33.9080459770115, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI115534021, Length=174, Percent_Identity=32.7586206896552, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71998419, Length=174, Percent_Identity=32.7586206896552, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324268, Length=299, Percent_Identity=30.4347826086957, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6319447, Length=174, Percent_Identity=32.7586206896552, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI22024126, Length=246, Percent_Identity=32.1138211382114, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24668781, Length=232, Percent_Identity=30.6034482758621, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355201, Length=183, Percent_Identity=32.7868852459016, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356513, Length=232, Percent_Identity=30.6034482758621, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19920494, Length=181, Percent_Identity=29.2817679558011, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSMB_HAEIN (P44788)

Other databases:

- EMBL:   L42023
- PIR:   F64155
- RefSeq:   NP_438784.1
- ProteinModelPortal:   P44788
- SMR:   P44788
- GeneID:   949681
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0624
- NMPDR:   fig|71421.1.peg.594
- TIGR:   HI_0624
- HOGENOM:   HBG726909
- OMA:   ANNAHPP
- ProtClustDB:   PRK10901
- BioCyc:   HINF71421:HI_0624-MONOMER
- GO:   GO:0005737
- InterPro:   IPR001678
- InterPro:   IPR018314
- InterPro:   IPR006027
- InterPro:   IPR004573
- Gene3D:   G3DSA:1.10.940.10
- TIGRFAMs:   TIGR00563

Pfam domain/function: PF01189 Nol1_Nop2_Fmu; PF01029 NusB; SSF48013 NusB_RsmB_TIM44

EC number: =2.1.1.176

Molecular weight: Translated: 50598; Mature: 50598

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS01153 NOL1_NOP2_SUN

Important sites: ACT_SITE 392-392 BINDING 289-289 BINDING 315-315 BINDING 339-339

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFSSKTIKAKNSVKMTALSTRAIAANLILQVLDEGKSLSALIPEVQLSVKAQDLPLLQ
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHEEEECCCCHHHH
EICFGVCRVLPRLEQIIKRLVDKPLKGKTRIVHCLLLVGLYQLLYMRVPAHAAVDEVVNA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TKSLKSDSFRGLVNAVLRRFLREQDEILAIIDKNWQTLHPEWFVNKLKKAYPNWREIIEA
HHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECHHHHHHHHHHHCCCHHHHHHC
NNQKPPMWLRVNSQKNALETYRTLLEEQGVSSKTSHHPNALCLDIPIAVQKLPHFEEGAV
CCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHCCCCCCCCE
TVQDLSAQWAATLLEPKNEEWILDACAAPGGKTTHILELAPQANVIALDVESHRLKRVEE
EHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHH
NLERLNQQAIVVCGDASKPDEWLAEIGKSAAKFDRILLDAPCSATGVIRRHPDIKWLRKE
HHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHCCCCHHHHHHH
TDIAQLVELQKKILSALWEKLKPNGVLLYATCSVLPEENCEQIQAFLNAHADAELLSLPF
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCEEECCC
SDDKSAVGFQFIPQPNSGDGFYYAKLLKRAS
CCCCCCCCEEECCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKKFSSKTIKAKNSVKMTALSTRAIAANLILQVLDEGKSLSALIPEVQLSVKAQDLPLLQ
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHEEEECCCCHHHH
EICFGVCRVLPRLEQIIKRLVDKPLKGKTRIVHCLLLVGLYQLLYMRVPAHAAVDEVVNA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TKSLKSDSFRGLVNAVLRRFLREQDEILAIIDKNWQTLHPEWFVNKLKKAYPNWREIIEA
HHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECHHHHHHHHHHHCCCHHHHHHC
NNQKPPMWLRVNSQKNALETYRTLLEEQGVSSKTSHHPNALCLDIPIAVQKLPHFEEGAV
CCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHCCCCCCCCE
TVQDLSAQWAATLLEPKNEEWILDACAAPGGKTTHILELAPQANVIALDVESHRLKRVEE
EHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHH
NLERLNQQAIVVCGDASKPDEWLAEIGKSAAKFDRILLDAPCSATGVIRRHPDIKWLRKE
HHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHCCCCHHHHHHH
TDIAQLVELQKKILSALWEKLKPNGVLLYATCSVLPEENCEQIQAFLNAHADAELLSLPF
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCEEECCC
SDDKSAVGFQFIPQPNSGDGFYYAKLLKRAS
CCCCCCCCEEECCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800