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The map label for this gene is zwf

Identifier: 16272501

GI number: 16272501

Start: 576891

End: 578375

Strand: Reverse

Name: zwf

Synonym: HI0558

Alternate gene names: 16272501

Gene position: 578375-576891 (Counterclockwise)

Preceding gene: 16272502

Following gene: 16272500

Centisome position: 31.6

GC content: 40.88

Gene sequence:

>1485_bases
ATGCAAACTGATAATAATTGTATCGTCATTTTTGGCGCGTCTGGTGACTTAACTCATCGTAAACTCATTCCAGCCCTTTA
TAATCTCTACAAAATCGGGCGTTTGAGTGAAAACTTTTCCGTTCTTGGTGTTGCACGTTCTGACTTGAACGATGAAACTT
TCCGCGAAAAAATGCGTGAGGCGTTAATTCATAATGAAGAAACAACACCAGAAACCTTAGATGCTTTCTGCTCTCATCTT
TATTACCAAGCAGTGAATACTTCGGATGCTCAAGATTACGGCAAACTTGTTCCACGCTTAGACGATCTTCACGATAAATA
TCAAACCTGTGGTAACACCTTTTACTATATGTCCACTCCACCAAGTCTTTATGGCGTGATTCCTGAGTGTTTGGCTGCAC
ATGGTTTAAATACGGAAGAATATGGCTGGAAACGTATTATCGTTGAAAAACCTTTTGGTTACGATGAAAAAACAGCGCAA
ACATTAGACGTACAAATCCACCGTTTCTTTGAAGAACACCAAATTTATCGTATCGATCATTATTTAGGTAAAGAAACCGT
TCAAAACTTGCTCGTATTACGTTTTTCAAATGGTTGGTTTGAACCGCTTTGGAACCGTAATTTCATTGATTATGTAGAAA
TTACTGGTGCAGAATCTATTGGCGTGGAAGAGCGCGGGGGCTATTATGATGGTTCTGGCGCAATGCGAGATATGTTCCAA
AACCATTTATTGCAAGTGTTAGCGATGGTGGCAATGGAGCCGCCAGCGATTATTAACGCGAATTCAATGCGTGATGAAGT
AGCAAAAGTGATGCATAGTTTGCGTCCATTAACTTCGGAGGATATGGAGAATAACCTTGTTTTGGGTCAATACACAGCGG
CTGAAATTAACGGCAAAATGGAAAAAGGCTATCTAGAAGAAAAAGGCGTACCGGCAAATTCTCGTACTGAAACCTACATC
GCATTACGTTGTGAAATTGAAAACTGGCGTTGGGCTGGTGTGCCGTTCTATGTTCGTACGGGTAAACGCTTACCAGCTCG
TGTGACTGAAATTGTGATCCATTTTAAAACTACGCCACATCCTGTATTCAGCCAAAATGCACCAGAGAATAAATTAATTA
TTCGTATTCAACCTGATGAAGCGATTTCAATGCGTTTTGGTTTGAAAAAACCAGGTGCAGGTTTTGAGGCGAAAGAAGTA
TCAATGGATTTCCGTTATGCAGATTTAGCAGGTGCGCAAGTATTAACCGCTTATGAACGTTTATTGTTGGATGCGATGAA
AGGCGATGCAACCTTGTTTGCTCGTACTGATGCTGTGCATGCCGCATGGAAATTTGTGCAACCGATTTTAGATTACAAAG
CCAATGGTGGTCGTATTCACGAATATGAAGCTGGCACTTGGGGGCCTGTTGCAGCTGATAAATTAATCGCAAAACAAGGC
AAAGTGTGGCGTAAACCAAGTGGATTGATGAAGAAAAAAGTTTAA

Upstream 100 bases:

>100_bases
GCGTTCTATCTTTCAATTTAATTGATTGGTTCGATTGGTTTTTTTCTCTAGAATACGGCATTATTTTCGACATTACTCGG
AAGCCGAATAAGGAATAATT

Downstream 100 bases:

>100_bases
CTAATCTAATGTAGGGTGGGCTTTAGCCACGCTCTTACTAACATAATAAATTGTGGGCTAAAGCCCACCCTACGGAAAAT
CAATGAACTATATCAGCTTC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFREKMREALIHNEETTPETLDAFCSHL
YYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTFYYMSTPPSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQ
TLDVQIHRFFEEHQIYRIDHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQ
NHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKMEKGYLEEKGVPANSRTETYI
ALRCEIENWRWAGVPFYVRTGKRLPARVTEIVIHFKTTPHPVFSQNAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEV
SMDFRYADLAGAQVLTAYERLLLDAMKGDATLFARTDAVHAAWKFVQPILDYKANGGRIHEYEAGTWGPVAADKLIAKQG
KVWRKPSGLMKKKV

Sequences:

>Translated_494_residues
MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFREKMREALIHNEETTPETLDAFCSHL
YYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTFYYMSTPPSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQ
TLDVQIHRFFEEHQIYRIDHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQ
NHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKMEKGYLEEKGVPANSRTETYI
ALRCEIENWRWAGVPFYVRTGKRLPARVTEIVIHFKTTPHPVFSQNAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEV
SMDFRYADLAGAQVLTAYERLLLDAMKGDATLFARTDAVHAAWKFVQPILDYKANGGRIHEYEAGTWGPVAADKLIAKQG
KVWRKPSGLMKKKV
>Mature_494_residues
MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFREKMREALIHNEETTPETLDAFCSHL
YYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTFYYMSTPPSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQ
TLDVQIHRFFEEHQIYRIDHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQ
NHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKMEKGYLEEKGVPANSRTETYI
ALRCEIENWRWAGVPFYVRTGKRLPARVTEIVIHFKTTPHPVFSQNAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEV
SMDFRYADLAGAQVLTAYERLLLDAMKGDATLFARTDAVHAAWKFVQPILDYKANGGRIHEYEAGTWGPVAADKLIAKQG
KVWRKPSGLMKKKV

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=39.7938144329897, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=39.7938144329897, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI52145310, Length=488, Percent_Identity=29.5081967213115, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI1788158, Length=492, Percent_Identity=43.6991869918699, Blast_Score=403, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17538218, Length=482, Percent_Identity=37.344398340249, Blast_Score=326, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6324088, Length=487, Percent_Identity=34.2915811088296, Blast_Score=285, Evalue=8e-78,
Organism=Drosophila melanogaster, GI24643350, Length=476, Percent_Identity=36.9747899159664, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24643352, Length=476, Percent_Identity=36.9747899159664, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=30.1652892561983, Blast_Score=221, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PD_HAEIN (P44311)

Other databases:

- EMBL:   L42023
- PIR:   E64077
- RefSeq:   NP_438715.1
- ProteinModelPortal:   P44311
- SMR:   P44311
- GeneID:   949608
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0558
- NMPDR:   fig|71421.1.peg.528
- TIGR:   HI_0558
- HOGENOM:   HBG322449
- OMA:   SRRWAGV
- ProtClustDB:   PRK05722
- BioCyc:   HINF71421:HI_0558-MONOMER
- BRENDA:   1.1.1.49
- GO:   GO:0005488
- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR23429
- PIRSF:   PIRSF000110
- PRINTS:   PR00079
- TIGRFAMs:   TIGR00871

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N

EC number: =1.1.1.49

Molecular weight: Translated: 56190; Mature: 56190

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: ACT_SITE 242-242 BINDING 14-14 BINDING 46-46 BINDING 180-180 BINDING 184-184

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFREKMRE
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHH
ALIHNEETTPETLDAFCSHLYYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTFYYMSTP
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCCEEEEECCC
PSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQTLDVQIHRFFEEHQIYRIDH
CHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEHHH
YLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQ
HHCHHHHHHEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCHHHHHHHH
NHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKM
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHCCCH
EKGYLEEKGVPANSRTETYIALRCEIENWRWAGVPFYVRTGKRLPARVTEIVIHFKTTPH
HCCCHHHCCCCCCCCCCEEEEEEEEECCCEECCCCEEEECCCCCCCCEEEEEEEEECCCC
PVFSQNAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEVSMDFRYADLAGAQVLTAYER
CCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHEEECEEEHHHHHHHHHHHHHH
LLLDAMKGDATLFARTDAVHAAWKFVQPILDYKANGGRIHEYEAGTWGPVAADKLIAKQG
HHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCC
KVWRKPSGLMKKKV
CCCCCCCCHHHCCC
>Mature Secondary Structure
MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFREKMRE
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHH
ALIHNEETTPETLDAFCSHLYYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTFYYMSTP
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCCEEEEECCC
PSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQTLDVQIHRFFEEHQIYRIDH
CHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEHHH
YLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQ
HHCHHHHHHEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCHHHHHHHH
NHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKM
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHCCCH
EKGYLEEKGVPANSRTETYIALRCEIENWRWAGVPFYVRTGKRLPARVTEIVIHFKTTPH
HCCCHHHCCCCCCCCCCEEEEEEEEECCCEECCCCEEEECCCCCCCCEEEEEEEEECCCC
PVFSQNAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEVSMDFRYADLAGAQVLTAYER
CCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHEEECEEEHHHHHHHHHHHHHH
LLLDAMKGDATLFARTDAVHAAWKFVQPILDYKANGGRIHEYEAGTWGPVAADKLIAKQG
HHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCC
KVWRKPSGLMKKKV
CCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800