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The map label for this gene is tyrP

Identifier: 16272424

GI number: 16272424

Start: 498427

End: 499629

Strand: Direct

Name: tyrP

Synonym: HI0477

Alternate gene names: 16272424

Gene position: 498427-499629 (Clockwise)

Preceding gene: 16272423

Following gene: 16272436

Centisome position: 27.23

GC content: 39.24

Gene sequence:

>1203_bases
ATGAACAAAACTGTAGGCAGCACACTTCTTGTTGCTGGTACGATGATTGGCGCGGGAATGTTGGCTATGCCACTCACTTC
CGCTGGCATTGGCTTCGGCTTTACTTTAGTCTTGTTATTGGGGCTTTGGGCATTATTAACTTTTAGCGCACTTTTATTCG
TTGAACTCTATCAAACTGCGGAAAGTGATGCAGGTATCGGCACACTTGCAGAACAATATTTTGGTAAAACAGGACGCATT
ATTGCCACAGCCGTGCTAATTATTTTCTTATACGCATTAATTGCCGCTTATATCAGCGGTGGCGGTTCACTACTAAAAGA
TTTATTACCAGAAAGTTTTGGCGATAAAGTTAGCGTCTTATTATTTACCGTGATTTTCGGTTCATTTATTGTCATCGGCA
CACATAGCGTAGATAAAATTAATCGCGTGTTATTTTTCGTTATGCTTGCTGCCTTTGCCGTGGTGTTAAGCTTAATGTTG
CCAGAAATCAAATTTGATAACTTAATGGCGACGCCAATTGATAAGGCTTTAATTATCTCTGCAAGCCCTGTATTTTTCAC
GGCATTTGGTTTCCACGGTTCCATTCCAAGTTTAAATAAATACTTAGATGGCAATGTAAAAGCATTGCGCTTCTCTATTT
TGGTCGGCTCTGCCATAACACTTTGTGCTTATATTCTATGGCAACTATCCACGCACGGCTTGCTTACACAAAATGAATTT
TTACAAATCTTAAAAGAAGATGCGACTTTAAATGGCTTAGTAAAAGCAACCTTCGCCATCACTGGAAGCAATGTGATCGC
AAGTGCGGTAAAATTATTTTCTACATTAGCACTTATCACTTCTTTCTTAGGTGTGGGATTAGGATTATTAGAATGTATTG
AAGATTTACTAAAACGTTCATTTAACGTTACAGCAGGTAGAATTTCACTTGGTTTACTGACTTTTATTCCACCACTTGTT
TTTGCATTATTTTACCCAGAAGGTTTTATTTTAGCACTAGGCTACGCAGGTCAAATGTTTGCATTCTACGCCGTAGTATT
GCCAGTTAGCCTTGTTTGGAAAGCTCGTCGTGCCCACGCTAATTTGCCATACAAAGTGTGGGGAGGAAATCTGACTTTAA
TTATCGTATTGGTATTAGGCGTGCTCATTACATCCATTCCATTTGCGATTCGTGCGGGTTATTTACCCTTTGTTGTAGGT
TAA

Upstream 100 bases:

>100_bases
AAGATAGTAAAAAATTCACAATTTATAAATTTTATTTACAGACTGTAAATTATACAATACAATTATCGTAAATTTTTTAT
TACATCATAAGGAAACAAAA

Downstream 100 bases:

>100_bases
AAACAAACTAAAAATTTACCGCACTTTTTATCTAAAAAAGAGTAAATATTGTCCTAATTAATTTAGATAAAAATTTCAGA
CAAAACTTATCATTAATCTT

Product: tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease 1

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNKTVGSTLLVAGTMIGAGMLAMPLTSAGIGFGFTLVLLLGLWALLTFSALLFVELYQTAESDAGIGTLAEQYFGKTGRI
IATAVLIIFLYALIAAYISGGGSLLKDLLPESFGDKVSVLLFTVIFGSFIVIGTHSVDKINRVLFFVMLAAFAVVLSLML
PEIKFDNLMATPIDKALIISASPVFFTAFGFHGSIPSLNKYLDGNVKALRFSILVGSAITLCAYILWQLSTHGLLTQNEF
LQILKEDATLNGLVKATFAITGSNVIASAVKLFSTLALITSFLGVGLGLLECIEDLLKRSFNVTAGRISLGLLTFIPPLV
FALFYPEGFILALGYAGQMFAFYAVVLPVSLVWKARRAHANLPYKVWGGNLTLIIVLVLGVLITSIPFAIRAGYLPFVVG

Sequences:

>Translated_400_residues
MNKTVGSTLLVAGTMIGAGMLAMPLTSAGIGFGFTLVLLLGLWALLTFSALLFVELYQTAESDAGIGTLAEQYFGKTGRI
IATAVLIIFLYALIAAYISGGGSLLKDLLPESFGDKVSVLLFTVIFGSFIVIGTHSVDKINRVLFFVMLAAFAVVLSLML
PEIKFDNLMATPIDKALIISASPVFFTAFGFHGSIPSLNKYLDGNVKALRFSILVGSAITLCAYILWQLSTHGLLTQNEF
LQILKEDATLNGLVKATFAITGSNVIASAVKLFSTLALITSFLGVGLGLLECIEDLLKRSFNVTAGRISLGLLTFIPPLV
FALFYPEGFILALGYAGQMFAFYAVVLPVSLVWKARRAHANLPYKVWGGNLTLIIVLVLGVLITSIPFAIRAGYLPFVVG
>Mature_400_residues
MNKTVGSTLLVAGTMIGAGMLAMPLTSAGIGFGFTLVLLLGLWALLTFSALLFVELYQTAESDAGIGTLAEQYFGKTGRI
IATAVLIIFLYALIAAYISGGGSLLKDLLPESFGDKVSVLLFTVIFGSFIVIGTHSVDKINRVLFFVMLAAFAVVLSLML
PEIKFDNLMATPIDKALIISASPVFFTAFGFHGSIPSLNKYLDGNVKALRFSILVGSAITLCAYILWQLSTHGLLTQNEF
LQILKEDATLNGLVKATFAITGSNVIASAVKLFSTLALITSFLGVGLGLLECIEDLLKRSFNVTAGRISLGLLTFIPPLV
FALFYPEGFILALGYAGQMFAFYAVVLPVSLVWKARRAHANLPYKVWGGNLTLIIVLVLGVLITSIPFAIRAGYLPFVVG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily

Homologues:

Organism=Escherichia coli, GI1788218, Length=401, Percent_Identity=46.8827930174564, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI1790145, Length=385, Percent_Identity=30.6493506493506, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789552, Length=370, Percent_Identity=27.027027027027, Blast_Score=144, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYRPA_HAEIN (P44727)

Other databases:

- EMBL:   L42023
- PIR:   B64071
- RefSeq:   NP_438637.1
- GeneID:   950656
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0477
- NMPDR:   fig|71421.1.peg.450
- TIGR:   HI_0477
- HOGENOM:   HBG482321
- OMA:   SMLFLMY
- ProtClustDB:   CLSK870223
- BioCyc:   HINF71421:HI_0477-MONOMER
- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227
- PRINTS:   PR00166
- TIGRFAMs:   TIGR00837

Pfam domain/function: PF03222 Trp_Tyr_perm

EC number: NA

Molecular weight: Translated: 42760; Mature: 42760

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xbe5c554)-; HASH(0xbc5f6b8)-; HASH(0xbd83a2c)-; HASH(0xcf7b4fc)-; HASH(0xc755a9c)-; HASH(0xc865334)-; HASH(0xccc4d68)-; HASH(0xcdeb4a0)-; HASH(0xcdeb764)-; HASH(0xc655acc)-; HASH(0xbf78fa0)-; HASH(0xcf735d8)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTVGSTLLVAGTMIGAGMLAMPLTSAGIGFGFTLVLLLGLWALLTFSALLFVELYQTA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESDAGIGTLAEQYFGKTGRIIATAVLIIFLYALIAAYISGGGSLLKDLLPESFGDKVSVL
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHH
LFTVIFGSFIVIGTHSVDKINRVLFFVMLAAFAVVLSLMLPEIKFDNLMATPIDKALIIS
HHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEE
ASPVFFTAFGFHGSIPSLNKYLDGNVKALRFSILVGSAITLCAYILWQLSTHGLLTQNEF
CCCHHHEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LQILKEDATLNGLVKATFAITGSNVIASAVKLFSTLALITSFLGVGLGLLECIEDLLKRS
HHHHHHCCHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNVTAGRISLGLLTFIPPLVFALFYPEGFILALGYAGQMFAFYAVVLPVSLVWKARRAHA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
NLPYKVWGGNLTLIIVLVLGVLITSIPFAIRAGYLPFVVG
CCCEEEECCCHHHHHHHHHHHHHHHCCHHHHCCCCCEECH
>Mature Secondary Structure
MNKTVGSTLLVAGTMIGAGMLAMPLTSAGIGFGFTLVLLLGLWALLTFSALLFVELYQTA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESDAGIGTLAEQYFGKTGRIIATAVLIIFLYALIAAYISGGGSLLKDLLPESFGDKVSVL
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHH
LFTVIFGSFIVIGTHSVDKINRVLFFVMLAAFAVVLSLMLPEIKFDNLMATPIDKALIIS
HHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEE
ASPVFFTAFGFHGSIPSLNKYLDGNVKALRFSILVGSAITLCAYILWQLSTHGLLTQNEF
CCCHHHEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LQILKEDATLNGLVKATFAITGSNVIASAVKLFSTLALITSFLGVGLGLLECIEDLLKRS
HHHHHHCCHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNVTAGRISLGLLTFIPPLVFALFYPEGFILALGYAGQMFAFYAVVLPVSLVWKARRAHA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCC
NLPYKVWGGNLTLIIVLVLGVLITSIPFAIRAGYLPFVVG
CCCEEEECCCHHHHHHHHHHHHHHHCCHHHHCCCCCEECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800