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The map label for this gene is pssA

Identifier: 16272373

GI number: 16272373

Start: 447351

End: 448718

Strand: Direct

Name: pssA

Synonym: HI0425

Alternate gene names: 16272373

Gene position: 447351-448718 (Clockwise)

Preceding gene: 16272371

Following gene: 30995374

Centisome position: 24.44

GC content: 37.35

Gene sequence:

>1368_bases
ATGTTAATCAATAAAACCAAACGAGCTGAACAAAATTTAAATAATTTGCCATTCCTTGCTTTGCAAGCTGAGCAAATTGA
ATTTTTGGGTAGCTCGGCTGAATTTAAAACTCAAATTATTGAATTAATCAGAAACGCAAAAAAACGTATTTATGTCACCG
CACTTTATTGGCAAAAAGATGAAGCGGGGCAGGAAATCCTCGATGAAATTTATCGCGTGAAGCAAGAAAATCCACACTTG
GATGTAAAAGTTCTCATAGATTGGCATCGCGCACAACGCAATTTATTAGGAGCGGAAAAATCTGCCACTAATGCAGACTG
GTATTGCGAGCAACGCCAAACTTATCAGTTACCTGATGATCCAAATATGTTCTTTGGCGTGCCAATTAACACACGCGAAG
TTTTTGGTGTATTGCATGTCAAAGGCTTTGTATTTGATGATACGGTGCTTTATAGCGGTGCAAGCATTAATAACGTCTAT
CTTCATCAATTTGAAAAATATCGTTACGACCGCTATCAAAAAATCACTCATGCCGAATTAGCTGATTCGATGGTAAATTT
CATCAATGATTACTTGTTAGATTTCAGTGCAGTTTATCCACTTGATGTGACCAACCGCCCTCGCACCAAAGAGATCCGTG
GCAATATTCGCGCTTATCGTAAAGACCTTGCTCAAAATGGTGAATATTCATTAAAAAGTGCGGTGAAATTACCGAATGTT
TTAAGCGTATCGCCACTGTTTGGCTTAGGCGCATCAGGCAATGAATTAAATCAAGTAATTGAAGATTTATTCTTACAAGT
ACAAAAAAAATTAGTGATTTGTACGCCATATTTTAATTTCCCACGCACATTGCAACATAAAATAGCAACGTTATTGGAAA
ACGGTAAACGAGTAGAAATTATTGTTGGCGATAAAGTCGCAAACGATTTTTACATTCCACCAGAACAACCATTCAAAATG
GCGGGGGCGTTACCTTATCTTTATGAAAGTAATCTTCGCCGTTTCTGTGAAAAATTTGAGACTCAAATTGAAAGTGGTCA
GCTTGTGGTGCGTTTATGGCGTGATGGCGATAATACCTACCACTTAAAAGGTGTGTGGGTAGATGACCGCTATATTTTAC
TCACGGGCAATAATCTTAACCCTCGAGCGTGGCGTTTGGATGCAGAAAATGGCTTATTAATTTACGATCCACAACAACAG
CTTTTAGCCCAAGTGGAAAAAGAGCAAAACCAAATTCGCCAACATACAAAAGTATTAAAACATTACACTGAATTAGAAGA
ATTGAATCAATACCCAGAACCAGTGCAAAAACTTTTGAAAAAATTTGCACGAATTAAAGCAGATAAATTGGTGAAAATGA
TTCTGTAA

Upstream 100 bases:

>100_bases
AAAATTTGTGAGCATTATAACGAAAAAAAGCCTTTTTTCTATTAATAAGCACGTGAAATATTGTAAACTAACGCACTAGT
CTTTAATCACGAGATGGATT

Downstream 100 bases:

>100_bases
TTATAAGAAAAGTTTTATATTTTTTCTTAAATTCGCTTCCAGTATTAATCTGATAAATTTTGTGGCAATCGTTCTAAAAT
GGCTTTCCAATAGGTTGAAG

Product: phosphatidylserine synthase

Products: NA

Alternate protein names: Phosphatidylserine synthase

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MLINKTKRAEQNLNNLPFLALQAEQIEFLGSSAEFKTQIIELIRNAKKRIYVTALYWQKDEAGQEILDEIYRVKQENPHL
DVKVLIDWHRAQRNLLGAEKSATNADWYCEQRQTYQLPDDPNMFFGVPINTREVFGVLHVKGFVFDDTVLYSGASINNVY
LHQFEKYRYDRYQKITHAELADSMVNFINDYLLDFSAVYPLDVTNRPRTKEIRGNIRAYRKDLAQNGEYSLKSAVKLPNV
LSVSPLFGLGASGNELNQVIEDLFLQVQKKLVICTPYFNFPRTLQHKIATLLENGKRVEIIVGDKVANDFYIPPEQPFKM
AGALPYLYESNLRRFCEKFETQIESGQLVVRLWRDGDNTYHLKGVWVDDRYILLTGNNLNPRAWRLDAENGLLIYDPQQQ
LLAQVEKEQNQIRQHTKVLKHYTELEELNQYPEPVQKLLKKFARIKADKLVKMIL

Sequences:

>Translated_455_residues
MLINKTKRAEQNLNNLPFLALQAEQIEFLGSSAEFKTQIIELIRNAKKRIYVTALYWQKDEAGQEILDEIYRVKQENPHL
DVKVLIDWHRAQRNLLGAEKSATNADWYCEQRQTYQLPDDPNMFFGVPINTREVFGVLHVKGFVFDDTVLYSGASINNVY
LHQFEKYRYDRYQKITHAELADSMVNFINDYLLDFSAVYPLDVTNRPRTKEIRGNIRAYRKDLAQNGEYSLKSAVKLPNV
LSVSPLFGLGASGNELNQVIEDLFLQVQKKLVICTPYFNFPRTLQHKIATLLENGKRVEIIVGDKVANDFYIPPEQPFKM
AGALPYLYESNLRRFCEKFETQIESGQLVVRLWRDGDNTYHLKGVWVDDRYILLTGNNLNPRAWRLDAENGLLIYDPQQQ
LLAQVEKEQNQIRQHTKVLKHYTELEELNQYPEPVQKLLKKFARIKADKLVKMIL
>Mature_455_residues
MLINKTKRAEQNLNNLPFLALQAEQIEFLGSSAEFKTQIIELIRNAKKRIYVTALYWQKDEAGQEILDEIYRVKQENPHL
DVKVLIDWHRAQRNLLGAEKSATNADWYCEQRQTYQLPDDPNMFFGVPINTREVFGVLHVKGFVFDDTVLYSGASINNVY
LHQFEKYRYDRYQKITHAELADSMVNFINDYLLDFSAVYPLDVTNRPRTKEIRGNIRAYRKDLAQNGEYSLKSAVKLPNV
LSVSPLFGLGASGNELNQVIEDLFLQVQKKLVICTPYFNFPRTLQHKIATLLENGKRVEIIVGDKVANDFYIPPEQPFKM
AGALPYLYESNLRRFCEKFETQIESGQLVVRLWRDGDNTYHLKGVWVDDRYILLTGNNLNPRAWRLDAENGLLIYDPQQQ
LLAQVEKEQNQIRQHTKVLKHYTELEELNQYPEPVQKLLKKFARIKADKLVKMIL

Specific function: Unknown

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains

Homologues:

Organism=Homo sapiens, GI84508631, Length=415, Percent_Identity=23.3734939759036, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082134, Length=431, Percent_Identity=50.8120649651972, Blast_Score=449, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI25143331, Length=458, Percent_Identity=23.1441048034935, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319842, Length=175, Percent_Identity=30.8571428571429, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28572961, Length=464, Percent_Identity=23.7068965517241, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSS_HAEIN (P44704)

Other databases:

- EMBL:   L42023
- PIR:   I64066
- RefSeq:   NP_438586.1
- PDB:   3HSI
- PDBsum:   3HSI
- ProteinModelPortal:   P44704
- GeneID:   950510
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0425
- NMPDR:   fig|71421.1.peg.399
- TIGR:   HI_0425
- HOGENOM:   HBG296973
- OMA:   HLKGFVI
- ProtClustDB:   PRK09428
- BioCyc:   HINF71421:HI_0425-MONOMER
- BRENDA:   2.7.8.8
- GO:   GO:0005737
- InterPro:   IPR016270
- InterPro:   IPR001736
- PIRSF:   PIRSF000850
- SMART:   SM00155

Pfam domain/function: PF00614 PLDc

EC number: =2.7.8.8

Molecular weight: Translated: 53080; Mature: 53080

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLINKTKRAEQNLNNLPFLALQAEQIEFLGSSAEFKTQIIELIRNAKKRIYVTALYWQKD
CCCCCCHHHHCCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCC
EAGQEILDEIYRVKQENPHLDVKVLIDWHRAQRNLLGAEKSATNADWYCEQRQTYQLPDD
HHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCC
PNMFFGVPINTREVFGVLHVKGFVFDDTVLYSGASINNVYLHQFEKYRYDRYQKITHAEL
CCEEEEECCCHHHHHEEHEEEEEEEECHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ADSMVNFINDYLLDFSAVYPLDVTNRPRTKEIRGNIRAYRKDLAQNGEYSLKSAVKLPNV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCC
LSVSPLFGLGASGNELNQVIEDLFLQVQKKLVICTPYFNFPRTLQHKIATLLENGKRVEI
EEECCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEE
IVGDKVANDFYIPPEQPFKMAGALPYLYESNLRRFCEKFETQIESGQLVVRLWRDGDNTY
EECCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEE
HLKGVWVDDRYILLTGNNLNPRAWRLDAENGLLIYDPQQQLLAQVEKEQNQIRQHTKVLK
EEEEEEECCEEEEEECCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
HYTELEELNQYPEPVQKLLKKFARIKADKLVKMIL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MLINKTKRAEQNLNNLPFLALQAEQIEFLGSSAEFKTQIIELIRNAKKRIYVTALYWQKD
CCCCCCHHHHCCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCC
EAGQEILDEIYRVKQENPHLDVKVLIDWHRAQRNLLGAEKSATNADWYCEQRQTYQLPDD
HHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCC
PNMFFGVPINTREVFGVLHVKGFVFDDTVLYSGASINNVYLHQFEKYRYDRYQKITHAEL
CCEEEEECCCHHHHHEEHEEEEEEEECHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ADSMVNFINDYLLDFSAVYPLDVTNRPRTKEIRGNIRAYRKDLAQNGEYSLKSAVKLPNV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCC
LSVSPLFGLGASGNELNQVIEDLFLQVQKKLVICTPYFNFPRTLQHKIATLLENGKRVEI
EEECCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEE
IVGDKVANDFYIPPEQPFKMAGALPYLYESNLRRFCEKFETQIESGQLVVRLWRDGDNTY
EECCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEE
HLKGVWVDDRYILLTGNNLNPRAWRLDAENGLLIYDPQQQLLAQVEKEQNQIRQHTKVLK
EEEEEEECCEEEEEECCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
HYTELEELNQYPEPVQKLLKKFARIKADKLVKMIL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800