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The map label for this gene is tolA

Identifier: 16272331

GI number: 16272331

Start: 403937

End: 405055

Strand: Reverse

Name: tolA

Synonym: HI0383

Alternate gene names: 16272331

Gene position: 405055-403937 (Counterclockwise)

Preceding gene: 16272332

Following gene: 16272330

Centisome position: 22.13

GC content: 42.18

Gene sequence:

>1119_bases
GTGCAAAATAATCGACAAAAGAAAGGAATCAATGCTTTTGCTATTTCTATCCTTTTGCACTTTATCTTGTTTGGCTTATT
GATTTTAAGCTCACTTTATCACACTGTTGAAATTATGGGTGGTGGAGAAGGTGAAGGAGATGTAATAGGGGCAGTGATTG
TTGATACTGGTACGGCTGCTCAGGAATGGGGGCGTATTCAACAACAAAAAAAAGGGCAAGCGGATAAACAAAAACGCCCA
GAACCTGTTGTGGAAGAAAAACCACCTGAGCCTAATCAAGAAGAGATTAAGCATCAACAAGAAGTTCAACGACAAGAAGA
GTTAAAACGTCAGCAAGAACAGCAACGTCAGCAAGAAATAAAAAAACAACAAGAGCAAGCTCGTCAAGAAGCGTTGGAAA
AACAGAAGCAAGCTGAAGAGGCTAAGGCTAAACAAGCGGCTGAAGCTGCAAAATTAAAAGCAGATGCAGAGGCTAAACGT
TTAGCTGCCGCGGCAAAACAAGCTGAAGAAGAGGCTAAAGCGAAAGCAGCAGAAATTGCTGCTCAAAAAGCAAAACAAGA
GGCGGAAGCTAAGGCGAAACTAGAAGCCGAAGCTAAGGCAAAAGCCGTTGCTGAAGCTAAAGCAAAGGCTGAAGCGGAGG
CAAAAGCGAAAGCGGCAGCAGAGGCAAAAGCAAAAGCTGATGCAGAAGCTAAAGCTGCTACGGAAGCGAAACGTAAAGCA
GATCAAGCAAGCCTAGATGATTTCTTAAATGGCGGAGATATTGGTGGCGGTAGTGCATCTAAAGGGGGAAACACAAATAA
AGGTGGAACTCAAGGTAGCGGTGCTGCACTTGGCTCTGGCGATGGTGGTAAGGTTGGGGATCAATACGCAGGTGTAATTA
AGAAAGAGATTCAACGTCGTTTCTTAAAAGATCCAAATTTTGCAGGAAAGGTTTGTCGTATTAAAATTCAATTAGGTCGA
GATGGCACAATCTTGGGGTATCAAAAAATTTCAGGCTCTGATGATATTTGTTCAGCTGCATTAAGTGCGGTGGCTAGAAC
GAAAAAAGTTCCAGCTGCGCCATCAGATGAAATTTATGAAAAATATAAATCACCAATTATTGACTTTGATATTCGATAA

Upstream 100 bases:

>100_bases
ACCTTATGAAGAAGTGATTAAGGCATTGAATTTACTTCATCTTGCAGGCATTAAATCTGTAGGTTTAATGACAAATCCCA
TTTAGCTAAGTAGGTAACAC

Downstream 100 bases:

>100_bases
TTCTTTAGAAAAATTTATTGTTAAATTTTAAAGGTAACAAAATGAAATTATTAAAACGTTTAGTGAGCGTATTCGCGATT
GTACTTGCTGTTGGAAGCAA

Product: cell envelope integrity inner membrane protein TolA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MQNNRQKKGINAFAISILLHFILFGLLILSSLYHTVEIMGGGEGEGDVIGAVIVDTGTAAQEWGRIQQQKKGQADKQKRP
EPVVEEKPPEPNQEEIKHQQEVQRQEELKRQQEQQRQQEIKKQQEQARQEALEKQKQAEEAKAKQAAEAAKLKADAEAKR
LAAAAKQAEEEAKAKAAEIAAQKAKQEAEAKAKLEAEAKAKAVAEAKAKAEAEAKAKAAAEAKAKADAEAKAATEAKRKA
DQASLDDFLNGGDIGGGSASKGGNTNKGGTQGSGAALGSGDGGKVGDQYAGVIKKEIQRRFLKDPNFAGKVCRIKIQLGR
DGTILGYQKISGSDDICSAALSAVARTKKVPAAPSDEIYEKYKSPIIDFDIR

Sequences:

>Translated_372_residues
MQNNRQKKGINAFAISILLHFILFGLLILSSLYHTVEIMGGGEGEGDVIGAVIVDTGTAAQEWGRIQQQKKGQADKQKRP
EPVVEEKPPEPNQEEIKHQQEVQRQEELKRQQEQQRQQEIKKQQEQARQEALEKQKQAEEAKAKQAAEAAKLKADAEAKR
LAAAAKQAEEEAKAKAAEIAAQKAKQEAEAKAKLEAEAKAKAVAEAKAKAEAEAKAKAAAEAKAKADAEAKAATEAKRKA
DQASLDDFLNGGDIGGGSASKGGNTNKGGTQGSGAALGSGDGGKVGDQYAGVIKKEIQRRFLKDPNFAGKVCRIKIQLGR
DGTILGYQKISGSDDICSAALSAVARTKKVPAAPSDEIYEKYKSPIIDFDIR
>Mature_372_residues
MQNNRQKKGINAFAISILLHFILFGLLILSSLYHTVEIMGGGEGEGDVIGAVIVDTGTAAQEWGRIQQQKKGQADKQKRP
EPVVEEKPPEPNQEEIKHQQEVQRQEELKRQQEQQRQQEIKKQQEQARQEALEKQKQAEEAKAKQAAEAAKLKADAEAKR
LAAAAKQAEEEAKAKAAEIAAQKAKQEAEAKAKLEAEAKAKAVAEAKAKAEAEAKAKAAAEAKAKADAEAKAATEAKRKA
DQASLDDFLNGGDIGGGSASKGGNTNKGGTQGSGAALGSGDGGKVGDQYAGVIKKEIQRRFLKDPNFAGKVCRIKIQLGR
DGTILGYQKISGSDDICSAALSAVARTKKVPAAPSDEIYEKYKSPIIDFDIR

Specific function: Involved in the tonB-independent uptake of proteins

COG id: COG3064

COG function: function code M; Membrane protein involved in colicin uptake

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TOLA_HAEIN (P44678)

Other databases:

- EMBL:   L42023
- EMBL:   U32470
- PIR:   G64064
- RefSeq:   NP_438544.1
- ProteinModelPortal:   P44678
- SMR:   P44678
- GeneID:   949487
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0383
- NMPDR:   fig|71421.1.peg.357
- TIGR:   HI_0383
- HOGENOM:   HBG611821
- OMA:   AVMVDTG
- ProtClustDB:   PRK09510
- BioCyc:   HINF71421:HI_0383-MONOMER
- InterPro:   IPR014161
- TIGRFAMs:   TIGR02794

Pfam domain/function: PF06519 TolA

EC number: NA

Molecular weight: Translated: 39831; Mature: 39831

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc3cbb40)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCCCCCH
>Mature Secondary Structure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HHCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800; 8921895