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The map label for this gene is relA

Identifier: 16272286

GI number: 16272286

Start: 361233

End: 363464

Strand: Direct

Name: relA

Synonym: HI0334

Alternate gene names: 16272286

Gene position: 361233-363464 (Clockwise)

Preceding gene: 16272285

Following gene: 16272287

Centisome position: 19.74

GC content: 40.73

Gene sequence:

>2232_bases
ATGGTTGCTGTTCGTGGTTCTCATTTGTTAAATCCGCAGGATTTTGTGATTGAACAATGGTGCACTGGCTTAAAACTAGC
AGAACAAACAGAAAAAAGTTTGATCGATGCGTGGTATTACGCACGTGATTTAATGAATGCCTACCCCGATGAAATGAAGA
ATGCGACCTTGATGCTGCAGTCTGGCGTGGAAATGGTAGAAATTTTGCACGAACTTAATATGGATGCGGAAACATTGCTT
ACTGCCATGTTGTTTCCTATTGTTGCAAATAAATTAACAGACTGGGAAAGTCTAAAAGAAAAATTTGGTGCGAAAATTAC
TAAATTACTTAAAGGCGTGTTGGAGATGGATAATATTCGCCAACTTAATGCCAGTCATTCCGCTAACGCTCTGCAAGTGG
ATAATGTTCGCCGTATGTTGTTGGCGATGGTGGACGATTTCCGCTGCGTGATCATTAAACTTGCCGAACGTATTACTTTC
TTGCGTGATGCAGAGCATCGTTGTGCAGAGGAAGACAAAGTCCTTGCCGTCAAAGAATGTTCTTATATTTATGCCCCTCT
TGCCAATCGTCTTGGAATTGGTCAGCTGAAATGGGAGTTAGAAGATTACTGCTTCCGTTATCTTCATCCTGAACAATATC
GCGCTATTGCTAAATTATTGCAGGAACGTCGTCTTGATCGTGAACATTACATTGCTGATTTCGTCAGTGAGTTGAGCGGT
TATTTACGTGAAAATATCGAGCAAGTGGAAGTCTATGGTCGTCCGAAACATATTTACAGCATTTGGCGTAAAATGCAGAA
AAAGCATCTTGAATTCAGCGGTTTATATGACGTAAGAGCGGTCAGAATTATCGTGCAAAAATTACAAGATTGTTACACCG
CACTTGGGATTGTTCATACTCAATTTAAACACTTACCCAAAGAATTTGACGATTATGTGGCGAACCCGAAACCGAACGGT
TATCAATCTATTCATACTGTTGTTTTAGGTAAAGGTGGCAAGCCAATTGAAGTGCAAATTCGAACCCAACAAATGCATGA
TGATGCAGAGTTAGGTATGGCGGCACACTGGAAATATAAAGAAGGCAATACAGGCAGTATGTCTGCCTATGAAGAAAAAA
TTGCGTGGTTGCGTAAATTGTTAGCTTGGCAAGATGATATTACGGATTCAGGCGAAGTGCTGGCAGAGTTGCGTAGCCAA
GTGTTTGATGATCGTGTATATGTGTTTACGCCAAAGGGCGAAGTGGTGGATTTGCCAACGGGATCTACACCATTAGATTT
TGCTTATGCCATTCATAGTGAAATTGGTCATCGCTGTATCGGGGCAAAAGTGGCGGGGCGTATTGTGCCATTTACCTATC
AGCTACAAATGGGCGATCAAATTGATATTATTACCCAGAAAAATCCGAACCCGAGCCGTGACTGGCTAAACCCAAATTTA
GGATTTACTCACACCGCAAAATCTCGAGCCAAAATTCAAGCGTGGTTTAAAAAACAAGATCGCGATAAAAATATTCCAGC
GGGTAAAGAATTACTCGATAATGAACTCGCGCTTTTGAATTTAAGTATTAAGCAAGTGGAACCTTATGCGTTACCACGCT
ATAACTTGAAAAATTTGGACGATCTTTATGCGGGCATTGGCAGTGGTGATATTCGTTTAAATAACTTAATCCATTTCTTG
CAAAGTAAATTGATTAAAGTGACTGCTGAAGAGGCTGATCAAGAAATTTTACGTCATGTTGCTAACAAAAGTGCGGTCAA
TTCTCAGCAGAAATCTGAAAAGAACAATGGCTGTGTGATTGTGGAGGGTGTGGACAATCTTATGCATCATATTGCGCGTT
GCTGCCAGCCGATACCAGGCGATGCGATTGTTGGCTATATTACAATGGGACGTGGTATTTCTATTCACCGAGCGGATTGT
GAACAATTCTTAGATTTGCAAGCGGCTCATCCAGAACGCGTAGTGGAATCAATTTGGGGCGAAAATTACGCAAGTGGTTT
CCATATTAATATCCGTATTGTGGCAGGCGATCGCAATGGCTTATTGCGTGATATTACAACGGTTCTAGCAAATGAAAAAA
TTAGCGTATTAGGGGTCTCAAGCCGTGCTGATACCAAAAAACAGCTTGCTACTATTGATATGGAAATTGAACTTCATAAT
GTTGAAAGTTTGAGTAAAATATTGGCTCGATTAGCAAAATTAGATGATGTTATCGAAGCGAAGCGTTTATAA

Upstream 100 bases:

>100_bases
TAACCTTATTCACTACAAAATAACTCGGTTATTCGGTACAATATCCACCCAAAATAAAAGCGACAGGAAGTTGCTTGCTC
TTCATCAACAAGGGGGTATT

Downstream 100 bases:

>100_bases
AAATAGGAAAATTTATGTATAAAACGACGGGGCTAACCCATTTAATCAACTCCACTAAATATTCATTACAAGGCTTAAAA
AGTGCGTTTAAAAATGAAAC

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I

Number of amino acids: Translated: 743; Mature: 743

Protein sequence:

>743_residues
MVAVRGSHLLNPQDFVIEQWCTGLKLAEQTEKSLIDAWYYARDLMNAYPDEMKNATLMLQSGVEMVEILHELNMDAETLL
TAMLFPIVANKLTDWESLKEKFGAKITKLLKGVLEMDNIRQLNASHSANALQVDNVRRMLLAMVDDFRCVIIKLAERITF
LRDAEHRCAEEDKVLAVKECSYIYAPLANRLGIGQLKWELEDYCFRYLHPEQYRAIAKLLQERRLDREHYIADFVSELSG
YLRENIEQVEVYGRPKHIYSIWRKMQKKHLEFSGLYDVRAVRIIVQKLQDCYTALGIVHTQFKHLPKEFDDYVANPKPNG
YQSIHTVVLGKGGKPIEVQIRTQQMHDDAELGMAAHWKYKEGNTGSMSAYEEKIAWLRKLLAWQDDITDSGEVLAELRSQ
VFDDRVYVFTPKGEVVDLPTGSTPLDFAYAIHSEIGHRCIGAKVAGRIVPFTYQLQMGDQIDIITQKNPNPSRDWLNPNL
GFTHTAKSRAKIQAWFKKQDRDKNIPAGKELLDNELALLNLSIKQVEPYALPRYNLKNLDDLYAGIGSGDIRLNNLIHFL
QSKLIKVTAEEADQEILRHVANKSAVNSQQKSEKNNGCVIVEGVDNLMHHIARCCQPIPGDAIVGYITMGRGISIHRADC
EQFLDLQAAHPERVVESIWGENYASGFHINIRIVAGDRNGLLRDITTVLANEKISVLGVSSRADTKKQLATIDMEIELHN
VESLSKILARLAKLDDVIEAKRL

Sequences:

>Translated_743_residues
MVAVRGSHLLNPQDFVIEQWCTGLKLAEQTEKSLIDAWYYARDLMNAYPDEMKNATLMLQSGVEMVEILHELNMDAETLL
TAMLFPIVANKLTDWESLKEKFGAKITKLLKGVLEMDNIRQLNASHSANALQVDNVRRMLLAMVDDFRCVIIKLAERITF
LRDAEHRCAEEDKVLAVKECSYIYAPLANRLGIGQLKWELEDYCFRYLHPEQYRAIAKLLQERRLDREHYIADFVSELSG
YLRENIEQVEVYGRPKHIYSIWRKMQKKHLEFSGLYDVRAVRIIVQKLQDCYTALGIVHTQFKHLPKEFDDYVANPKPNG
YQSIHTVVLGKGGKPIEVQIRTQQMHDDAELGMAAHWKYKEGNTGSMSAYEEKIAWLRKLLAWQDDITDSGEVLAELRSQ
VFDDRVYVFTPKGEVVDLPTGSTPLDFAYAIHSEIGHRCIGAKVAGRIVPFTYQLQMGDQIDIITQKNPNPSRDWLNPNL
GFTHTAKSRAKIQAWFKKQDRDKNIPAGKELLDNELALLNLSIKQVEPYALPRYNLKNLDDLYAGIGSGDIRLNNLIHFL
QSKLIKVTAEEADQEILRHVANKSAVNSQQKSEKNNGCVIVEGVDNLMHHIARCCQPIPGDAIVGYITMGRGISIHRADC
EQFLDLQAAHPERVVESIWGENYASGFHINIRIVAGDRNGLLRDITTVLANEKISVLGVSSRADTKKQLATIDMEIELHN
VESLSKILARLAKLDDVIEAKRL
>Mature_743_residues
MVAVRGSHLLNPQDFVIEQWCTGLKLAEQTEKSLIDAWYYARDLMNAYPDEMKNATLMLQSGVEMVEILHELNMDAETLL
TAMLFPIVANKLTDWESLKEKFGAKITKLLKGVLEMDNIRQLNASHSANALQVDNVRRMLLAMVDDFRCVIIKLAERITF
LRDAEHRCAEEDKVLAVKECSYIYAPLANRLGIGQLKWELEDYCFRYLHPEQYRAIAKLLQERRLDREHYIADFVSELSG
YLRENIEQVEVYGRPKHIYSIWRKMQKKHLEFSGLYDVRAVRIIVQKLQDCYTALGIVHTQFKHLPKEFDDYVANPKPNG
YQSIHTVVLGKGGKPIEVQIRTQQMHDDAELGMAAHWKYKEGNTGSMSAYEEKIAWLRKLLAWQDDITDSGEVLAELRSQ
VFDDRVYVFTPKGEVVDLPTGSTPLDFAYAIHSEIGHRCIGAKVAGRIVPFTYQLQMGDQIDIITQKNPNPSRDWLNPNL
GFTHTAKSRAKIQAWFKKQDRDKNIPAGKELLDNELALLNLSIKQVEPYALPRYNLKNLDDLYAGIGSGDIRLNNLIHFL
QSKLIKVTAEEADQEILRHVANKSAVNSQQKSEKNNGCVIVEGVDNLMHHIARCCQPIPGDAIVGYITMGRGISIHRADC
EQFLDLQAAHPERVVESIWGENYASGFHINIRIVAGDRNGLLRDITTVLANEKISVLGVSSRADTKKQLATIDMEIELHN
VESLSKILARLAKLDDVIEAKRL

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain

Homologues:

Organism=Escherichia coli, GI1789147, Length=748, Percent_Identity=62.5668449197861, Blast_Score=988, Evalue=0.0,
Organism=Escherichia coli, GI1790082, Length=721, Percent_Identity=32.5936199722608, Blast_Score=399, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RELA_HAEIN (P44644)

Other databases:

- EMBL:   L42023
- PIR:   D64062
- RefSeq:   NP_438498.1
- ProteinModelPortal:   P44644
- SMR:   P44644
- GeneID:   950822
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0334
- NMPDR:   fig|71421.1.peg.313
- TIGR:   HI_0334
- HOGENOM:   HBG594146
- OMA:   DLGHRCR
- ProtClustDB:   CLSK870646
- BioCyc:   HINF71421:HI_0334-MONOMER
- BRENDA:   2.7.6.5
- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676
- Gene3D:   G3DSA:3.10.20.30
- SMART:   SM00954
- TIGRFAMs:   TIGR00691

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS; SSF81271 TGS-like

EC number: =2.7.6.5

Molecular weight: Translated: 84568; Mature: 84568

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVRGSHLLNPQDFVIEQWCTGLKLAEQTEKSLIDAWYYARDLMNAYPDEMKNATLMLQ
CEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEHH
SGVEMVEILHELNMDAETLLTAMLFPIVANKLTDWESLKEKFGAKITKLLKGVLEMDNIR
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QLNASHSANALQVDNVRRMLLAMVDDFRCVIIKLAERITFLRDAEHRCAEEDKVLAVKEC
HHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHH
SYIYAPLANRLGIGQLKWELEDYCFRYLHPEQYRAIAKLLQERRLDREHYIADFVSELSG
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YLRENIEQVEVYGRPKHIYSIWRKMQKKHLEFSGLYDVRAVRIIVQKLQDCYTALGIVHT
HHHCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QFKHLPKEFDDYVANPKPNGYQSIHTVVLGKGGKPIEVQIRTQQMHDDAELGMAAHWKYK
HHHHCCHHHHHHCCCCCCCCHHHEEEEEEECCCCEEEEEEEHHHCCCHHHCCCEEEEEEC
EGNTGSMSAYEEKIAWLRKLLAWQDDITDSGEVLAELRSQVFDDRVYVFTPKGEVVDLPT
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEECCC
GSTPLDFAYAIHSEIGHRCIGAKVAGRIVPFTYQLQMGDQIDIITQKNPNPSRDWLNPNL
CCCCHHHHHHHHHHHHHHHHHHHHHCCEECEEEEEECCCEEEEEECCCCCCCCCCCCCCC
GFTHTAKSRAKIQAWFKKQDRDKNIPAGKELLDNELALLNLSIKQVEPYALPRYNLKNLD
CCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEEEEEHHHCCCCCCCCCCCCCHH
DLYAGIGSGDIRLNNLIHFLQSKLIKVTAEEADQEILRHVANKSAVNSQQKSEKNNGCVI
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEE
VEGVDNLMHHIARCCQPIPGDAIVGYITMGRGISIHRADCEQFLDLQAAHPERVVESIWG
EECHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHCCCCCHHHHHHHHCC
ENYASGFHINIRIVAGDRNGLLRDITTVLANEKISVLGVSSRADTKKQLATIDMEIELHN
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHEEEEEEEEECC
VESLSKILARLAKLDDVIEAKRL
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVAVRGSHLLNPQDFVIEQWCTGLKLAEQTEKSLIDAWYYARDLMNAYPDEMKNATLMLQ
CEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEHH
SGVEMVEILHELNMDAETLLTAMLFPIVANKLTDWESLKEKFGAKITKLLKGVLEMDNIR
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QLNASHSANALQVDNVRRMLLAMVDDFRCVIIKLAERITFLRDAEHRCAEEDKVLAVKEC
HHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHH
SYIYAPLANRLGIGQLKWELEDYCFRYLHPEQYRAIAKLLQERRLDREHYIADFVSELSG
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YLRENIEQVEVYGRPKHIYSIWRKMQKKHLEFSGLYDVRAVRIIVQKLQDCYTALGIVHT
HHHCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QFKHLPKEFDDYVANPKPNGYQSIHTVVLGKGGKPIEVQIRTQQMHDDAELGMAAHWKYK
HHHHCCHHHHHHCCCCCCCCHHHEEEEEEECCCCEEEEEEEHHHCCCHHHCCCEEEEEEC
EGNTGSMSAYEEKIAWLRKLLAWQDDITDSGEVLAELRSQVFDDRVYVFTPKGEVVDLPT
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCEEECCC
GSTPLDFAYAIHSEIGHRCIGAKVAGRIVPFTYQLQMGDQIDIITQKNPNPSRDWLNPNL
CCCCHHHHHHHHHHHHHHHHHHHHHCCEECEEEEEECCCEEEEEECCCCCCCCCCCCCCC
GFTHTAKSRAKIQAWFKKQDRDKNIPAGKELLDNELALLNLSIKQVEPYALPRYNLKNLD
CCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEEEEEHHHCCCCCCCCCCCCCHH
DLYAGIGSGDIRLNNLIHFLQSKLIKVTAEEADQEILRHVANKSAVNSQQKSEKNNGCVI
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEE
VEGVDNLMHHIARCCQPIPGDAIVGYITMGRGISIHRADCEQFLDLQAAHPERVVESIWG
EECHHHHHHHHHHHCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHCCCCCHHHHHHHHCC
ENYASGFHINIRIVAGDRNGLLRDITTVLANEKISVLGVSSRADTKKQLATIDMEIELHN
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHEEEEEEEEECC
VESLSKILARLAKLDDVIEAKRL
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800