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The map label for this gene is proC

Identifier: 16272262

GI number: 16272262

Start: 340637

End: 341452

Strand: Direct

Name: proC

Synonym: HI0307

Alternate gene names: 16272262

Gene position: 340637-341452 (Clockwise)

Preceding gene: 16272260

Following gene: 16272263

Centisome position: 18.61

GC content: 41.3

Gene sequence:

>816_bases
ATGCAACACAAATTGATTGCCTTTATTGGTGGCGGCAATATGGCACAAGCTATTATTCTTGGATTATTGAAACAAGGTTA
TCCTGCCGAGCAAATTATTGTGAATGATCCAAATGAAGAAAAAAGAGCATTTTTTGCTAATCTTGACGTGGCAACTTCAG
AAAATAATGTGGGAAGTGCAATCAAAGCTGAGGTTGTGTTGCTTGCGGTAAAACCTCAAATGATGGCTGAAGTTTGTTCG
CCACTAAGTGCGGTGGATTTTTCCGACAAATTGTTAATTTCCATTGCTGCGGGTATTTCAACTGAACGCTTGAACGCATT
AATTCCAAGCGTAAAATCGATAGTACGCGTCATGCCAAATACGCCCGCATTGGTGGGGGAAGGTATGGCGGGTTTATTTG
CACCGAAAAATACGAGTGAAAATTACCGCACTTTTGCACAAGATTTATTGGGAGCAGTGGGAAGAACGGTTTGGGTGAAT
GATGAAACTCAAATGCACGCAGTCACTGCCGCGTCAGGAAGTAGCCCTGCCTATTTCTTTTTAATGCTGGAAGCAATGCA
GAAAGCCTTAATCAAAATGAATATTGATGAAAAAACAGCGCGTGAATTAGTCCAGCAATCTATGCTTGGTGCAGCAAAAA
TGGTGACAGAAAATCCGCAAATTGCACTTTCAACTTTGCGTGAAAATGTTACCTCGAAAGGTGGCACTACTGCGGCAGCG
TTAGCAGTATTTGACGCACAACATTTTAATCAAACAATAGAGCAAGCTATGCAGGCTTGTTTGTCTCGTTCACAAGAAAT
GGAAACTTTATTCTAA

Upstream 100 bases:

>100_bases
GTCAGTCTATAAGTCATTAAATTTTTGAACCACATCGTAACACTTCCTTCAATATAGGGTAGAATGTGCGGTATTATAGC
CCATAAAAGTAGGAAAAACG

Downstream 100 bases:

>100_bases
TGCAAGTCCGTCCTTTTTATTGGCTCGCACTGAGCTTTCTAGGTTACTACTGCGCTTATGGCGTGTTTTTGCCGTTCTTC
CCCGCATGGTTGAAATCGCA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MQHKLIAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEKRAFFANLDVATSENNVGSAIKAEVVLLAVKPQMMAEVCS
PLSAVDFSDKLLISIAAGISTERLNALIPSVKSIVRVMPNTPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVN
DETQMHAVTAASGSSPAYFFLMLEAMQKALIKMNIDEKTARELVQQSMLGAAKMVTENPQIALSTLRENVTSKGGTTAAA
LAVFDAQHFNQTIEQAMQACLSRSQEMETLF

Sequences:

>Translated_271_residues
MQHKLIAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEKRAFFANLDVATSENNVGSAIKAEVVLLAVKPQMMAEVCS
PLSAVDFSDKLLISIAAGISTERLNALIPSVKSIVRVMPNTPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVN
DETQMHAVTAASGSSPAYFFLMLEAMQKALIKMNIDEKTARELVQQSMLGAAKMVTENPQIALSTLRENVTSKGGTTAAA
LAVFDAQHFNQTIEQAMQACLSRSQEMETLF
>Mature_271_residues
MQHKLIAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEKRAFFANLDVATSENNVGSAIKAEVVLLAVKPQMMAEVCS
PLSAVDFSDKLLISIAAGISTERLNALIPSVKSIVRVMPNTPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVN
DETQMHAVTAASGSSPAYFFLMLEAMQKALIKMNIDEKTARELVQQSMLGAAKMVTENPQIALSTLRENVTSKGGTTAAA
LAVFDAQHFNQTIEQAMQACLSRSQEMETLF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family

Homologues:

Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=29.0566037735849, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=32, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=32, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI21361454, Length=274, Percent_Identity=31.021897810219, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1786585, Length=276, Percent_Identity=33.695652173913, Blast_Score=137, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=264, Percent_Identity=31.8181818181818, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17540664, Length=277, Percent_Identity=30.3249097472924, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=203, Percent_Identity=33.9901477832512, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=33.0855018587361, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=31.1594202898551, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=32.3529411764706, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): P5CR_HAEIN (P43869)

Other databases:

- EMBL:   L42023
- PIR:   I64060
- RefSeq:   NP_438474.1
- ProteinModelPortal:   P43869
- SMR:   P43869
- GeneID:   949427
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0307
- NMPDR:   fig|71421.1.peg.289
- TIGR:   HI_0307
- HOGENOM:   HBG726602
- OMA:   RTFNEHQ
- ProtClustDB:   PRK11880
- BioCyc:   HINF71421:HI_0307-MONOMER
- BRENDA:   1.5.1.2
- GO:   GO:0005737
- GO:   GO:0005488
- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11645
- PIRSF:   PIRSF000193
- TIGRFAMs:   TIGR00112

Pfam domain/function: PF03807 F420_oxidored; SSF48179 6DGDH_C_like

EC number: =1.5.1.2

Molecular weight: Translated: 29124; Mature: 29124

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHKLIAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEKRAFFANLDVATSENNVGSA
CCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHEEEECEEEECCCCCCCH
IKAEVVLLAVKPQMMAEVCSPLSAVDFSDKLLISIAAGISTERLNALIPSVKSIVRVMPN
HEEEEEEEEECHHHHHHHHCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
TPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVNDETQMHAVTAASGSSPAYFF
CCCHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCCCHHHH
LMLEAMQKALIKMNIDEKTARELVQQSMLGAAKMVTENPQIALSTLRENVTSKGGTTAAA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHH
LAVFDAQHFNQTIEQAMQACLSRSQEMETLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHKLIAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEKRAFFANLDVATSENNVGSA
CCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHEEEECEEEECCCCCCCH
IKAEVVLLAVKPQMMAEVCSPLSAVDFSDKLLISIAAGISTERLNALIPSVKSIVRVMPN
HEEEEEEEEECHHHHHHHHCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
TPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVNDETQMHAVTAASGSSPAYFF
CCCHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCCCHHHH
LMLEAMQKALIKMNIDEKTARELVQQSMLGAAKMVTENPQIALSTLRENVTSKGGTTAAA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHH
LAVFDAQHFNQTIEQAMQACLSRSQEMETLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800