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The map label for this gene is corC

Identifier: 16272256

GI number: 16272256

Start: 335399

End: 336298

Strand: Direct

Name: corC

Synonym: HI0301

Alternate gene names: 16272256

Gene position: 335399-336298 (Clockwise)

Preceding gene: 16272255

Following gene: 30995366

Centisome position: 18.33

GC content: 36.22

Gene sequence:

>900_bases
ATGAACGACGAACAGCAAAATTCAAACCAATCTGAAAATACAAAAAAACCTTTTTTCCAATCTTTATTTGGTCGCTTTTT
TCAAGGCGAATTAAAAAATCGTGAAGAACTTGTGGAAGTGATTCGCGATTCAGAACAAAATGATTTAATTGATCAAAATA
CGCGCGAAATGATTGAAGGCGTGATGGAAATTGCGGAACTTCGTGTTCGCGATATTATGATTCCTCGTTCACAAATTATT
TTTATTGAAGATCAACAAGATTTAAATACTTGTTTAAACACAATTATTGAATCCGCTCATTCTCGTTTTCCTGTGATTGC
CGATGCGGATGATCGCGATAATATAGTGGGCATTTTGCACGCAAAAGATTTATTAAAATTTTTACGTGAAGATGCGGAAG
TCTTTGATTTATCTTCATTATTGCGCCCCGTCGTGATTGTGCCAGAAAGCAAAAGAGTGGATCGTATGTTGAAAGATTTC
CGCTCAGAGCGTTTTCATATGGCCATTGTGGTGGATGAATTTGGTGCGGTATCAGGTCTTGTTACCATTGAAGATATTTT
GGAACAAATTGTTGGCGATATTGAAGATGAATTTGATGAAGAAGAGATTGCGGATATTCGTCAGCTTTCTCGTCATACTT
ATGCTGTGCGTGCGCTCACAGATATTGATGATTTCAATGCGCAATTTAATACGGATTTTGATGATGAAGAAGTGGATACC
ATTGGAGGTCTGATTATGCAGACTTTTGGTTATTTACCAAAACGTGGGGAAGAAATTATTTTGAAAAATCTTCAATTTAA
AGTAACTTCTGCAGATAGTCGTCGATTAATTCAACTTCGAGTCACAGTGCCAGATGAACATTTGGCAGAAATGAATAATG
TAGATGAAAAATCTGAATAG

Upstream 100 bases:

>100_bases
TGCGGTTATTTTTTATTGATTTTCCTCTTTTCGCGTTTTGCGATTTTTTCTAAAATATGATAATTTTTCGCCGTCAATAA
GACATCAAACACAAATCAAT

Downstream 100 bases:

>100_bases
GATTTTATTATCAATTAAATTTATGAATAAATATTTTACTTATCTTATTGCGATTATATCAGGTTTACTCGGCGTTTTTG
CCTTTTCGCCATTTGATTAT

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MNDEQQNSNQSENTKKPFFQSLFGRFFQGELKNREELVEVIRDSEQNDLIDQNTREMIEGVMEIAELRVRDIMIPRSQII
FIEDQQDLNTCLNTIIESAHSRFPVIADADDRDNIVGILHAKDLLKFLREDAEVFDLSSLLRPVVIVPESKRVDRMLKDF
RSERFHMAIVVDEFGAVSGLVTIEDILEQIVGDIEDEFDEEEIADIRQLSRHTYAVRALTDIDDFNAQFNTDFDDEEVDT
IGGLIMQTFGYLPKRGEEIILKNLQFKVTSADSRRLIQLRVTVPDEHLAEMNNVDEKSE

Sequences:

>Translated_299_residues
MNDEQQNSNQSENTKKPFFQSLFGRFFQGELKNREELVEVIRDSEQNDLIDQNTREMIEGVMEIAELRVRDIMIPRSQII
FIEDQQDLNTCLNTIIESAHSRFPVIADADDRDNIVGILHAKDLLKFLREDAEVFDLSSLLRPVVIVPESKRVDRMLKDF
RSERFHMAIVVDEFGAVSGLVTIEDILEQIVGDIEDEFDEEEIADIRQLSRHTYAVRALTDIDDFNAQFNTDFDDEEVDT
IGGLIMQTFGYLPKRGEEIILKNLQFKVTSADSRRLIQLRVTVPDEHLAEMNNVDEKSE
>Mature_299_residues
MNDEQQNSNQSENTKKPFFQSLFGRFFQGELKNREELVEVIRDSEQNDLIDQNTREMIEGVMEIAELRVRDIMIPRSQII
FIEDQQDLNTCLNTIIESAHSRFPVIADADDRDNIVGILHAKDLLKFLREDAEVFDLSSLLRPVVIVPESKRVDRMLKDF
RSERFHMAIVVDEFGAVSGLVTIEDILEQIVGDIEDEFDEEEIADIRQLSRHTYAVRALTDIDDFNAQFNTDFDDEEVDT
IGGLIMQTFGYLPKRGEEIILKNLQFKVTSADSRRLIQLRVTVPDEHLAEMNNVDEKSE

Specific function: Plays a role in the transport of magnesium and cobalt ions

COG id: COG4535

COG function: function code P; Putative Mg2+ and Co2+ transporter CorC

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains

Homologues:

Organism=Homo sapiens, GI310128564, Length=209, Percent_Identity=32.5358851674641, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI94681046, Length=194, Percent_Identity=35.5670103092784, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI40068055, Length=187, Percent_Identity=33.1550802139037, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI40068053, Length=187, Percent_Identity=33.1550802139037, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1786879, Length=286, Percent_Identity=63.986013986014, Blast_Score=350, Evalue=5e-98,
Organism=Escherichia coli, GI87082033, Length=271, Percent_Identity=30.2583025830258, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI145693175, Length=230, Percent_Identity=26.0869565217391, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1788119, Length=230, Percent_Identity=30.8695652173913, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1790664, Length=251, Percent_Identity=26.2948207171315, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CORC_HAEIN (Q57368)

Other databases:

- EMBL:   L42023
- PIR:   G64060
- RefSeq:   NP_438468.1
- ProteinModelPortal:   Q57368
- SMR:   Q57368
- GeneID:   949422
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0301
- NMPDR:   fig|71421.1.peg.283
- TIGR:   HI_0301
- HOGENOM:   HBG673071
- OMA:   RSQIIFI
- ProtClustDB:   CLSK870340
- BioCyc:   HINF71421:HI_0301-MONOMER
- GO:   GO:0006810
- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170
- Gene3D:   G3DSA:3.30.465.10
- SMART:   SM00116

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC

EC number: NA

Molecular weight: Translated: 34584; Mature: 34584

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: PS51371 CBS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDEQQNSNQSENTKKPFFQSLFGRFFQGELKNREELVEVIRDSEQNDLIDQNTREMIEG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHH
VMEIAELRVRDIMIPRSQIIFIEDQQDLNTCLNTIIESAHSRFPVIADADDRDNIVGILH
HHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEHH
AKDLLKFLREDAEVFDLSSLLRPVVIVPESKRVDRMLKDFRSERFHMAIVVDEFGAVSGL
HHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCHHHHH
VTIEDILEQIVGDIEDEFDEEEIADIRQLSRHTYAVRALTDIDDFNAQFNTDFDDEEVDT
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
IGGLIMQTFGYLPKRGEEIILKNLQFKVTSADSRRLIQLRVTVPDEHLAEMNNVDEKSE
HHHHHHHHHCCCCCCCHHHHHHCCEEEEECCCCCEEEEEEEECCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNDEQQNSNQSENTKKPFFQSLFGRFFQGELKNREELVEVIRDSEQNDLIDQNTREMIEG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHH
VMEIAELRVRDIMIPRSQIIFIEDQQDLNTCLNTIIESAHSRFPVIADADDRDNIVGILH
HHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEHH
AKDLLKFLREDAEVFDLSSLLRPVVIVPESKRVDRMLKDFRSERFHMAIVVDEFGAVSGL
HHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCEEEEEEEECCCHHHHH
VTIEDILEQIVGDIEDEFDEEEIADIRQLSRHTYAVRALTDIDDFNAQFNTDFDDEEVDT
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
IGGLIMQTFGYLPKRGEEIILKNLQFKVTSADSRRLIQLRVTVPDEHLAEMNNVDEKSE
HHHHHHHHHCCCCCCCHHHHHHCCEEEEECCCCCEEEEEEEECCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800