Click here to switch to the map view.

The map label for this gene is serS [H]

Identifier: 16272084

GI number: 16272084

Start: 117827

End: 119116

Strand: Direct

Name: serS [H]

Synonym: HI0110

Alternate gene names: 16272084

Gene position: 117827-119116 (Clockwise)

Preceding gene: 16272082

Following gene: 16272085

Centisome position: 6.44

GC content: 39.92

Gene sequence:

>1290_bases
ATGATCGATCCAAATTTACTCCGTAATAATTTAGCAGAAGTCGCAGAAAAATTAAAAGTAAAACGCAACTTTATGCTTGA
TACGGAAAAACTCACCGCGTTAGAAGATCAGCGCAAAAACTTACAAGTCACTACCGAAAACTTACAAGCGGAACGTAATG
CTCGTTCCAAAGCCATTGGTGCTGCTAAAGCGCGTGGTGAAGATATCGCACCATTATTGGCAGAAATGGATGATATGGGC
AATCAATTGACTGAAGCAAAAGCACAATTAGATGCGGTACTTGCAGAAATCAATCAAATTGCATTAAGTATTCCAAATCT
ACCCGCAGACGAAGTGCCATTAGGCAAAGATGACACAGAAAATAAAGAAATCTTACGTTGGGGTACACCGCGTACATTTG
ATTTTGAAGTGAAAGATCATATCACTTTGGGTGAAGAAGCAAATGGCTTAGATTTTGCTGCTGGGGCTAAATTAGCTGGT
GCACGTTTTGCCGTAATGAAAGGTCAAATCGCTAAAATGCACCGTGCATTGGCACAATTCATGTTAGATCTTCATACGGA
ACAACACGGCTATTTAGAAACCTATGTGCCTTATTTAGTAAATCACGCCACACTTTATGGAACAGGGCAATTACCAAAAT
TCGGGGAAGATTTATTCCATACTTTAGCCTTAGAAGGCGAACAACCTTACGCATTAATTCCAACTGCAGAAGTGCCCGTC
ACTAATTTAGTGCGTGACGTGATTATTGATGAAGCAGAATTACCAATAAAAATGACCGCACATACGCCATGTTTCCGTTC
TGAAGCAGGTTCTTACGGTCGTGATACTCGTGGTTTAATTCGTATGCACCAATTTGATAAAGTAGAAATGGTACAAATCG
TTGATCCAGATAAATCAATGGAAGCACTTGAAGAATTAACAGGTCATGCGGAAAAAGTATTGCAATTATTAAATTTACCA
TACCGTAAAGTTTTACTTTGCACAGGCGATATGGGCTTTGGTTCTTGCAAAACTTACGATTTAGAAGTTTGGGTGCCTGC
ACAAAATACTTATCGAGAAATTTCTTCTTGCTCAAATATGTGGGATTTCCAAGCTCGCCGTATGCAAGCACGTTGTAAAG
CAAAAGGCGATAAGAAAACTCGCTTAGTGCACACATTAAATGGTTCAGGCTTAGCGGTTGGTCGTACTTTAGTGGCTGTA
CTTGAAAACTATCAAAATGCCGATGGTTCAATTACCGTGCCAGAAGAGCTACGTCCATATATGGGCGGATTAGACGTTAT
CGGAAAATAA

Upstream 100 bases:

>100_bases
TTTCTTTATTTTTATACGTTGGCTTTTAAACTGGTTTATTTGAAGAAAGCACGCTAGAATAAGGTTGTTTTCATTTCAAC
GAAAAAAGTAAGGAAATTCT

Downstream 100 bases:

>100_bases
TCCTTCTAGAAGATAAAAAAGCGTGGATTTTAAAATTTCCACGCTTTTTTATTATCAAAGCCTTACAATAACTGTTTTAA
ATTTTTTGGTATTCAAGCCA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MIDPNLLRNNLAEVAEKLKVKRNFMLDTEKLTALEDQRKNLQVTTENLQAERNARSKAIGAAKARGEDIAPLLAEMDDMG
NQLTEAKAQLDAVLAEINQIALSIPNLPADEVPLGKDDTENKEILRWGTPRTFDFEVKDHITLGEEANGLDFAAGAKLAG
ARFAVMKGQIAKMHRALAQFMLDLHTEQHGYLETYVPYLVNHATLYGTGQLPKFGEDLFHTLALEGEQPYALIPTAEVPV
TNLVRDVIIDEAELPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVDPDKSMEALEELTGHAEKVLQLLNLP
YRKVLLCTGDMGFGSCKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARCKAKGDKKTRLVHTLNGSGLAVGRTLVAV
LENYQNADGSITVPEELRPYMGGLDVIGK

Sequences:

>Translated_429_residues
MIDPNLLRNNLAEVAEKLKVKRNFMLDTEKLTALEDQRKNLQVTTENLQAERNARSKAIGAAKARGEDIAPLLAEMDDMG
NQLTEAKAQLDAVLAEINQIALSIPNLPADEVPLGKDDTENKEILRWGTPRTFDFEVKDHITLGEEANGLDFAAGAKLAG
ARFAVMKGQIAKMHRALAQFMLDLHTEQHGYLETYVPYLVNHATLYGTGQLPKFGEDLFHTLALEGEQPYALIPTAEVPV
TNLVRDVIIDEAELPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVDPDKSMEALEELTGHAEKVLQLLNLP
YRKVLLCTGDMGFGSCKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARCKAKGDKKTRLVHTLNGSGLAVGRTLVAV
LENYQNADGSITVPEELRPYMGGLDVIGK
>Mature_429_residues
MIDPNLLRNNLAEVAEKLKVKRNFMLDTEKLTALEDQRKNLQVTTENLQAERNARSKAIGAAKARGEDIAPLLAEMDDMG
NQLTEAKAQLDAVLAEINQIALSIPNLPADEVPLGKDDTENKEILRWGTPRTFDFEVKDHITLGEEANGLDFAAGAKLAG
ARFAVMKGQIAKMHRALAQFMLDLHTEQHGYLETYVPYLVNHATLYGTGQLPKFGEDLFHTLALEGEQPYALIPTAEVPV
TNLVRDVIIDEAELPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVDPDKSMEALEELTGHAEKVLQLLNLP
YRKVLLCTGDMGFGSCKTYDLEVWVPAQNTYREISSCSNMWDFQARRMQARCKAKGDKKTRLVHTLNGSGLAVGRTLVAV
LENYQNADGSITVPEELRPYMGGLDVIGK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=333, Percent_Identity=36.6366366366366, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI8923421, Length=400, Percent_Identity=26.75, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI225579074, Length=324, Percent_Identity=29.0123456790123, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=77.262180974478, Blast_Score=692, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=437, Percent_Identity=31.350114416476, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=327, Percent_Identity=31.1926605504587, Blast_Score=141, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=398, Percent_Identity=32.9145728643216, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6321799, Length=390, Percent_Identity=28.2051282051282, Blast_Score=166, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24581334, Length=463, Percent_Identity=30.6695464362851, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17737985, Length=270, Percent_Identity=32.2222222222222, Blast_Score=138, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47722; Mature: 47722

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPNLLRNNLAEVAEKLKVKRNFMLDTEKLTALEDQRKNLQVTTENLQAERNARSKAIG
CCCHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
AAKARGEDIAPLLAEMDDMGNQLTEAKAQLDAVLAEINQIALSIPNLPADEVPLGKDDTE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NKEILRWGTPRTFDFEVKDHITLGEEANGLDFAAGAKLAGARFAVMKGQIAKMHRALAQF
CCCEEECCCCCEEEEEECCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MLDLHTEQHGYLETYVPYLVNHATLYGTGQLPKFGEDLFHTLALEGEQPYALIPTAEVPV
HHHHHCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCH
TNLVRDVIIDEAELPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVDPDKSM
HHHHHHHHHCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHH
EALEELTGHAEKVLQLLNLPYRKVLLCTGDMGFGSCKTYDLEVWVPAQNTYREISSCSNM
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHHHHH
WDFQARRMQARCKAKGDKKTRLVHTLNGSGLAVGRTLVAVLENYQNADGSITVPEELRPY
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHH
MGGLDVIGK
HCCCHHCCC
>Mature Secondary Structure
MIDPNLLRNNLAEVAEKLKVKRNFMLDTEKLTALEDQRKNLQVTTENLQAERNARSKAIG
CCCHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
AAKARGEDIAPLLAEMDDMGNQLTEAKAQLDAVLAEINQIALSIPNLPADEVPLGKDDTE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NKEILRWGTPRTFDFEVKDHITLGEEANGLDFAAGAKLAGARFAVMKGQIAKMHRALAQF
CCCEEECCCCCEEEEEECCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MLDLHTEQHGYLETYVPYLVNHATLYGTGQLPKFGEDLFHTLALEGEQPYALIPTAEVPV
HHHHHCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCH
TNLVRDVIIDEAELPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVDPDKSM
HHHHHHHHHCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEEEECCCHHH
EALEELTGHAEKVLQLLNLPYRKVLLCTGDMGFGSCKTYDLEVWVPAQNTYREISSCSNM
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHHHHH
WDFQARRMQARCKAKGDKKTRLVHTLNGSGLAVGRTLVAVLENYQNADGSITVPEELRPY
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHH
MGGLDVIGK
HCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA