Click here to switch to the map view.

The map label for this gene is ispA [H]

Identifier: 162448166

GI number: 162448166

Start: 1384020

End: 1384856

Strand: Direct

Name: ispA [H]

Synonym: ACL_1327

Alternate gene names: 162448166

Gene position: 1384020-1384856 (Clockwise)

Preceding gene: 162448165

Following gene: 162448170

Centisome position: 92.45

GC content: 32.5

Gene sequence:

>837_bases
ATGCCAACAATTGAAAATAGACTAAAAGCTTATATCGAAACATTACCTGAAAGTAAATTAAAAGCGGCTATGGCCTATGC
ATTACTCGGTGGTGGTAAACGCATAAGACCTATGTTAGGGATGACCTTACTTGAAAGTAAAGGTGTTGATCCAACACCTT
ACATAGAAGCATTTTTAGCTGTTGAAATGATTCACACTTATTCGCTTATTCATGACGATCTTCCTGCAATGGATGATGAT
ACACTAAGACGTGGAAAACCAACTGTACATATTGCTTTTGACGAAGCTATAGCCATCCTAGCTGGTGATGCACTTCTAAC
AGATAGTTTTAGACTTGTTACTCAAAACAAATATCTAAGCACTCTACAAAAAGTTGAGATCATCGATATCATTTCTTCTA
AAGCTGGTAGTACCGGTATGGTCTTTGGTCAAATCAAGGATATTGAATCCGAAGACAAAATGGTTACAATAGAAGATTTA
AATTTAATGTATGAGCTTAAAACAGCAAACCTCATTCAAGCCAGTCTTATGATTGCTGGCGTTATTCTTTCAGATCATGA
TATAAAAAGTTATGAGGATTTAGGTTACTATATTGGACTTATTTTCCAAATTCAAGATGACATATTAGAATATACATTAT
CACCTGAGGAATTTGGTAAATCTAAATCAGATGACATTAGAAATAAACCTACCTATGTGTCACTGCTTGGTTTAGATAAA
GCCAATCAAGTACTAAATACATATGTTGATACATTAAATACATTAATCGAGTCTCTATATATTAAAGATACTGTTATACA
TACACAAATTAAACTATTATTAAATAGAAGAAAATAA

Upstream 100 bases:

>100_bases
AAATATTAGTCGCTTATCATAATTATGTTACAATAGGTTTTACATAAAACTAAACATTAAGGAGACCAGTAATATTTCAT
ATATTATTGGAGTACATTTT

Downstream 100 bases:

>100_bases
TAAAAAGAACTATCAAATTTATTTTGATAGTTCTTTTACTTTTGTTTACTCTGATACATCATTTGATCTACTCTGTTGAT
TAGTTGATCTATAGTTTCCC

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MPTIENRLKAYIETLPESKLKAAMAYALLGGGKRIRPMLGMTLLESKGVDPTPYIEAFLAVEMIHTYSLIHDDLPAMDDD
TLRRGKPTVHIAFDEAIAILAGDALLTDSFRLVTQNKYLSTLQKVEIIDIISSKAGSTGMVFGQIKDIESEDKMVTIEDL
NLMYELKTANLIQASLMIAGVILSDHDIKSYEDLGYYIGLIFQIQDDILEYTLSPEEFGKSKSDDIRNKPTYVSLLGLDK
ANQVLNTYVDTLNTLIESLYIKDTVIHTQIKLLLNRRK

Sequences:

>Translated_278_residues
MPTIENRLKAYIETLPESKLKAAMAYALLGGGKRIRPMLGMTLLESKGVDPTPYIEAFLAVEMIHTYSLIHDDLPAMDDD
TLRRGKPTVHIAFDEAIAILAGDALLTDSFRLVTQNKYLSTLQKVEIIDIISSKAGSTGMVFGQIKDIESEDKMVTIEDL
NLMYELKTANLIQASLMIAGVILSDHDIKSYEDLGYYIGLIFQIQDDILEYTLSPEEFGKSKSDDIRNKPTYVSLLGLDK
ANQVLNTYVDTLNTLIESLYIKDTVIHTQIKLLLNRRK
>Mature_277_residues
PTIENRLKAYIETLPESKLKAAMAYALLGGGKRIRPMLGMTLLESKGVDPTPYIEAFLAVEMIHTYSLIHDDLPAMDDDT
LRRGKPTVHIAFDEAIAILAGDALLTDSFRLVTQNKYLSTLQKVEIIDIISSKAGSTGMVFGQIKDIESEDKMVTIEDLN
LMYELKTANLIQASLMIAGVILSDHDIKSYEDLGYYIGLIFQIQDDILEYTLSPEEFGKSKSDDIRNKPTYVSLLGLDKA
NQVLNTYVDTLNTLIESLYIKDTVIHTQIKLLLNRRK

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:
GO:0004337: Geranyltranstransferase
GO:0008299: Geranyltranstransferase
GO:0016740: Geranyltranstransferase

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=224, Percent_Identity=30.3571428571429, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786623, Length=260, Percent_Identity=38.0769230769231, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789578, Length=210, Percent_Identity=32.8571428571429, Blast_Score=111, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17505681, Length=174, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24651612, Length=225, Percent_Identity=27.5555555555556, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31167; Mature: 31035

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIENRLKAYIETLPESKLKAAMAYALLGGGKRIRPMLGMTLLESKGVDPTPYIEAFLA
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
VEMIHTYSLIHDDLPAMDDDTLRRGKPTVHIAFDEAIAILAGDALLTDSFRLVTQNKYLS
HHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEEHHEEHHHCCCHHHCCCCCEEECHHHHH
TLQKVEIIDIISSKAGSTGMVFGQIKDIESEDKMVTIEDLNLMYELKTANLIQASLMIAG
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCEEEEECHHHHHHHHHHHHH
VILSDHDIKSYEDLGYYIGLIFQIQDDILEYTLSPEEFGKSKSDDIRNKPTYVSLLGLDK
HHCCCCCCCHHHHHHHHHHHHEEEHHHHHHHCCCHHHHCCCCCCCCCCCCCEEEEEECCH
ANQVLNTYVDTLNTLIESLYIKDTVIHTQIKLLLNRRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTIENRLKAYIETLPESKLKAAMAYALLGGGKRIRPMLGMTLLESKGVDPTPYIEAFLA
CCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
VEMIHTYSLIHDDLPAMDDDTLRRGKPTVHIAFDEAIAILAGDALLTDSFRLVTQNKYLS
HHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEEEHHEEHHHCCCHHHCCCCCEEECHHHHH
TLQKVEIIDIISSKAGSTGMVFGQIKDIESEDKMVTIEDLNLMYELKTANLIQASLMIAG
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCEEEEECHHHHHHHHHHHHH
VILSDHDIKSYEDLGYYIGLIFQIQDDILEYTLSPEEFGKSKSDDIRNKPTYVSLLGLDK
HHCCCCCCCHHHHHHHHHHHHEEEHHHHHHHCCCHHHHCCCCCCCCCCCCCEEEEEECCH
ANQVLNTYVDTLNTLIESLYIKDTVIHTQIKLLLNRRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]