BacMap

Definition	Acholeplasma laidlawii PG-8A chromosome, complete genome.
Accession	NC_010163
Length	1,496,992

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The map label for this gene is rotA [H]

Identifier: 162447660

GI number: 162447660

Start: 837893

End: 838399

Strand: Direct

Name: rotA [H]

Synonym: ACL_0801

Alternate gene names: 162447660

Gene position: 837893-838399 (Clockwise)

Preceding gene: 162447655

Following gene: 162447661

Centisome position: 55.97

GC content: 31.16

Gene sequence:

>507_bases
ATGTCAGAAATTCTATTATCAATGGAGATTGAAGAATTTGGTACTTTAAAGGTAGAACTCTATCCAAATATCGCACCAAA
CACAGTCTCTAATTTTATGAACTATGTGAATAAAAACTTCTATGATGGTCTAATTTTCCATCGTATCATCAAAGGTTTTA
TGATTCAAGGAGGCGCAAATCCTAAAGCTAGAGAAATGCCAATTAAAGGTGAATTTGCATCTAACGGATTTAAAAATGAT
TTAAAACATGCGAGAGGTGTTTTATCTATGGCAAGAACAATGGATAAAAACTCTGCAACTTCACAATTCTTTATAATGCA
CCAAGATTCACCACACTTAGATGGTCAATATGCATCATTTGGTAAAGTTATTGAAGGGATTGAAATTGTTGATAAAATCG
CTTCAGTTAAAACAGATGGTTATGATCAACCTTTAAAGGATGTCAAGATTAAACATATTACTGTATTAAAAAATGAGGCA
AATTTAGAACCTGTAAAATACGTATAA

Upstream 100 bases:

>100_bases
ATGTCCAAAATCTATCATAAATTTATCGCTCACTTTCTATCTCCATTATATCATGATATGATAAAATGAAATTAATAATA
TTTGAAAGGACTCAAAAAAT

Downstream 100 bases:

>100_bases
AGAAGGTAAATTTATGAACCAATTCATTGATATTCATCCAAAAGTGTTAGATGCCCTAAGATCAGGTAAGCCTGTTGTTG
CGTTAGAATCTACGATTATT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MSEILLSMEIEEFGTLKVELYPNIAPNTVSNFMNYVNKNFYDGLIFHRIIKGFMIQGGANPKAREMPIKGEFASNGFKND
LKHARGVLSMARTMDKNSATSQFFIMHQDSPHLDGQYASFGKVIEGIEIVDKIASVKTDGYDQPLKDVKIKHITVLKNEA
NLEPVKYV

Sequences:

>Translated_168_residues
MSEILLSMEIEEFGTLKVELYPNIAPNTVSNFMNYVNKNFYDGLIFHRIIKGFMIQGGANPKAREMPIKGEFASNGFKND
LKHARGVLSMARTMDKNSATSQFFIMHQDSPHLDGQYASFGKVIEGIEIVDKIASVKTDGYDQPLKDVKIKHITVLKNEA
NLEPVKYV
>Mature_167_residues
SEILLSMEIEEFGTLKVELYPNIAPNTVSNFMNYVNKNFYDGLIFHRIIKGFMIQGGANPKAREMPIKGEFASNGFKNDL
KHARGVLSMARTMDKNSATSQFFIMHQDSPHLDGQYASFGKVIEGIEIVDKIASVKTDGYDQPLKDVKIKHITVLKNEAN
LEPVKYV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=152, Percent_Identity=40.1315789473684, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI24308049, Length=147, Percent_Identity=40.8163265306122, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI6631100, Length=165, Percent_Identity=35.1515151515151, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI7706339, Length=141, Percent_Identity=38.2978723404255, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI22547212, Length=152, Percent_Identity=36.1842105263158, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI7657473, Length=152, Percent_Identity=36.1842105263158, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI4758950, Length=153, Percent_Identity=42.483660130719, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI22547215, Length=152, Percent_Identity=36.1842105263158, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI5454154, Length=161, Percent_Identity=34.7826086956522, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI4505991, Length=148, Percent_Identity=38.5135135135135, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI42560244, Length=152, Percent_Identity=32.8947368421053, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI4826932, Length=163, Percent_Identity=35.5828220858896, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI10863927, Length=135, Percent_Identity=37.037037037037, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI310110104, Length=136, Percent_Identity=38.9705882352941, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310129267, Length=136, Percent_Identity=38.2352941176471, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI310120620, Length=136, Percent_Identity=38.2352941176471, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI310127646, Length=136, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI310114371, Length=136, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI310119221, Length=136, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI256017253, Length=132, Percent_Identity=34.8484848484849, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI221139811, Length=132, Percent_Identity=34.8484848484849, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI256017251, Length=132, Percent_Identity=34.8484848484849, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1789763, Length=153, Percent_Identity=45.7516339869281, Blast_Score=114, Evalue=3e-27,
Organism=Escherichia coli, GI1786736, Length=159, Percent_Identity=41.5094339622642, Blast_Score=106, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71980594, Length=149, Percent_Identity=39.5973154362416, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17539496, Length=141, Percent_Identity=40.4255319148936, Blast_Score=99, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71980590, Length=136, Percent_Identity=40.4411764705882, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17551282, Length=164, Percent_Identity=36.5853658536585, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17551284, Length=164, Percent_Identity=36.5853658536585, Blast_Score=90, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17506311, Length=148, Percent_Identity=34.4594594594595, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=155, Percent_Identity=34.1935483870968, Blast_Score=83, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17506307, Length=166, Percent_Identity=37.3493975903614, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17552780, Length=166, Percent_Identity=34.3373493975904, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565860, Length=169, Percent_Identity=36.094674556213, Blast_Score=76, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17552784, Length=172, Percent_Identity=33.7209302325581, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17559074, Length=159, Percent_Identity=35.2201257861635, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=143, Percent_Identity=32.8671328671329, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539498, Length=136, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552782, Length=138, Percent_Identity=39.8550724637681, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=135, Percent_Identity=37.037037037037, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71997782, Length=147, Percent_Identity=34.0136054421769, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32563659, Length=157, Percent_Identity=29.9363057324841, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=154, Percent_Identity=38.961038961039, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323246, Length=163, Percent_Identity=34.3558282208589, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321848, Length=150, Percent_Identity=36.6666666666667, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320359, Length=148, Percent_Identity=36.4864864864865, Blast_Score=75, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323562, Length=133, Percent_Identity=39.8496240601504, Blast_Score=72, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922376, Length=149, Percent_Identity=34.2281879194631, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17986117, Length=141, Percent_Identity=39.0070921985816, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24652460, Length=151, Percent_Identity=34.4370860927152, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20130249, Length=154, Percent_Identity=40.2597402597403, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24650807, Length=152, Percent_Identity=35.5263157894737, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19922912, Length=141, Percent_Identity=36.8794326241135, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24586038, Length=160, Percent_Identity=31.875, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45549139, Length=138, Percent_Identity=36.231884057971, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664125, Length=133, Percent_Identity=37.593984962406, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357783, Length=133, Percent_Identity=37.593984962406, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136360, Length=156, Percent_Identity=32.6923076923077, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18931; Mature: 18800

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEILLSMEIEEFGTLKVELYPNIAPNTVSNFMNYVNKNFYDGLIFHRIIKGFMIQGGAN
CCCEEEEEEHHHCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
PKAREMPIKGEFASNGFKNDLKHARGVLSMARTMDKNSATSQFFIMHQDSPHLDGQYASF
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHH
GKVIEGIEIVDKIASVKTDGYDQPLKDVKIKHITVLKNEANLEPVKYV
HHHHHHHHHHHHHHHHCCCCCCCCHHHCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SEILLSMEIEEFGTLKVELYPNIAPNTVSNFMNYVNKNFYDGLIFHRIIKGFMIQGGAN
CCEEEEEEHHHCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
PKAREMPIKGEFASNGFKNDLKHARGVLSMARTMDKNSATSQFFIMHQDSPHLDGQYASF
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHH
GKVIEGIEIVDKIASVKTDGYDQPLKDVKIKHITVLKNEANLEPVKYV
HHHHHHHHHHHHHHHHCCCCCCCCHHHCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7948017 [H]