| Definition | Acholeplasma laidlawii PG-8A chromosome, complete genome. |
|---|---|
| Accession | NC_010163 |
| Length | 1,496,992 |
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The map label for this gene is yvgN [H]
Identifier: 162447625
GI number: 162447625
Start: 801648
End: 802466
Strand: Direct
Name: yvgN [H]
Synonym: ACL_0765
Alternate gene names: 162447625
Gene position: 801648-802466 (Clockwise)
Preceding gene: 162447621
Following gene: 162447628
Centisome position: 53.55
GC content: 33.33
Gene sequence:
>819_bases ATGAAAGTTATTAATCAGCATTACACATTAAGCAATGGGGTCAAAATACCAAAAATTGGACTAGGTACTTGGCAGGTAAA AGATGGTGATGAGGCATATAATTCTGTCTTAATTGCCCTTAAAAATGGCTATCGTCATATTGATACTGCAGAAGGCTATC GGAATGAAGCATCTGTTGGACGCGCCATTAAAGATTCAGGCATTCCTCGTGATGAAATATTTGTCACCTCTAAACTAGAA TCACATATTAAAACGTATGAAGGTGCACTTGAAGCATTTGACAAGACACTAAAAGCCCTTGATTTTGAATATTTAGATTT ATTCTTAATTCATGCACCTTGGCCATGGGATGAAGTTGGTAAAGAATGTCATGAAGGTAATGTATTAGCTTATAAAGCCA TGGAAAAACTATATAAAGATGGAAAAATTAGAGCAATCGGAATATCTAATTTTGAACCAGTTGACATAGAAAATATCATT ACTCATTGTGAAATTGTTCCACATGTGAATCAAATTGCTTACTTTATTGGACTAGATCAATCAAAAACTATTGAAAGTTG TAATAAGCATAATATATTTGTTGAAGCCTACTCTCCTTTAGGTACAGGCCGTTTATTATCTAATGAAGTTATAGTTCAAA TGGCAGAAAAATATCAAGTATCACCCGCACAAATCTGTATCCGTTACTGCTTACAAAAAGGCACTGCACCATTACCAAAA TCAACACATGAAGAACGTATTATTATGAATACAAAAGTGGATTTTGAAATTAGTACTGATGATATGAATGTCTTAGATCA CGTCAAGAAGAATTTCTAA
Upstream 100 bases:
>100_bases ATTTGATGAGTTCATGCATATAAATTATAAACTTAGAAGTTTGATAATTTGCTTCGTGATATAATGTAGTTATACTAAAT ATATTAAAGGAGCGCTTCAT
Downstream 100 bases:
>100_bases ACATACCTATTTTGATATTTAATGAAAAACCTTACTTTTCGTAAGGTTTTTTTGAACATCATGTTTAATTTTTTAGGTAC TTTTTAAATCATAAAATGAA
Product: aldo/keto reductase family oxidoreductase
Products: NA
Alternate protein names: GR; Methylglyoxal reductase [H]
Number of amino acids: Translated: 272; Mature: 272
Protein sequence:
>272_residues MKVINQHYTLSNGVKIPKIGLGTWQVKDGDEAYNSVLIALKNGYRHIDTAEGYRNEASVGRAIKDSGIPRDEIFVTSKLE SHIKTYEGALEAFDKTLKALDFEYLDLFLIHAPWPWDEVGKECHEGNVLAYKAMEKLYKDGKIRAIGISNFEPVDIENII THCEIVPHVNQIAYFIGLDQSKTIESCNKHNIFVEAYSPLGTGRLLSNEVIVQMAEKYQVSPAQICIRYCLQKGTAPLPK STHEERIIMNTKVDFEISTDDMNVLDHVKKNF
Sequences:
>Translated_272_residues MKVINQHYTLSNGVKIPKIGLGTWQVKDGDEAYNSVLIALKNGYRHIDTAEGYRNEASVGRAIKDSGIPRDEIFVTSKLE SHIKTYEGALEAFDKTLKALDFEYLDLFLIHAPWPWDEVGKECHEGNVLAYKAMEKLYKDGKIRAIGISNFEPVDIENII THCEIVPHVNQIAYFIGLDQSKTIESCNKHNIFVEAYSPLGTGRLLSNEVIVQMAEKYQVSPAQICIRYCLQKGTAPLPK STHEERIIMNTKVDFEISTDDMNVLDHVKKNF >Mature_272_residues MKVINQHYTLSNGVKIPKIGLGTWQVKDGDEAYNSVLIALKNGYRHIDTAEGYRNEASVGRAIKDSGIPRDEIFVTSKLE SHIKTYEGALEAFDKTLKALDFEYLDLFLIHAPWPWDEVGKECHEGNVLAYKAMEKLYKDGKIRAIGISNFEPVDIENII THCEIVPHVNQIAYFIGLDQSKTIESCNKHNIFVEAYSPLGTGRLLSNEVIVQMAEKYQVSPAQICIRYCLQKGTAPLPK STHEERIIMNTKVDFEISTDDMNVLDHVKKNF
Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=290, Percent_Identity=37.2413793103448, Blast_Score=170, Evalue=1e-42, Organism=Homo sapiens, GI5174391, Length=290, Percent_Identity=37.2413793103448, Blast_Score=170, Evalue=1e-42, Organism=Homo sapiens, GI223468663, Length=293, Percent_Identity=34.1296928327645, Blast_Score=152, Evalue=3e-37, Organism=Homo sapiens, GI24497585, Length=298, Percent_Identity=33.5570469798658, Blast_Score=148, Evalue=5e-36, Organism=Homo sapiens, GI24497583, Length=303, Percent_Identity=32.3432343234323, Blast_Score=147, Evalue=1e-35, Organism=Homo sapiens, GI310109920, Length=297, Percent_Identity=32.996632996633, Blast_Score=147, Evalue=1e-35, Organism=Homo sapiens, GI45446745, Length=297, Percent_Identity=32.996632996633, Blast_Score=146, Evalue=2e-35, Organism=Homo sapiens, GI4503285, Length=297, Percent_Identity=32.996632996633, Blast_Score=146, Evalue=2e-35, Organism=Homo sapiens, GI5453543, Length=297, Percent_Identity=32.3232323232323, Blast_Score=144, Evalue=6e-35, Organism=Homo sapiens, GI310109922, Length=286, Percent_Identity=32.8671328671329, Blast_Score=144, Evalue=1e-34, Organism=Homo sapiens, GI5174695, Length=294, Percent_Identity=32.6530612244898, Blast_Score=143, Evalue=2e-34, Organism=Homo sapiens, GI4502049, Length=291, Percent_Identity=38.1443298969072, Blast_Score=142, Evalue=2e-34, Organism=Homo sapiens, GI300116273, Length=275, Percent_Identity=33.4545454545455, Blast_Score=136, Evalue=2e-32, Organism=Homo sapiens, GI291291012, Length=266, Percent_Identity=32.7067669172932, Blast_Score=127, Evalue=1e-29, Organism=Homo sapiens, GI93277124, Length=298, Percent_Identity=31.2080536912752, Blast_Score=122, Evalue=4e-28, Organism=Homo sapiens, GI300116271, Length=284, Percent_Identity=30.2816901408451, Blast_Score=117, Evalue=1e-26, Organism=Homo sapiens, GI310109924, Length=152, Percent_Identity=32.2368421052632, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI310109926, Length=110, Percent_Identity=38.1818181818182, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI207028673, Length=110, Percent_Identity=38.1818181818182, Blast_Score=74, Evalue=1e-13, Organism=Escherichia coli, GI87082198, Length=258, Percent_Identity=35.6589147286822, Blast_Score=155, Evalue=3e-39, Organism=Escherichia coli, GI1786400, Length=258, Percent_Identity=35.2713178294574, Blast_Score=142, Evalue=2e-35, Organism=Escherichia coli, GI1788081, Length=281, Percent_Identity=30.6049822064057, Blast_Score=102, Evalue=4e-23, Organism=Caenorhabditis elegans, GI71998625, Length=259, Percent_Identity=37.0656370656371, Blast_Score=174, Evalue=3e-44, Organism=Caenorhabditis elegans, GI17564128, Length=291, Percent_Identity=35.3951890034364, Blast_Score=167, Evalue=7e-42, Organism=Caenorhabditis elegans, GI17566692, Length=286, Percent_Identity=34.965034965035, Blast_Score=154, Evalue=4e-38, Organism=Caenorhabditis elegans, GI17537075, Length=294, Percent_Identity=35.3741496598639, Blast_Score=154, Evalue=6e-38, Organism=Caenorhabditis elegans, GI17550248, Length=288, Percent_Identity=34.375, Blast_Score=152, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=35.0340136054422, Blast_Score=152, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17552492, Length=262, Percent_Identity=34.3511450381679, Blast_Score=150, Evalue=6e-37, Organism=Caenorhabditis elegans, GI17538386, Length=269, Percent_Identity=35.3159851301115, Blast_Score=147, Evalue=6e-36, Organism=Caenorhabditis elegans, GI17561298, Length=266, Percent_Identity=31.9548872180451, Blast_Score=139, Evalue=1e-33, Organism=Caenorhabditis elegans, GI17562292, Length=281, Percent_Identity=28.8256227758007, Blast_Score=129, Evalue=2e-30, Organism=Caenorhabditis elegans, GI17537079, Length=296, Percent_Identity=28.0405405405405, Blast_Score=122, Evalue=1e-28, Organism=Caenorhabditis elegans, GI17561300, Length=254, Percent_Identity=31.8897637795276, Blast_Score=120, Evalue=1e-27, Organism=Caenorhabditis elegans, GI17550246, Length=78, Percent_Identity=43.5897435897436, Blast_Score=68, Evalue=4e-12, Organism=Saccharomyces cerevisiae, GI6324694, Length=285, Percent_Identity=39.6491228070175, Blast_Score=191, Evalue=1e-49, Organism=Saccharomyces cerevisiae, GI6320576, Length=287, Percent_Identity=39.3728222996516, Blast_Score=187, Evalue=2e-48, Organism=Saccharomyces cerevisiae, GI6320079, Length=268, Percent_Identity=36.9402985074627, Blast_Score=150, Evalue=2e-37, Organism=Saccharomyces cerevisiae, GI6319625, Length=290, Percent_Identity=34.8275862068965, Blast_Score=149, Evalue=4e-37, Organism=Saccharomyces cerevisiae, GI6322556, Length=278, Percent_Identity=33.4532374100719, Blast_Score=137, Evalue=3e-33, Organism=Saccharomyces cerevisiae, GI6321896, Length=298, Percent_Identity=30.8724832214765, Blast_Score=135, Evalue=5e-33, Organism=Drosophila melanogaster, GI20129731, Length=278, Percent_Identity=38.1294964028777, Blast_Score=167, Evalue=8e-42, Organism=Drosophila melanogaster, GI24657054, Length=288, Percent_Identity=37.1527777777778, Blast_Score=162, Evalue=3e-40, Organism=Drosophila melanogaster, GI24663317, Length=283, Percent_Identity=36.3957597173145, Blast_Score=159, Evalue=3e-39, Organism=Drosophila melanogaster, GI21356425, Length=281, Percent_Identity=35.9430604982206, Blast_Score=154, Evalue=5e-38, Organism=Drosophila melanogaster, GI24644950, Length=297, Percent_Identity=31.986531986532, Blast_Score=150, Evalue=6e-37, Organism=Drosophila melanogaster, GI45553081, Length=277, Percent_Identity=33.9350180505415, Blast_Score=150, Evalue=7e-37, Organism=Drosophila melanogaster, GI221378297, Length=317, Percent_Identity=29.3375394321767, Blast_Score=143, Evalue=1e-34, Organism=Drosophila melanogaster, GI24662789, Length=294, Percent_Identity=32.6530612244898, Blast_Score=142, Evalue=3e-34, Organism=Drosophila melanogaster, GI281366140, Length=244, Percent_Identity=33.6065573770492, Blast_Score=133, Evalue=1e-31, Organism=Drosophila melanogaster, GI24662781, Length=275, Percent_Identity=36.7272727272727, Blast_Score=131, Evalue=5e-31, Organism=Drosophila melanogaster, GI24662785, Length=273, Percent_Identity=36.6300366300366, Blast_Score=126, Evalue=1e-29,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.283 [H]
Molecular weight: Translated: 30805; Mature: 30805
Theoretical pI: Translated: 6.18; Mature: 6.18
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.8 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 1.8 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 3.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKVINQHYTLSNGVKIPKIGLGTWQVKDGDEAYNSVLIALKNGYRHIDTAEGYRNEASVG CCCCCCCEECCCCCCCCEECCCEEEECCCHHHHHHEEEEEECCCCCCCCCCCCCCHHHHC RAIKDSGIPRDEIFVTSKLESHIKTYEGALEAFDKTLKALDFEYLDLFLIHAPWPWDEVG CHHHHCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEEEEECCCCHHHHH KECHEGNVLAYKAMEKLYKDGKIRAIGISNFEPVDIENIITHCEIVPHVNQIAYFIGLDQ HHHCCCCEEHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHEEEEEECCC SKTIESCNKHNIFVEAYSPLGTGRLLSNEVIVQMAEKYQVSPAQICIRYCLQKGTAPLPK CHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC STHEERIIMNTKVDFEISTDDMNVLDHVKKNF CCCCCEEEEEEEEEEEECCCCHHHHHHHHHCC >Mature Secondary Structure MKVINQHYTLSNGVKIPKIGLGTWQVKDGDEAYNSVLIALKNGYRHIDTAEGYRNEASVG CCCCCCCEECCCCCCCCEECCCEEEECCCHHHHHHEEEEEECCCCCCCCCCCCCCHHHHC RAIKDSGIPRDEIFVTSKLESHIKTYEGALEAFDKTLKALDFEYLDLFLIHAPWPWDEVG CHHHHCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEEEEECCCCHHHHH KECHEGNVLAYKAMEKLYKDGKIRAIGISNFEPVDIENIITHCEIVPHVNQIAYFIGLDQ HHHCCCCEEHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHEEEEEECCC SKTIESCNKHNIFVEAYSPLGTGRLLSNEVIVQMAEKYQVSPAQICIRYCLQKGTAPLPK CHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC STHEERIIMNTKVDFEISTDDMNVLDHVKKNF CCCCCEEEEEEEEEEEECCCCHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9639930; 9384377 [H]