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The map label for this gene is hemN [H]

Identifier: 162447538

GI number: 162447538

Start: 712160

End: 713251

Strand: Direct

Name: hemN [H]

Synonym: ACL_0678

Alternate gene names: 162447538

Gene position: 712160-713251 (Clockwise)

Preceding gene: 162447537

Following gene: 162447539

Centisome position: 47.57

GC content: 29.03

Gene sequence:

>1092_bases
ATGAAGGGTTTATATATCCATATACCATTTTGCGAGTACATCTGTCACTATTGTGATTTTGTTAAAAGAGTCCCTAAAAA
TCAAAATATGATAGATCAATATTTAATTAAATTAAGAGAAGAAATCATGACTTATGAGAGTCATTTTGATTCTATAGAGA
CAATCTTTGTTGGTGGAGGAACACCTTCCATGTTAACTGTAGATCAATTAACCTACCTGTTTGACTCGCTTGTAAGAATT
AAACCAGTAGAATTTTCAATTGAACTTAATCCAGAAAGCTACACACATGAAAAAGGTTTAGTATTTAAAAAATATGGCAT
TAATCGTATATCCATGGGTGTCCAGAGTTTTGATGATAAAATACTAGCTTATTTAAATAGAGGTCATAAGACAGAACAAG
TGTTTTCTATCATAAAAGACTTAAAAGACCTAGGCATCCCTTATATTTCTATTGACTTAATATTTGCAATACCGGGACAA
ACCCTAGATCATATTAAGTATGATTTAGAGCAGTTCTTAAAATTGGATATCACACATATTTCTTATTACTCTCTAATATT
AGAAGATAAGACCTATTTTTATCATCAGTATTTAAAAGGTAACTTCAAACCGATGGATGAAGATAATGAAGCTATTATGT
ATGAGTATGTCATGAATTTTTTAACAAATCATGGTTATGATCAATATGAAATAAGCAACTATGCAAAAAATAATCATTAT
TCACTACACAATAATATCTATTGGACATTAGGTGAATATATTGGTGTAGGATTAGGGGCACATGGGTTTATTGATAATTA
TAGAACATACAATGAACGCGGAATGGGTCAATATATGGATCATTTCTTAAAGGAAAAAACACTTCAAACTGAGGATTTAA
AACTACAAGATGAACTTATATTTGGCTTAAGATTAACTAAGGGTGTATACATTCCTAGACTAGAACAAAAATATAAAATA
AAATTAACTGAAAAATACCCCCAAATTCATGATAAAATAAAACTAGGATTACTTGAAATTAAAGATGACTATATACGTCT
AACTAAGGAAGGTACAATGCTTGGTAATCAAGTATTTATGATATTTGTATGA

Upstream 100 bases:

>100_bases
AGGATAAAAAAATTCTTTTCTCTCTCTTATAAAGAGGTATCTATTCAGGCTAGATACCTCTTTATTTTGATATAATAGTA
ATAGAAGGTAGGTTTTTACT

Downstream 100 bases:

>100_bases
CCTATTTAATCAAAGATTTTTCTTATTATTTGAATAATGAATTGGGTTTATCCAAGAATACCATTGATGCATATATGAGA
GATTTAAAGGACTATGAATC

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MKGLYIHIPFCEYICHYCDFVKRVPKNQNMIDQYLIKLREEIMTYESHFDSIETIFVGGGTPSMLTVDQLTYLFDSLVRI
KPVEFSIELNPESYTHEKGLVFKKYGINRISMGVQSFDDKILAYLNRGHKTEQVFSIIKDLKDLGIPYISIDLIFAIPGQ
TLDHIKYDLEQFLKLDITHISYYSLILEDKTYFYHQYLKGNFKPMDEDNEAIMYEYVMNFLTNHGYDQYEISNYAKNNHY
SLHNNIYWTLGEYIGVGLGAHGFIDNYRTYNERGMGQYMDHFLKEKTLQTEDLKLQDELIFGLRLTKGVYIPRLEQKYKI
KLTEKYPQIHDKIKLGLLEIKDDYIRLTKEGTMLGNQVFMIFV

Sequences:

>Translated_363_residues
MKGLYIHIPFCEYICHYCDFVKRVPKNQNMIDQYLIKLREEIMTYESHFDSIETIFVGGGTPSMLTVDQLTYLFDSLVRI
KPVEFSIELNPESYTHEKGLVFKKYGINRISMGVQSFDDKILAYLNRGHKTEQVFSIIKDLKDLGIPYISIDLIFAIPGQ
TLDHIKYDLEQFLKLDITHISYYSLILEDKTYFYHQYLKGNFKPMDEDNEAIMYEYVMNFLTNHGYDQYEISNYAKNNHY
SLHNNIYWTLGEYIGVGLGAHGFIDNYRTYNERGMGQYMDHFLKEKTLQTEDLKLQDELIFGLRLTKGVYIPRLEQKYKI
KLTEKYPQIHDKIKLGLLEIKDDYIRLTKEGTMLGNQVFMIFV
>Mature_363_residues
MKGLYIHIPFCEYICHYCDFVKRVPKNQNMIDQYLIKLREEIMTYESHFDSIETIFVGGGTPSMLTVDQLTYLFDSLVRI
KPVEFSIELNPESYTHEKGLVFKKYGINRISMGVQSFDDKILAYLNRGHKTEQVFSIIKDLKDLGIPYISIDLIFAIPGQ
TLDHIKYDLEQFLKLDITHISYYSLILEDKTYFYHQYLKGNFKPMDEDNEAIMYEYVMNFLTNHGYDQYEISNYAKNNHY
SLHNNIYWTLGEYIGVGLGAHGFIDNYRTYNERGMGQYMDHFLKEKTLQTEDLKLQDELIFGLRLTKGVYIPRLEQKYKI
KLTEKYPQIHDKIKLGLLEIKDDYIRLTKEGTMLGNQVFMIFV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:
GO:0003824: Oxygen-independent coproporphyrinogen III oxidase
GO:0004109: Oxygen-independent coproporphyrinogen III oxidase
GO:0005737: Oxygen-independent coproporphyrinogen III oxidase
GO:0006779: Oxygen-independent coproporphyrinogen III oxidase
GO:0016491: Oxygen-independent coproporphyrinogen III oxidase
GO:0051536: Oxygen-independent coproporphyrinogen III oxidase
GO:0051989: Oxygen-independent coproporphyrinogen III oxidase
GO:0055114: Oxygen-independent coproporphyrinogen III oxidase

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=308, Percent_Identity=30.8441558441558, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1789325, Length=381, Percent_Identity=31.496062992126, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI87082341, Length=393, Percent_Identity=25.6997455470738, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42946; Mature: 42946

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLYIHIPFCEYICHYCDFVKRVPKNQNMIDQYLIKLREEIMTYESHFDSIETIFVGGG
CCCEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
TPSMLTVDQLTYLFDSLVRIKPVEFSIELNPESYTHEKGLVFKKYGINRISMGVQSFDDK
CCCEEHHHHHHHHHHHHHHEECEEEEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHHH
ILAYLNRGHKTEQVFSIIKDLKDLGIPYISIDLIFAIPGQTLDHIKYDLEQFLKLDITHI
HHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHE
SYYSLILEDKTYFYHQYLKGNFKPMDEDNEAIMYEYVMNFLTNHGYDQYEISNYAKNNHY
EEEEEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHCCCCCE
SLHNNIYWTLGEYIGVGLGAHGFIDNYRTYNERGMGQYMDHFLKEKTLQTEDLKLQDELI
EEECCEEEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHH
FGLRLTKGVYIPRLEQKYKIKLTEKYPQIHDKIKLGLLEIKDDYIRLTKEGTMLGNQVFM
EEEECCCCEECCCCCCEEEEEEEHHCHHHHHHHHEEEEEECCCCEEEECCCCEECCEEEE
IFV
EEC
>Mature Secondary Structure
MKGLYIHIPFCEYICHYCDFVKRVPKNQNMIDQYLIKLREEIMTYESHFDSIETIFVGGG
CCCEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
TPSMLTVDQLTYLFDSLVRIKPVEFSIELNPESYTHEKGLVFKKYGINRISMGVQSFDDK
CCCEEHHHHHHHHHHHHHHEECEEEEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHHH
ILAYLNRGHKTEQVFSIIKDLKDLGIPYISIDLIFAIPGQTLDHIKYDLEQFLKLDITHI
HHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHE
SYYSLILEDKTYFYHQYLKGNFKPMDEDNEAIMYEYVMNFLTNHGYDQYEISNYAKNNHY
EEEEEEEECCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHCCCCCE
SLHNNIYWTLGEYIGVGLGAHGFIDNYRTYNERGMGQYMDHFLKEKTLQTEDLKLQDELI
EEECCEEEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHH
FGLRLTKGVYIPRLEQKYKIKLTEKYPQIHDKIKLGLLEIKDDYIRLTKEGTMLGNQVFM
EEEECCCCEECCCCCCEEEEEEEHHCHHHHHHHHEEEEEECCCCEEEECCCCEECCEEEE
IFV
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]