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The map label for this gene is uvrX [H]

Identifier: 162447279

GI number: 162447279

Start: 433765

End: 435111

Strand: Direct

Name: uvrX [H]

Synonym: ACL_0414

Alternate gene names: 162447279

Gene position: 433765-435111 (Clockwise)

Preceding gene: 162447278

Following gene: 162447280

Centisome position: 28.98

GC content: 32.74

Gene sequence:

>1347_bases
ATGATGTGTATTTTCAACTTGCTTTCATCAAATTGCTTGTATATAATGAAGAAACTAGGGAGGCGAAATAAAATGGAAGA
CCTTAAAATATACCAACTAAATAAAACAATTTTATGTATCGATCTTAAAAGTTTTTATGCATCAGTTGAATGTGTTTTAA
GAGGACTCGATCCATTTAAAACACCACTAGTTGTTGCTGATAAATCTAGGGGCGGTGGCTCTATTGTACTTGCGGTGTCA
CCTTACTTAAAATCTTTAGGTGTACCTTCACGCTGCAGAATATTTGAACTACCTGAGGATTTAAACATCATTTATGCAAA
ACCTCAGATGCAAACATATCTAGAATATTCAGCATCAGTCATTGGCGTCTATCTAGATTTTATAAGTGAAGCTGATCTTT
ATGTATATTCTATTGATGAAGCATTTCTAGATTTAACAAGTTACCTAGCATATTATAAAAAGACAGATATAGAACTTGCA
GAAGAAATACTAAATACCATTACATCTAAATTAGGTTTAACTGCAACGTGTGGTATTGGACCTAATATGATAATGTCTAA
ATTAAGTATGGATATTGAAGCTAAAAAGAACCCTAATAATATTGCTAAATGGAACTATGATGATATTAAAGATCACTTAT
GGCCAGTGACACCACTTTCTAAAATGTGGGGGATTGGTCATCGAATGGAATCCCATTTAAATAAGCTTGGATTATTTACG
ATAGGAGATATCGCAAACTATCCTAAAGAGAAGTTAAAACGTAGATTTGGTGTCTTAGGAGAAGAGTTATGGTATCACAC
CCATGGCATCGATCTAAGTGAAATTAAAGATAAATATAAACTTAGAACAAAACCTAAATCATTTGGTTCTGGTCAAGTGC
TATTCAGAGATTATAGTGAAACGGAAATCATGACCATTATATTAGAGATGGTAGATGATGTAACGCGTAGACTTAGAATT
GCTAAAAAGCGTGCCCAAACGATTAGTCTATCTATAGGCTATACTAAAAGTGTAGCCGGTGGTTTTTCTAGACAAGTAAC
GCTTGAACAACCCACATCATCTGAAGCTACCATATATCAAACATGTCAAGACTTATTTGATATGTATTATGAAGGGTATC
CAATTCGTACAGTAGGTGTACACCTTTCTAAATTAACAGATAGTAAAGTATATCAATATTCATTATTTGAAGATGCACAT
CAGTTAGAAAAAGAATACCAACTCCATATGACAATGGATAAAATCAAACATAAATTTGGTAAAAATTCAGTTATTAGATT
ATCTTCTGAACAAGAACATGCAACTGCCAAACAAAGAAACAAACAAATAGGTGGCCATCATGTATAA

Upstream 100 bases:

>100_bases
TGTATATAAATCATAGTATTTACATTATGTAAAATATGCTAATTACTACAAAATATCATCACCAAGCAGTTAACTGCTAT
GGTGATTTTTTGTATCTAAA

Downstream 100 bases:

>100_bases
GGATAGAGGCATTATTAAGTGGGCACCATTTGATGCATTAAATGGATTTCATGAAACAATTGAAGCCTATAAATATGAAA
AAGGTAAAAAGGATAGACCA

Product: DNA-damage repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MMCIFNLLSSNCLYIMKKLGRRNKMEDLKIYQLNKTILCIDLKSFYASVECVLRGLDPFKTPLVVADKSRGGGSIVLAVS
PYLKSLGVPSRCRIFELPEDLNIIYAKPQMQTYLEYSASVIGVYLDFISEADLYVYSIDEAFLDLTSYLAYYKKTDIELA
EEILNTITSKLGLTATCGIGPNMIMSKLSMDIEAKKNPNNIAKWNYDDIKDHLWPVTPLSKMWGIGHRMESHLNKLGLFT
IGDIANYPKEKLKRRFGVLGEELWYHTHGIDLSEIKDKYKLRTKPKSFGSGQVLFRDYSETEIMTIILEMVDDVTRRLRI
AKKRAQTISLSIGYTKSVAGGFSRQVTLEQPTSSEATIYQTCQDLFDMYYEGYPIRTVGVHLSKLTDSKVYQYSLFEDAH
QLEKEYQLHMTMDKIKHKFGKNSVIRLSSEQEHATAKQRNKQIGGHHV

Sequences:

>Translated_448_residues
MMCIFNLLSSNCLYIMKKLGRRNKMEDLKIYQLNKTILCIDLKSFYASVECVLRGLDPFKTPLVVADKSRGGGSIVLAVS
PYLKSLGVPSRCRIFELPEDLNIIYAKPQMQTYLEYSASVIGVYLDFISEADLYVYSIDEAFLDLTSYLAYYKKTDIELA
EEILNTITSKLGLTATCGIGPNMIMSKLSMDIEAKKNPNNIAKWNYDDIKDHLWPVTPLSKMWGIGHRMESHLNKLGLFT
IGDIANYPKEKLKRRFGVLGEELWYHTHGIDLSEIKDKYKLRTKPKSFGSGQVLFRDYSETEIMTIILEMVDDVTRRLRI
AKKRAQTISLSIGYTKSVAGGFSRQVTLEQPTSSEATIYQTCQDLFDMYYEGYPIRTVGVHLSKLTDSKVYQYSLFEDAH
QLEKEYQLHMTMDKIKHKFGKNSVIRLSSEQEHATAKQRNKQIGGHHV
>Mature_448_residues
MMCIFNLLSSNCLYIMKKLGRRNKMEDLKIYQLNKTILCIDLKSFYASVECVLRGLDPFKTPLVVADKSRGGGSIVLAVS
PYLKSLGVPSRCRIFELPEDLNIIYAKPQMQTYLEYSASVIGVYLDFISEADLYVYSIDEAFLDLTSYLAYYKKTDIELA
EEILNTITSKLGLTATCGIGPNMIMSKLSMDIEAKKNPNNIAKWNYDDIKDHLWPVTPLSKMWGIGHRMESHLNKLGLFT
IGDIANYPKEKLKRRFGVLGEELWYHTHGIDLSEIKDKYKLRTKPKSFGSGQVLFRDYSETEIMTIILEMVDDVTRRLRI
AKKRAQTISLSIGYTKSVAGGFSRQVTLEQPTSSEATIYQTCQDLFDMYYEGYPIRTVGVHLSKLTDSKVYQYSLFEDAH
QLEKEYQLHMTMDKIKHKFGKNSVIRLSSEQEHATAKQRNKQIGGHHV

Specific function: Involved In Uv Protection And Mutation. Essential For Induced (Or Sos) Mutagenesis. May Modify The DNA Replication Machinery To Allow Bypass Synthesis Across A Damaged Template. [C]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=275, Percent_Identity=25.4545454545455, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI7706681, Length=275, Percent_Identity=25.4545454545455, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1787432, Length=400, Percent_Identity=25, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786425, Length=363, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19923006, Length=311, Percent_Identity=23.7942122186495, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 51291; Mature: 51291

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMCIFNLLSSNCLYIMKKLGRRNKMEDLKIYQLNKTILCIDLKSFYASVECVLRGLDPFK
CEEEHHHHHCCHHHHHHHHCCCCCCCCCEEEEECCEEEEEEHHHHHHHHHHHHHCCCCCC
TPLVVADKSRGGGSIVLAVSPYLKSLGVPSRCRIFELPEDLNIIYAKPQMQTYLEYSASV
CCEEEEECCCCCCEEEEEECHHHHHCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHH
IGVYLDFISEADLYVYSIDEAFLDLTSYLAYYKKTDIELAEEILNTITSKLGLTATCGIG
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEECCCC
PNMIMSKLSMDIEAKKNPNNIAKWNYDDIKDHLWPVTPLSKMWGIGHRMESHLNKLGLFT
HHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHCCCEE
IGDIANYPKEKLKRRFGVLGEELWYHTHGIDLSEIKDKYKLRTKPKSFGSGQVLFRDYSE
ECHHHCCCHHHHHHHHCCHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCH
TEIMTIILEMVDDVTRRLRIAKKRAQTISLSIGYTKSVAGGFSRQVTLEQPTSSEATIYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHCCCCCCEEEEECCCCCCHHHHH
TCQDLFDMYYEGYPIRTVGVHLSKLTDSKVYQYSLFEDAHQLEKEYQLHMTMDKIKHKFG
HHHHHHHHHHCCCCEEEHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KNSVIRLSSEQEHATAKQRNKQIGGHHV
CCCEEEECCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMCIFNLLSSNCLYIMKKLGRRNKMEDLKIYQLNKTILCIDLKSFYASVECVLRGLDPFK
CEEEHHHHHCCHHHHHHHHCCCCCCCCCEEEEECCEEEEEEHHHHHHHHHHHHHCCCCCC
TPLVVADKSRGGGSIVLAVSPYLKSLGVPSRCRIFELPEDLNIIYAKPQMQTYLEYSASV
CCEEEEECCCCCCEEEEEECHHHHHCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHH
IGVYLDFISEADLYVYSIDEAFLDLTSYLAYYKKTDIELAEEILNTITSKLGLTATCGIG
HHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEECCCC
PNMIMSKLSMDIEAKKNPNNIAKWNYDDIKDHLWPVTPLSKMWGIGHRMESHLNKLGLFT
HHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHCCCEE
IGDIANYPKEKLKRRFGVLGEELWYHTHGIDLSEIKDKYKLRTKPKSFGSGQVLFRDYSE
ECHHHCCCHHHHHHHHCCHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCH
TEIMTIILEMVDDVTRRLRIAKKRAQTISLSIGYTKSVAGGFSRQVTLEQPTSSEATIYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHCCCCCCEEEEECCCCCCHHHHH
TCQDLFDMYYEGYPIRTVGVHLSKLTDSKVYQYSLFEDAHQLEKEYQLHMTMDKIKHKFG
HHHHHHHHHHCCCCEEEHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KNSVIRLSSEQEHATAKQRNKQIGGHHV
CCCEEEECCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9722542; 9384377 [H]