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The map label for this gene is upp

Identifier: 162447076

GI number: 162447076

Start: 197288

End: 197914

Strand: Direct

Name: upp

Synonym: ACL_0206

Alternate gene names: 162447076

Gene position: 197288-197914 (Clockwise)

Preceding gene: 162447075

Following gene: 162447078

Centisome position: 13.18

GC content: 35.89

Gene sequence:

>627_bases
ATGGGCAAACTTGTTGTATTAAATCACCCATTAATCGATCATAAAATGGCACTTATAAGAGATAAAAACACCAGTACAAA
AACATTTAGAGAAACTGTTGGAGAAATTGGTGCATTAATCACTTATGAAATCACAAAAGATCTAGAAACTGTTGAAATTG
AAGTGGAAACTCCAATTCAAAAAACAATTTGTAGACAATTAAAAAAACAACTTGTTATCGTTCCAATTTTAAGAGCAGGA
CTCGGTATGGTGAATGGTATTCATGATATGGTACCAAGTGCAAAAATAGGCCATATTGGTTTATATAGAGATGAAAAATC
TCTAGAACCAGTATCTTATTATGCAAAATTCCCAACAGACATATTAGATGGTGTAGTGTTAGTTGTTGACCCAATGCTTG
CAACGGGTGGATCAGCTACTGCAGCAATCACTGAACTTAAAAATCGTGGAGCTAAAGATGTTAGATTTGTTGGTCTAGTA
GGGTGTCCTGAAGGTGTTAAACGTCTTCAAATGGATCATCCGGATGTACCAATATATTTAGCAGCATTAGATGAGAAACT
TAATGAGGTTGGCTACATTGTACCAGGACTTGGAGATGCAGGAGACCGCCTCTTCGGTACTAAATAA

Upstream 100 bases:

>100_bases
ATCAAAAATTATTGTTGATGCATATTTAAATGCACATGAAGAATCTCGTCATCAACATCGCGTAGACAAGATTGCAGCTA
TTGAAAATGGTGAGTAAACC

Downstream 100 bases:

>100_bases
TGAATCCATATGTGACTTATATTGTATTTTGGTCTGTATTTGTAGTAGGTTTCTTCGTAAGTTTTAGAATTCTACAAGCA
ATAGAAATAGAAAAATATTT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MGKLVVLNHPLIDHKMALIRDKNTSTKTFRETVGEIGALITYEITKDLETVEIEVETPIQKTICRQLKKQLVIVPILRAG
LGMVNGIHDMVPSAKIGHIGLYRDEKSLEPVSYYAKFPTDILDGVVLVVDPMLATGGSATAAITELKNRGAKDVRFVGLV
GCPEGVKRLQMDHPDVPIYLAALDEKLNEVGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_208_residues
MGKLVVLNHPLIDHKMALIRDKNTSTKTFRETVGEIGALITYEITKDLETVEIEVETPIQKTICRQLKKQLVIVPILRAG
LGMVNGIHDMVPSAKIGHIGLYRDEKSLEPVSYYAKFPTDILDGVVLVVDPMLATGGSATAAITELKNRGAKDVRFVGLV
GCPEGVKRLQMDHPDVPIYLAALDEKLNEVGYIVPGLGDAGDRLFGTK
>Mature_207_residues
GKLVVLNHPLIDHKMALIRDKNTSTKTFRETVGEIGALITYEITKDLETVEIEVETPIQKTICRQLKKQLVIVPILRAGL
GMVNGIHDMVPSAKIGHIGLYRDEKSLEPVSYYAKFPTDILDGVVLVVDPMLATGGSATAAITELKNRGAKDVRFVGLVG
CPEGVKRLQMDHPDVPIYLAALDEKLNEVGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=207, Percent_Identity=28.5024154589372, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI57863312, Length=207, Percent_Identity=28.5024154589372, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI21450816, Length=208, Percent_Identity=29.8076923076923, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=50.2415458937198, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17539892, Length=207, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17539894, Length=207, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=38.0208333333333, Blast_Score=111, Evalue=7e-26,
Organism=Drosophila melanogaster, GI45550449, Length=204, Percent_Identity=31.3725490196078, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=31.0344827586207, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=31.0344827586207, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=31.0344827586207, Blast_Score=84, Evalue=7e-17,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_ACHLI (A9NEQ2)

Other databases:

- EMBL:   CP000896
- RefSeq:   YP_001620208.1
- ProteinModelPortal:   A9NEQ2
- SMR:   A9NEQ2
- GeneID:   5803569
- GenomeReviews:   CP000896_GR
- KEGG:   acl:ACL_0206
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- BioCyc:   ALAI441768:ACL_0206-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22687; Mature: 22556

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLVVLNHPLIDHKMALIRDKNTSTKTFRETVGEIGALITYEITKDLETVEIEVETPIQ
CCCEEEECCCCHHHHEEEEECCCCCHHHHHHHHHHHHCEEEEEECCCCEEEEEEECCCHH
KTICRQLKKQLVIVPILRAGLGMVNGIHDMVPSAKIGHIGLYRDEKSLEPVSYYAKFPTD
HHHHHHHHHHEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHCCHH
ILDGVVLVVDPMLATGGSATAAITELKNRGAKDVRFVGLVGCPEGVKRLQMDHPDVPIYL
HHCCCCEEECHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHCCCCCCCCEEH
AALDEKLNEVGYIVPGLGDAGDRLFGTK
HHHHHHHHHCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GKLVVLNHPLIDHKMALIRDKNTSTKTFRETVGEIGALITYEITKDLETVEIEVETPIQ
CCEEEECCCCHHHHEEEEECCCCCHHHHHHHHHHHHCEEEEEECCCCEEEEEEECCCHH
KTICRQLKKQLVIVPILRAGLGMVNGIHDMVPSAKIGHIGLYRDEKSLEPVSYYAKFPTD
HHHHHHHHHHEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHCCHH
ILDGVVLVVDPMLATGGSATAAITELKNRGAKDVRFVGLVGCPEGVKRLQMDHPDVPIYL
HHCCCCEEECHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHCCCCCCCCEEH
AALDEKLNEVGYIVPGLGDAGDRLFGTK
HHHHHHHHHCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA