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The map label for this gene is lacA [H]

Identifier: 162446910

GI number: 162446910

Start: 28419

End: 29027

Strand: Direct

Name: lacA [H]

Synonym: ACL_0023

Alternate gene names: 162446910

Gene position: 28419-29027 (Clockwise)

Preceding gene: 162446909

Following gene: 162446911

Centisome position: 1.9

GC content: 32.68

Gene sequence:

>609_bases
ATGAGCCAATTAAAACGTATGCTAAGTGGTGAACTCTATATGGCTGAAGGCGAAGAGTTAGGCAAAATAAGAGATAATAT
GCTTGATAAACTTTATCAGTATAACCATGCACACTATAACAATCACAAACTAAGAGATGAACTTATTAAAGAGATTCTTG
GCGGTTATAAAGATAAATTAAAAATTACACCACCGGTTTATTTTGATTATGGTAAACATACTTTTGTAGGAAAGAATTTC
TATGCTAATTTTGATTGTATTTTCTTAGATGTAAATACAATCACCATTGGAGACAATGTCATGTTTGGTCCACGTGTTGG
ATTATATACTGCAGGACATCCAATTGATAAAGATGTAAGAATTACAGGTTTAGAATATGGTCTACCAATCACCATCGGTA
ACAACGTATGGATTGGTGGTAATGTAGTTGTAATGCCTGGTGTACATATTGGAGATAATACCATCATTGGAAGTGGTAGT
GTTGTAACTAAAGATATACCAAGTGATGTGATTGCTGCTGGAAACCCATGTAAAGTTATAAGAAAAATCACAACAGAAGA
TAAGATCTATTGGGAAGGTAAGAAGAAAATATATGAAGAAAGTTTTTAA

Upstream 100 bases:

>100_bases
CTATGGAAAAAGGGCTTAGAGTGGCGCTTTGCGGGATAACTACTAAAGAAGTTATAGGTCTTGCAAAACGTATTAAAAAT
GTTGTAGGAGCGTAACAAGT

Downstream 100 bases:

>100_bases
TATCTTAAGATATGTTCACATCATCTTAACTGTAGTTACGATACTTAGTTTTTTCTTATATTTAATTTACTTTAAAACAG
ATTATAAAAATGTGACTGCA

Product: galactoside O-acetyltransferase

Products: NA

Alternate protein names: GAT; Thiogalactoside acetyltransferase [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MSQLKRMLSGELYMAEGEELGKIRDNMLDKLYQYNHAHYNNHKLRDELIKEILGGYKDKLKITPPVYFDYGKHTFVGKNF
YANFDCIFLDVNTITIGDNVMFGPRVGLYTAGHPIDKDVRITGLEYGLPITIGNNVWIGGNVVVMPGVHIGDNTIIGSGS
VVTKDIPSDVIAAGNPCKVIRKITTEDKIYWEGKKKIYEESF

Sequences:

>Translated_202_residues
MSQLKRMLSGELYMAEGEELGKIRDNMLDKLYQYNHAHYNNHKLRDELIKEILGGYKDKLKITPPVYFDYGKHTFVGKNF
YANFDCIFLDVNTITIGDNVMFGPRVGLYTAGHPIDKDVRITGLEYGLPITIGNNVWIGGNVVVMPGVHIGDNTIIGSGS
VVTKDIPSDVIAAGNPCKVIRKITTEDKIYWEGKKKIYEESF
>Mature_201_residues
SQLKRMLSGELYMAEGEELGKIRDNMLDKLYQYNHAHYNNHKLRDELIKEILGGYKDKLKITPPVYFDYGKHTFVGKNFY
ANFDCIFLDVNTITIGDNVMFGPRVGLYTAGHPIDKDVRITGLEYGLPITIGNNVWIGGNVVVMPGVHIGDNTIIGSGSV
VTKDIPSDVIAAGNPCKVIRKITTEDKIYWEGKKKIYEESF

Specific function: May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell [H]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1786537, Length=193, Percent_Identity=47.6683937823834, Blast_Score=190, Evalue=5e-50,
Organism=Escherichia coli, GI1786664, Length=182, Percent_Identity=46.1538461538462, Blast_Score=182, Evalue=1e-47,
Organism=Escherichia coli, GI1788367, Length=131, Percent_Identity=33.587786259542, Blast_Score=64, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322243, Length=189, Percent_Identity=50.7936507936508, Blast_Score=197, Evalue=7e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.18 [H]

Molecular weight: Translated: 22752; Mature: 22620

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLKRMLSGELYMAEGEELGKIRDNMLDKLYQYNHAHYNNHKLRDELIKEILGGYKDKL
CHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCE
KITPPVYFDYGKHTFVGKNFYANFDCIFLDVNTITIGDNVMFGPRVGLYTAGHPIDKDVR
EECCCEEEECCCEEEECCCEECCEEEEEEEEEEEEECCCEEECCCCCEEECCCCCCCCEE
ITGLEYGLPITIGNNVWIGGNVVVMPGVHIGDNTIIGSGSVVTKDIPSDVIAAGNPCKVI
EEEEECCCEEEECCEEEECCCEEEECCEEECCCEEEECCCEEECCCCCHHHCCCCHHHHH
RKITTEDKIYWEGKKKIYEESF
HHHCCCCEEEECCCHHHHCCCC
>Mature Secondary Structure 
SQLKRMLSGELYMAEGEELGKIRDNMLDKLYQYNHAHYNNHKLRDELIKEILGGYKDKL
HHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCE
KITPPVYFDYGKHTFVGKNFYANFDCIFLDVNTITIGDNVMFGPRVGLYTAGHPIDKDVR
EECCCEEEECCCEEEECCCEECCEEEEEEEEEEEEECCCEEECCCCCEEECCCCCCCCEE
ITGLEYGLPITIGNNVWIGGNVVVMPGVHIGDNTIIGSGSVVTKDIPSDVIAAGNPCKVI
EEEEECCCEEEECCEEEECCCEEEECCEEECCCEEEECCCEEECCCCCHHHCCCCHHHHH
RKITTEDKIYWEGKKKIYEESF
HHHCCCCEEEECCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3922433; 3901000; 9278503; 6444453; 11937062 [H]