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The map label for this gene is tyrB [H]

Identifier: 162446909

GI number: 162446909

Start: 27232

End: 28413

Strand: Direct

Name: tyrB [H]

Synonym: ACL_0022

Alternate gene names: 162446909

Gene position: 27232-28413 (Clockwise)

Preceding gene: 162446908

Following gene: 162446910

Centisome position: 1.82

GC content: 32.15

Gene sequence:

>1182_bases
ATGTCTAAAATTGATATATTAAAAATTGCTAAATCAGCACAAATAGCAAAGTCTAAAAATGAGCATGTCATTGATGCTAC
AATCGGCATGTTTTATAATGATGACTCTAAACTCATCATACCAGCAGTAGAAAAAGCATATTATGATCTAGATTTACTAG
ATGCATTTAAATATGGTGCTACCGATGGTGGGCCTATGTTTGTAGAAAACGTCATAGATTGGGTATTAGATGATAAAAGA
AAATCAGTGGAAGAAAAGTTTTTAATAGGAGCACTATCTACACCGGGTGGTAGTGGTGCAATTTCACTTATTTTTAATAC
CTATGGTCATGTCGGTGATAAAGTCTTAGTACCGAATTTAAGATGGCGTTATGAATACTTTTTGAATGCAGCTAAGCTTA
AAGTGCATGAGCATAATATGTTTAAGGGTGACGGATTTGATTTGGAAGATTTTAAAACACAATTAAACTATTTAACCAGT
ATTCAAAAGCGTGTGATTGTTGTTATTAACGATCCATGTCATAATCCAACAGGTTTTAGCTTATCAGATAAAGAGTGGCA
AAGTATCATTGAAATACTAAATAGTTTTGATAAGAATGAACTTATTTTAGTCTACGATATAGCCTACTTTGATTATGATC
CTAAAGGTTTTAAAAATGCTAGAAATAACTTCTTAGCATTTAAACAACTGAAACCACACGTTCAAGTATTAACCGCCTTT
AGTGCATCTAAATCATTTGCAATGTATGGCGTAAGACTAGGTGGTTTATTAGGTTTATTTCATACAAAGGAACAACAAGC
ATTCTTTAAAGTTCACGTTCTTGAAGATGCACTTGGTAAATGGTCAACAGCACCATCTGTAGGTGTAGGTATCTTTAATA
AACTTGCTACTAAAAAAGATGAATATGTTCAGTACTTAATTACACTCACATCAACACTTAAACAAAGAGGTGAGATATTC
ATTAAAGAAGCCTTAGAAAATAATTTAGATATCTATCCTTATAGAGGCGGATTCTTTGTTTTAGTAAAATCAAATAATCC
AGAAAAAGATTATGAAAAACTAATAGATGATAACATCTACCTTATTCCTATGGAAAAAGGGCTTAGAGTGGCGCTTTGCG
GGATAACTACTAAAGAAGTTATAGGTCTTGCAAAACGTATTAAAAATGTTGTAGGAGCGTAA

Upstream 100 bases:

>100_bases
CTATTTTAAAAACATTTCTGATAAATAACCACAAAAGTTACGTAATCATAATACATGCTAAAATGATATATATAAATATG
TTTTAGCGAAGGAGAATCTA

Downstream 100 bases:

>100_bases
CAAGTATGAGCCAATTAAAACGTATGCTAAGTGGTGAACTCTATATGGCTGAAGGCGAAGAGTTAGGCAAAATAAGAGAT
AATATGCTTGATAAACTTTA

Product: aromatic-amino-acid transaminase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSKIDILKIAKSAQIAKSKNEHVIDATIGMFYNDDSKLIIPAVEKAYYDLDLLDAFKYGATDGGPMFVENVIDWVLDDKR
KSVEEKFLIGALSTPGGSGAISLIFNTYGHVGDKVLVPNLRWRYEYFLNAAKLKVHEHNMFKGDGFDLEDFKTQLNYLTS
IQKRVIVVINDPCHNPTGFSLSDKEWQSIIEILNSFDKNELILVYDIAYFDYDPKGFKNARNNFLAFKQLKPHVQVLTAF
SASKSFAMYGVRLGGLLGLFHTKEQQAFFKVHVLEDALGKWSTAPSVGVGIFNKLATKKDEYVQYLITLTSTLKQRGEIF
IKEALENNLDIYPYRGGFFVLVKSNNPEKDYEKLIDDNIYLIPMEKGLRVALCGITTKEVIGLAKRIKNVVGA

Sequences:

>Translated_393_residues
MSKIDILKIAKSAQIAKSKNEHVIDATIGMFYNDDSKLIIPAVEKAYYDLDLLDAFKYGATDGGPMFVENVIDWVLDDKR
KSVEEKFLIGALSTPGGSGAISLIFNTYGHVGDKVLVPNLRWRYEYFLNAAKLKVHEHNMFKGDGFDLEDFKTQLNYLTS
IQKRVIVVINDPCHNPTGFSLSDKEWQSIIEILNSFDKNELILVYDIAYFDYDPKGFKNARNNFLAFKQLKPHVQVLTAF
SASKSFAMYGVRLGGLLGLFHTKEQQAFFKVHVLEDALGKWSTAPSVGVGIFNKLATKKDEYVQYLITLTSTLKQRGEIF
IKEALENNLDIYPYRGGFFVLVKSNNPEKDYEKLIDDNIYLIPMEKGLRVALCGITTKEVIGLAKRIKNVVGA
>Mature_392_residues
SKIDILKIAKSAQIAKSKNEHVIDATIGMFYNDDSKLIIPAVEKAYYDLDLLDAFKYGATDGGPMFVENVIDWVLDDKRK
SVEEKFLIGALSTPGGSGAISLIFNTYGHVGDKVLVPNLRWRYEYFLNAAKLKVHEHNMFKGDGFDLEDFKTQLNYLTSI
QKRVIVVINDPCHNPTGFSLSDKEWQSIIEILNSFDKNELILVYDIAYFDYDPKGFKNARNNFLAFKQLKPHVQVLTAFS
ASKSFAMYGVRLGGLLGLFHTKEQQAFFKVHVLEDALGKWSTAPSVGVGIFNKLATKKDEYVQYLITLTSTLKQRGEIFI
KEALENNLDIYPYRGGFFVLVKSNNPEKDYEKLIDDNIYLIPMEKGLRVALCGITTKEVIGLAKRIKNVVGA

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:
GO:0003824: Aromatic-amino-acid transaminase
GO:0008483: Aromatic-amino-acid transaminase
GO:0008793: Aromatic-amino-acid transaminase
GO:0009058: Aromatic-amino-acid transaminase
GO:0016740: Aromatic-amino-acid transaminase
GO:0016769: Aromatic-amino-acid transaminase
GO:0030170: Aromatic-amino-acid transaminase

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790488, Length=395, Percent_Identity=25.5696202531646, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787159, Length=384, Percent_Identity=23.6979166666667, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17569539, Length=389, Percent_Identity=21.0796915167095, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 44388; Mature: 44256

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIDILKIAKSAQIAKSKNEHVIDATIGMFYNDDSKLIIPAVEKAYYDLDLLDAFKYGA
CCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEHHHHHCCHHHHHHHHCCC
TDGGPMFVENVIDWVLDDKRKSVEEKFLIGALSTPGGSGAISLIFNTYGHVGDKVLVPNL
CCCCCHHHHHHHHHHHCCHHHHHHHHHEEEEECCCCCCCEEEEEEEHHCCCCCEEECCCC
RWRYEYFLNAAKLKVHEHNMFKGDGFDLEDFKTQLNYLTSIQKRVIVVINDPCHNPTGFS
HHHHHHHCCHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
LSDKEWQSIIEILNSFDKNELILVYDIAYFDYDPKGFKNARNNFLAFKQLKPHVQVLTAF
CCHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCHHHHHHCCEEEHHHCCCHHHHHHHH
SASKSFAMYGVRLGGLLGLFHTKEQQAFFKVHVLEDALGKWSTAPSVGVGIFNKLATKKD
HCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEEHHHHHCCCCCCCCHHHHHHHHHHCCHH
EYVQYLITLTSTLKQRGEIFIKEALENNLDIYPYRGGFFVLVKSNNPEKDYEKLIDDNIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHCCCEE
LIPMEKGLRVALCGITTKEVIGLAKRIKNVVGA
EEECCCCCEEEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKIDILKIAKSAQIAKSKNEHVIDATIGMFYNDDSKLIIPAVEKAYYDLDLLDAFKYGA
CCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEHHHHHCCHHHHHHHHCCC
TDGGPMFVENVIDWVLDDKRKSVEEKFLIGALSTPGGSGAISLIFNTYGHVGDKVLVPNL
CCCCCHHHHHHHHHHHCCHHHHHHHHHEEEEECCCCCCCEEEEEEEHHCCCCCEEECCCC
RWRYEYFLNAAKLKVHEHNMFKGDGFDLEDFKTQLNYLTSIQKRVIVVINDPCHNPTGFS
HHHHHHHCCHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
LSDKEWQSIIEILNSFDKNELILVYDIAYFDYDPKGFKNARNNFLAFKQLKPHVQVLTAF
CCHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCHHHHHHCCEEEHHHCCCHHHHHHHH
SASKSFAMYGVRLGGLLGLFHTKEQQAFFKVHVLEDALGKWSTAPSVGVGIFNKLATKKD
HCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEEHHHHHCCCCCCCCHHHHHHHHHHCCHH
EYVQYLITLTSTLKQRGEIFIKEALENNLDIYPYRGGFFVLVKSNNPEKDYEKLIDDNIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHCCCEE
LIPMEKGLRVALCGITTKEVIGLAKRIKNVVGA
EEECCCCCEEEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]