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The map label for this gene is gyrA [H]

Identifier: 162446894

GI number: 162446894

Start: 7655

End: 10258

Strand: Direct

Name: gyrA [H]

Synonym: ACL_0007

Alternate gene names: 162446894

Gene position: 7655-10258 (Clockwise)

Preceding gene: 162446893

Following gene: 162446895

Centisome position: 0.51

GC content: 33.53

Gene sequence:

>2604_bases
ATGAGTGAAAATACAGATAAACTACATGATAAGATTAAAGAAGTAAACATTACTTCAGAGATGAAAACATCCTTCTTAAA
CTATGCGATGAGTGTTATTGTATCTCGTGCACTTCCAAATGCTAAAGACGGATTAAAACCAGTTCAAAGACGTATTCTTT
ACGGTATGCATGAAAATAACATGTATGCAAATACGGCACATAAAAAATCAGCGAGAATCGTTGGGGATGTTATGGGGAAA
TATCACCCTCATGGTGACTCTTCAATTTATGATGCCATGGTGCGTATGGCACAACCATTTAGTTATAGAAAACCATTAGT
TGACGGTCATGGTAACTTTGGTTCTGTTGACGGTGATGGTGCTGCTGCGATGCGTTATACCGAAGCTAGACTATCTAAGA
TAGCTGGTGAAATGGTTAGAGATATCGACAAAAACACAGTAAATTTTGTAGATAACTATGATGGTTCAGAACGTGAACCA
CAAGTACTACCATCAAGATATCCAAACTTACTAGTAAACGGTTCAACCGGTATTGCTGTTGGTATGGCTACAAATATTCC
ACCACATAATTTAGGTGAAGTGATTGATGCAATCTTTGCATATTTAGATAATCCTGATATTACAGTACTTGAATTAATGC
AATACATTAAGGGACCAGACTTCCCAACAGGTGGTCAAATTCTTGGTATTACAGGTCTTCGTCAAGCATATGAAACAGGT
AAAGGTATTATTGCTGTTCGTGCACAACATGAAATTGTTGAAACTAAAAATAGAACAGAATTAATCATTACTGAAATACC
TTACCAAGTAAATAAAACAACATTAATTGAAAGAATCGCTGAAGTTGTTAAAAATAAGATCATCGAAGGTATTTCAGACT
TAAGAGATGAATCCAATAGAAAAGGTATGCGTATCGTTATTGAACTTAGAAAAGATACTAATCCATCTGTTACCTTAAAT
AACTTATATAAACATACTCAACTTCAAACATCCTTTGGTATTAATATGATTGCTTTAGTCGATGGACAACCAAGACTACT
TAGTTTAAAAGATGCATTAACACATTATATTGCACACCAAATTGAAATTATTACACGTCGTACACAATTTGATTTAGAAA
AAGCTGAAGCTAGAATGCATATATTAGAAGCACTTGTTAAAGCTTTAAATGATGTAGATAATGTCATTAAAATCATCAAA
GATGCAAAAAATCCTGAAGATGCTAGAAATAATTTAATAGCAACTTATGATTTCACAGAAATTCAAGCTCGTTCTATTTT
AACGATGCAACTTCAAAGATTAACAGGTCTTGAAATCGATAAAATTCATGAAGAAGCAGATAATTTAGCACATAAAATTA
CTGAATACAAACAAATTTTAGGTGATGAAGATCTAAAAATCGAAATCATAAAGTCTGAACTTCAAGAAATTAAAGATAAA
TATGATGATCCTCGTATGTCAGAAGTGAATTTATATGAAGATCTTGATATTGATAATGAAGATTTAATCCCTGTTGAAGA
TATCGTTGTAACTGTAACAAATAATGGTTACATCAAACGTATGAATTTAGATGAGTATAAATTACAAAACAGAGGTGGCG
TCGGCATGAGTGGTGTTAAACTACATGACGATGACTTTGTTGAGCATATTGCGATGACATCAACACATGACTTCCACTTA
TTCTTTACCAACCTAGGTCGAGTATTTAAACTTAAAGGGTATACCTTACCATCTGGATCACGTCAATCTAAAGGGGTACC
AATTGTAAACTACCTAAACTTCCAACCAGGAGAAAAATTAGCAAGCTTTACAACCATTAAAGACTTTGATGCTGAAGATC
ACTATCTATTCTTTGTTACAAAGAGGGGTATCGTAAAACGTACACATATTAATAACTACAAGAATATTAGACAAAACGGT
ATTATAGCAATCAGTTTAAGGGAAGATGATGAACTCTTAGTGACGAAATCAACCAATGGTCATAAACATATCTTACTAGG
TGCATCAAACGGTAAAGCTATCCACTTCCTTGAAACAGATATTAGAGAAATTGGACGTACAGCAACCGGTGTCCGTGGTA
TGGACATACCAGATGATGAAGAAATTGTTGGATTTGCAGTTGTAGACGGTATTGAAGACGATATCTTAGTCATTACCGAA
AACGGCTATGGAAAGCGTACATCGATTACTGAATATAGACTTCAAAACAGAGGCGGTAAAGGTGTTAAGACATTAAATGT
AACAGATAAAAACGGTAAGTTAAAAACTTTACGTAAAGTTACAAACGATGAAGACATCATTGTAGTAAGTGATAGAGGTA
TTACAATACGTATGCCAATTGATCAAATCTCACAAACAAAACGTGCAACTCAAGGTGTAAGAATTATTACATTAAAAGGT
GATCAAAAAGTATCAACAATCGCGATTGTAGATCATCAGGAACCTGAAGAAGAAGTTGTATCTAATGAAGCTGTAGTAAC
TCAAGAACAAATGGCTCTAAGCAATCAAAAAAAGGTCTTAGAAGTTGTTGAACTTGAAGCACTAGAAGAATCAGTAGATG
AAGAAGATACAAAAAACGCCAAACAAACTAAATTAGATTTATAA

Upstream 100 bases:

>100_bases
TATGTTAATGGGTGAAGAAGTTGAACCAAGAAAAGAATTTATTCAAAATAATGCACAATATGCAACAGATATTGACGCAT
AGGAAAGGATGTAAATAATA

Downstream 100 bases:

>100_bases
TCATATAAAACAAAAACCACAGACCAATATAATTACTTTATTTGGTCTGTGGTTTTTTTATATATTAAGGATGATAGTTA
ATTCTTAGTATTATTCTTTA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 867; Mature: 866

Protein sequence:

>867_residues
MSENTDKLHDKIKEVNITSEMKTSFLNYAMSVIVSRALPNAKDGLKPVQRRILYGMHENNMYANTAHKKSARIVGDVMGK
YHPHGDSSIYDAMVRMAQPFSYRKPLVDGHGNFGSVDGDGAAAMRYTEARLSKIAGEMVRDIDKNTVNFVDNYDGSEREP
QVLPSRYPNLLVNGSTGIAVGMATNIPPHNLGEVIDAIFAYLDNPDITVLELMQYIKGPDFPTGGQILGITGLRQAYETG
KGIIAVRAQHEIVETKNRTELIITEIPYQVNKTTLIERIAEVVKNKIIEGISDLRDESNRKGMRIVIELRKDTNPSVTLN
NLYKHTQLQTSFGINMIALVDGQPRLLSLKDALTHYIAHQIEIITRRTQFDLEKAEARMHILEALVKALNDVDNVIKIIK
DAKNPEDARNNLIATYDFTEIQARSILTMQLQRLTGLEIDKIHEEADNLAHKITEYKQILGDEDLKIEIIKSELQEIKDK
YDDPRMSEVNLYEDLDIDNEDLIPVEDIVVTVTNNGYIKRMNLDEYKLQNRGGVGMSGVKLHDDDFVEHIAMTSTHDFHL
FFTNLGRVFKLKGYTLPSGSRQSKGVPIVNYLNFQPGEKLASFTTIKDFDAEDHYLFFVTKRGIVKRTHINNYKNIRQNG
IIAISLREDDELLVTKSTNGHKHILLGASNGKAIHFLETDIREIGRTATGVRGMDIPDDEEIVGFAVVDGIEDDILVITE
NGYGKRTSITEYRLQNRGGKGVKTLNVTDKNGKLKTLRKVTNDEDIIVVSDRGITIRMPIDQISQTKRATQGVRIITLKG
DQKVSTIAIVDHQEPEEEVVSNEAVVTQEQMALSNQKKVLEVVELEALEESVDEEDTKNAKQTKLDL

Sequences:

>Translated_867_residues
MSENTDKLHDKIKEVNITSEMKTSFLNYAMSVIVSRALPNAKDGLKPVQRRILYGMHENNMYANTAHKKSARIVGDVMGK
YHPHGDSSIYDAMVRMAQPFSYRKPLVDGHGNFGSVDGDGAAAMRYTEARLSKIAGEMVRDIDKNTVNFVDNYDGSEREP
QVLPSRYPNLLVNGSTGIAVGMATNIPPHNLGEVIDAIFAYLDNPDITVLELMQYIKGPDFPTGGQILGITGLRQAYETG
KGIIAVRAQHEIVETKNRTELIITEIPYQVNKTTLIERIAEVVKNKIIEGISDLRDESNRKGMRIVIELRKDTNPSVTLN
NLYKHTQLQTSFGINMIALVDGQPRLLSLKDALTHYIAHQIEIITRRTQFDLEKAEARMHILEALVKALNDVDNVIKIIK
DAKNPEDARNNLIATYDFTEIQARSILTMQLQRLTGLEIDKIHEEADNLAHKITEYKQILGDEDLKIEIIKSELQEIKDK
YDDPRMSEVNLYEDLDIDNEDLIPVEDIVVTVTNNGYIKRMNLDEYKLQNRGGVGMSGVKLHDDDFVEHIAMTSTHDFHL
FFTNLGRVFKLKGYTLPSGSRQSKGVPIVNYLNFQPGEKLASFTTIKDFDAEDHYLFFVTKRGIVKRTHINNYKNIRQNG
IIAISLREDDELLVTKSTNGHKHILLGASNGKAIHFLETDIREIGRTATGVRGMDIPDDEEIVGFAVVDGIEDDILVITE
NGYGKRTSITEYRLQNRGGKGVKTLNVTDKNGKLKTLRKVTNDEDIIVVSDRGITIRMPIDQISQTKRATQGVRIITLKG
DQKVSTIAIVDHQEPEEEVVSNEAVVTQEQMALSNQKKVLEVVELEALEESVDEEDTKNAKQTKLDL
>Mature_866_residues
SENTDKLHDKIKEVNITSEMKTSFLNYAMSVIVSRALPNAKDGLKPVQRRILYGMHENNMYANTAHKKSARIVGDVMGKY
HPHGDSSIYDAMVRMAQPFSYRKPLVDGHGNFGSVDGDGAAAMRYTEARLSKIAGEMVRDIDKNTVNFVDNYDGSEREPQ
VLPSRYPNLLVNGSTGIAVGMATNIPPHNLGEVIDAIFAYLDNPDITVLELMQYIKGPDFPTGGQILGITGLRQAYETGK
GIIAVRAQHEIVETKNRTELIITEIPYQVNKTTLIERIAEVVKNKIIEGISDLRDESNRKGMRIVIELRKDTNPSVTLNN
LYKHTQLQTSFGINMIALVDGQPRLLSLKDALTHYIAHQIEIITRRTQFDLEKAEARMHILEALVKALNDVDNVIKIIKD
AKNPEDARNNLIATYDFTEIQARSILTMQLQRLTGLEIDKIHEEADNLAHKITEYKQILGDEDLKIEIIKSELQEIKDKY
DDPRMSEVNLYEDLDIDNEDLIPVEDIVVTVTNNGYIKRMNLDEYKLQNRGGVGMSGVKLHDDDFVEHIAMTSTHDFHLF
FTNLGRVFKLKGYTLPSGSRQSKGVPIVNYLNFQPGEKLASFTTIKDFDAEDHYLFFVTKRGIVKRTHINNYKNIRQNGI
IAISLREDDELLVTKSTNGHKHILLGASNGKAIHFLETDIREIGRTATGVRGMDIPDDEEIVGFAVVDGIEDDILVITEN
GYGKRTSITEYRLQNRGGKGVKTLNVTDKNGKLKTLRKVTNDEDIIVVSDRGITIRMPIDQISQTKRATQGVRIITLKGD
QKVSTIAIVDHQEPEEEVVSNEAVVTQEQMALSNQKKVLEVVELEALEESVDEEDTKNAKQTKLDL

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=316, Percent_Identity=27.2151898734177, Blast_Score=92, Evalue=3e-18,
Organism=Homo sapiens, GI19913406, Length=321, Percent_Identity=27.1028037383178, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1788562, Length=848, Percent_Identity=45.872641509434, Blast_Score=754, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=692, Percent_Identity=35.8381502890173, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI212645845, Length=447, Percent_Identity=24.6085011185682, Blast_Score=80, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=182, Percent_Identity=31.8681318681319, Blast_Score=80, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=170, Percent_Identity=32.3529411764706, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=397, Percent_Identity=24.6851385390428, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136538, Length=390, Percent_Identity=25.1282051282051, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR010235
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV; PF08780 NTase_sub_bind [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 97543; Mature: 97412

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENTDKLHDKIKEVNITSEMKTSFLNYAMSVIVSRALPNAKDGLKPVQRRILYGMHENN
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
MYANTAHKKSARIVGDVMGKYHPHGDSSIYDAMVRMAQPFSYRKPLVDGHGNFGSVDGDG
EEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
AAAMRYTEARLSKIAGEMVRDIDKNTVNFVDNYDGSEREPQVLPSRYPNLLVNGSTGIAV
CHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
GMATNIPPHNLGEVIDAIFAYLDNPDITVLELMQYIKGPDFPTGGQILGITGLRQAYETG
EEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCC
KGIIAVRAQHEIVETKNRTELIITEIPYQVNKTTLIERIAEVVKNKIIEGISDLRDESNR
CCEEEEECCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KGMRIVIELRKDTNPSVTLNNLYKHTQLQTSFGINMIALVDGQPRLLSLKDALTHYIAHQ
CCEEEEEEEECCCCCCEEHHHHHHHHEEHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHH
IEIITRRTQFDLEKAEARMHILEALVKALNDVDNVIKIIKDAKNPEDARNNLIATYDFTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEEECCHH
IQARSILTMQLQRLTGLEIDKIHEEADNLAHKITEYKQILGDEDLKIEIIKSELQEIKDK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
YDDPRMSEVNLYEDLDIDNEDLIPVEDIVVTVTNNGYIKRMNLDEYKLQNRGGVGMSGVK
CCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEECCCEEEECCCHHHHHCCCCCCCCCCEE
LHDDDFVEHIAMTSTHDFHLFFTNLGRVFKLKGYTLPSGSRQSKGVPIVNYLNFQPGEKL
ECCHHHHHHHHHCCCCCEEEEEECCCCEEEEECEECCCCCCCCCCCCEEEEECCCCCHHH
ASFTTIKDFDAEDHYLFFVTKRGIVKRTHINNYKNIRQNGIIAISLREDDELLVTKSTNG
HHCCEEECCCCCCCEEEEEECCCCEEECCCCCHHHHCCCCEEEEEECCCCCEEEEECCCC
HKHILLGASNGKAIHFLETDIREIGRTATGVRGMDIPDDEEIVGFAVVDGIEDDILVITE
CEEEEEECCCCCEEEEEHHHHHHHCCHHCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEC
NGYGKRTSITEYRLQNRGGKGVKTLNVTDKNGKLKTLRKVTNDEDIIVVSDRGITIRMPI
CCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCCEEEEECCCEEEEECH
DQISQTKRATQGVRIITLKGDQKVSTIAIVDHQEPEEEVVSNEAVVTQEQMALSNQKKVL
HHHHHHHHHHCCEEEEEEECCCCEEEEEEEECCCCHHHHHCCCHHEEHHHHHHHHHHHHH
EVVELEALEESVDEEDTKNAKQTKLDL
HHHHHHHHHHHCCHHHCCCHHHHCCCC
>Mature Secondary Structure 
SENTDKLHDKIKEVNITSEMKTSFLNYAMSVIVSRALPNAKDGLKPVQRRILYGMHENN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
MYANTAHKKSARIVGDVMGKYHPHGDSSIYDAMVRMAQPFSYRKPLVDGHGNFGSVDGDG
EEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
AAAMRYTEARLSKIAGEMVRDIDKNTVNFVDNYDGSEREPQVLPSRYPNLLVNGSTGIAV
CHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
GMATNIPPHNLGEVIDAIFAYLDNPDITVLELMQYIKGPDFPTGGQILGITGLRQAYETG
EEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCC
KGIIAVRAQHEIVETKNRTELIITEIPYQVNKTTLIERIAEVVKNKIIEGISDLRDESNR
CCEEEEECCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KGMRIVIELRKDTNPSVTLNNLYKHTQLQTSFGINMIALVDGQPRLLSLKDALTHYIAHQ
CCEEEEEEEECCCCCCEEHHHHHHHHEEHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHH
IEIITRRTQFDLEKAEARMHILEALVKALNDVDNVIKIIKDAKNPEDARNNLIATYDFTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEEECCHH
IQARSILTMQLQRLTGLEIDKIHEEADNLAHKITEYKQILGDEDLKIEIIKSELQEIKDK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
YDDPRMSEVNLYEDLDIDNEDLIPVEDIVVTVTNNGYIKRMNLDEYKLQNRGGVGMSGVK
CCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEECCCEEEECCCHHHHHCCCCCCCCCCEE
LHDDDFVEHIAMTSTHDFHLFFTNLGRVFKLKGYTLPSGSRQSKGVPIVNYLNFQPGEKL
ECCHHHHHHHHHCCCCCEEEEEECCCCEEEEECEECCCCCCCCCCCCEEEEECCCCCHHH
ASFTTIKDFDAEDHYLFFVTKRGIVKRTHINNYKNIRQNGIIAISLREDDELLVTKSTNG
HHCCEEECCCCCCCEEEEEECCCCEEECCCCCHHHHCCCCEEEEEECCCCCEEEEECCCC
HKHILLGASNGKAIHFLETDIREIGRTATGVRGMDIPDDEEIVGFAVVDGIEDDILVITE
CEEEEEECCCCCEEEEEHHHHHHHCCHHCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEC
NGYGKRTSITEYRLQNRGGKGVKTLNVTDKNGKLKTLRKVTNDEDIIVVSDRGITIRMPI
CCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCCEEEEECCCEEEEECH
DQISQTKRATQGVRIITLKGDQKVSTIAIVDHQEPEEEVVSNEAVVTQEQMALSNQKKVL
HHHHHHHHHHCCEEEEEEECCCCEEEEEEEECCCCHHHHHCCCHHEEHHHHHHHHHHHHH
EVVELEALEESVDEEDTKNAKQTKLDL
HHHHHHHHHHHCCHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10427704; 11058132 [H]