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The map label for this gene is lpd [H]

Identifier: 162210119

GI number: 162210119

Start: 2017895

End: 2019274

Strand: Direct

Name: lpd [H]

Synonym: BURPS1710b_A1652

Alternate gene names: 162210119

Gene position: 2017895-2019274 (Clockwise)

Preceding gene: 76819555

Following gene: 76818407

Centisome position: 63.42

GC content: 68.84

Gene sequence:

>1380_bases
ATGACTCGACGTTTCGATGCGATCATCATCGGCACCGGTCAATCCGGTCCCCCGCTCGCCGCCCGGCTCTCCGCCGCGGG
CATGAAGGTGGCCGTCGTCGAGCGCGGGCGCTTCGGCGGCACCTGCGTGAACACGGGCTGCATTCCGACGAAGACCTTGA
TCGCGAGCGCGTACGCCGCGCACCTCGCGCGGCGCGCCGACGAATACGGCGTGACGCTCGGCGGCCCCGTGGCGGTCGAC
ATGAAGAAGGTGAAGGCGCGCAAGGATCAGGTGGCCGCGCGCTCGAACCGCGGCGTCGAGCAATGGGTTCGCGGTCTCGA
GAACGGCGCGGTCTACCACGGGCATGCGCGCTTCGAGAGCGCGCGCACGGTGCGCGTCGGCGAAGCGCTGCTCGAAGCCG
AGCGGATCTTCATCGATGTCGGCGGGCGCGCGCTGATTCCGCCGATCCCGGGCCTCGATCAGGTGCCGTATTTCACGAAC
TCGACGATGATGGATGTCGATTTCCTGCCCGAGCACCTGATCGTTCTCGGCGGCAGCTACGTGGGGCTCGAGTTCGGCCA
GATGTACCGGCGCTTCGGCGCGCGCGTGACGATCGTCGAGAAGGGCCCGCGGCTGATCGCGCGCGAGGACGAGGACGTGT
CCCACGCGGTGCGCGAGATCCTGGAGGGCGAGGGCATCGACGTTCGACTCGACGCCGATTGCCTGAGCGTGCGCCGCGAC
GGCGGCGGGATCGCCGTCGGCCTCGATTGCGCGGCCGGCGCGCGCGAAGTGCGCGGCTCGCACCTGCTGCTCGCCGTCGG
GCGCGTGCCGAACACCGACGATCTCGGGCTCGAGCACGCCGGCGTCGAAACCGATGCGCGCGGCTACATCCGGGTGGACG
AGCAGTTGCGCACGAACGTGGCGGGCATCTGGGCGATGGGCGACTGCAACGGCCGCGGCGCGTTCACGCATACGTCGTAC
AACGATTACGAGATCGTCGCGGCGAATCTTCTCGACGGCGATCCGCGCAAGGTGTCGGATCGCATTCCGGCCTACGCGAT
GTTCATCGATCCGCCGCTTGCCCGCGTCGGCCTCACGCAGGCCGAGGCCGCGCGTTCGGGGCGCCGGCTGCTGGTCGGCA
CGCGCCCGATGACACGCGTCGGGCGCGCGGTCGAGAAAGGCGAGAGCCTCGGCTTCATGAAAGTGATCGTGGACGCGGAC
AGCCACGCGATTCTCGGCGCGTCGATTCTCGGCGTGACGGGCGACGAAGTCGTGCATTCGCTGCTCGACGCGATGTACGC
GAAAGCGCCGTACACGACGATCAGCCGCGCGATGCACATTCATCCGACCGTCTCGGAGCTCGTGCCGACGCTGCTTCAGG
ACCTGCATCCGCCCGCATAG

Upstream 100 bases:

>100_bases
CGCTTACCATAGCCGGGCGGTCATCCCTCGAACCCGGAACCGGGGCACGCGGATTGCTCGCCGGATCCGTTCCATGCTGC
AGCCCACGAAGGAGTGCGCC

Downstream 100 bases:

>100_bases
CGCAGCCGCCGATGCGCGAGCCCGCGCATCGGCGGCGCGCCGTCCGGCCGCGCGCCGCATCGCGTCGTGCGGTGCCTTGC
CGTTCCGTGTGCCGTGTACC

Product: mercuric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTRRFDAIIIGTGQSGPPLAARLSAAGMKVAVVERGRFGGTCVNTGCIPTKTLIASAYAAHLARRADEYGVTLGGPVAVD
MKKVKARKDQVAARSNRGVEQWVRGLENGAVYHGHARFESARTVRVGEALLEAERIFIDVGGRALIPPIPGLDQVPYFTN
STMMDVDFLPEHLIVLGGSYVGLEFGQMYRRFGARVTIVEKGPRLIAREDEDVSHAVREILEGEGIDVRLDADCLSVRRD
GGGIAVGLDCAAGAREVRGSHLLLAVGRVPNTDDLGLEHAGVETDARGYIRVDEQLRTNVAGIWAMGDCNGRGAFTHTSY
NDYEIVAANLLDGDPRKVSDRIPAYAMFIDPPLARVGLTQAEAARSGRRLLVGTRPMTRVGRAVEKGESLGFMKVIVDAD
SHAILGASILGVTGDEVVHSLLDAMYAKAPYTTISRAMHIHPTVSELVPTLLQDLHPPA

Sequences:

>Translated_459_residues
MTRRFDAIIIGTGQSGPPLAARLSAAGMKVAVVERGRFGGTCVNTGCIPTKTLIASAYAAHLARRADEYGVTLGGPVAVD
MKKVKARKDQVAARSNRGVEQWVRGLENGAVYHGHARFESARTVRVGEALLEAERIFIDVGGRALIPPIPGLDQVPYFTN
STMMDVDFLPEHLIVLGGSYVGLEFGQMYRRFGARVTIVEKGPRLIAREDEDVSHAVREILEGEGIDVRLDADCLSVRRD
GGGIAVGLDCAAGAREVRGSHLLLAVGRVPNTDDLGLEHAGVETDARGYIRVDEQLRTNVAGIWAMGDCNGRGAFTHTSY
NDYEIVAANLLDGDPRKVSDRIPAYAMFIDPPLARVGLTQAEAARSGRRLLVGTRPMTRVGRAVEKGESLGFMKVIVDAD
SHAILGASILGVTGDEVVHSLLDAMYAKAPYTTISRAMHIHPTVSELVPTLLQDLHPPA
>Mature_458_residues
TRRFDAIIIGTGQSGPPLAARLSAAGMKVAVVERGRFGGTCVNTGCIPTKTLIASAYAAHLARRADEYGVTLGGPVAVDM
KKVKARKDQVAARSNRGVEQWVRGLENGAVYHGHARFESARTVRVGEALLEAERIFIDVGGRALIPPIPGLDQVPYFTNS
TMMDVDFLPEHLIVLGGSYVGLEFGQMYRRFGARVTIVEKGPRLIAREDEDVSHAVREILEGEGIDVRLDADCLSVRRDG
GGIAVGLDCAAGAREVRGSHLLLAVGRVPNTDDLGLEHAGVETDARGYIRVDEQLRTNVAGIWAMGDCNGRGAFTHTSYN
DYEIVAANLLDGDPRKVSDRIPAYAMFIDPPLARVGLTQAEAARSGRRLLVGTRPMTRVGRAVEKGESLGFMKVIVDADS
HAILGASILGVTGDEVVHSLLDAMYAKAPYTTISRAMHIHPTVSELVPTLLQDLHPPA

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=26.5795206971678, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=28.0172413793103, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI22035672, Length=463, Percent_Identity=29.5896328293737, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI33519430, Length=436, Percent_Identity=23.8532110091743, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI33519428, Length=436, Percent_Identity=23.8532110091743, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI33519426, Length=436, Percent_Identity=23.8532110091743, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI148277065, Length=436, Percent_Identity=23.8532110091743, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI148277071, Length=436, Percent_Identity=23.8532110091743, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI291045266, Length=437, Percent_Identity=23.5697940503432, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI291045268, Length=430, Percent_Identity=23.2558139534884, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI87081717, Length=459, Percent_Identity=34.640522875817, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=31.1258278145695, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1789915, Length=459, Percent_Identity=28.9760348583878, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=24.5652173913043, Blast_Score=135, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=456, Percent_Identity=26.9736842105263, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71983429, Length=472, Percent_Identity=28.3898305084746, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=472, Percent_Identity=28.3898305084746, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=26.5822784810127, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71982272, Length=484, Percent_Identity=24.5867768595041, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17559934, Length=179, Percent_Identity=27.3743016759777, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=28.1115879828326, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=480, Percent_Identity=25.2083333333333, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6325240, Length=466, Percent_Identity=23.6051502145923, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=28.1045751633987, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=25.9023354564756, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=25.9023354564756, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=25.9023354564756, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17737741, Length=469, Percent_Identity=23.0277185501066, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 49286; Mature: 49155

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRFDAIIIGTGQSGPPLAARLSAAGMKVAVVERGRFGGTCVNTGCIPTKTLIASAYAA
CCCEEEEEEEECCCCCCCHHHHHHHCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
HLARRADEYGVTLGGPVAVDMKKVKARKDQVAARSNRGVEQWVRGLENGAVYHGHARFES
HHHHHHHHCCCEECCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEECCHHHCC
ARTVRVGEALLEAERIFIDVGGRALIPPIPGLDQVPYFTNSTMMDVDFLPEHLIVLGGSY
CCEEHHHHHHHHCEEEEEEECCEEECCCCCCCCCCCEECCCEEEEHHHCCCEEEEECCCE
VGLEFGQMYRRFGARVTIVEKGPRLIAREDEDVSHAVREILEGEGIDVRLDADCLSVRRD
ECHHHHHHHHHHCCEEEEEECCCCEEECCCCHHHHHHHHHHCCCCCEEEECHHHHHEEEC
GGGIAVGLDCAAGAREVRGSHLLLAVGRVPNTDDLGLEHAGVETDARGYIRVDEQLRTNV
CCCEEEEEECCCCHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECHHHHCCE
AGIWAMGDCNGRGAFTHTSYNDYEIVAANLLDGDPRKVSDRIPAYAMFIDPPLARVGLTQ
EEEEEEECCCCCCCEEECCCCCEEEEEEECCCCCCHHHHHCCCEEEEEECCCHHHHCCCH
AEAARSGRRLLVGTRPMTRVGRAVEKGESLGFMKVIVDADSHAILGASILGVTGDEVVHS
HHHHHCCCEEEEECCCHHHHHHHHHCCCCCCEEEEEEECCCCEEECEEEECCCHHHHHHH
LLDAMYAKAPYTTISRAMHIHPTVSELVPTLLQDLHPPA
HHHHHHHCCCHHHHHHEEECCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TRRFDAIIIGTGQSGPPLAARLSAAGMKVAVVERGRFGGTCVNTGCIPTKTLIASAYAA
CCEEEEEEEECCCCCCCHHHHHHHCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
HLARRADEYGVTLGGPVAVDMKKVKARKDQVAARSNRGVEQWVRGLENGAVYHGHARFES
HHHHHHHHCCCEECCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEECCHHHCC
ARTVRVGEALLEAERIFIDVGGRALIPPIPGLDQVPYFTNSTMMDVDFLPEHLIVLGGSY
CCEEHHHHHHHHCEEEEEEECCEEECCCCCCCCCCCEECCCEEEEHHHCCCEEEEECCCE
VGLEFGQMYRRFGARVTIVEKGPRLIAREDEDVSHAVREILEGEGIDVRLDADCLSVRRD
ECHHHHHHHHHHCCEEEEEECCCCEEECCCCHHHHHHHHHHCCCCCEEEECHHHHHEEEC
GGGIAVGLDCAAGAREVRGSHLLLAVGRVPNTDDLGLEHAGVETDARGYIRVDEQLRTNV
CCCEEEEEECCCCHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECHHHHCCE
AGIWAMGDCNGRGAFTHTSYNDYEIVAANLLDGDPRKVSDRIPAYAMFIDPPLARVGLTQ
EEEEEEECCCCCCCEEECCCCCEEEEEEECCCCCCHHHHHCCCEEEEEECCCHHHHCCCH
AEAARSGRRLLVGTRPMTRVGRAVEKGESLGFMKVIVDADSHAILGASILGVTGDEVVHS
HHHHHCCCEEEEECCCHHHHHHHHHCCCCCCEEEEEEECCCCEEECEEEECCCHHHHHHH
LLDAMYAKAPYTTISRAMHIHPTVSELVPTLLQDLHPPA
HHHHHHHCCCHHHHHHEEECCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]