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The map label for this gene is murC

Identifier: 162148962

GI number: 162148962

Start: 3280095

End: 3281537

Strand: Direct

Name: murC

Synonym: GDI_3192

Alternate gene names: 162148962

Gene position: 3280095-3281537 (Clockwise)

Preceding gene: 162148961

Following gene: 162148963

Centisome position: 83.16

GC content: 69.72

Gene sequence:

>1443_bases
ATGAGAGCCCTGCCCCTATCCATCGGCACCATCCACTTCGTCGGGATCGGCGGCATCGGCATGTCCGGCATTGCCGAGGT
GCTGCACATGCTGGGCTATGCCGTGCAGGGTTCGGACATCGCCGAGAACGCGAACGTGCAGCGCCTGCGCGCCGCCGGCA
TCACGGTGGCGATCGGCCATGACGCCGCCAACCTGGGCGCGGCGCAGGTCGTGGTGACATCGACCGCCGTCCGCCGCGAC
AATCCGGAAGTGGTGGCCGCCCGCGCGCGGCTGATCCCCGTCGTCCGGCGGGCCGAGATGCTGGCCGAGCTGATGCGCCT
GCGCTGGGCCGTCGCGGTCGGCGGCACGCACGGCAAGACCACGACCACCAGCCTGATCGCGGCGGTGCTGGAAGCGGCGC
GCCTGGACCCTACGGTCATCAATGGCGGCATCATCGAGGCCTACGGCACCAACACCCGCATGGGATCGGGCGACTGGATG
GTGGTCGAGGCCGACGAATCCGACGGATCGTTCCTGCGCCTGCCCTCGGTCATCACCGTCGTGACCAACATGGACCCCGA
GCATCTGGACCATTGGGGCACCGCCGAGGCGATGCAGGCGGCGTACGACCAGTTCGTCTCCAACATTCCGTTCTACGGCT
TCGCGGTGCTGTGCATCGACCATCCGGCGGTGCAGCAGATGATCCCGCGCCTGTCGGACCACCGGATCGTGACCTATGGC
TTTTCGCCCCAGGCCGACATCCGGGCCGAGAAGGTCATCACCGACAAGCTGGGCGCGACGTTCGAGGTCGTGGTGACCAA
CCGCAACCGCAACCGCACGCGCCGCGCCGGTCCGTTCCGCCTGCCGATGCTGGGCCACCACAACGTGCAGAACGCGCTGG
CCGCGATCGCCGTCGGGGTCGAGATGGATATCGACGACGCCACCCTGCGCTCGGCCTTCGCGGGATTCCGTGGGGTCAAG
CGCCGCTTCACCCGCACCGGCGAGACCGGCGGCATCACCGTGATCGACGATTACGGCCACCACCCGGTGGAAATCGCCGC
CGTGCTGAAGGCCGCGCGCCAGGCCGGCGCGCGCGACGTCATCGCCGTGGTCCAGCCGCACCGCTATTCCCGGCTGCAGA
CGCTGTTCGGCGAATTCTGCACCTGCATGAACGATGCCGGCACCGTCATCGTGGCCGACGTCTATGCCGCGGGCGAGGCC
CCGATCCCGGGTGTGGACCGCGACGCGCTGGTCGAGGGCCTGCGCGAGCGCGGCCACCGTTCGGTGGTGCCGCTGCCCGA
CCCGGAACACCTGGCGGAAATGGTCCACGCCATCGCCCGCCCCGGCGACTTCGTCGTCTGCCTGGGGGCCGGCAGCATCA
CCAACTGGGCGCAGGCCCTGCCCGGCCAACTGGCGGCGTTGCAGAACCCGGCCGCGGCGCGAAAGGGCGAATGCGCGGCA
TGA

Upstream 100 bases:

>100_bases
CAAGCCTGTTCGCCGACCTGATCACCGATACGATCGAAGGACGCTTGCGTCCGCCCCCCCGCCCCGCCTATCCGACAGCC
GCGAAGACGGAGACCCACGC

Downstream 100 bases:

>100_bases
CCACGCCCCCCGCCCCTTCGGATGCATCCTGGACCGCCGAGGTACGCGCAATGCTGGCCGGCCTGCGCGGACGGCTGACC
CAGGGTGCGCCGCTGGGCCC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MRALPLSIGTIHFVGIGGIGMSGIAEVLHMLGYAVQGSDIAENANVQRLRAAGITVAIGHDAANLGAAQVVVTSTAVRRD
NPEVVAARARLIPVVRRAEMLAELMRLRWAVAVGGTHGKTTTTSLIAAVLEAARLDPTVINGGIIEAYGTNTRMGSGDWM
VVEADESDGSFLRLPSVITVVTNMDPEHLDHWGTAEAMQAAYDQFVSNIPFYGFAVLCIDHPAVQQMIPRLSDHRIVTYG
FSPQADIRAEKVITDKLGATFEVVVTNRNRNRTRRAGPFRLPMLGHHNVQNALAAIAVGVEMDIDDATLRSAFAGFRGVK
RRFTRTGETGGITVIDDYGHHPVEIAAVLKAARQAGARDVIAVVQPHRYSRLQTLFGEFCTCMNDAGTVIVADVYAAGEA
PIPGVDRDALVEGLRERGHRSVVPLPDPEHLAEMVHAIARPGDFVVCLGAGSITNWAQALPGQLAALQNPAAARKGECAA

Sequences:

>Translated_480_residues
MRALPLSIGTIHFVGIGGIGMSGIAEVLHMLGYAVQGSDIAENANVQRLRAAGITVAIGHDAANLGAAQVVVTSTAVRRD
NPEVVAARARLIPVVRRAEMLAELMRLRWAVAVGGTHGKTTTTSLIAAVLEAARLDPTVINGGIIEAYGTNTRMGSGDWM
VVEADESDGSFLRLPSVITVVTNMDPEHLDHWGTAEAMQAAYDQFVSNIPFYGFAVLCIDHPAVQQMIPRLSDHRIVTYG
FSPQADIRAEKVITDKLGATFEVVVTNRNRNRTRRAGPFRLPMLGHHNVQNALAAIAVGVEMDIDDATLRSAFAGFRGVK
RRFTRTGETGGITVIDDYGHHPVEIAAVLKAARQAGARDVIAVVQPHRYSRLQTLFGEFCTCMNDAGTVIVADVYAAGEA
PIPGVDRDALVEGLRERGHRSVVPLPDPEHLAEMVHAIARPGDFVVCLGAGSITNWAQALPGQLAALQNPAAARKGECAA
>Mature_480_residues
MRALPLSIGTIHFVGIGGIGMSGIAEVLHMLGYAVQGSDIAENANVQRLRAAGITVAIGHDAANLGAAQVVVTSTAVRRD
NPEVVAARARLIPVVRRAEMLAELMRLRWAVAVGGTHGKTTTTSLIAAVLEAARLDPTVINGGIIEAYGTNTRMGSGDWM
VVEADESDGSFLRLPSVITVVTNMDPEHLDHWGTAEAMQAAYDQFVSNIPFYGFAVLCIDHPAVQQMIPRLSDHRIVTYG
FSPQADIRAEKVITDKLGATFEVVVTNRNRNRTRRAGPFRLPMLGHHNVQNALAAIAVGVEMDIDDATLRSAFAGFRGVK
RRFTRTGETGGITVIDDYGHHPVEIAAVLKAARQAGARDVIAVVQPHRYSRLQTLFGEFCTCMNDAGTVIVADVYAAGEA
PIPGVDRDALVEGLRERGHRSVVPLPDPEHLAEMVHAIARPGDFVVCLGAGSITNWAQALPGQLAALQNPAAARKGECAA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=41.8655097613883, Blast_Score=324, Evalue=6e-90,
Organism=Escherichia coli, GI1790680, Length=475, Percent_Identity=29.2631578947368, Blast_Score=163, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_GLUDA (A9H0J3)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001603423.1
- RefSeq:   YP_002277514.1
- ProteinModelPortal:   A9H0J3
- SMR:   A9H0J3
- GeneID:   5790609
- GeneID:   6976607
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_3169
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51222; Mature: 51222

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALPLSIGTIHFVGIGGIGMSGIAEVLHMLGYAVQGSDIAENANVQRLRAAGITVAIGH
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCEEEEECC
DAANLGAAQVVVTSTAVRRDNPEVVAARARLIPVVRRAEMLAELMRLRWAVAVGGTHGKT
CCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCH
TTTSLIAAVLEAARLDPTVINGGIIEAYGTNTRMGSGDWMVVEADESDGSFLRLPSVITV
HHHHHHHHHHHHHCCCCEEECCCEEEECCCCCCCCCCCEEEEEECCCCCCEEECCCEEEE
VTNMDPEHLDHWGTAEAMQAAYDQFVSNIPFYGFAVLCIDHPAVQQMIPRLSDHRIVTYG
EECCCHHHHHCCCHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHCCCCCEEEEEC
FSPQADIRAEKVITDKLGATFEVVVTNRNRNRTRRAGPFRLPMLGHHNVQNALAAIAVGV
CCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCE
EMDIDDATLRSAFAGFRGVKRRFTRTGETGGITVIDDYGHHPVEIAAVLKAARQAGARDV
EECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCE
IAVVQPHRYSRLQTLFGEFCTCMNDAGTVIVADVYAAGEAPIPGVDRDALVEGLRERGHR
EEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCC
SVVPLPDPEHLAEMVHAIARPGDFVVCLGAGSITNWAQALPGQLAALQNPAAARKGECAA
CCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRALPLSIGTIHFVGIGGIGMSGIAEVLHMLGYAVQGSDIAENANVQRLRAAGITVAIGH
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCEEEEECC
DAANLGAAQVVVTSTAVRRDNPEVVAARARLIPVVRRAEMLAELMRLRWAVAVGGTHGKT
CCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCH
TTTSLIAAVLEAARLDPTVINGGIIEAYGTNTRMGSGDWMVVEADESDGSFLRLPSVITV
HHHHHHHHHHHHHCCCCEEECCCEEEECCCCCCCCCCCEEEEEECCCCCCEEECCCEEEE
VTNMDPEHLDHWGTAEAMQAAYDQFVSNIPFYGFAVLCIDHPAVQQMIPRLSDHRIVTYG
EECCCHHHHHCCCHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHCCCCCEEEEEC
FSPQADIRAEKVITDKLGATFEVVVTNRNRNRTRRAGPFRLPMLGHHNVQNALAAIAVGV
CCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCE
EMDIDDATLRSAFAGFRGVKRRFTRTGETGGITVIDDYGHHPVEIAAVLKAARQAGARDV
EECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCE
IAVVQPHRYSRLQTLFGEFCTCMNDAGTVIVADVYAAGEAPIPGVDRDALVEGLRERGHR
EEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCC
SVVPLPDPEHLAEMVHAIARPGDFVVCLGAGSITNWAQALPGQLAALQNPAAARKGECAA
CCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA