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The map label for this gene is sufS [H]

Identifier: 162148827

GI number: 162148827

Start: 3148986

End: 3150233

Strand: Reverse

Name: sufS [H]

Synonym: GDI_3056

Alternate gene names: 162148827

Gene position: 3150233-3148986 (Counterclockwise)

Preceding gene: 162148828

Following gene: 162148826

Centisome position: 79.87

GC content: 68.27

Gene sequence:

>1248_bases
ATGGATGTCTCGCCCGCCGTCATGCCCGACCCGATCGACGCCCTGCGCGCCCGCCGCGACGATTTCCCGATCCTGAACGA
GAGGGTGCACGGCAAGCCGCTGGTCTTCCTGGACAGCGCGGCCTCGGCCCAGAAGCCGCTTCCGGTCATCGAGGCGATGG
CGGAGACGATGCGTACCCAGTACGCCAACATCCATCGCGGCCTGCACTGGATGAGCGAGCGGACCACCGACGCGTACGAG
GGCGTGCGCGACCAGGTCGCCGGCCTGATCGGTGCGGCGCGCGAGGAAATCATCTTCACGCGCAACAGCACCGAGGCGAT
CAACCTGGTCGCCCATTCCTTCGGCAGCCTGATGCGTCCGGGCCAGGCGGTCGTGATCTCGGAAATGGAGCATCACGCCA
ACCTGGTGCCCTGGCAGATGCTGCGCGACCGCGCGGGCATCGAACTGCGCGTGGCGCCGATCAGCGATTCCGGCGACCTG
GAACTGGATGCCCTGGCGCGGCTGCTGGATGACGGCAAGGTGGCGCTGGTGGCCGTCACCCACATGTCCAACGTGCTGGG
CACCATCACCCCGGCGCGCAAGATCGCGGACATCGCGCATGCCGCCGGTGCGCGGGTGCTGTTCGACGGCAGCCAGATGG
TGGTCCATCACCGGGTGGACGTGCGGGCGATCGACGCCGATTTCTACACCTTCACCGGGCACAAGCTGTACGGCCCCACG
GGCATCGGCGTGCTGTGGGGGCGGCGCGAACTGCTGGAGGAAATGCCGCCCTTCCTGGGCGGGGGCGACATGATTTCCTC
CGTCCGGTTCGAGGGATCGAGCTGGGCGACCGTGCCCCACAAGTTCGAGGCCGGCACGCCCGCCATTATCGAGACCATCG
GGCTGGGGGCCGCCATCTCCTACGTCGAATCGGTGGGATATGACGCCATCGCGGCGCATGAATCCGCGCTGCTGGACCAT
GCGCTGCGGCGGCTGGGCGAGGTGCCCGGCCTGCACGTGGTGGGGTCGCCGGTCGAACGCGGCGGCGTGATCTCGTTCAC
CATGGACGACGTGCATCCGCATGACATCGCCACCCTGCTGGACCGGAACGGCATCGCGATCCGGGCCGGCCATCATTGCG
CGGAACCGCTGATGCGGCGCCTGGGGCTGTCCGCCACCGCGCGGGCCAGCTTCGGCCTCTATACGACGCGCGAGGAGGTG
GACGCTCTGGCCAGGACGCTGGAGCAGATCCGCTCCTTCTTCCTGTAA

Upstream 100 bases:

>100_bases
GCCTTCCTGCACGATGCGGTCGAATTGATCGGGGACGAGAGCCTGCGCGCGGTGCTGGATCGCGCGGTCGAATCCTGGTG
GAACCGGAAGGACGCGTAAC

Downstream 100 bases:

>100_bases
GGCGCGGGGGGAAGAGGACGATGGACCAGGACGGGCTCTACCAGCGGCAGGTGATCGAGCGGGCCCGCGCGCCCGTTCAT
GCCGGCCCGCTGGACGGGGC

Product: cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MDVSPAVMPDPIDALRARRDDFPILNERVHGKPLVFLDSAASAQKPLPVIEAMAETMRTQYANIHRGLHWMSERTTDAYE
GVRDQVAGLIGAAREEIIFTRNSTEAINLVAHSFGSLMRPGQAVVISEMEHHANLVPWQMLRDRAGIELRVAPISDSGDL
ELDALARLLDDGKVALVAVTHMSNVLGTITPARKIADIAHAAGARVLFDGSQMVVHHRVDVRAIDADFYTFTGHKLYGPT
GIGVLWGRRELLEEMPPFLGGGDMISSVRFEGSSWATVPHKFEAGTPAIIETIGLGAAISYVESVGYDAIAAHESALLDH
ALRRLGEVPGLHVVGSPVERGGVISFTMDDVHPHDIATLLDRNGIAIRAGHHCAEPLMRRLGLSATARASFGLYTTREEV
DALARTLEQIRSFFL

Sequences:

>Translated_415_residues
MDVSPAVMPDPIDALRARRDDFPILNERVHGKPLVFLDSAASAQKPLPVIEAMAETMRTQYANIHRGLHWMSERTTDAYE
GVRDQVAGLIGAAREEIIFTRNSTEAINLVAHSFGSLMRPGQAVVISEMEHHANLVPWQMLRDRAGIELRVAPISDSGDL
ELDALARLLDDGKVALVAVTHMSNVLGTITPARKIADIAHAAGARVLFDGSQMVVHHRVDVRAIDADFYTFTGHKLYGPT
GIGVLWGRRELLEEMPPFLGGGDMISSVRFEGSSWATVPHKFEAGTPAIIETIGLGAAISYVESVGYDAIAAHESALLDH
ALRRLGEVPGLHVVGSPVERGGVISFTMDDVHPHDIATLLDRNGIAIRAGHHCAEPLMRRLGLSATARASFGLYTTREEV
DALARTLEQIRSFFL
>Mature_415_residues
MDVSPAVMPDPIDALRARRDDFPILNERVHGKPLVFLDSAASAQKPLPVIEAMAETMRTQYANIHRGLHWMSERTTDAYE
GVRDQVAGLIGAAREEIIFTRNSTEAINLVAHSFGSLMRPGQAVVISEMEHHANLVPWQMLRDRAGIELRVAPISDSGDL
ELDALARLLDDGKVALVAVTHMSNVLGTITPARKIADIAHAAGARVLFDGSQMVVHHRVDVRAIDADFYTFTGHKLYGPT
GIGVLWGRRELLEEMPPFLGGGDMISSVRFEGSSWATVPHKFEAGTPAIIETIGLGAAISYVESVGYDAIAAHESALLDH
ALRRLGEVPGLHVVGSPVERGGVISFTMDDVHPHDIATLLDRNGIAIRAGHHCAEPLMRRLGLSATARASFGLYTTREEV
DALARTLEQIRSFFL

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=388, Percent_Identity=26.8041237113402, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI156713448, Length=322, Percent_Identity=25.776397515528, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787970, Length=406, Percent_Identity=50.4926108374384, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1789175, Length=393, Percent_Identity=39.1857506361323, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI48994898, Length=402, Percent_Identity=26.1194029850746, Blast_Score=105, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=406, Percent_Identity=24.384236453202, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193211090, Length=380, Percent_Identity=26.0526315789474, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=392, Percent_Identity=25, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20129463, Length=413, Percent_Identity=28.8135593220339, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 45154; Mature: 45154

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVSPAVMPDPIDALRARRDDFPILNERVHGKPLVFLDSAASAQKPLPVIEAMAETMRTQ
CCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
YANIHRGLHWMSERTTDAYEGVRDQVAGLIGAAREEIIFTRNSTEAINLVAHSFGSLMRP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCC
GQAVVISEMEHHANLVPWQMLRDRAGIELRVAPISDSGDLELDALARLLDDGKVALVAVT
CCEEEEECHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEHH
HMSNVLGTITPARKIADIAHAAGARVLFDGSQMVVHHRVDVRAIDADFYTFTGHKLYGPT
HHHHHHHCCCHHHHHHHHHHHCCCEEEECCCEEEEEEECEEEEECCCEEEECCCEEECCC
GIGVLWGRRELLEEMPPFLGGGDMISSVRFEGSSWATVPHKFEAGTPAIIETIGLGAAIS
CCHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCCEECCCCCCCCCCHHHHHHHHHHHHHH
YVESVGYDAIAAHESALLDHALRRLGEVPGLHVVGSPVERGGVISFTMDDVHPHDIATLL
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHCCCEEEEEECCCCHHHHHHHH
DRNGIAIRAGHHCAEPLMRRLGLSATARASFGLYTTREEVDALARTLEQIRSFFL
CCCCEEEECCCHHHHHHHHHHCCCCHHHCCCCCEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDVSPAVMPDPIDALRARRDDFPILNERVHGKPLVFLDSAASAQKPLPVIEAMAETMRTQ
CCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
YANIHRGLHWMSERTTDAYEGVRDQVAGLIGAAREEIIFTRNSTEAINLVAHSFGSLMRP
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCC
GQAVVISEMEHHANLVPWQMLRDRAGIELRVAPISDSGDLELDALARLLDDGKVALVAVT
CCEEEEECHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEHH
HMSNVLGTITPARKIADIAHAAGARVLFDGSQMVVHHRVDVRAIDADFYTFTGHKLYGPT
HHHHHHHCCCHHHHHHHHHHHCCCEEEECCCEEEEEEECEEEEECCCEEEECCCEEECCC
GIGVLWGRRELLEEMPPFLGGGDMISSVRFEGSSWATVPHKFEAGTPAIIETIGLGAAIS
CCHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCCEECCCCCCCCCCHHHHHHHHHHHHHH
YVESVGYDAIAAHESALLDHALRRLGEVPGLHVVGSPVERGGVISFTMDDVHPHDIATLL
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHCCCEEEEEECCCCHHHHHHHH
DRNGIAIRAGHHCAEPLMRRLGLSATARASFGLYTTREEVDALARTLEQIRSFFL
CCCCEEEECCCHHHHHHHHHHCCCCHHHCCCCCEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11251816 [H]