Click here to switch to the map view.

The map label for this gene is clpP [H]

Identifier: 162148815

GI number: 162148815

Start: 3136769

End: 3137407

Strand: Reverse

Name: clpP [H]

Synonym: GDI_3044

Alternate gene names: 162148815

Gene position: 3137407-3136769 (Counterclockwise)

Preceding gene: 162148816

Following gene: 162148814

Centisome position: 79.55

GC content: 64.95

Gene sequence:

>639_bases
ATGAGGGATCGGGATCCCGTGGAGATTTTCAGCAGCGCCCTAGTGCCCATGGTGGTCGAGCAGACCTCGCGCGGGGAACG
GGCCTTCGACATCTATTCCCGCCTGCTGCAGGAACGGATCATCTTCCTGACCGGGCCGGTCTACGATCAGGTGGCCGCCG
TGGTGTCGGCGCAGCTCCTGTATCTGGAGAGCGTGAATCCGACCAAGGAAATCTCGTTCTACATCAACAGCCCGGGCGGC
GTCGTGTCGGCCGGACTCGCGATCTACGACACGATGCAGTACATTCGCAGCCCGGTCAGCACCGTGTGCATCGGCCAGGC
GGCATCCATGGGCTCGCTGCTGCTGGCCGGCGGCGAGAAGGGGCGGCGCTTCGCCCTGCCGAACGCACGGGTCATGGTGC
ATCAGCCCTCGGGCGGCGCGCAGGGGCAGGCCAGCGACATCGAAATCCAGGCGCGCGAGATCCTGACGATCCGCCAGCGC
CTGAACGAGATCTACGAGACCCATACCGGCCAGACGCTCGAGGATATCGAGCGCAGGCTGGAACGCGACAGCTACATGTC
GGCCGAAGAGGCCCAGGCCTTTGGCATCGTGGACGAAGTGGTACGCAATCACGCGGCTCCGGCATCGGCCAAGAGCTGA

Upstream 100 bases:

>100_bases
TAACCGGGGAACGACCCGGCCACCGGCTTCGACCGGCGCCCATGGCGCCGTTCCCAGGCGGTGCGTCGGGTCTTCGCGTT
TCAGGAACGGGAATGATACT

Downstream 100 bases:

>100_bases
GGGGCGGGGGCGGGCACGCTTTTTTAGCTTGGCGGCGCCCGCGGGCTTGGGCAGGGTTGATGAAACCCTGTCGTGAGTCA
GGATTTTCGACCCCGGTCCG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MRDRDPVEIFSSALVPMVVEQTSRGERAFDIYSRLLQERIIFLTGPVYDQVAAVVSAQLLYLESVNPTKEISFYINSPGG
VVSAGLAIYDTMQYIRSPVSTVCIGQAASMGSLLLAGGEKGRRFALPNARVMVHQPSGGAQGQASDIEIQAREILTIRQR
LNEIYETHTGQTLEDIERRLERDSYMSAEEAQAFGIVDEVVRNHAAPASAKS

Sequences:

>Translated_212_residues
MRDRDPVEIFSSALVPMVVEQTSRGERAFDIYSRLLQERIIFLTGPVYDQVAAVVSAQLLYLESVNPTKEISFYINSPGG
VVSAGLAIYDTMQYIRSPVSTVCIGQAASMGSLLLAGGEKGRRFALPNARVMVHQPSGGAQGQASDIEIQAREILTIRQR
LNEIYETHTGQTLEDIERRLERDSYMSAEEAQAFGIVDEVVRNHAAPASAKS
>Mature_212_residues
MRDRDPVEIFSSALVPMVVEQTSRGERAFDIYSRLLQERIIFLTGPVYDQVAAVVSAQLLYLESVNPTKEISFYINSPGG
VVSAGLAIYDTMQYIRSPVSTVCIGQAASMGSLLLAGGEKGRRFALPNARVMVHQPSGGAQGQASDIEIQAREILTIRQR
LNEIYETHTGQTLEDIERRLERDSYMSAEEAQAFGIVDEVVRNHAAPASAKS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=63.8297872340426, Blast_Score=255, Evalue=2e-68,
Organism=Escherichia coli, GI1786641, Length=189, Percent_Identity=64.5502645502645, Blast_Score=271, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17538017, Length=195, Percent_Identity=57.948717948718, Blast_Score=235, Evalue=1e-62,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=60.5263157894737, Blast_Score=254, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23279; Mature: 23279

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDRDPVEIFSSALVPMVVEQTSRGERAFDIYSRLLQERIIFLTGPVYDQVAAVVSAQLL
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHH
YLESVNPTKEISFYINSPGGVVSAGLAIYDTMQYIRSPVSTVCIGQAASMGSLLLAGGEK
HHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHHCCCCEEEECCCC
GRRFALPNARVMVHQPSGGAQGQASDIEIQAREILTIRQRLNEIYETHTGQTLEDIERRL
CCEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ERDSYMSAEEAQAFGIVDEVVRNHAAPASAKS
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRDRDPVEIFSSALVPMVVEQTSRGERAFDIYSRLLQERIIFLTGPVYDQVAAVVSAQLL
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHH
YLESVNPTKEISFYINSPGGVVSAGLAIYDTMQYIRSPVSTVCIGQAASMGSLLLAGGEK
HHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCHHCCCCEEEECCCC
GRRFALPNARVMVHQPSGGAQGQASDIEIQAREILTIRQRLNEIYETHTGQTLEDIERRL
CCEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ERDSYMSAEEAQAFGIVDEVVRNHAAPASAKS
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA