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The map label for this gene is parC [H]

Identifier: 162148787

GI number: 162148787

Start: 3103434

End: 3105665

Strand: Reverse

Name: parC [H]

Synonym: GDI_3016

Alternate gene names: 162148787

Gene position: 3105665-3103434 (Counterclockwise)

Preceding gene: 162148788

Following gene: 162148783

Centisome position: 78.74

GC content: 67.25

Gene sequence:

>2232_bases
ATGTCAGTGGATACCAGCGGCCATATCGAGGAAACCCGTCTCGCGGACGCGTTGAGCGAGCGGTACCTGGCCTATGCGAT
GTCCACCATCATGTCGCGTTCGCTGCCCGACGTGCGCGACGGGCTGAAGCCGGTGCATCGCCGGATGATCTATGCGATGC
GGCAATTGCGCCTGGACCCGACATCGGGGTTCAAGAAATGCGCCCGCGTCGTCGGTGACGTCATCGGTAAATACCACCCC
CACGGCGATGCTTCGGTCTACGAGGCGCTGGTGCGCCTGGCGCAGGATTTCGCCGTCCGCTACCCACTGGTCGAGGGGCA
GGGCAATTTCGGCTCGATCGACGGCGATAACGCGGCGGCGATGCGTTATACCGAAGCCCGGATGACCGAGGTCGCGCGCG
CCCTTCTGGAAGGGATCGACGACGATTCGGTCGATTTCCGCCCGACCTATGACGGCGAGGAGCAGGAACCCGTTGTCCTG
TCGGCGGCCTTTCCGAACCTGCTGGCCAACGGCGCGGCCGGCATCGCGGTCGGCATGGCCACCAGCATTCCCCCCCATAA
TGTCGGCGAGATCTGTTCGGCCGCGATCAGGCTGATCCGGTCGCCTGATGCGACGGTGGCGGACCTGATGGAGGACATGC
CCGGTCCGGACTTCCCGACCGGCGGCCTGATCGTCGAGGACCGCACGACCCTGTTGCAGGCCTACGAGACCGGGCGCGGC
AGCATGCGCATCCGCGCCCGCTGGTCGGTCGAGCAGGGCCGATTCGGCACCTGGCAGGTCGTGGTGACGGAAATTCCGTA
CCAGGTGCAGAAATCCCGCCTGATCGAGCAGATCGCCGACCTGATGGAACAGAAGAAGCTGCCGCTTCTGGGCGATATCC
GCGACGAAAGCACGACCGACATCCGCCTGGTGCTGGAGCCCAAGTCGCGCGGTGTGGAACCCGAAGTGCTGATGGAAACG
CTGTTTCGCGCCACCGCGCTGGAAAGCCGCTTCGCCCTGAACATGAACGTGCTGGGCGCCGACCGCGTGCCCGGCGTACG
CAGCCTGCGCGAGGTCCTGCGCGCGTGGCTGGACCATCGGCATGATGTGCTGCAACGCCGCAGCCGCCACCGGCTGCAGG
CGGTGGACCGCAGGTTGGAAATCCTGGACGGGTTCCTGGCCGTCTATCTGAACCTGGATGAAGTCATTCGCATCATCCGC
GAAGAAGACGACGCCAAGGCCGGGCTGATGGCCACGTTCTCGCTGACCGAATTGCAGGCCGAGTCGATCCTGAACATGCG
CCTGCGCAGCCTGCGCCGGCTCGAGGAACTGGAGATCCGCAAGGAACACGCGGCGCTGACGGCCGAACGCGGTGACCTGA
CGGCCCTGCTGGGCAGCGAGCCCCTGCGCTGGAAGAAAATCACCGAGGAAGTGAAGGCCATCCGCAAGGCATTCGGCGCC
GGCGCGCTGGGCACGCGGCGCAGCGAACTGGCCGCCCCGCCGCGCGCGATCGAACTGTCGGCCATCGAGGCGGTGGAGCG
CGAGCCGCTGACCCTGATCCTGTCCGCCAAGGGCTGGGTCAAGACGCTGAAGGGCCACGGCATCGACCCGACGGCCCAGA
AATTCAAGGAAGGCGACGGGTTCCGCCTGGCGGTGGAATGCCAGTCCACCGACCGGCTGTGCGTCTTCGCCACCGACGGC
CGTGCCTTCACCCTGCGCGCCGCCGACCTGCCGCGCGGGCGCGGCGACGGCCAGCCGATCCGCCTGCTGATCGAACTGTC
GAATGACGAGGATCTGGTGGCGGTCTTCCCGGTGCGCGAGGGCACGCGCCACCTGCTGGCTTCCAGCGCCGGGCGGGGCC
TGGTGATCCGCGACGAGGACCTGGTGGCCGAAAAGCGTACCGGCAAGCAGGTGCTGAACCTGAAGGATGCCGAAAGTGCG
CGGATCTGCCTGCCGGTCGAGGGCGACCACGTCGTGGTGCTGGGGCAGAACCGGCGCATGCTGGTCTTCCCGGTAGCGCA
ACTGCCGGAAATGGCGCGCGGCCTGGGCGTGGCCTTGCAGAAATACAAGGAAGGCGGCCTGATGGACGCCTGCCTCCTGT
CCTCGACGGACGGCGCGGCGTGGCCCGATCCGGCGCGAATCCGTCCCTTTGCCGATTTCCGTGACTATCTGGGCAAGCGC
GCCGATGTCGGCCGACCCGCCCCGGCCTGGGCGACCCGCAAGCCCAAACCGAAGACCCCGGCCGGCGGGTAG

Upstream 100 bases:

>100_bases
GCCCTTCAGCCCGGCGCCCTCCACCCCGACGATTGAGGCACGCACGCGATGGACAAATCGCGGATTTTCTCTATCTGTTC
CCGGGACAGGAGGAGTGCGC

Downstream 100 bases:

>100_bases
GTCGGTCTACTCGGTCAGGCTGGCCGGGAAGCGGGCGGGCCCGCGATCGCCTTCCTCGGGCAGGCGGTCGCGGTCCAGCG
GCGTCCAGGCGCCGTGGAAC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MSVDTSGHIEETRLADALSERYLAYAMSTIMSRSLPDVRDGLKPVHRRMIYAMRQLRLDPTSGFKKCARVVGDVIGKYHP
HGDASVYEALVRLAQDFAVRYPLVEGQGNFGSIDGDNAAAMRYTEARMTEVARALLEGIDDDSVDFRPTYDGEEQEPVVL
SAAFPNLLANGAAGIAVGMATSIPPHNVGEICSAAIRLIRSPDATVADLMEDMPGPDFPTGGLIVEDRTTLLQAYETGRG
SMRIRARWSVEQGRFGTWQVVVTEIPYQVQKSRLIEQIADLMEQKKLPLLGDIRDESTTDIRLVLEPKSRGVEPEVLMET
LFRATALESRFALNMNVLGADRVPGVRSLREVLRAWLDHRHDVLQRRSRHRLQAVDRRLEILDGFLAVYLNLDEVIRIIR
EEDDAKAGLMATFSLTELQAESILNMRLRSLRRLEELEIRKEHAALTAERGDLTALLGSEPLRWKKITEEVKAIRKAFGA
GALGTRRSELAAPPRAIELSAIEAVEREPLTLILSAKGWVKTLKGHGIDPTAQKFKEGDGFRLAVECQSTDRLCVFATDG
RAFTLRAADLPRGRGDGQPIRLLIELSNDEDLVAVFPVREGTRHLLASSAGRGLVIRDEDLVAEKRTGKQVLNLKDAESA
RICLPVEGDHVVVLGQNRRMLVFPVAQLPEMARGLGVALQKYKEGGLMDACLLSSTDGAAWPDPARIRPFADFRDYLGKR
ADVGRPAPAWATRKPKPKTPAGG

Sequences:

>Translated_743_residues
MSVDTSGHIEETRLADALSERYLAYAMSTIMSRSLPDVRDGLKPVHRRMIYAMRQLRLDPTSGFKKCARVVGDVIGKYHP
HGDASVYEALVRLAQDFAVRYPLVEGQGNFGSIDGDNAAAMRYTEARMTEVARALLEGIDDDSVDFRPTYDGEEQEPVVL
SAAFPNLLANGAAGIAVGMATSIPPHNVGEICSAAIRLIRSPDATVADLMEDMPGPDFPTGGLIVEDRTTLLQAYETGRG
SMRIRARWSVEQGRFGTWQVVVTEIPYQVQKSRLIEQIADLMEQKKLPLLGDIRDESTTDIRLVLEPKSRGVEPEVLMET
LFRATALESRFALNMNVLGADRVPGVRSLREVLRAWLDHRHDVLQRRSRHRLQAVDRRLEILDGFLAVYLNLDEVIRIIR
EEDDAKAGLMATFSLTELQAESILNMRLRSLRRLEELEIRKEHAALTAERGDLTALLGSEPLRWKKITEEVKAIRKAFGA
GALGTRRSELAAPPRAIELSAIEAVEREPLTLILSAKGWVKTLKGHGIDPTAQKFKEGDGFRLAVECQSTDRLCVFATDG
RAFTLRAADLPRGRGDGQPIRLLIELSNDEDLVAVFPVREGTRHLLASSAGRGLVIRDEDLVAEKRTGKQVLNLKDAESA
RICLPVEGDHVVVLGQNRRMLVFPVAQLPEMARGLGVALQKYKEGGLMDACLLSSTDGAAWPDPARIRPFADFRDYLGKR
ADVGRPAPAWATRKPKPKTPAGG
>Mature_742_residues
SVDTSGHIEETRLADALSERYLAYAMSTIMSRSLPDVRDGLKPVHRRMIYAMRQLRLDPTSGFKKCARVVGDVIGKYHPH
GDASVYEALVRLAQDFAVRYPLVEGQGNFGSIDGDNAAAMRYTEARMTEVARALLEGIDDDSVDFRPTYDGEEQEPVVLS
AAFPNLLANGAAGIAVGMATSIPPHNVGEICSAAIRLIRSPDATVADLMEDMPGPDFPTGGLIVEDRTTLLQAYETGRGS
MRIRARWSVEQGRFGTWQVVVTEIPYQVQKSRLIEQIADLMEQKKLPLLGDIRDESTTDIRLVLEPKSRGVEPEVLMETL
FRATALESRFALNMNVLGADRVPGVRSLREVLRAWLDHRHDVLQRRSRHRLQAVDRRLEILDGFLAVYLNLDEVIRIIRE
EDDAKAGLMATFSLTELQAESILNMRLRSLRRLEELEIRKEHAALTAERGDLTALLGSEPLRWKKITEEVKAIRKAFGAG
ALGTRRSELAAPPRAIELSAIEAVEREPLTLILSAKGWVKTLKGHGIDPTAQKFKEGDGFRLAVECQSTDRLCVFATDGR
AFTLRAADLPRGRGDGQPIRLLIELSNDEDLVAVFPVREGTRHLLASSAGRGLVIRDEDLVAEKRTGKQVLNLKDAESAR
ICLPVEGDHVVVLGQNRRMLVFPVAQLPEMARGLGVALQKYKEGGLMDACLLSSTDGAAWPDPARIRPFADFRDYLGKRA
DVGRPAPAWATRKPKPKTPAGG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=394, Percent_Identity=27.1573604060914, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI19913408, Length=342, Percent_Identity=25.4385964912281, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1789396, Length=662, Percent_Identity=43.3534743202417, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1788562, Length=660, Percent_Identity=38.7878787878788, Blast_Score=432, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI212645845, Length=478, Percent_Identity=25.3138075313808, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=439, Percent_Identity=25.5125284738041, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=442, Percent_Identity=24.8868778280543, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=387, Percent_Identity=25.5813953488372, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17136538, Length=180, Percent_Identity=32.7777777777778, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82170; Mature: 82039

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDTSGHIEETRLADALSERYLAYAMSTIMSRSLPDVRDGLKPVHRRMIYAMRQLRLDP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
TSGFKKCARVVGDVIGKYHPHGDASVYEALVRLAQDFAVRYPLVEGQGNFGSIDGDNAAA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCHH
MRYTEARMTEVARALLEGIDDDSVDFRPTYDGEEQEPVVLSAAFPNLLANGAAGIAVGMA
EEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEEEE
TSIPPHNVGEICSAAIRLIRSPDATVADLMEDMPGPDFPTGGLIVEDRTTLLQAYETGRG
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHCCCC
SMRIRARWSVEQGRFGTWQVVVTEIPYQVQKSRLIEQIADLMEQKKLPLLGDIRDESTTD
CEEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCE
IRLVLEPKSRGVEPEVLMETLFRATALESRFALNMNVLGADRVPGVRSLREVLRAWLDHR
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHH
HDVLQRRSRHRLQAVDRRLEILDGFLAVYLNLDEVIRIIREEDDAKAGLMATFSLTELQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEEEHHHHHHH
ESILNMRLRSLRRLEELEIRKEHAALTAERGDLTALLGSEPLRWKKITEEVKAIRKAFGA
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCC
GALGTRRSELAAPPRAIELSAIEAVEREPLTLILSAKGWVKTLKGHGIDPTAQKFKEGDG
CCCCCCHHHHCCCCCEEEHHHHHHHCCCCEEEEEECCHHHHHHCCCCCCHHHHHHCCCCC
FRLAVECQSTDRLCVFATDGRAFTLRAADLPRGRGDGQPIRLLIELSNDEDLVAVFPVRE
EEEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCC
GTRHLLASSAGRGLVIRDEDLVAEKRTGKQVLNLKDAESARICLPVEGDHVVVLGQNRRM
CHHHHHHCCCCCEEEEECHHHHHHHHCCHHHHCCCCCCCCEEEEEECCCEEEEECCCCEE
LVFPVAQLPEMARGLGVALQKYKEGGLMDACLLSSTDGAAWPDPARIRPFADFRDYLGKR
EEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCC
ADVGRPAPAWATRKPKPKTPAGG
CCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVDTSGHIEETRLADALSERYLAYAMSTIMSRSLPDVRDGLKPVHRRMIYAMRQLRLDP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
TSGFKKCARVVGDVIGKYHPHGDASVYEALVRLAQDFAVRYPLVEGQGNFGSIDGDNAAA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCHH
MRYTEARMTEVARALLEGIDDDSVDFRPTYDGEEQEPVVLSAAFPNLLANGAAGIAVGMA
EEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEEEE
TSIPPHNVGEICSAAIRLIRSPDATVADLMEDMPGPDFPTGGLIVEDRTTLLQAYETGRG
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHCCCC
SMRIRARWSVEQGRFGTWQVVVTEIPYQVQKSRLIEQIADLMEQKKLPLLGDIRDESTTD
CEEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCE
IRLVLEPKSRGVEPEVLMETLFRATALESRFALNMNVLGADRVPGVRSLREVLRAWLDHR
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHH
HDVLQRRSRHRLQAVDRRLEILDGFLAVYLNLDEVIRIIREEDDAKAGLMATFSLTELQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEEEHHHHHHH
ESILNMRLRSLRRLEELEIRKEHAALTAERGDLTALLGSEPLRWKKITEEVKAIRKAFGA
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCC
GALGTRRSELAAPPRAIELSAIEAVEREPLTLILSAKGWVKTLKGHGIDPTAQKFKEGDG
CCCCCCHHHHCCCCCEEEHHHHHHHCCCCEEEEEECCHHHHHHCCCCCCHHHHHHCCCCC
FRLAVECQSTDRLCVFATDGRAFTLRAADLPRGRGDGQPIRLLIELSNDEDLVAVFPVRE
EEEEEEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEEEEECCC
GTRHLLASSAGRGLVIRDEDLVAEKRTGKQVLNLKDAESARICLPVEGDHVVVLGQNRRM
CHHHHHHCCCCCEEEEECHHHHHHHHCCHHHHCCCCCCCCEEEEEECCCEEEEECCCCEE
LVFPVAQLPEMARGLGVALQKYKEGGLMDACLLSSTDGAAWPDPARIRPFADFRDYLGKR
EEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCC
ADVGRPAPAWATRKPKPKTPAGG
CCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]