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The map label for this gene is dxs [C]

Identifier: 162148781

GI number: 162148781

Start: 3096449

End: 3097411

Strand: Reverse

Name: dxs [C]

Synonym: GDI_3010

Alternate gene names: 162148781

Gene position: 3097411-3096449 (Counterclockwise)

Preceding gene: 162148782

Following gene: 162148780

Centisome position: 78.53

GC content: 57.42

Gene sequence:

>963_bases
CTGGCGCGCCTGGGGCCAAGGGCCACCTATGGCCAGACGCTGACCACCCTGGCGGGTGCCGACAGAAATATCATCGCCAT
AAGCGCGGATCTTGGACGGTCTTCGGGGCTCGACCGCTTTTCCAGGGAGCTTCCGGATCAGTTCGTGAATGTCGGCATTG
CCGAGCAGACGATGGTCGGCTGTGCGGCGGGCCTTGCCCGCATGGGATTCGACGTCTTCGCCTCGACATTCGCGCCCTTC
GCCTCGATGCGGGCGAGCGAACAGGTGCGGATGAACATGGGCTACATGCGCGAACCGGTTAAACTGGTAGCGCTCGGAAG
CGGGTTGTCGATGGCGTATCTCGGCAATTCGCACTTCGGCCTCGAAGATGTCGCGGTGATGCGTACTGTGCCGGGGCTTA
CGATCATCTCGCCAGCCGATTGCGTGGAAATCCAGAAGACGCTTTATGCCTGTGTCGGATACGGCCAGCCAGTATACATG
AGACTGACCGGCGCCTCGAGTACCCCCATAATTTATACCAGCGACTATGTATTCGAGATCGGGAGGGCGGTCTGGCTTAC
ACCTGTCCGCAAGATCATGTTGATCTCAAGCGGGACAACCGTGGCGCATTGTCTCAGGGCGACCGAGACACTTGCGCAAA
TGGATATCGAGGCAGGCGTTCTCAACATGCACACGATCAAGCCGCTCGATGAGAATGCACTCGAAAAAATCGCGCAGGAA
ACCGACGCCATTTTTGTCATCGAGGAGCACAAAGTTGCTGGGGGATTGGGCAGCGCTATTTTGGAATATTATAATGCCGC
GAGTATATCATGCCCCCCGATCATCCTGCATGGGATTGCCGATCGATTTGTCGAAACCGGAGACTATGCCTTCATGCTGA
AACAGAACCGCCTGGATGCTGAAGGCATAGCCGGTTTTGTGAGGGAGCGTCTGGGCGCGGTGGTGTCTGCCGATGAACGA
TAG

Upstream 100 bases:

>100_bases
TTCGAAAGATGTCTGAAGGTTCTGGACGGTTGCGATCTGCCGAAGCTTGATGCGTCAGGAGAGCCGAGTGTCTGAAATTT
CGAATTCCAGCGCCCGCGCA

Downstream 100 bases:

>100_bases
TCCGTGGTACGTGTATGGTGCCGGCGGTCTCGGCGTTGAAACCATGGACATATTACAAAGCGCCATAAATCATGGATCGG
AAAAGCCGCATCGCCTGGCC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MARLGPRATYGQTLTTLAGADRNIIAISADLGRSSGLDRFSRELPDQFVNVGIAEQTMVGCAAGLARMGFDVFASTFAPF
ASMRASEQVRMNMGYMREPVKLVALGSGLSMAYLGNSHFGLEDVAVMRTVPGLTIISPADCVEIQKTLYACVGYGQPVYM
RLTGASSTPIIYTSDYVFEIGRAVWLTPVRKIMLISSGTTVAHCLRATETLAQMDIEAGVLNMHTIKPLDENALEKIAQE
TDAIFVIEEHKVAGGLGSAILEYYNAASISCPPIILHGIADRFVETGDYAFMLKQNRLDAEGIAGFVRERLGAVVSADER

Sequences:

>Translated_320_residues
MARLGPRATYGQTLTTLAGADRNIIAISADLGRSSGLDRFSRELPDQFVNVGIAEQTMVGCAAGLARMGFDVFASTFAPF
ASMRASEQVRMNMGYMREPVKLVALGSGLSMAYLGNSHFGLEDVAVMRTVPGLTIISPADCVEIQKTLYACVGYGQPVYM
RLTGASSTPIIYTSDYVFEIGRAVWLTPVRKIMLISSGTTVAHCLRATETLAQMDIEAGVLNMHTIKPLDENALEKIAQE
TDAIFVIEEHKVAGGLGSAILEYYNAASISCPPIILHGIADRFVETGDYAFMLKQNRLDAEGIAGFVRERLGAVVSADER
>Mature_319_residues
ARLGPRATYGQTLTTLAGADRNIIAISADLGRSSGLDRFSRELPDQFVNVGIAEQTMVGCAAGLARMGFDVFASTFAPFA
SMRASEQVRMNMGYMREPVKLVALGSGLSMAYLGNSHFGLEDVAVMRTVPGLTIISPADCVEIQKTLYACVGYGQPVYMR
LTGASSTPIIYTSDYVFEIGRAVWLTPVRKIMLISSGTTVAHCLRATETLAQMDIEAGVLNMHTIKPLDENALEKIAQET
DAIFVIEEHKVAGGLGSAILEYYNAASISCPPIILHGIADRFVETGDYAFMLKQNRLDAEGIAGFVRERLGAVVSADER

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=311, Percent_Identity=33.1189710610932, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4507521, Length=311, Percent_Identity=33.1189710610932, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI225637461, Length=282, Percent_Identity=32.2695035460993, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI225637463, Length=282, Percent_Identity=32.2695035460993, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI225637459, Length=282, Percent_Identity=32.2695035460993, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI133778974, Length=281, Percent_Identity=30.6049822064057, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1786622, Length=303, Percent_Identity=28.0528052805281, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17539652, Length=262, Percent_Identity=34.7328244274809, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24666278, Length=316, Percent_Identity=31.9620253164557, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24645119, Length=259, Percent_Identity=33.5907335907336, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45551847, Length=259, Percent_Identity=33.5907335907336, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45550715, Length=259, Percent_Identity=33.5907335907336, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 34505; Mature: 34374

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLGPRATYGQTLTTLAGADRNIIAISADLGRSSGLDRFSRELPDQFVNVGIAEQTMVG
CCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCHHHHHCCCHHHHHHH
CAAGLARMGFDVFASTFAPFASMRASEQVRMNMGYMREPVKLVALGSGLSMAYLGNSHFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCC
LEDVAVMRTVPGLTIISPADCVEIQKTLYACVGYGQPVYMRLTGASSTPIIYTSDYVFEI
HHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECHHHHHH
GRAVWLTPVRKIMLISSGTTVAHCLRATETLAQMDIEAGVLNMHTIKPLDENALEKIAQE
HHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHC
TDAIFVIEEHKVAGGLGSAILEYYNAASISCPPIILHGIADRFVETGDYAFMLKQNRLDA
CCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCH
EGIAGFVRERLGAVVSADER
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ARLGPRATYGQTLTTLAGADRNIIAISADLGRSSGLDRFSRELPDQFVNVGIAEQTMVG
CCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCHHHHHCCCHHHHHHH
CAAGLARMGFDVFASTFAPFASMRASEQVRMNMGYMREPVKLVALGSGLSMAYLGNSHFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCC
LEDVAVMRTVPGLTIISPADCVEIQKTLYACVGYGQPVYMRLTGASSTPIIYTSDYVFEI
HHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECHHHHHH
GRAVWLTPVRKIMLISSGTTVAHCLRATETLAQMDIEAGVLNMHTIKPLDENALEKIAQE
HHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHC
TDAIFVIEEHKVAGGLGSAILEYYNAASISCPPIILHGIADRFVETGDYAFMLKQNRLDA
CCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCH
EGIAGFVRERLGAVVSADER
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]