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The map label for this gene is cda [H]

Identifier: 162148746

GI number: 162148746

Start: 3062765

End: 3063163

Strand: Direct

Name: cda [H]

Synonym: GDI_2974

Alternate gene names: 162148746

Gene position: 3062765-3063163 (Clockwise)

Preceding gene: 162148742

Following gene: 162148752

Centisome position: 77.65

GC content: 70.93

Gene sequence:

>399_bases
ATGTCCGACGATCCGCTGATCGATGCCGCGGTGGCCGTCCGCGCCAACGCCTATGCCCCCTATTCGCGCTTCCACGTCGG
TGCGGCGCTGCGCTGCGCGGACGGCCGGATCTTCGTGGGCTGCAACACCGAAAACGCGGCCTATCCCGAAGGCATCTGCG
CCGAAGGGGGAGCGATCGCGGCCATGGTGGCCGGCGGCGGCCGGCAGATTGCCGACATCGTCATCAGCGGCGGGGGCGAT
CGGGCCTGCGCGCCCTGCGGCGGATGCCGGCAGAAGATCCGTGAATTCAGCGCCCCCGGCCTGACCGTTCGCATGGTCGG
GCCGCAGGGCACGCCGCTGCTTGTCCGCTCGCTGGCCGAATTGCTGCCCGACGCGTTCGGCCCCGAAGACCTGGCCTGA

Upstream 100 bases:

>100_bases
CTCCGGCCCACGGTTCCAAGGTCCGCGCGCATGGGCCGCGCGATACTGTTCGCAGCACCGGCGATCCGATAGACAGACCC
TGCCTTCGGGAGGAACGACA

Downstream 100 bases:

>100_bases
CTCTGCCTAGGCCCGCCGCCCTGCATTCAGCCGCCGTTCGCCCGCCACGTCGCGCGACGCCGCCAGCCCCCATCCGACCA
TCAGGAAGAACCACCCCGCC

Product: cytidine deaminase

Products: NA

Alternate protein names: CDA; Cytidine aminohydrolase [H]

Number of amino acids: Translated: 132; Mature: 131

Protein sequence:

>132_residues
MSDDPLIDAAVAVRANAYAPYSRFHVGAALRCADGRIFVGCNTENAAYPEGICAEGGAIAAMVAGGGRQIADIVISGGGD
RACAPCGGCRQKIREFSAPGLTVRMVGPQGTPLLVRSLAELLPDAFGPEDLA

Sequences:

>Translated_132_residues
MSDDPLIDAAVAVRANAYAPYSRFHVGAALRCADGRIFVGCNTENAAYPEGICAEGGAIAAMVAGGGRQIADIVISGGGD
RACAPCGGCRQKIREFSAPGLTVRMVGPQGTPLLVRSLAELLPDAFGPEDLA
>Mature_131_residues
SDDPLIDAAVAVRANAYAPYSRFHVGAALRCADGRIFVGCNTENAAYPEGICAEGGAIAAMVAGGGRQIADIVISGGGDR
ACAPCGGCRQKIREFSAPGLTVRMVGPQGTPLLVRSLAELLPDAFGPEDLA

Specific function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis [H]

COG id: COG0295

COG function: function code F; Cytidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI11386157, Length=127, Percent_Identity=48.8188976377953, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17551074, Length=130, Percent_Identity=40.7692307692308, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17540514, Length=131, Percent_Identity=39.6946564885496, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323274, Length=130, Percent_Identity=38.4615384615385, Blast_Score=88, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19920920, Length=140, Percent_Identity=41.4285714285714, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24582741, Length=130, Percent_Identity=40.7692307692308, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24582744, Length=136, Percent_Identity=38.2352941176471, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR006262
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.5 [H]

Molecular weight: Translated: 13448; Mature: 13317

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDPLIDAAVAVRANAYAPYSRFHVGAALRCADGRIFVGCNTENAAYPEGICAEGGAIA
CCCCCCHHHHEEEECCCCCCHHHEECCEEEEECCCEEEEEECCCCCCCCCCEECCCCEEE
AMVAGGGRQIADIVISGGGDRACAPCGGCRQKIREFSAPGLTVRMVGPQGTPLLVRSLAE
EEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
LLPDAFGPEDLA
HCCCCCCCCCCC
>Mature Secondary Structure 
SDDPLIDAAVAVRANAYAPYSRFHVGAALRCADGRIFVGCNTENAAYPEGICAEGGAIA
CCCCCHHHHEEEECCCCCCHHHEECCEEEEECCCEEEEEECCCCCCCCCCEECCCCEEE
AMVAGGGRQIADIVISGGGDRACAPCGGCRQKIREFSAPGLTVRMVGPQGTPLLVRSLAE
EEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
LLPDAFGPEDLA
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2526291; 8969508; 9384377 [H]