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The map label for this gene is clcA [H]

Identifier: 162148558

GI number: 162148558

Start: 2868385

End: 2869680

Strand: Direct

Name: clcA [H]

Synonym: GDI_2782

Alternate gene names: 162148558

Gene position: 2868385-2869680 (Clockwise)

Preceding gene: 162148557

Following gene: 162148560

Centisome position: 72.72

GC content: 66.36

Gene sequence:

>1296_bases
GTGATACAAACGCCTGAAAACGATCCTCCCTGCGGCCTGACGGTTCTTTCGTTGCTGTCGATCCTGACGGGCCTCGTCGC
GGGCGTGATCTGCGGATCGTTCCGGCTGCTCCTCGAATGGTCTGACGGGTTGCGCACGGCGTTCGCTCTTGGTCCGTGGC
ACGGCTTTCCGGCCGGCCTGCTCCTGATTCTGGCATCGAGCCTTGCCTCCTTCCTTGCGGCGCTGATGGTGCGGCGGCTG
GCCCCGCTCGCCTCTGGCAGCGGTATTCCGCATGTCGAGGCTGTCCTGGCCGGATCGACCACGCCCGCTTCGGCTGGTCT
GATACCTGTGAAATTCGTCGGTGGTTTGCTTGCGATTGGTGGCGGGCTGGCACTCGGGCGCGAAGGACCGAGCGTGCAGA
TGGGGGCAACGGCTGCGAACACAATCGGCCGCGTGCTCCGGCTCGGCCGGTCGGACTGTCGGGTCTTGCTGGCGGCGGGC
GCCGGGGCGGGTCTCGCGACCGCGTTCAACGCGCCGGGGGCAGGGGCCATCTTCGTTCTGGAAGAACTCGTCGGCCGCTT
CGAAGCCCGCACTGTCTGCTCGGCACTGGGAGCCTCCGTCTCCGCCATTCTCGTGGCCCGCGCCATGCTGGGTGGGAACC
CGGATTTCATGGTCTCTGTAGCGCCCGCAGTGATCGACGTTTCGACCCAGCTCCTGTTTCTGCTGACCGGGCTCGCGATG
GGTGTCCTCTCCGTCCTGTATAACCGGACTGTCCTTACAACACTGCGGTTCGCGGAAGGTCTGCCGGTCGGAGTGGAGAC
GCGCGCGGCGCTGATCGGCGCTCTGGCAGGCGTCGTCGTCTGGCTGACCCCGCATCTGGCGGGAGGCGGAGACTGGCTGA
CGCAAAGCGCGATCAATGGCACCATCGCATGGTCGGTCATCTCGGGGCTGTTCGTCTTGCGTCTGGCTCTGGGAGCGCTC
TCCTATGCGGCCGCGACGCCGGGCGGCCTGTTTGCGCCCATGCTGGCGCTCGGCGCACTTGCCGGGCTCGGCTGCGGCGA
TATCGCACATGTGCTTGAACCGCGTCTGGCGGGCGATACCGCTCCCTTCGTTATTGTCGGAATGGCCGCGATGTTCGCTG
GGTCCGTCCGTGCGCCCCTGACGGGAATCATTCTCGTCACGGAGATGACCAATGCGACCAGCCTGCTGCTGCCGCTTCTC
TCCGGGAGCTTCGCCGCGATGCTAGTCGCGGACGGCATGCAGGAGGCGCCTATCTACGAAGCCCTCCGCAACCGGGCCGC
CGTCGCCAAACGCTAA

Upstream 100 bases:

>100_bases
CGGTATTCGGGCTTCTGTTGTCGCCCATGATCGGAGGCGCGGCCATGGCGCTCTCCTCCGTCACGGTCATCACCAACGCG
CTGCGGCTTGGAAAAACCCC

Downstream 100 bases:

>100_bases
CTGGGCGAGCGGTACATCTTGCTCTCGGTTCGAACGACGAGTGATTCTGTGGACCGTCATCACTGCGCGTGCCAACCGCC
GCCGGGTGTTCTATGATCAA

Product: H(+)/Cl(-) exchange transporter

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MIQTPENDPPCGLTVLSLLSILTGLVAGVICGSFRLLLEWSDGLRTAFALGPWHGFPAGLLLILASSLASFLAALMVRRL
APLASGSGIPHVEAVLAGSTTPASAGLIPVKFVGGLLAIGGGLALGREGPSVQMGATAANTIGRVLRLGRSDCRVLLAAG
AGAGLATAFNAPGAGAIFVLEELVGRFEARTVCSALGASVSAILVARAMLGGNPDFMVSVAPAVIDVSTQLLFLLTGLAM
GVLSVLYNRTVLTTLRFAEGLPVGVETRAALIGALAGVVVWLTPHLAGGGDWLTQSAINGTIAWSVISGLFVLRLALGAL
SYAAATPGGLFAPMLALGALAGLGCGDIAHVLEPRLAGDTAPFVIVGMAAMFAGSVRAPLTGIILVTEMTNATSLLLPLL
SGSFAAMLVADGMQEAPIYEALRNRAAVAKR

Sequences:

>Translated_431_residues
MIQTPENDPPCGLTVLSLLSILTGLVAGVICGSFRLLLEWSDGLRTAFALGPWHGFPAGLLLILASSLASFLAALMVRRL
APLASGSGIPHVEAVLAGSTTPASAGLIPVKFVGGLLAIGGGLALGREGPSVQMGATAANTIGRVLRLGRSDCRVLLAAG
AGAGLATAFNAPGAGAIFVLEELVGRFEARTVCSALGASVSAILVARAMLGGNPDFMVSVAPAVIDVSTQLLFLLTGLAM
GVLSVLYNRTVLTTLRFAEGLPVGVETRAALIGALAGVVVWLTPHLAGGGDWLTQSAINGTIAWSVISGLFVLRLALGAL
SYAAATPGGLFAPMLALGALAGLGCGDIAHVLEPRLAGDTAPFVIVGMAAMFAGSVRAPLTGIILVTEMTNATSLLLPLL
SGSFAAMLVADGMQEAPIYEALRNRAAVAKR
>Mature_431_residues
MIQTPENDPPCGLTVLSLLSILTGLVAGVICGSFRLLLEWSDGLRTAFALGPWHGFPAGLLLILASSLASFLAALMVRRL
APLASGSGIPHVEAVLAGSTTPASAGLIPVKFVGGLLAIGGGLALGREGPSVQMGATAANTIGRVLRLGRSDCRVLLAAG
AGAGLATAFNAPGAGAIFVLEELVGRFEARTVCSALGASVSAILVARAMLGGNPDFMVSVAPAVIDVSTQLLFLLTGLAM
GVLSVLYNRTVLTTLRFAEGLPVGVETRAALIGALAGVVVWLTPHLAGGGDWLTQSAINGTIAWSVISGLFVLRLALGAL
SYAAATPGGLFAPMLALGALAGLGCGDIAHVLEPRLAGDTAPFVIVGMAAMFAGSVRAPLTGIILVTEMTNATSLLLPLL
SGSFAAMLVADGMQEAPIYEALRNRAAVAKR

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI153252026, Length=422, Percent_Identity=23.9336492890995, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI55770838, Length=414, Percent_Identity=23.4299516908213, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI55770840, Length=414, Percent_Identity=23.4299516908213, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4557473, Length=160, Percent_Identity=32.5, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI189217923, Length=160, Percent_Identity=32.5, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI189217921, Length=160, Percent_Identity=32.5, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786350, Length=376, Percent_Identity=35.9042553191489, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI87081943, Length=416, Percent_Identity=26.4423076923077, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532615, Length=400, Percent_Identity=23.5, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71996455, Length=407, Percent_Identity=25.0614250614251, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71996452, Length=407, Percent_Identity=25.0614250614251, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71980828, Length=421, Percent_Identity=23.2779097387173, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980824, Length=421, Percent_Identity=23.2779097387173, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71985148, Length=226, Percent_Identity=27.8761061946903, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71985141, Length=226, Percent_Identity=27.8761061946903, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980820, Length=426, Percent_Identity=23.0046948356808, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24665008, Length=423, Percent_Identity=25.0591016548463, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45551566, Length=408, Percent_Identity=24.7549019607843, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 43444; Mature: 43444

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQTPENDPPCGLTVLSLLSILTGLVAGVICGSFRLLLEWSDGLRTAFALGPWHGFPAGL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHEECCCCCCHHHH
LLILASSLASFLAALMVRRLAPLASGSGIPHVEAVLAGSTTPASAGLIPVKFVGGLLAIG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHC
GGLALGREGPSVQMGATAANTIGRVLRLGRSDCRVLLAAGAGAGLATAFNAPGAGAIFVL
CCCEECCCCCCEEECCHHHHHHHHHHHHCCHHHEEEEEECCCCCHHHHCCCCCCHHHHHH
EELVGRFEARTVCSALGASVSAILVARAMLGGNPDFMVSVAPAVIDVSTQLLFLLTGLAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
GVLSVLYNRTVLTTLRFAEGLPVGVETRAALIGALAGVVVWLTPHLAGGGDWLTQSAING
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
TIAWSVISGLFVLRLALGALSYAAATPGGLFAPMLALGALAGLGCGDIAHVLEPRLAGDT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHCCCC
APFVIVGMAAMFAGSVRAPLTGIILVTEMTNATSLLLPLLSGSFAAMLVADGMQEAPIYE
CHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHCCHHHHHHHHCCCCCCHHHH
ALRNRAAVAKR
HHHHHHHHCCC
>Mature Secondary Structure
MIQTPENDPPCGLTVLSLLSILTGLVAGVICGSFRLLLEWSDGLRTAFALGPWHGFPAGL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHEECCCCCCHHHH
LLILASSLASFLAALMVRRLAPLASGSGIPHVEAVLAGSTTPASAGLIPVKFVGGLLAIG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHC
GGLALGREGPSVQMGATAANTIGRVLRLGRSDCRVLLAAGAGAGLATAFNAPGAGAIFVL
CCCEECCCCCCEEECCHHHHHHHHHHHHCCHHHEEEEEECCCCCHHHHCCCCCCHHHHHH
EELVGRFEARTVCSALGASVSAILVARAMLGGNPDFMVSVAPAVIDVSTQLLFLLTGLAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
GVLSVLYNRTVLTTLRFAEGLPVGVETRAALIGALAGVVVWLTPHLAGGGDWLTQSAING
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
TIAWSVISGLFVLRLALGALSYAAATPGGLFAPMLALGALAGLGCGDIAHVLEPRLAGDT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHCCCC
APFVIVGMAAMFAGSVRAPLTGIILVTEMTNATSLLLPLLSGSFAAMLVADGMQEAPIYE
CHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHCCHHHHHHHHCCCCCCHHHH
ALRNRAAVAKR
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA