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The map label for this gene is yvrD [H]

Identifier: 162148457

GI number: 162148457

Start: 2773494

End: 2774195

Strand: Reverse

Name: yvrD [H]

Synonym: GDI_2677

Alternate gene names: 162148457

Gene position: 2774195-2773494 (Counterclockwise)

Preceding gene: 162148458

Following gene: 162148452

Centisome position: 70.34

GC content: 61.54

Gene sequence:

>702_bases
GTGGCGTTGAGTGACAAGGAGGCGGGGCCCCTGCAGGACGCGGTCGCGGAACTCTCGCGATTCGGACAAGTTCGCGGATT
TCCGGCCGATCTGACGGATGCGCGCCAGGTGCAGGGGCTTCATGCCCAGGTGACGGCGGAGATGGGCAATCCGGACATCG
TCATATCGGCGGCGGGAATAACCGGTCCGACCGGGCTCTTCCACGAATTGACCGAAAAGGACTGGAACCTGGTCCTGGAC
GTCAATTTTCTAAGTGCCGTCCGCGTGGCGCACGCCTTCGTACCTGCGATGCGGAAGGCAGGGTGGGGGCGTGTCGTTTT
CGTGGCCTCCGAAGACGCGGTGCAGCCGTATGTGGACGAACTGCCCTATTGTGCGTCCAAGGCGGCGATTCTCAGCCTCG
CCAAGGGTCTTTCGAATACCTATGGCCAGGACGGAATTACCGTCAATACAGTGTCCCCGGCCTTCATCGCCACGCCTATG
ACGGATGCGATGATGGAAAAGCGTTCGGCCCGTGACAACGTGTCCTTCGATGATGCCGTCCGGACGTTTCTGGAGGACGA
ACGTCCGATGATGGTCATCAAACGCCGTGGCCGGGCAGAGGAAGTGGCGGCGGCAATCGTATATCTGACATCGGCGCAGG
CCGAGTTCACGACAGGGGCGGTCCTTCGCGTGGATGGCGGTTCGGTGGGCACCATGGTTTGA

Upstream 100 bases:

>100_bases
CATGGATCTGGAAATTCGTGATCGCCTGGCTTTGATTACCGGCGGGGATTCCGGAATCGGCTTTGCCACCGCCCGGCTTC
TGTTGCGCGAGGGCGCGCGG

Downstream 100 bases:

>100_bases
CATCCTGTGGAAGAATGGGATGTCTGCCGGGTTATTGATGCCAGCTCAGGCCTTTCGGTACAAGCGAGAAGCCGCAGGCG
CGCAGGGCCGTGTCCAGGCT

Product: short-chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MALSDKEAGPLQDAVAELSRFGQVRGFPADLTDARQVQGLHAQVTAEMGNPDIVISAAGITGPTGLFHELTEKDWNLVLD
VNFLSAVRVAHAFVPAMRKAGWGRVVFVASEDAVQPYVDELPYCASKAAILSLAKGLSNTYGQDGITVNTVSPAFIATPM
TDAMMEKRSARDNVSFDDAVRTFLEDERPMMVIKRRGRAEEVAAAIVYLTSAQAEFTTGAVLRVDGGSVGTMV

Sequences:

>Translated_233_residues
MALSDKEAGPLQDAVAELSRFGQVRGFPADLTDARQVQGLHAQVTAEMGNPDIVISAAGITGPTGLFHELTEKDWNLVLD
VNFLSAVRVAHAFVPAMRKAGWGRVVFVASEDAVQPYVDELPYCASKAAILSLAKGLSNTYGQDGITVNTVSPAFIATPM
TDAMMEKRSARDNVSFDDAVRTFLEDERPMMVIKRRGRAEEVAAAIVYLTSAQAEFTTGAVLRVDGGSVGTMV
>Mature_232_residues
ALSDKEAGPLQDAVAELSRFGQVRGFPADLTDARQVQGLHAQVTAEMGNPDIVISAAGITGPTGLFHELTEKDWNLVLDV
NFLSAVRVAHAFVPAMRKAGWGRVVFVASEDAVQPYVDELPYCASKAAILSLAKGLSNTYGQDGITVNTVSPAFIATPMT
DAMMEKRSARDNVSFDDAVRTFLEDERPMMVIKRRGRAEEVAAAIVYLTSAQAEFTTGAVLRVDGGSVGTMV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=215, Percent_Identity=31.1627906976744, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI66933014, Length=217, Percent_Identity=27.6497695852535, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI32483357, Length=228, Percent_Identity=29.3859649122807, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI126723750, Length=179, Percent_Identity=28.4916201117318, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI40254992, Length=201, Percent_Identity=26.865671641791, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI59889578, Length=200, Percent_Identity=26.5, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=207, Percent_Identity=29.4685990338164, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1790717, Length=226, Percent_Identity=27.8761061946903, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87082100, Length=203, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1789208, Length=209, Percent_Identity=26.7942583732057, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1786812, Length=199, Percent_Identity=30.1507537688442, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI2367365, Length=209, Percent_Identity=31.5789473684211, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789378, Length=201, Percent_Identity=27.363184079602, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788459, Length=186, Percent_Identity=27.9569892473118, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI2367175, Length=208, Percent_Identity=31.25, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787905, Length=233, Percent_Identity=25.3218884120172, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=203, Percent_Identity=30.0492610837438, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=181, Percent_Identity=31.4917127071823, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=186, Percent_Identity=31.1827956989247, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115534694, Length=163, Percent_Identity=34.3558282208589, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=176, Percent_Identity=26.7045454545455, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=203, Percent_Identity=28.0788177339901, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=210, Percent_Identity=21.9047619047619, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=210, Percent_Identity=27.1428571428571, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI21357041, Length=199, Percent_Identity=30.1507537688442, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI23397609, Length=188, Percent_Identity=31.3829787234043, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355319, Length=226, Percent_Identity=26.5486725663717, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24639444, Length=228, Percent_Identity=29.8245614035088, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28571526, Length=201, Percent_Identity=30.3482587064677, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24644339, Length=231, Percent_Identity=25.974025974026, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644337, Length=229, Percent_Identity=28.3842794759825, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24923; Mature: 24791

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSDKEAGPLQDAVAELSRFGQVRGFPADLTDARQVQGLHAQVTAEMGNPDIVISAAGI
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCCCCEEEEECCC
TGPTGLFHELTEKDWNLVLDVNFLSAVRVAHAFVPAMRKAGWGRVVFVASEDAVQPYVDE
CCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
LPYCASKAAILSLAKGLSNTYGQDGITVNTVSPAFIATPMTDAMMEKRSARDNVSFDDAV
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCHHHHHHHHHHHCCCCCHHHHH
RTFLEDERPMMVIKRRGRAEEVAAAIVYLTSAQAEFTTGAVLRVDGGSVGTMV
HHHHCCCCCEEEEHHCCCHHHHHHHHHHEECCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
ALSDKEAGPLQDAVAELSRFGQVRGFPADLTDARQVQGLHAQVTAEMGNPDIVISAAGI
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCCCCEEEEECCC
TGPTGLFHELTEKDWNLVLDVNFLSAVRVAHAFVPAMRKAGWGRVVFVASEDAVQPYVDE
CCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
LPYCASKAAILSLAKGLSNTYGQDGITVNTVSPAFIATPMTDAMMEKRSARDNVSFDDAV
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCHHHHHHHHHHHCCCCCHHHHH
RTFLEDERPMMVIKRRGRAEEVAAAIVYLTSAQAEFTTGAVLRVDGGSVGTMV
HHHHCCCCCEEEEHHCCCHHHHHHHHHHEECCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]