Click here to switch to the map view.

The map label for this gene is nuoI [H]

Identifier: 162148247

GI number: 162148247

Start: 2553769

End: 2554218

Strand: Reverse

Name: nuoI [H]

Synonym: GDI_2464

Alternate gene names: 162148247

Gene position: 2554218-2553769 (Counterclockwise)

Preceding gene: 162148248

Following gene: 162148246

Centisome position: 64.76

GC content: 62.22

Gene sequence:

>450_bases
GTGGGCTATCCCGAGACCAAGCCGCCGCTGCCGCCGCGCTATCGCGGGCGCATCATCCTGTCGCGCGATCCCGACGGGCA
GGAACGCTGCGTCGCCTGCGGCCTGTGCGCCGTGGCCTGCCCGGTGGACTGCATCAGTCTGCAGAAAACGGAACAGGACG
GGCGCTGGTACCCGGATTATTTCCGTATCAATTTTTCCCGCTGCATCTTCTGCGGATTCTGCGAGGAAGCCTGCCCGACC
TACGCGATTCAGCTGACCCCCGATTTCGAGATGAGCGAATATGTCCGCCCCAGCCTGGTCTATGAAAAGGAGGACCTGCT
GATTTCGGGAACCGGGAAATATCCCGATTACAGCTTCTATCTCGTGTCCGGCGTGACGATCCCGGGCAAGGACAAGGGGG
AAGCGGAACGCGAATCCCCGCCAGTCGACGTGCGCAGCCTGATGCCCTGA

Upstream 100 bases:

>100_bases
GTGCTGCTGCTGCGCGCGCCGGGATAGGGGGCCCGCGATGTTCGATATCCTGCGCACGCTGTGGCTGACCTTCCGGCACA
TGACCCATCGCCGGGTCACG

Downstream 100 bases:

>100_bases
GGGTGATGGACATGAATGTCTCCTTCGCCCTGTCCGCGCTGGTGGTCGTGCTGGCCGCCTTCATGACGGTCACGCGCGCG
AATGCCGTGCACGCGCTGCT

Product: NADH-quinone oxidoreductase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I 1; NDH-1 subunit I 1 [H]

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MGYPETKPPLPPRYRGRIILSRDPDGQERCVACGLCAVACPVDCISLQKTEQDGRWYPDYFRINFSRCIFCGFCEEACPT
YAIQLTPDFEMSEYVRPSLVYEKEDLLISGTGKYPDYSFYLVSGVTIPGKDKGEAERESPPVDVRSLMP

Sequences:

>Translated_149_residues
MGYPETKPPLPPRYRGRIILSRDPDGQERCVACGLCAVACPVDCISLQKTEQDGRWYPDYFRINFSRCIFCGFCEEACPT
YAIQLTPDFEMSEYVRPSLVYEKEDLLISGTGKYPDYSFYLVSGVTIPGKDKGEAERESPPVDVRSLMP
>Mature_148_residues
GYPETKPPLPPRYRGRIILSRDPDGQERCVACGLCAVACPVDCISLQKTEQDGRWYPDYFRINFSRCIFCGFCEEACPTY
AIQLTPDFEMSEYVRPSLVYEKEDLLISGTGKYPDYSFYLVSGVTIPGKDKGEAERESPPVDVRSLMP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=111, Percent_Identity=44.1441441441441, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788617, Length=148, Percent_Identity=76.3513513513514, Blast_Score=237, Evalue=2e-64,
Organism=Escherichia coli, GI1789075, Length=146, Percent_Identity=25.3424657534247, Blast_Score=61, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17555194, Length=122, Percent_Identity=40.9836065573771, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17864306, Length=111, Percent_Identity=45.045045045045, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 16869; Mature: 16738

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
6.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYPETKPPLPPRYRGRIILSRDPDGQERCVACGLCAVACPVDCISLQKTEQDGRWYPDY
CCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCE
FRINFSRCIFCGFCEEACPTYAIQLTPDFEMSEYVRPSLVYEKEDLLISGTGKYPDYSFY
EEEEHHHEEEEECCHHCCCEEEEEECCCCCHHHHCCCCEEEECCCEEEECCCCCCCEEEE
LVSGVTIPGKDKGEAERESPPVDVRSLMP
EEEEEEECCCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
GYPETKPPLPPRYRGRIILSRDPDGQERCVACGLCAVACPVDCISLQKTEQDGRWYPDY
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCE
FRINFSRCIFCGFCEEACPTYAIQLTPDFEMSEYVRPSLVYEKEDLLISGTGKYPDYSFY
EEEEHHHEEEEECCHHCCCEEEEEECCCCCHHHHCCCCEEEECCCEEEECCCCCCCEEEE
LVSGVTIPGKDKGEAERESPPVDVRSLMP
EEEEEEECCCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA