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The map label for this gene is nuoL [H]

Identifier: 162148244

GI number: 162148244

Start: 2551066

End: 2552943

Strand: Reverse

Name: nuoL [H]

Synonym: GDI_2461

Alternate gene names: 162148244

Gene position: 2552943-2551066 (Counterclockwise)

Preceding gene: 162148245

Following gene: 162148243

Centisome position: 64.73

GC content: 70.93

Gene sequence:

>1878_bases
ATGACCGCGCTGCCGCCGCTGATCGTCCTGTGCCCGCTCCTGGCCGCCACGATCCTGTTCCTGTTTCCCCTGTTCCTGCG
GTCGGGCCGTATGTCCACCCGCGCGGCCTGCATCATTGCCGCCGGGGCGCTGGGCCTGTCGGCGCTGCTGACCGGATGGC
TGGCGGTGGACCTGCTGCCCGCGCCCCATCCGGCCCTGCGGATCGTGCTGTGGCAGTGGATGCGCGTGGACGGGTTCGAC
GCGCATGTGTCGTTCGCGGTCGATCCGCTGTCGCTCGTGATGATGCTGGTCGTGACCGGGATCGGGTTCCTGATCCACCT
GTATGCGTGCGGATATATGTGGGACGACCCCGATATCGCACGATTCTTCGGCGGCATGACGCTGTTCGTCGCCGCCATGC
TGGTACTGGTCCTGTCGTCCGACCTGCTGTGCCTCTATGTGGGGTGGGAGGGCGTGGGCCTGTGTTCCTACCTGCTGATC
GGCTTCTGGTACCGCGAGGTCGCGAACGGCGCCGCCGCGCGCAAGGCCTTCATCGTCACGCGGATCGGCGACGTGCTGCT
GCTGTGCGGGCTGCTGCTGCTGGCGACGCGCGCGGGCAGCCTGGACATCGACCGCGTGCTGGACGCCACGCGCTTCCTGC
GCGGCCCGGGCGCCGAACTGGTGGCGCTGCTGCTGCTGTGCGGCGCGGTGGCCAAGTCGGCGCAGGTTCCGTTCCAGATC
TGGCTGCCCGACGCCATGGCCGGTCCCACGCCGGTTTCGGCCCTGATCCACGCGGCGACGATGGTGACGGCCGGGGTCTA
CCTGATCGCGCGGCTGCATGCGCTGTTCGAGCCGGCGCCGGTGGTGATGGGGGTGATCTCGGTCGTGGGGCTGGTGACGC
TGCTGCTGGCGGGGGGCAGCGCCCTGGTCCAGACGGATATCAAGCGTATCCTGGCCTATTCCACCATCAGCCAGCTTGGC
TACATGTTCCTGGCGCTGGGCACCGGGGCGTGGGGGGCCGCGATCTTCCACCTGGTGACGCATGCGATGTTCAAGGCGCT
GCTGTTCATGGCGGCGGGCGCGGTGATCCTGCGCATGCATCACCAGCAGGATATCTTTCACATGGGCGGGCTGCGGCGGG
CGATGCCGGGCGTCTTCGCCGCCTTCGTGGCGGGGGCGGCGGCGCTGGCGGGCGTGCCGCTGGTCTCCGCCGGGTTCTAC
AGCAAGGAAGCGATCCTGCAGGGCGCGTGGGACAGTTCCCCCCTGCTGTGGGCGGGGGCGCTGCTGGGGGCGTTCCTGAC
CGGGCTGTACAGTTTCCGCTGCGTCTTCATCGTCTTCCTGGGCGCGCCGCGCGGCACCGCGACGGGCAGCACCGGCTGGT
CGATGGCGGTGCCGCTGGCGTGCCTGTCCGTCCTGGCGGTCGTCGGCGGGATGATCGAAATGCCCGATGTCATCGCGCCG
GTGCACCTGCTGTCGCACCTGCTGGCGCCGGTGCTGGGCGGGGCCGAGGCGGAATCGGGCGGCGAGGGTGGTCGTGCGTT
GCTGGCGGCCGGGTCCCTGGCGCCGCTGGCCGGGATCGCGCTGGCCTGGGTGTTCTGGCAACCGGGACGTGTGCCGCAGC
CGGCCTCCGGCGTGCTGGCGGGGCTGGCGCGGGCGGGGTGGGGGTTCGATGCGGCGTACGGCGTGCTGGTGGTGCGCCCG
TTCACCGCCCTGGGCCGGTGGATGAAGCGGGACGTGTTCGACATCCTGCCCGACCTGCTGGCGGCGGGGGCCGTCTGGGG
CGGCAAGGCACTGGGACTGATGCAGGACGGCCAGGTCCGGCGCTATGCCGGGTGGCTGGCCGTGGGTACGGCGGTCGCCC
TGTGCCTGGCGGTGCAGCCATGGGGGGGACGGCCATGA

Upstream 100 bases:

>100_bases
CCGAGGCCGCGATCGGGCTGGCGATCCTGCTGCGGATGCACCAGGCGGGGCGGCCGACCCTGGACGCCGATACCGGCAAC
CGCCTGAAGGGATAGCGATC

Downstream 100 bases:

>100_bases
TCGCGTTGCCGGCCCTGGTCCTGCTGCCGCTGGCCGGCGGGACGGCGGCGTGGCTGGCCGGACGCGGCGCCGGCCCGCGC
GGGCCGTGGCGCGTGACGCT

Product: NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L; NUO12 [H]

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MTALPPLIVLCPLLAATILFLFPLFLRSGRMSTRAACIIAAGALGLSALLTGWLAVDLLPAPHPALRIVLWQWMRVDGFD
AHVSFAVDPLSLVMMLVVTGIGFLIHLYACGYMWDDPDIARFFGGMTLFVAAMLVLVLSSDLLCLYVGWEGVGLCSYLLI
GFWYREVANGAAARKAFIVTRIGDVLLLCGLLLLATRAGSLDIDRVLDATRFLRGPGAELVALLLLCGAVAKSAQVPFQI
WLPDAMAGPTPVSALIHAATMVTAGVYLIARLHALFEPAPVVMGVISVVGLVTLLLAGGSALVQTDIKRILAYSTISQLG
YMFLALGTGAWGAAIFHLVTHAMFKALLFMAAGAVILRMHHQQDIFHMGGLRRAMPGVFAAFVAGAAALAGVPLVSAGFY
SKEAILQGAWDSSPLLWAGALLGAFLTGLYSFRCVFIVFLGAPRGTATGSTGWSMAVPLACLSVLAVVGGMIEMPDVIAP
VHLLSHLLAPVLGGAEAESGGEGGRALLAAGSLAPLAGIALAWVFWQPGRVPQPASGVLAGLARAGWGFDAAYGVLVVRP
FTALGRWMKRDVFDILPDLLAAGAVWGGKALGLMQDGQVRRYAGWLAVGTAVALCLAVQPWGGRP

Sequences:

>Translated_625_residues
MTALPPLIVLCPLLAATILFLFPLFLRSGRMSTRAACIIAAGALGLSALLTGWLAVDLLPAPHPALRIVLWQWMRVDGFD
AHVSFAVDPLSLVMMLVVTGIGFLIHLYACGYMWDDPDIARFFGGMTLFVAAMLVLVLSSDLLCLYVGWEGVGLCSYLLI
GFWYREVANGAAARKAFIVTRIGDVLLLCGLLLLATRAGSLDIDRVLDATRFLRGPGAELVALLLLCGAVAKSAQVPFQI
WLPDAMAGPTPVSALIHAATMVTAGVYLIARLHALFEPAPVVMGVISVVGLVTLLLAGGSALVQTDIKRILAYSTISQLG
YMFLALGTGAWGAAIFHLVTHAMFKALLFMAAGAVILRMHHQQDIFHMGGLRRAMPGVFAAFVAGAAALAGVPLVSAGFY
SKEAILQGAWDSSPLLWAGALLGAFLTGLYSFRCVFIVFLGAPRGTATGSTGWSMAVPLACLSVLAVVGGMIEMPDVIAP
VHLLSHLLAPVLGGAEAESGGEGGRALLAAGSLAPLAGIALAWVFWQPGRVPQPASGVLAGLARAGWGFDAAYGVLVVRP
FTALGRWMKRDVFDILPDLLAAGAVWGGKALGLMQDGQVRRYAGWLAVGTAVALCLAVQPWGGRP
>Mature_624_residues
TALPPLIVLCPLLAATILFLFPLFLRSGRMSTRAACIIAAGALGLSALLTGWLAVDLLPAPHPALRIVLWQWMRVDGFDA
HVSFAVDPLSLVMMLVVTGIGFLIHLYACGYMWDDPDIARFFGGMTLFVAAMLVLVLSSDLLCLYVGWEGVGLCSYLLIG
FWYREVANGAAARKAFIVTRIGDVLLLCGLLLLATRAGSLDIDRVLDATRFLRGPGAELVALLLLCGAVAKSAQVPFQIW
LPDAMAGPTPVSALIHAATMVTAGVYLIARLHALFEPAPVVMGVISVVGLVTLLLAGGSALVQTDIKRILAYSTISQLGY
MFLALGTGAWGAAIFHLVTHAMFKALLFMAAGAVILRMHHQQDIFHMGGLRRAMPGVFAAFVAGAAALAGVPLVSAGFYS
KEAILQGAWDSSPLLWAGALLGAFLTGLYSFRCVFIVFLGAPRGTATGSTGWSMAVPLACLSVLAVVGGMIEMPDVIAPV
HLLSHLLAPVLGGAEAESGGEGGRALLAAGSLAPLAGIALAWVFWQPGRVPQPASGVLAGLARAGWGFDAAYGVLVVRPF
TALGRWMKRDVFDILPDLLAAGAVWGGKALGLMQDGQVRRYAGWLAVGTAVALCLAVQPWGGRP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=376, Percent_Identity=38.563829787234, Blast_Score=256, Evalue=7e-68,
Organism=Escherichia coli, GI1788614, Length=613, Percent_Identity=45.6769983686786, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1788829, Length=331, Percent_Identity=36.2537764350453, Blast_Score=153, Evalue=4e-38,
Organism=Escherichia coli, GI1788827, Length=401, Percent_Identity=31.4214463840399, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788831, Length=359, Percent_Identity=29.8050139275766, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI2367154, Length=428, Percent_Identity=28.5046728971963, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788613, Length=383, Percent_Identity=25.065274151436, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI145693160, Length=272, Percent_Identity=27.9411764705882, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 65526; Mature: 65395

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALPPLIVLCPLLAATILFLFPLFLRSGRMSTRAACIIAAGALGLSALLTGWLAVDLLP
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
APHPALRIVLWQWMRVDGFDAHVSFAVDPLSLVMMLVVTGIGFLIHLYACGYMWDDPDIA
CCCHHHHHHHHHHHHCCCCCCHHEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
RFFGGMTLFVAAMLVLVLSSDLLCLYVGWEGVGLCSYLLIGFWYREVANGAAARKAFIVT
HHHCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RIGDVLLLCGLLLLATRAGSLDIDRVLDATRFLRGPGAELVALLLLCGAVAKSAQVPFQI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEE
WLPDAMAGPTPVSALIHAATMVTAGVYLIARLHALFEPAPVVMGVISVVGLVTLLLAGGS
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ALVQTDIKRILAYSTISQLGYMFLALGTGAWGAAIFHLVTHAMFKALLFMAAGAVILRMH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HQQDIFHMGGLRRAMPGVFAAFVAGAAALAGVPLVSAGFYSKEAILQGAWDSSPLLWAGA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHCCCCCCCHHHHHH
LLGAFLTGLYSFRCVFIVFLGAPRGTATGSTGWSMAVPLACLSVLAVVGGMIEMPDVIAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCHHHHH
VHLLSHLLAPVLGGAEAESGGEGGRALLAAGSLAPLAGIALAWVFWQPGRVPQPASGVLA
HHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
GLARAGWGFDAAYGVLVVRPFTALGRWMKRDVFDILPDLLAAGAVWGGKALGLMQDGQVR
HHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHH
RYAGWLAVGTAVALCLAVQPWGGRP
HHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TALPPLIVLCPLLAATILFLFPLFLRSGRMSTRAACIIAAGALGLSALLTGWLAVDLLP
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
APHPALRIVLWQWMRVDGFDAHVSFAVDPLSLVMMLVVTGIGFLIHLYACGYMWDDPDIA
CCCHHHHHHHHHHHHCCCCCCHHEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
RFFGGMTLFVAAMLVLVLSSDLLCLYVGWEGVGLCSYLLIGFWYREVANGAAARKAFIVT
HHHCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
RIGDVLLLCGLLLLATRAGSLDIDRVLDATRFLRGPGAELVALLLLCGAVAKSAQVPFQI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEE
WLPDAMAGPTPVSALIHAATMVTAGVYLIARLHALFEPAPVVMGVISVVGLVTLLLAGGS
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ALVQTDIKRILAYSTISQLGYMFLALGTGAWGAAIFHLVTHAMFKALLFMAAGAVILRMH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HQQDIFHMGGLRRAMPGVFAAFVAGAAALAGVPLVSAGFYSKEAILQGAWDSSPLLWAGA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHCCCCCCCHHHHHH
LLGAFLTGLYSFRCVFIVFLGAPRGTATGSTGWSMAVPLACLSVLAVVGGMIEMPDVIAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCHHHHH
VHLLSHLLAPVLGGAEAESGGEGGRALLAAGSLAPLAGIALAWVFWQPGRVPQPASGVLA
HHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
GLARAGWGFDAAYGVLVVRPFTALGRWMKRDVFDILPDLLAAGAVWGGKALGLMQDGQVR
HHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHH
RYAGWLAVGTAVALCLAVQPWGGRP
HHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7690854; 9205837; 9278503 [H]