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The map label for this gene is klb [C]

Identifier: 162148180

GI number: 162148180

Start: 2481893

End: 2483179

Strand: Direct

Name: klb [C]

Synonym: GDI_2397

Alternate gene names: 162148180

Gene position: 2481893-2483179 (Clockwise)

Preceding gene: 162148179

Following gene: 162148185

Centisome position: 62.93

GC content: 66.51

Gene sequence:

>1287_bases
ATGACGGGACCGAAATTCGGCCGACGCCTCGGCGAACGCATCAAGCTGCTGGCCAGCCTGTCCGGTGCCGCACCGGCCCA
GACAGGCTCGCGCGGCTGGTCCCTGCCGGGCGTGGAGGAAATGGAGTTCATGGCGAAGCGCGCGGCGGCGCTCGGCATCG
CCGATCCGTTCTTCCGCCAGCATGACGGACTCGACGGGGCCACGACGTCGATCGACGGACGCAGCTACATCAATTTCTCG
TCCTACGACTATCTCGGCCTGAACGGCGATCCCCGGATCATCGCCCGGGTCGAGGACGCGCTGCGCAAATATGGCACGAC
GGTTTCGGCCAGCCGCATGGTGTCGGGGGAACGCCCGTTCCATCGGGAACTGGAACATGCGCTGGCCGAATGGCACGGCG
CCGAGGACTGCGTCGTGATGGTATCGGGCCATGCGACCAACGTGACGACACTGGCCCAGTTGATGCGGCCCGGCGACCTG
ATCGTCCATGACGCCCTGGCCCATAACAGCCTGATCCAGGGCGCGATCCTGTCCGGCGCCCGCCGCGTCGCCTTCGCCCA
CAACGACGTCGCCGCCGCGCGCGAGCAGCTATGGATGCACCGCAAGGCTCATAAGCGCGCGCTGCTGGTGCTGGAAGGCC
ATTACAGCATGGATGGCGATATTCCCGACCTCGCGGCCTTCGTGGCCCTGGCGCGGGAATTCGACTGCATGTCGCTGGTG
GATGAAGCCCATTCGACCGGCGTGCTGGGCGCGGGCGGGCACGGCATTGCCGAACAGGCCGGCGTTGCACCGGATTCGGT
CGACCTGTGGATGGGGACCCTCAGCAAAAGCCTGGTATCCTGCGGCGGATACATCGCCGGGCGCGCGGATGTCATTACCT
ACCTCAAGCGTACGGCCGCCGGATTCGTCTATTCCGTCGGCCTGCCGCCGCCCGGCGCCGCCGCCTCGCTGGCCGCACTG
GACATCATACGCGAGGAACCGTGGCGCATCGCGCGCCTGCGCGAAAACTCGGTCCATCTTCTGCGTCTTTTCCAGGATGC
GGGGTTCGATACCGGCAGTTCCGCCGGCTACGGCATCGTGCCGCTGGTCACCGGCAGTTCGGTGACGGCCGGTCGCCTGT
CGCAGGCCGTATTCGAACAGGGCATCAACGTCCAGCCGATCATCCATCCCGCGGTGCCAGAACGGGCTGCGCGCCTGCGC
TTCTTCGTCAGCGCATCGCACACGACCGATCAGATCGAAACGACGGCGGCGGTTCTCGTGCGGGAATTGCAGGCCCTGTC
GGAATAG

Upstream 100 bases:

>100_bases
CGGACGAGGCCGTGCTGGACCGCCATCTGTCCGCCGAGGAACGGCAGGCCGCCTCGGCGTCGTCCGAACCCGTCTCCCAG
AACAATGAAGAACTGACCAC

Downstream 100 bases:

>100_bases
GCGGACAGGATCCGCCGAACCGATCCCTCGACCGCCAGCGCCCGTCCTTCGGGGGTGAAGAAATCACCCTCGACCAGCAC
CTCCTGGATCAGCATGCGGC

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTGPKFGRRLGERIKLLASLSGAAPAQTGSRGWSLPGVEEMEFMAKRAAALGIADPFFRQHDGLDGATTSIDGRSYINFS
SYDYLGLNGDPRIIARVEDALRKYGTTVSASRMVSGERPFHRELEHALAEWHGAEDCVVMVSGHATNVTTLAQLMRPGDL
IVHDALAHNSLIQGAILSGARRVAFAHNDVAAAREQLWMHRKAHKRALLVLEGHYSMDGDIPDLAAFVALAREFDCMSLV
DEAHSTGVLGAGGHGIAEQAGVAPDSVDLWMGTLSKSLVSCGGYIAGRADVITYLKRTAAGFVYSVGLPPPGAAASLAAL
DIIREEPWRIARLRENSVHLLRLFQDAGFDTGSSAGYGIVPLVTGSSVTAGRLSQAVFEQGINVQPIIHPAVPERAARLR
FFVSASHTTDQIETTAAVLVRELQALSE

Sequences:

>Translated_428_residues
MTGPKFGRRLGERIKLLASLSGAAPAQTGSRGWSLPGVEEMEFMAKRAAALGIADPFFRQHDGLDGATTSIDGRSYINFS
SYDYLGLNGDPRIIARVEDALRKYGTTVSASRMVSGERPFHRELEHALAEWHGAEDCVVMVSGHATNVTTLAQLMRPGDL
IVHDALAHNSLIQGAILSGARRVAFAHNDVAAAREQLWMHRKAHKRALLVLEGHYSMDGDIPDLAAFVALAREFDCMSLV
DEAHSTGVLGAGGHGIAEQAGVAPDSVDLWMGTLSKSLVSCGGYIAGRADVITYLKRTAAGFVYSVGLPPPGAAASLAAL
DIIREEPWRIARLRENSVHLLRLFQDAGFDTGSSAGYGIVPLVTGSSVTAGRLSQAVFEQGINVQPIIHPAVPERAARLR
FFVSASHTTDQIETTAAVLVRELQALSE
>Mature_427_residues
TGPKFGRRLGERIKLLASLSGAAPAQTGSRGWSLPGVEEMEFMAKRAAALGIADPFFRQHDGLDGATTSIDGRSYINFSS
YDYLGLNGDPRIIARVEDALRKYGTTVSASRMVSGERPFHRELEHALAEWHGAEDCVVMVSGHATNVTTLAQLMRPGDLI
VHDALAHNSLIQGAILSGARRVAFAHNDVAAAREQLWMHRKAHKRALLVLEGHYSMDGDIPDLAAFVALAREFDCMSLVD
EAHSTGVLGAGGHGIAEQAGVAPDSVDLWMGTLSKSLVSCGGYIAGRADVITYLKRTAAGFVYSVGLPPPGAAASLAALD
IIREEPWRIARLRENSVHLLRLFQDAGFDTGSSAGYGIVPLVTGSSVTAGRLSQAVFEQGINVQPIIHPAVPERAARLRF
FVSASHTTDQIETTAAVLVRELQALSE

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=361, Percent_Identity=33.7950138504155, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI4758668, Length=356, Percent_Identity=32.3033707865169, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI7657118, Length=358, Percent_Identity=31.0055865921788, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI284448556, Length=345, Percent_Identity=31.0144927536232, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI83977444, Length=342, Percent_Identity=30.7017543859649, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI83977442, Length=342, Percent_Identity=30.7017543859649, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI83977440, Length=342, Percent_Identity=30.7017543859649, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI4502025, Length=348, Percent_Identity=32.183908045977, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI40316939, Length=348, Percent_Identity=32.183908045977, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI5454084, Length=381, Percent_Identity=28.6089238845144, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1790046, Length=355, Percent_Identity=32.9577464788732, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=34.9431818181818, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI32566772, Length=355, Percent_Identity=33.8028169014084, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI71994529, Length=355, Percent_Identity=30.7042253521127, Blast_Score=181, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17560914, Length=410, Percent_Identity=29.0243902439024, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17560912, Length=410, Percent_Identity=29.0243902439024, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71982625, Length=295, Percent_Identity=31.1864406779661, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71982617, Length=295, Percent_Identity=31.1864406779661, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6320267, Length=352, Percent_Identity=30.6818181818182, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320438, Length=358, Percent_Identity=28.2122905027933, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=242, Percent_Identity=24.7933884297521, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24662918, Length=341, Percent_Identity=31.9648093841642, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI17137420, Length=355, Percent_Identity=31.5492957746479, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17136286, Length=353, Percent_Identity=30.3116147308782, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24653280, Length=288, Percent_Identity=30.9027777777778, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24653276, Length=288, Percent_Identity=30.9027777777778, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24653278, Length=288, Percent_Identity=30.9027777777778, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 45783; Mature: 45651

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPKFGRRLGERIKLLASLSGAAPAQTGSRGWSLPGVEEMEFMAKRAAALGIADPFFRQ
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
HDGLDGATTSIDGRSYINFSSYDYLGLNGDPRIIARVEDALRKYGTTVSASRMVSGERPF
CCCCCCCCCCCCCCCEEEECCCEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCH
HRELEHALAEWHGAEDCVVMVSGHATNVTTLAQLMRPGDLIVHDALAHNSLIQGAILSGA
HHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCC
RRVAFAHNDVAAAREQLWMHRKAHKRALLVLEGHYSMDGDIPDLAAFVALAREFDCMSLV
HHEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHH
DEAHSTGVLGAGGHGIAEQAGVAPDSVDLWMGTLSKSLVSCGGYIAGRADVITYLKRTAA
HHHHCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
GFVYSVGLPPPGAAASLAALDIIREEPWRIARLRENSVHLLRLFQDAGFDTGSSAGYGIV
CEEEECCCCCCCHHHHHHHHHHHHCCCHHEEHHCCCCHHHHHHHHHCCCCCCCCCCCCEE
PLVTGSSVTAGRLSQAVFEQGINVQPIIHPAVPERAARLRFFVSASHTTDQIETTAAVLV
EEEECCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHEEEEEECCCCHHHHHHHHHHHH
RELQALSE
HHHHHHCC
>Mature Secondary Structure 
TGPKFGRRLGERIKLLASLSGAAPAQTGSRGWSLPGVEEMEFMAKRAAALGIADPFFRQ
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
HDGLDGATTSIDGRSYINFSSYDYLGLNGDPRIIARVEDALRKYGTTVSASRMVSGERPF
CCCCCCCCCCCCCCCEEEECCCEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCH
HRELEHALAEWHGAEDCVVMVSGHATNVTTLAQLMRPGDLIVHDALAHNSLIQGAILSGA
HHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCC
RRVAFAHNDVAAAREQLWMHRKAHKRALLVLEGHYSMDGDIPDLAAFVALAREFDCMSLV
HHEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHH
DEAHSTGVLGAGGHGIAEQAGVAPDSVDLWMGTLSKSLVSCGGYIAGRADVITYLKRTAA
HHHHCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
GFVYSVGLPPPGAAASLAALDIIREEPWRIARLRENSVHLLRLFQDAGFDTGSSAGYGIV
CEEEECCCCCCCHHHHHHHHHHHHCCCHHEEHHCCCCHHHHHHHHHCCCCCCCCCCCCEE
PLVTGSSVTAGRLSQAVFEQGINVQPIIHPAVPERAARLRFFVSASHTTDQIETTAAVLV
EEEECCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHEEEEEECCCCHHHHHHHHHHHH
RELQALSE
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA