Click here to switch to the map view.

The map label for this gene is spe [H]

Identifier: 162148102

GI number: 162148102

Start: 2382669

End: 2383538

Strand: Reverse

Name: spe [H]

Synonym: GDI_2319

Alternate gene names: 162148102

Gene position: 2383538-2382669 (Counterclockwise)

Preceding gene: 162148103

Following gene: 162148100

Centisome position: 60.43

GC content: 66.67

Gene sequence:

>870_bases
ATGACTGAAGCATGGATCGGCGAAACACTCTATGACGGCTGGCAGCAGCGCTTCCGGGTCCGCACCGAGCTGGCCCGCAC
CAGGAGCGCGTTCCAGGATATCGTGGTTTTCGAAAGCGAGACGCATGGCCGCGTCCTCGTGCTCGACGGCGTGATCCAGA
TCACCGAGGGTGACGAGTTCGTCTATCAGGAAATGCTGACCCACGTGCCGCTGCTGGCCCACGGCAACGCCGCCAGCGTG
CTGATCATCGGCGCGGGTGACGGCGGCGTGCTGCGCCGGGTGCTGCAGCATCGCGGCGTGACCCGGGCGGTGATGGTGGA
AATTGACGGCGAGGTGATCGCGCTGTCCAGGCAGTTCCTGCCCGGCATTGCCGGCGACGCCTGGACCGACCCCCGCGCCG
AGGTGATCGTGGGCGACGGCATCGACTACGTCGCGCGCGCCGAAACCGGATCGGTCGATGTGATCATCGTCGATAGCACC
GACCCGATCGGCGTGGGCGAGGTGCTGTTTACCGATTCGTTCTACGAACATTGCGCGCGCATCCTGACGCCGAACGGCAT
CATCGTGAATCAGTGCGGCGTGCCCTTCATGCAGGCCGACGAACTGCGCGACACCAGCCTGCGCCGCGCGCGGTTCTTCC
CGCACGTGTCGGCCTATGTCGCGGCGGTGCCGACCTATGTCGGCGGGTTCATGACGCTGGGCGTCGCGGCGAAAGGCACG
AATCCGGCCACACCGTCGGTCGAGACGATTCGCGCCCGGGCCGAGGCGGCGGGCATCCTGGGGACCACCGGCTACTGGAC
GCCGGAAATCCACACCGGCGCCTTCAACCTGCCGCCCTATATCGCGAAGCACCTGCCCGCGGCGAAGTAA

Upstream 100 bases:

>100_bases
CCTGACGCCGTTCCTGCCCGCATAGAACCCGGGGGCCGGATTTATCCGGCCTCTTTTTTTATGTCCGGCGTCCATCCGTG
GACACGAGGGGAAATGAGCA

Downstream 100 bases:

>100_bases
GGCAGGAGGGGGCAGGGCGTTCATGCCCTGCCTTTCTTTCTGGTGGGCCTTTCAGGCAGGCTGCGTCGTCAGCATCCGCA
CCTTGACGATCTCGACGCCC

Product: spermidine synthase

Products: NA

Alternate protein names: Putrescine aminopropyltransferase 1; PAPT 1; SPDSY 1 [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MTEAWIGETLYDGWQQRFRVRTELARTRSAFQDIVVFESETHGRVLVLDGVIQITEGDEFVYQEMLTHVPLLAHGNAASV
LIIGAGDGGVLRRVLQHRGVTRAVMVEIDGEVIALSRQFLPGIAGDAWTDPRAEVIVGDGIDYVARAETGSVDVIIVDST
DPIGVGEVLFTDSFYEHCARILTPNGIIVNQCGVPFMQADELRDTSLRRARFFPHVSAYVAAVPTYVGGFMTLGVAAKGT
NPATPSVETIRARAEAAGILGTTGYWTPEIHTGAFNLPPYIAKHLPAAK

Sequences:

>Translated_289_residues
MTEAWIGETLYDGWQQRFRVRTELARTRSAFQDIVVFESETHGRVLVLDGVIQITEGDEFVYQEMLTHVPLLAHGNAASV
LIIGAGDGGVLRRVLQHRGVTRAVMVEIDGEVIALSRQFLPGIAGDAWTDPRAEVIVGDGIDYVARAETGSVDVIIVDST
DPIGVGEVLFTDSFYEHCARILTPNGIIVNQCGVPFMQADELRDTSLRRARFFPHVSAYVAAVPTYVGGFMTLGVAAKGT
NPATPSVETIRARAEAAGILGTTGYWTPEIHTGAFNLPPYIAKHLPAAK
>Mature_288_residues
TEAWIGETLYDGWQQRFRVRTELARTRSAFQDIVVFESETHGRVLVLDGVIQITEGDEFVYQEMLTHVPLLAHGNAASVL
IIGAGDGGVLRRVLQHRGVTRAVMVEIDGEVIALSRQFLPGIAGDAWTDPRAEVIVGDGIDYVARAETGSVDVIIVDSTD
PIGVGEVLFTDSFYEHCARILTPNGIIVNQCGVPFMQADELRDTSLRRARFFPHVSAYVAAVPTYVGGFMTLGVAAKGTN
PATPSVETIRARAEAAGILGTTGYWTPEIHTGAFNLPPYIAKHLPAAK

Specific function: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor [H]

COG id: COG0421

COG function: function code E; Spermidine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the spermidine/spermine synthase family [H]

Homologues:

Organism=Homo sapiens, GI63253298, Length=285, Percent_Identity=38.2456140350877, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1786312, Length=280, Percent_Identity=46.4285714285714, Blast_Score=259, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI25154106, Length=288, Percent_Identity=37.1527777777778, Blast_Score=170, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI212645616, Length=239, Percent_Identity=41.8410041841004, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323175, Length=283, Percent_Identity=38.86925795053, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6325326, Length=281, Percent_Identity=35.9430604982206, Blast_Score=182, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24645443, Length=290, Percent_Identity=37.9310344827586, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI21355941, Length=223, Percent_Identity=35.8744394618834, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21358269, Length=169, Percent_Identity=33.1360946745562, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24663238, Length=169, Percent_Identity=33.1360946745562, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001045 [H]

Pfam domain/function: PF01564 Spermine_synth [H]

EC number: =2.5.1.16 [H]

Molecular weight: Translated: 31318; Mature: 31187

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS51006 SPERMIDINE_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAWIGETLYDGWQQRFRVRTELARTRSAFQDIVVFESETHGRVLVLDGVIQITEGDEF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECEEEEECCCHH
VYQEMLTHVPLLAHGNAASVLIIGAGDGGVLRRVLQHRGVTRAVMVEIDGEVIALSRQFL
HHHHHHHHCCEEECCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCEEEEEHHHC
PGIAGDAWTDPRAEVIVGDGIDYVARAETGSVDVIIVDSTDPIGVGEVLFTDSFYEHCAR
CCCCCCCCCCCCCEEEEECCCCEEEECCCCCEEEEEEECCCCCCCCHHEECHHHHHHHHH
ILTPNGIIVNQCGVPFMQADELRDTSLRRARFFPHVSAYVAAVPTYVGGFMTLGVAAKGT
HHCCCCEEEECCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEECCC
NPATPSVETIRARAEAAGILGTTGYWTPEIHTGAFNLPPYIAKHLPAAK
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCHHHHHHCCCCC
>Mature Secondary Structure 
TEAWIGETLYDGWQQRFRVRTELARTRSAFQDIVVFESETHGRVLVLDGVIQITEGDEF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECEEEEECCCHH
VYQEMLTHVPLLAHGNAASVLIIGAGDGGVLRRVLQHRGVTRAVMVEIDGEVIALSRQFL
HHHHHHHHCCEEECCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCEEEEEHHHC
PGIAGDAWTDPRAEVIVGDGIDYVARAETGSVDVIIVDSTDPIGVGEVLFTDSFYEHCAR
CCCCCCCCCCCCCEEEEECCCCEEEECCCCCEEEEEEECCCCCCCCHHEECHHHHHHHHH
ILTPNGIIVNQCGVPFMQADELRDTSLRRARFFPHVSAYVAAVPTYVGGFMTLGVAAKGT
HHCCCCEEEECCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEEECCC
NPATPSVETIRARAEAAGILGTTGYWTPEIHTGAFNLPPYIAKHLPAAK
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]