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The map label for this gene is gcvT [H]

Identifier: 162148100

GI number: 162148100

Start: 2380771

End: 2382000

Strand: Reverse

Name: gcvT [H]

Synonym: GDI_2317

Alternate gene names: 162148100

Gene position: 2382000-2380771 (Counterclockwise)

Preceding gene: 162148102

Following gene: 162148099

Centisome position: 60.39

GC content: 70.89

Gene sequence:

>1230_bases
TTGGATTCAGGAGGCTCTGTTCATGTCACGCGGTTCGTTATCCCCCTGTCCGTTTCCCTTTCTTCCTGGCCTGACGGCCC
GCATGCGGGGGGCGGCATGACCCAGCCCCTGCTGCGCACGCCGCTGCACGACCTGCATCTGTCGCTGGGCGCGCGCATGG
TCCCCTTCGGGGGGTACGAGATGCCGGTCCAGTACCGCGCCGGCGTCATGGCCGAACATCAGCACACCCGCGCCGCCGCC
GGCCTGTTCGACGTGTCCCATATGGGCCAGATCCGCCTGCGTGCGCGCTCGGGCCGTGTCGAGGACGCCGCCCTGGCGCT
GGAGCGCCTGGTACCGGCCGACATCCTGTCGCTGAAGCCGGGCCGGCAGCGCTATGCCCTGCTGACCAACGAACAGGGCG
GGATCATCGACGACCTGATGGTGTCGCGTGTCGGTGACACGCTGCTGCTGGTGGTCAATGCGGCGTGCAAGGACGCCGAC
CTGGCGCATATCACGGCGGCGCTGGACGATGCCTGTATTGTCGAATCCCTGCCGGACCGGGCGCTGATCGCGCTGCAGGG
GCCGCTGGCGGGCGCGGCCCTGGCCCGGCTGGCGCCGGCATCGGCGGACATGCGCTTCATGGATGTCGCGGAATTCGACG
TCGCGGGCGTGCCCTGTATCGTTTCGCGTTCGGGCTATACCGGCGAGGACGGGTTCGAACTCGGCATGGAATCCGGCGGC
ACGGTGCGCGTGGCCGAGGCGCTGCTGGCGCAGGCCGAGGTCGAACCGGTGGGCCTGGGCGCGCGCGACAGCCTGCGGCT
GGAAGCGGGGCTGTGCCTGTATGGATCGGATATCGGTCCCGACACCACGCCGGTCGAAGGCGCGCTGGAATGGTCGATCC
AGAAGAGCCGTCGCGCCGGCGGGGCGCGGGCAGGGGGCTTCCCCGGGGCCGACATCATCCTGGCCCGGATTCAGGACGGC
GCCGCCCGTCGCCGGGTCGGGATCGCGGTCGATGGCCGCGCGCCCGTGCGGGGCGGCGCGCGCCTGTTCGCCGATGCCGA
GGGGCATCGTCCGGTGGGCCACGTGACGTCGGGCGCGTTCGGCCCCACGGCCGGGGCGCCGGTGGCCATGGGATATGTCG
ATATCGCGCATGCGGCGACGGGCACCGCCCTGTTCGCCGAACTGCGCGGCAAATACGTGCCGGTCACGGTCGCGGCTCTG
CCGTTCGTGGCACCGGGATTCAAGCGTTGA

Upstream 100 bases:

>100_bases
GGACCGCCCGGCATCGACTTCTGGAGAGAGACGCCCCGAGCGTCCGCCGACGGGATAGCGATCTCAGGCAAACCGACAGA
AGGGGCATTCGGATCCGATC

Downstream 100 bases:

>100_bases
CGCATTGGGTGGAGTTTTGAACATGACCGTCTATTACACAAAAGATCACGAGTGGCTGCGCATCGAGGGTGACGTCGCGA
CGGTGGGGATCACCGCCCAT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MDSGGSVHVTRFVIPLSVSLSSWPDGPHAGGGMTQPLLRTPLHDLHLSLGARMVPFGGYEMPVQYRAGVMAEHQHTRAAA
GLFDVSHMGQIRLRARSGRVEDAALALERLVPADILSLKPGRQRYALLTNEQGGIIDDLMVSRVGDTLLLVVNAACKDAD
LAHITAALDDACIVESLPDRALIALQGPLAGAALARLAPASADMRFMDVAEFDVAGVPCIVSRSGYTGEDGFELGMESGG
TVRVAEALLAQAEVEPVGLGARDSLRLEAGLCLYGSDIGPDTTPVEGALEWSIQKSRRAGGARAGGFPGADIILARIQDG
AARRRVGIAVDGRAPVRGGARLFADAEGHRPVGHVTSGAFGPTAGAPVAMGYVDIAHAATGTALFAELRGKYVPVTVAAL
PFVAPGFKR

Sequences:

>Translated_409_residues
MDSGGSVHVTRFVIPLSVSLSSWPDGPHAGGGMTQPLLRTPLHDLHLSLGARMVPFGGYEMPVQYRAGVMAEHQHTRAAA
GLFDVSHMGQIRLRARSGRVEDAALALERLVPADILSLKPGRQRYALLTNEQGGIIDDLMVSRVGDTLLLVVNAACKDAD
LAHITAALDDACIVESLPDRALIALQGPLAGAALARLAPASADMRFMDVAEFDVAGVPCIVSRSGYTGEDGFELGMESGG
TVRVAEALLAQAEVEPVGLGARDSLRLEAGLCLYGSDIGPDTTPVEGALEWSIQKSRRAGGARAGGFPGADIILARIQDG
AARRRVGIAVDGRAPVRGGARLFADAEGHRPVGHVTSGAFGPTAGAPVAMGYVDIAHAATGTALFAELRGKYVPVTVAAL
PFVAPGFKR
>Mature_409_residues
MDSGGSVHVTRFVIPLSVSLSSWPDGPHAGGGMTQPLLRTPLHDLHLSLGARMVPFGGYEMPVQYRAGVMAEHQHTRAAA
GLFDVSHMGQIRLRARSGRVEDAALALERLVPADILSLKPGRQRYALLTNEQGGIIDDLMVSRVGDTLLLVVNAACKDAD
LAHITAALDDACIVESLPDRALIALQGPLAGAALARLAPASADMRFMDVAEFDVAGVPCIVSRSGYTGEDGFELGMESGG
TVRVAEALLAQAEVEPVGLGARDSLRLEAGLCLYGSDIGPDTTPVEGALEWSIQKSRRAGGARAGGFPGADIILARIQDG
AARRRVGIAVDGRAPVRGGARLFADAEGHRPVGHVTSGAFGPTAGAPVAMGYVDIAHAATGTALFAELRGKYVPVTVAAL
PFVAPGFKR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=382, Percent_Identity=44.2408376963351, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI257796258, Length=362, Percent_Identity=44.7513812154696, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI257796254, Length=375, Percent_Identity=40.8, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI257796256, Length=317, Percent_Identity=43.217665615142, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI197927446, Length=321, Percent_Identity=27.4143302180685, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI21361378, Length=321, Percent_Identity=27.4143302180685, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI24797151, Length=350, Percent_Identity=24, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1789272, Length=381, Percent_Identity=33.3333333333333, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17560118, Length=383, Percent_Identity=37.3368146214099, Blast_Score=218, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6320222, Length=391, Percent_Identity=37.5959079283887, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI20129441, Length=385, Percent_Identity=42.0779220779221, Blast_Score=271, Evalue=4e-73,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 42524; Mature: 42524

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSGGSVHVTRFVIPLSVSLSSWPDGPHAGGGMTQPLLRTPLHDLHLSLGARMVPFGGYE
CCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHCCHHHHHHHHCCEEECCCCCC
MPVQYRAGVMAEHQHTRAAAGLFDVSHMGQIRLRARSGRVEDAALALERLVPADILSLKP
CCHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHCCC
GRQRYALLTNEQGGIIDDLMVSRVGDTLLLVVNAACKDADLAHITAALDDACIVESLPDR
CCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHCCHHHHHCCCCC
ALIALQGPLAGAALARLAPASADMRFMDVAEFDVAGVPCIVSRSGYTGEDGFELGMESGG
EEEEEECCCHHHHHHHHCCCCCCEEEEEEHHCCCCCCCEEEECCCCCCCCCHHCCCCCCC
TVRVAEALLAQAEVEPVGLGARDSLRLEAGLCLYGSDIGPDTTPVEGALEWSIQKSRRAG
EEHHHHHHHHHCCCCEECCCCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEHHHHHCC
GARAGGFPGADIILARIQDGAARRRVGIAVDGRAPVRGGARLFADAEGHRPVGHVTSGAF
CCCCCCCCCHHEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCC
GPTAGAPVAMGYVDIAHAATGTALFAELRGKYVPVTVAALPFVAPGFKR
CCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCC
>Mature Secondary Structure
MDSGGSVHVTRFVIPLSVSLSSWPDGPHAGGGMTQPLLRTPLHDLHLSLGARMVPFGGYE
CCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHCCHHHHHHHHCCEEECCCCCC
MPVQYRAGVMAEHQHTRAAAGLFDVSHMGQIRLRARSGRVEDAALALERLVPADILSLKP
CCHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHCCC
GRQRYALLTNEQGGIIDDLMVSRVGDTLLLVVNAACKDADLAHITAALDDACIVESLPDR
CCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHCCHHHHHCCCCC
ALIALQGPLAGAALARLAPASADMRFMDVAEFDVAGVPCIVSRSGYTGEDGFELGMESGG
EEEEEECCCHHHHHHHHCCCCCCEEEEEEHHCCCCCCCEEEECCCCCCCCCHHCCCCCCC
TVRVAEALLAQAEVEPVGLGARDSLRLEAGLCLYGSDIGPDTTPVEGALEWSIQKSRRAG
EEHHHHHHHHHCCCCEECCCCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEHHHHHCC
GARAGGFPGADIILARIQDGAARRRVGIAVDGRAPVRGGARLFADAEGHRPVGHVTSGAF
CCCCCCCCCHHEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCC
GPTAGAPVAMGYVDIAHAATGTALFAELRGKYVPVTVAALPFVAPGFKR
CCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA