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The map label for this gene is hisZ [H]

Identifier: 162148040

GI number: 162148040

Start: 2313414

End: 2314595

Strand: Reverse

Name: hisZ [H]

Synonym: GDI_2256

Alternate gene names: 162148040

Gene position: 2314595-2313414 (Counterclockwise)

Preceding gene: 162148041

Following gene: 162148039

Centisome position: 58.68

GC content: 72.08

Gene sequence:

>1182_bases
ATGACGAATGGCCGGGACGGTGCTATAGGCGCGCGCATGACGGACGACCCGCCTCCCAATCCCGCCCTGCTGCCCGCGGG
CTTTGTCGACCTGCTTCCTTCCGATGCCGAGGCCGAGGCCGCCGGCATGGAAGACCTGATGCGGGTCTTCGCGACGCACG
GATACAGCCGCGTGAAGCCGCCGCTGCTGGAATTCGAGGATACGCTGCTGAGCGGATCGGGCGCGGCCGTGGCCGACCAG
GCCTTTCGCCTGATGGACCCGGACACGCGGCGGATGATGGCGCTGCGTCCCGACATCACGCCGCAGATCGCGCGGATCGC
GGCGACCCGGCTGGCCGATGTGCCGCGTCCGCTGCGCCTGTCCTATACCGGGCTGTGCGTGCTGGCCAGCGGCGGGGCGC
GGGAAAGCGACCGCCAGATTTCCCAGGCCGGGATCGAACTGATCGGCCCGGACTCGCCCCAGGCCGACGCTGAAATCATC
GCACTGGGGGCCGAAGGCCTGGCGGTGCTGGGGGTGCCCGGCGTGTCGTTCGACCTGACGATGCCCTCGCTGGCGCCGGC
GCTGATCGCGGAAATCGACTACACCCCGGCCGAGCGGCAGGCGCTGATGCGCGCCCTGGACCGCAAGGACGCGGCGGCCG
TCGCGCGCCTGGCCGGCGGCCTGGCGCCGGTGCTGACCGAATTGCTGCATGCGGCGGGTCCTGCCGAACGCGCGCTGGCG
GTGCTGGGTGGGCTGGTCCTGCCGGAACCGGTCCGGGCGCTGAGCGACCGGCTGGCCGCCACCTGTGCCGCGATCAAGGC
GCGCGTGCCCGATATCCGCCTGACGGTCGATCCGGTCGAATTCCGGGGCTGGCGCTACCATACCGGCGTGTGCGTGACCG
TGTACGCCCGTGGCCAGCATGAAGAACTGGGCCGGGGCGGGCGCTATATTTCCAACAATGACGAACCGGCCTGCGGCCTG
ACCCTGCGCCCCGAGGCCCTGCTGCGGGCCGCCCCGACCCGGCCCGGACGCATCCGCGTGTTCCTGCCCGCCGGGTGCGA
CCCGGCGCTGGGCCGGCGGCTGCGGACCGAAGGCTATGCCACGGTCGACGCCCTGGCACCGGTCGCCGACCAGGCGGCCG
AGGCAAGGCGCCTGGGTTGCACGATGATCGCGGCCGGCGACGGAATCGTGGCGTTAGACTGA

Upstream 100 bases:

>100_bases
GGGCGGTGCGACGGTCGAATCCGGTGACCTGCGCGCCCTGATGCCGTGGCTGGACTGGGCCGAGGCCCAGGTACGAGCCG
AATACGCCTGACGGGCGGGC

Downstream 100 bases:

>100_bases
CACATTTGTTAAAGCCGGGCGCCATCTGCCGCCCGTCCCGTTTTTCCAAGGAGCACCTTATGTCCAACGTCACCGTCATC
GGCGCCCAGTGGGGTGACGA

Product: histidyl-tRNA synthetase

Products: AMP; diphosphate; L-histidyl-tRNA(His)

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTNGRDGAIGARMTDDPPPNPALLPAGFVDLLPSDAEAEAAGMEDLMRVFATHGYSRVKPPLLEFEDTLLSGSGAAVADQ
AFRLMDPDTRRMMALRPDITPQIARIAATRLADVPRPLRLSYTGLCVLASGGARESDRQISQAGIELIGPDSPQADAEII
ALGAEGLAVLGVPGVSFDLTMPSLAPALIAEIDYTPAERQALMRALDRKDAAAVARLAGGLAPVLTELLHAAGPAERALA
VLGGLVLPEPVRALSDRLAATCAAIKARVPDIRLTVDPVEFRGWRYHTGVCVTVYARGQHEELGRGGRYISNNDEPACGL
TLRPEALLRAAPTRPGRIRVFLPAGCDPALGRRLRTEGYATVDALAPVADQAAEARRLGCTMIAAGDGIVALD

Sequences:

>Translated_393_residues
MTNGRDGAIGARMTDDPPPNPALLPAGFVDLLPSDAEAEAAGMEDLMRVFATHGYSRVKPPLLEFEDTLLSGSGAAVADQ
AFRLMDPDTRRMMALRPDITPQIARIAATRLADVPRPLRLSYTGLCVLASGGARESDRQISQAGIELIGPDSPQADAEII
ALGAEGLAVLGVPGVSFDLTMPSLAPALIAEIDYTPAERQALMRALDRKDAAAVARLAGGLAPVLTELLHAAGPAERALA
VLGGLVLPEPVRALSDRLAATCAAIKARVPDIRLTVDPVEFRGWRYHTGVCVTVYARGQHEELGRGGRYISNNDEPACGL
TLRPEALLRAAPTRPGRIRVFLPAGCDPALGRRLRTEGYATVDALAPVADQAAEARRLGCTMIAAGDGIVALD
>Mature_392_residues
TNGRDGAIGARMTDDPPPNPALLPAGFVDLLPSDAEAEAAGMEDLMRVFATHGYSRVKPPLLEFEDTLLSGSGAAVADQA
FRLMDPDTRRMMALRPDITPQIARIAATRLADVPRPLRLSYTGLCVLASGGARESDRQISQAGIELIGPDSPQADAEIIA
LGAEGLAVLGVPGVSFDLTMPSLAPALIAEIDYTPAERQALMRALDRKDAAAVARLAGGLAPVLTELLHAAGPAERALAV
LGGLVLPEPVRALSDRLAATCAAIKARVPDIRLTVDPVEFRGWRYHTGVCVTVYARGQHEELGRGGRYISNNDEPACGLT
LRPEALLRAAPTRPGRIRVFLPAGCDPALGRRLRTEGYATVDALAPVADQAAEARRLGCTMIAAGDGIVALD

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: 6.1.1.21

Molecular weight: Translated: 41333; Mature: 41202

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNGRDGAIGARMTDDPPPNPALLPAGFVDLLPSDAEAEAAGMEDLMRVFATHGYSRVKP
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHCCHHHHHHHHHHCCCCCCCC
PLLEFEDTLLSGSGAAVADQAFRLMDPDTRRMMALRPDITPQIARIAATRLADVPRPLRL
CHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHEEEECCCCCHHHHHHHHHHHHCCCCCCEE
SYTGLCVLASGGARESDRQISQAGIELIGPDSPQADAEIIALGAEGLAVLGVPGVSFDLT
EECEEEEEECCCCCCHHHHHHHCCCEEECCCCCCCCCEEEEECCCCEEEEECCCCEEECC
MPSLAPALIAEIDYTPAERQALMRALDRKDAAAVARLAGGLAPVLTELLHAAGPAERALA
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHH
VLGGLVLPEPVRALSDRLAATCAAIKARVPDIRLTVDPVEFRGWRYHTGVCVTVYARGQH
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCEEEECCEEEEEEECCCH
EELGRGGRYISNNDEPACGLTLRPEALLRAAPTRPGRIRVFLPAGCDPALGRRLRTEGYA
HHHCCCCCCCCCCCCCCCCEEECHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCE
TVDALAPVADQAAEARRLGCTMIAAGDGIVALD
EHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEC
>Mature Secondary Structure 
TNGRDGAIGARMTDDPPPNPALLPAGFVDLLPSDAEAEAAGMEDLMRVFATHGYSRVKP
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHCCHHHHHHHHHHCCCCCCCC
PLLEFEDTLLSGSGAAVADQAFRLMDPDTRRMMALRPDITPQIARIAATRLADVPRPLRL
CHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHEEEECCCCCHHHHHHHHHHHHCCCCCCEE
SYTGLCVLASGGARESDRQISQAGIELIGPDSPQADAEIIALGAEGLAVLGVPGVSFDLT
EECEEEEEECCCCCCHHHHHHHCCCEEECCCCCCCCCEEEEECCCCEEEEECCCCEEECC
MPSLAPALIAEIDYTPAERQALMRALDRKDAAAVARLAGGLAPVLTELLHAAGPAERALA
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHH
VLGGLVLPEPVRALSDRLAATCAAIKARVPDIRLTVDPVEFRGWRYHTGVCVTVYARGQH
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCEEEECCEEEEEEECCCH
EELGRGGRYISNNDEPACGLTLRPEALLRAAPTRPGRIRVFLPAGCDPALGRRLRTEGYA
HHHCCCCCCCCCCCCCCCCEEECHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCE
TVDALAPVADQAAEARRLGCTMIAAGDGIVALD
EHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine; tRNA(His)

Specific reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA