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The map label for this gene is rnc [H]

Identifier: 162147937

GI number: 162147937

Start: 2205800

End: 2206549

Strand: Reverse

Name: rnc [H]

Synonym: GDI_2153

Alternate gene names: 162147937

Gene position: 2206549-2205800 (Counterclockwise)

Preceding gene: 162147938

Following gene: 162147936

Centisome position: 55.94

GC content: 72.4

Gene sequence:

>750_bases
ATGACCGCGTCTGAAAGCGGTGGCGCGGACGGTGTGGTGGCGTCGGTCGAGGCGCGGGTCGGCTACCGGTTCCGCCGCCC
CGACCTGCTGCGCGAGGCGCTGACCCATCGCTCGGCCGCCCATCAGCGCAATGGCGGGGGCGCGCGCCGGTCGCGTCAGC
CGGCCGCGCGGCGCGGTGCGGGGTCGAACGAACGGCTGGAATTCATCGGCGACCGGGTGCTGGGGCTGGTGATGGCCGAA
TGGCTGCTGGAACGCTTCCCTGACGAACAGGAGGGGGCGCTGGGTCCGCGCCACGCCCATCTGGTGTCACGTCCGGTCCT
GGCCGCCATCGCCGGGACCATGAATCTGCAGCAGGCGCTGGACGTGGCGGAACACGAGGCCCGGGCGGGCGTGCGGCAGG
TGGCCAACGTCCTGGCCGACGCGGTCGAGGCGATCCTGGGCGCCATCTACCTGGATGGCGGGCTGGAGCCGGCCCGCCGC
TTCGTGCGTGCGGCGTGGAACGAGGCGATCGTGGCCCAGGCGCAGCCTCCCAAGGACCCCAAGACAGCCTTGCAGGAATG
GGTCCTGGCGCGCGGCCTGCCGCTGCCGGCCTATCGGACGGTGCAGATGGACGGGCCCTCCCATGCGCCACGCTTCGTCA
TCGCGGTGACGGCGGCGGGCCAGTCGGCCGAGGGAATCGCCGGCAGCAAGCGCGCGGCCGAAAGTGCCGCCGCCGCCGAC
CTGCTGAGGCTGGTTGATGAGAGACAATAA

Upstream 100 bases:

>100_bases
CCAAATGGATCTTCCTGTCGATCGACGCGCGCTATCCGGCGTGGGAATTCTGGATGTGGCCGGTCGAGATCCGCTGGGAC
CGCCTGTTCCAGGGGGTGCG

Downstream 100 bases:

>100_bases
CGGGCGGGATCGCGGATGCCGCCGGAAGGGATACAGGATATGACCACCCGCTGCGGCTTCGTCGCGATCGTGGGCGCGCC
GAATGCCGGGAAGTCGACGC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MTASESGGADGVVASVEARVGYRFRRPDLLREALTHRSAAHQRNGGGARRSRQPAARRGAGSNERLEFIGDRVLGLVMAE
WLLERFPDEQEGALGPRHAHLVSRPVLAAIAGTMNLQQALDVAEHEARAGVRQVANVLADAVEAILGAIYLDGGLEPARR
FVRAAWNEAIVAQAQPPKDPKTALQEWVLARGLPLPAYRTVQMDGPSHAPRFVIAVTAAGQSAEGIAGSKRAAESAAAAD
LLRLVDERQ

Sequences:

>Translated_249_residues
MTASESGGADGVVASVEARVGYRFRRPDLLREALTHRSAAHQRNGGGARRSRQPAARRGAGSNERLEFIGDRVLGLVMAE
WLLERFPDEQEGALGPRHAHLVSRPVLAAIAGTMNLQQALDVAEHEARAGVRQVANVLADAVEAILGAIYLDGGLEPARR
FVRAAWNEAIVAQAQPPKDPKTALQEWVLARGLPLPAYRTVQMDGPSHAPRFVIAVTAAGQSAEGIAGSKRAAESAAAAD
LLRLVDERQ
>Mature_248_residues
TASESGGADGVVASVEARVGYRFRRPDLLREALTHRSAAHQRNGGGARRSRQPAARRGAGSNERLEFIGDRVLGLVMAEW
LLERFPDEQEGALGPRHAHLVSRPVLAAIAGTMNLQQALDVAEHEARAGVRQVANVLADAVEAILGAIYLDGGLEPARRF
VRAAWNEAIVAQAQPPKDPKTALQEWVLARGLPLPAYRTVQMDGPSHAPRFVIAVTAAGQSAEGIAGSKRAAESAAAADL
LRLVDERQ

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=192, Percent_Identity=32.2916666666667, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI155030234, Length=192, Percent_Identity=32.2916666666667, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788920, Length=221, Percent_Identity=33.9366515837104, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193202651, Length=238, Percent_Identity=29.4117647058824, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17506883, Length=238, Percent_Identity=29.4117647058824, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17137682, Length=235, Percent_Identity=28.936170212766, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26576; Mature: 26445

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS50137 DS_RBD ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASESGGADGVVASVEARVGYRFRRPDLLREALTHRSAAHQRNGGGARRSRQPAARRGA
CCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCC
GSNERLEFIGDRVLGLVMAEWLLERFPDEQEGALGPRHAHLVSRPVLAAIAGTMNLQQAL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DVAEHEARAGVRQVANVLADAVEAILGAIYLDGGLEPARRFVRAAWNEAIVAQAQPPKDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCCCH
KTALQEWVLARGLPLPAYRTVQMDGPSHAPRFVIAVTAAGQSAEGIAGSKRAAESAAAAD
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHH
LLRLVDERQ
HHHHHHCCC
>Mature Secondary Structure 
TASESGGADGVVASVEARVGYRFRRPDLLREALTHRSAAHQRNGGGARRSRQPAARRGA
CCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCC
GSNERLEFIGDRVLGLVMAEWLLERFPDEQEGALGPRHAHLVSRPVLAAIAGTMNLQQAL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DVAEHEARAGVRQVANVLADAVEAILGAIYLDGGLEPARRFVRAAWNEAIVAQAQPPKDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEECCCCCCCH
KTALQEWVLARGLPLPAYRTVQMDGPSHAPRFVIAVTAAGQSAEGIAGSKRAAESAAAAD
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHH
LLRLVDERQ
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA