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The map label for this gene is era [H]

Identifier: 162147936

GI number: 162147936

Start: 2204867

End: 2205784

Strand: Reverse

Name: era [H]

Synonym: GDI_2152

Alternate gene names: 162147936

Gene position: 2205784-2204867 (Counterclockwise)

Preceding gene: 162147937

Following gene: 162147935

Centisome position: 55.93

GC content: 68.85

Gene sequence:

>918_bases
ATGCCGCCGGAAGGGATACAGGATATGACCACCCGCTGCGGCTTCGTCGCGATCGTGGGCGCGCCGAATGCCGGGAAGTC
GACGCTGCTGAACCGTATGGCCGGGGCCAAGCTGTCGATCGTCAGCCCCAAGGCGCAGACGACGCGCTTTCGCGTCCTGG
GCATCCTGATGCGCGGGGAAAGCCAGATCCTGCTGGTGGACACGCCCGGCATCTTCCAGCCCCGGCGCAAGCTGGACCGC
GCGATGGTGGCGGCGGCCTGGACCGGGGCCGAGGATGCCGACATCACGCTGCTGCTGGTCGATGCCCGGCGTGGCCTGTC
CGAATCGGTGCGCGCGATCGTCGAGCGGCTGGCGCAGTCCCGCCGCCGGGTCTGGCTGGTCCTGAACAAGACCGACCTGG
TGGACCGGCAGGCCCTGCTGCCGCTGACGGCGGAACTGTCGGCGCTGCTGGATGTGGAACATGTCTACATGGTCAGCGCC
CGCAGCGGCGACGGGGTCGAGGACCTGCTGTCCGCGCTGGCCGCTTCCCTGCCCGAAGGGCCATACCTGTATCCCGAGGA
CGATCTGACCGACCTGCCGGACCGGCTGCTGGCGGCGGAACTGGTGCGTGAACAGATCTTCCTGCAGACGCACGAGGAAG
TGCCCTATGCCGCGACCGCCGAGACCGAAAGCTTTCGCGAACTGCCGGACGGATCGGTCCGGATCGAGGTCACGATCTAC
GTCGCGCGGGCCGGGCACAAGGCGATTCTGATCGGCGAGAAGGGCAGCCGGATTCGCTCGATCGGCGAGCGCGCGCGCAA
GGACCTGTCCCGCCTGCTGGACCGCACCTGCCACCTGTTCCTGAACGTGAAGGAACGGGCCGGCTGGGACGAGGAACGGG
CCCGCCTGCGGGCCATCGGGCTGGACGACACGCCCTGA

Upstream 100 bases:

>100_bases
GGCCGAGGGAATCGCCGGCAGCAAGCGCGCGGCCGAAAGTGCCGCCGCCGCCGACCTGCTGAGGCTGGTTGATGAGAGAC
AATAACGGGCGGGATCGCGG

Downstream 100 bases:

>100_bases
TGGGCATGGCCGGGCGATGAGCGTGCTTGTGACCGCTCGCAACCGGCTATAAGAGGGTCTGCATGGGTGAGGTCCCGGCC
GGGGCGTCCCCCGCATTCGT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MPPEGIQDMTTRCGFVAIVGAPNAGKSTLLNRMAGAKLSIVSPKAQTTRFRVLGILMRGESQILLVDTPGIFQPRRKLDR
AMVAAAWTGAEDADITLLLVDARRGLSESVRAIVERLAQSRRRVWLVLNKTDLVDRQALLPLTAELSALLDVEHVYMVSA
RSGDGVEDLLSALAASLPEGPYLYPEDDLTDLPDRLLAAELVREQIFLQTHEEVPYAATAETESFRELPDGSVRIEVTIY
VARAGHKAILIGEKGSRIRSIGERARKDLSRLLDRTCHLFLNVKERAGWDEERARLRAIGLDDTP

Sequences:

>Translated_305_residues
MPPEGIQDMTTRCGFVAIVGAPNAGKSTLLNRMAGAKLSIVSPKAQTTRFRVLGILMRGESQILLVDTPGIFQPRRKLDR
AMVAAAWTGAEDADITLLLVDARRGLSESVRAIVERLAQSRRRVWLVLNKTDLVDRQALLPLTAELSALLDVEHVYMVSA
RSGDGVEDLLSALAASLPEGPYLYPEDDLTDLPDRLLAAELVREQIFLQTHEEVPYAATAETESFRELPDGSVRIEVTIY
VARAGHKAILIGEKGSRIRSIGERARKDLSRLLDRTCHLFLNVKERAGWDEERARLRAIGLDDTP
>Mature_304_residues
PPEGIQDMTTRCGFVAIVGAPNAGKSTLLNRMAGAKLSIVSPKAQTTRFRVLGILMRGESQILLVDTPGIFQPRRKLDRA
MVAAAWTGAEDADITLLLVDARRGLSESVRAIVERLAQSRRRVWLVLNKTDLVDRQALLPLTAELSALLDVEHVYMVSAR
SGDGVEDLLSALAASLPEGPYLYPEDDLTDLPDRLLAAELVREQIFLQTHEEVPYAATAETESFRELPDGSVRIEVTIYV
ARAGHKAILIGEKGSRIRSIGERARKDLSRLLDRTCHLFLNVKERAGWDEERARLRAIGLDDTP

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=306, Percent_Identity=30.0653594771242, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1788919, Length=296, Percent_Identity=38.5135135135135, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI87082120, Length=165, Percent_Identity=30.9090909090909, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323665, Length=167, Percent_Identity=26.9461077844311, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 33698; Mature: 33567

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00037 MYB_1 ; PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPEGIQDMTTRCGFVAIVGAPNAGKSTLLNRMAGAKLSIVSPKAQTTRFRVLGILMRGE
CCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEEECCCCHHHHEEEEEEEEECC
SQILLVDTPGIFQPRRKLDRAMVAAAWTGAEDADITLLLVDARRGLSESVRAIVERLAQS
CCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHC
RRRVWLVLNKTDLVDRQALLPLTAELSALLDVEHVYMVSARSGDGVEDLLSALAASLPEG
CCEEEEEEECCCCCCHHHHCCHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHCCCC
PYLYPEDDLTDLPDRLLAAELVREQIFLQTHEEVPYAATAETESFRELPDGSVRIEVTIY
CEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHCCCCCEEEEEEEE
VARAGHKAILIGEKGSRIRSIGERARKDLSRLLDRTCHLFLNVKERAGWDEERARLRAIG
EEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCCCHHHHHEEEEC
LDDTP
CCCCC
>Mature Secondary Structure 
PPEGIQDMTTRCGFVAIVGAPNAGKSTLLNRMAGAKLSIVSPKAQTTRFRVLGILMRGE
CCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEEECCCCHHHHEEEEEEEEECC
SQILLVDTPGIFQPRRKLDRAMVAAAWTGAEDADITLLLVDARRGLSESVRAIVERLAQS
CCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHC
RRRVWLVLNKTDLVDRQALLPLTAELSALLDVEHVYMVSARSGDGVEDLLSALAASLPEG
CCEEEEEEECCCCCCHHHHCCHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHCCCC
PYLYPEDDLTDLPDRLLAAELVREQIFLQTHEEVPYAATAETESFRELPDGSVRIEVTIY
CEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHCCCCCEEEEEEEE
VARAGHKAILIGEKGSRIRSIGERARKDLSRLLDRTCHLFLNVKERAGWDEERARLRAIG
EEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCCCHHHHHEEEEC
LDDTP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]