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The map label for this gene is uvrB [H]

Identifier: 162147890

GI number: 162147890

Start: 2154517

End: 2156748

Strand: Reverse

Name: uvrB [H]

Synonym: GDI_2106

Alternate gene names: 162147890

Gene position: 2156748-2154517 (Counterclockwise)

Preceding gene: 162147892

Following gene: 162147889

Centisome position: 54.68

GC content: 65.99

Gene sequence:

>2232_bases
ATGCCCGCGCCCGCCAGCAAGAAGACCCGCCGTCCCGATCCGTCGGACGAGATCGTGACCTTCCAGCCCGAACGGCAGCC
GCCGAAGGAGAAGACGCGGCGACTGACCATCCAGTCGCCCTACGAACCGGCGGGCGACCAGCCGCGTGCCATCGGCGAAC
TGGTGGCGGGGGTCGAAGGCGGCGAGCGCGACCAGGTGCTGCTGGGCGTTACCGGGTCGGGCAAGACCTTCACGATGGCC
AAGATCATCGAGGCGACGCAGAAACCCACCCTGATCCTGGCGCCGAACAAGACGCTGGCGGCCCAGCTCTATGGCGAGAT
GAAGCAGTTCTTCCCCGACAACGCGGTGGAATATTTCGTCAGCTACTACGATTACTACCAGCCCGAGGCCTATGTCCCGC
GCTCGGACACCTATATCGAAAAAGACAGCCAGATCAACGAACAGATCGACCGTATGCGCCACGCCGCGACCCAGGCGCTG
CTGGAACGCAACGACGTCATCATCGTGGCCTCGGTGTCGTGCATCTACGGTATCGGCTCGGTCGAAACCTATTCGCGCAT
GGTGGTGCGGCTGGAGGTCGGGGGGGAGATCGACCGCGACCGGCTGGTCAAGGCGCTGGTGGACCTGCAATACCGGCGCA
ACGACGCGGCCTTCCAGCGCGGAACCTTTCGCGTGCGCGGTGAAAGCGTGGACGTGTTCCCGGTGCAGAACGAGGACCGG
GCCTGGCGGATCTCGCTGTTCGGCGACGAAATCGACGCCATCACCGAATTCGATCCGCTGACGGGCGACAAGACCGGCGA
CCTGCAGGAGGTCAGCATCTACGCCAACAGCCATTATGTCACGCCGCGCCCCACGCTGAACCAGGCGGTGATCGGCATCA
AGCATGAACTGCGCCAGCGCCTGAACGACCTGACGGAAGAGGGCAAGCTGCTGGAGGCCGAGCGGTTGCAGCAGCGCACC
ACGTTCGACCTGGAGATGATCGAGACCACCGGGGTGTGCAAGGGAATCGAGAATTATTCCCGCTACCTGTCCGGCCGCCA
GCCCGGCGATCCGCCGCCGACCCTGTTCGAATATTTGCCCGAGGACGCGCTGCTGATCGTCGATGAAAGCCACGTCACCG
TGCCGCAGATCGGCGGCATGGAGCGGGGGGATTTCGCGCGCAAGTCCATCCTGTCGGAATTCGGCTTCCGCCTGCCGTCC
TGCCTGGACAACCGGCCGCTGAAATTCGCGGAATGGGACCTGTTCCGGCCGCAGACGATCTTCGTCAGCGCCACCCCCGG
CCCGTGGGAAATGGAACGCGTGGGCGGCGTCTTTGCCGAACAGGTCATCCGCCCCACCGGGCTGATCGACCCGGTGACCG
ATATCCGCCCGGTGGAACGGCAGGTCGATGATCTGCTGGCGGAATGCCGCCTGACCATCGCAGCAGGGGGGAGGGTGCTG
GTCACGACCCTGACCAAGCGCATGGCCGAGGACCTGACCGATTACATGAACGAGGCCGGGATTCGCGTCCGCTACCTGCA
TTCGGACGTCGATACGCTGGAACGGATCGAAATCATCCGCGACCTGCGCCTGGGCGCGTTCGACGTTCTGATCGGCATCA
ACCTGCTGCGCGAGGGGCTGGACATTCCCGAATGTTCGCTGGTCGCGATCCTGGACGCGGACAAGGAGGGCTTCCTGCGC
TCGCGCACCTCGCTGGTCCAGACGATCGGGCGCGCGGCGCGCAACGTGGACGGGCGCGTCGTGCTCTATGCCGACAAGAT
GACCGACAGCCTGCGCTACGCCATCGAGGAAACGGCGCGGCGGCGGGAAAAGCAGTCGGCCTGGAACGCGGCGCACGGGA
TCACGCCGCAATCGGTCCGCAAGCAGATCGGCGAGGCCCTGTCTTCGGTGTTCGAGCAGGATTACGTCACCGTCGCGCCC
ACGAAGGATGGGGATGTCGCGGAATTCGTCGGCAAGGATTTGGGCAGCGCGATCGCCGAGTTGGAAAAGCGGATGCGCGC
GGCGGCGGCGGACCTGGAATTCGAAACCGCGGCGCGGCTGCGCGACGAGATCAAGCGGCTGGAGGCGCTGGAACTGGGAC
TGGACCCGGTACCGGTGCCCGTCTCGACGGCAGGCACCGGGCGGCCGCCCCGGCGCAAGGCGGGCAAGGGACCCGAGCCG
TTGGGGCCGGGCGGCGGCGGATATGATCCGTCCAAGGGGCGTGGACCGCGCCGCCGAGGTGGGGGACGATAG

Upstream 100 bases:

>100_bases
GGCCGCGCGGGCGAGATGCCAAGGCCGAATTGCGGCGGGGGGCGGGTGTGCGTGCGATGGGCCTTGCGTCCGGGTCGCGC
GATCCCCACAGTCCGCAACT

Downstream 100 bases:

>100_bases
AAAGACGTCGTCACGGCAACGCAACCGGCGACGCGGGAGAACGAACGGAATGATCGAACTGACTGCCGGAACGGGCCGGC
TGGGATTGCTGCCCGAACTG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MPAPASKKTRRPDPSDEIVTFQPERQPPKEKTRRLTIQSPYEPAGDQPRAIGELVAGVEGGERDQVLLGVTGSGKTFTMA
KIIEATQKPTLILAPNKTLAAQLYGEMKQFFPDNAVEYFVSYYDYYQPEAYVPRSDTYIEKDSQINEQIDRMRHAATQAL
LERNDVIIVASVSCIYGIGSVETYSRMVVRLEVGGEIDRDRLVKALVDLQYRRNDAAFQRGTFRVRGESVDVFPVQNEDR
AWRISLFGDEIDAITEFDPLTGDKTGDLQEVSIYANSHYVTPRPTLNQAVIGIKHELRQRLNDLTEEGKLLEAERLQQRT
TFDLEMIETTGVCKGIENYSRYLSGRQPGDPPPTLFEYLPEDALLIVDESHVTVPQIGGMERGDFARKSILSEFGFRLPS
CLDNRPLKFAEWDLFRPQTIFVSATPGPWEMERVGGVFAEQVIRPTGLIDPVTDIRPVERQVDDLLAECRLTIAAGGRVL
VTTLTKRMAEDLTDYMNEAGIRVRYLHSDVDTLERIEIIRDLRLGAFDVLIGINLLREGLDIPECSLVAILDADKEGFLR
SRTSLVQTIGRAARNVDGRVVLYADKMTDSLRYAIEETARRREKQSAWNAAHGITPQSVRKQIGEALSSVFEQDYVTVAP
TKDGDVAEFVGKDLGSAIAELEKRMRAAAADLEFETAARLRDEIKRLEALELGLDPVPVPVSTAGTGRPPRRKAGKGPEP
LGPGGGGYDPSKGRGPRRRGGGR

Sequences:

>Translated_743_residues
MPAPASKKTRRPDPSDEIVTFQPERQPPKEKTRRLTIQSPYEPAGDQPRAIGELVAGVEGGERDQVLLGVTGSGKTFTMA
KIIEATQKPTLILAPNKTLAAQLYGEMKQFFPDNAVEYFVSYYDYYQPEAYVPRSDTYIEKDSQINEQIDRMRHAATQAL
LERNDVIIVASVSCIYGIGSVETYSRMVVRLEVGGEIDRDRLVKALVDLQYRRNDAAFQRGTFRVRGESVDVFPVQNEDR
AWRISLFGDEIDAITEFDPLTGDKTGDLQEVSIYANSHYVTPRPTLNQAVIGIKHELRQRLNDLTEEGKLLEAERLQQRT
TFDLEMIETTGVCKGIENYSRYLSGRQPGDPPPTLFEYLPEDALLIVDESHVTVPQIGGMERGDFARKSILSEFGFRLPS
CLDNRPLKFAEWDLFRPQTIFVSATPGPWEMERVGGVFAEQVIRPTGLIDPVTDIRPVERQVDDLLAECRLTIAAGGRVL
VTTLTKRMAEDLTDYMNEAGIRVRYLHSDVDTLERIEIIRDLRLGAFDVLIGINLLREGLDIPECSLVAILDADKEGFLR
SRTSLVQTIGRAARNVDGRVVLYADKMTDSLRYAIEETARRREKQSAWNAAHGITPQSVRKQIGEALSSVFEQDYVTVAP
TKDGDVAEFVGKDLGSAIAELEKRMRAAAADLEFETAARLRDEIKRLEALELGLDPVPVPVSTAGTGRPPRRKAGKGPEP
LGPGGGGYDPSKGRGPRRRGGGR
>Mature_742_residues
PAPASKKTRRPDPSDEIVTFQPERQPPKEKTRRLTIQSPYEPAGDQPRAIGELVAGVEGGERDQVLLGVTGSGKTFTMAK
IIEATQKPTLILAPNKTLAAQLYGEMKQFFPDNAVEYFVSYYDYYQPEAYVPRSDTYIEKDSQINEQIDRMRHAATQALL
ERNDVIIVASVSCIYGIGSVETYSRMVVRLEVGGEIDRDRLVKALVDLQYRRNDAAFQRGTFRVRGESVDVFPVQNEDRA
WRISLFGDEIDAITEFDPLTGDKTGDLQEVSIYANSHYVTPRPTLNQAVIGIKHELRQRLNDLTEEGKLLEAERLQQRTT
FDLEMIETTGVCKGIENYSRYLSGRQPGDPPPTLFEYLPEDALLIVDESHVTVPQIGGMERGDFARKSILSEFGFRLPSC
LDNRPLKFAEWDLFRPQTIFVSATPGPWEMERVGGVFAEQVIRPTGLIDPVTDIRPVERQVDDLLAECRLTIAAGGRVLV
TTLTKRMAEDLTDYMNEAGIRVRYLHSDVDTLERIEIIRDLRLGAFDVLIGINLLREGLDIPECSLVAILDADKEGFLRS
RTSLVQTIGRAARNVDGRVVLYADKMTDSLRYAIEETARRREKQSAWNAAHGITPQSVRKQIGEALSSVFEQDYVTVAPT
KDGDVAEFVGKDLGSAIAELEKRMRAAAADLEFETAARLRDEIKRLEALELGLDPVPVPVSTAGTGRPPRRKAGKGPEPL
GPGGGGYDPSKGRGPRRRGGGR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=672, Percent_Identity=59.672619047619, Blast_Score=787, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 82826; Mature: 82695

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPASKKTRRPDPSDEIVTFQPERQPPKEKTRRLTIQSPYEPAGDQPRAIGELVAGVEG
CCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHEEEEECCCCCCCCCHHHHHHHHHCCCC
GERDQVLLGVTGSGKTFTMAKIIEATQKPTLILAPNKTLAAQLYGEMKQFFPDNAVEYFV
CCCCEEEEEECCCCCEEHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
SYYDYYQPEAYVPRSDTYIEKDSQINEQIDRMRHAATQALLERNDVIIVASVSCIYGIGS
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCC
VETYSRMVVRLEVGGEIDRDRLVKALVDLQYRRNDAAFQRGTFRVRGESVDVFPVQNEDR
HHHHEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEECCEEEEEECCCCCC
AWRISLFGDEIDAITEFDPLTGDKTGDLQEVSIYANSHYVTPRPTLNQAVIGIKHELRQR
EEEEEEECCCHHHHHCCCCCCCCCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHH
LNDLTEEGKLLEAERLQQRTTFDLEMIETTGVCKGIENYSRYLSGRQPGDPPPTLFEYLP
HHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC
EDALLIVDESHVTVPQIGGMERGDFARKSILSEFGFRLPSCLDNRPLKFAEWDLFRPQTI
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCEEECCCCCCCCEE
FVSATPGPWEMERVGGVFAEQVIRPTGLIDPVTDIRPVERQVDDLLAECRLTIAAGGRVL
EEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHEEEEECCCEEH
VTTLTKRMAEDLTDYMNEAGIRVRYLHSDVDTLERIEIIRDLRLGAFDVLIGINLLREGL
HHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DIPECSLVAILDADKEGFLRSRTSLVQTIGRAARNVDGRVVLYADKMTDSLRYAIEETAR
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
RREKQSAWNAAHGITPQSVRKQIGEALSSVFEQDYVTVAPTKDGDVAEFVGKDLGSAIAE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHH
LEKRMRAAAADLEFETAARLRDEIKRLEALELGLDPVPVPVSTAGTGRPPRRKAGKGPEP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCC
LGPGGGGYDPSKGRGPRRRGGGR
CCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PAPASKKTRRPDPSDEIVTFQPERQPPKEKTRRLTIQSPYEPAGDQPRAIGELVAGVEG
CCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHEEEEECCCCCCCCCHHHHHHHHHCCCC
GERDQVLLGVTGSGKTFTMAKIIEATQKPTLILAPNKTLAAQLYGEMKQFFPDNAVEYFV
CCCCEEEEEECCCCCEEHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHH
SYYDYYQPEAYVPRSDTYIEKDSQINEQIDRMRHAATQALLERNDVIIVASVSCIYGIGS
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCC
VETYSRMVVRLEVGGEIDRDRLVKALVDLQYRRNDAAFQRGTFRVRGESVDVFPVQNEDR
HHHHEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEECCEEEEEECCCCCC
AWRISLFGDEIDAITEFDPLTGDKTGDLQEVSIYANSHYVTPRPTLNQAVIGIKHELRQR
EEEEEEECCCHHHHHCCCCCCCCCCCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHH
LNDLTEEGKLLEAERLQQRTTFDLEMIETTGVCKGIENYSRYLSGRQPGDPPPTLFEYLP
HHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCC
EDALLIVDESHVTVPQIGGMERGDFARKSILSEFGFRLPSCLDNRPLKFAEWDLFRPQTI
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCEEECCCCCCCCEE
FVSATPGPWEMERVGGVFAEQVIRPTGLIDPVTDIRPVERQVDDLLAECRLTIAAGGRVL
EEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHEEEEECCCEEH
VTTLTKRMAEDLTDYMNEAGIRVRYLHSDVDTLERIEIIRDLRLGAFDVLIGINLLREGL
HHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DIPECSLVAILDADKEGFLRSRTSLVQTIGRAARNVDGRVVLYADKMTDSLRYAIEETAR
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHH
RREKQSAWNAAHGITPQSVRKQIGEALSSVFEQDYVTVAPTKDGDVAEFVGKDLGSAIAE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHH
LEKRMRAAAADLEFETAARLRDEIKRLEALELGLDPVPVPVSTAGTGRPPRRKAGKGPEP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCC
LGPGGGGYDPSKGRGPRRRGGGR
CCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]