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The map label for this gene is thrC [H]

Identifier: 162147872

GI number: 162147872

Start: 2137693

End: 2139090

Strand: Direct

Name: thrC [H]

Synonym: GDI_2088

Alternate gene names: 162147872

Gene position: 2137693-2139090 (Clockwise)

Preceding gene: 162147871

Following gene: 162147873

Centisome position: 54.2

GC content: 68.38

Gene sequence:

>1398_bases
ATGCGCTATCTTTCCACCCGGGGACAGGCCCCCGTCCGTGACTTTTCCTCGGTCCTGCTGGCCGGCCTGGCCGAGGACGG
CGGGCTGTACCTGCCGGAAACCTGGCCCGTCCTGACCGCCGACGACTGGCGGGCACTGCGCGGCCTGCCCTATCCCGACC
TGGCCGCGCGGATCATCGCGCCCTTTACCGCGGGCTGCATCGCGCCGGATGTGCTGCAGCGGCTCTGCCGCGAATCATAT
GCCGGGTTCGACCACGCCGCCATCGTTCCGCTGACGCAGGTCGAGGACGGGCTGTTCGTCCAGGAACTGTTCCACGGGCC
GACGTTGGCCTTCAAGGACATGGCGATGCAGTTGCTGGGGCGGCTGTTCGACCATGTGCTGGCCGAGCGCGACGCGCATG
TGACCATCGTGGGCGCCACGTCGGGCGATACCGGATCGGCGGCGATCGAGGCCTGCCGCGGGCGCGAACGGGTGAAGATC
GTCATCCTGCACCCCGAGGGCCGGACATCGGACGTGCAGCGGCGGCAGATGACCACGGTGCTGGAACCGAACGTGACCAA
CCTGGCGGTGCAGGGCACGTTCGACGATTGCCAGGACCTGGTGAAGGCGATGTTCGCCGACGCCCCCTTCCGGCAGGACA
TGCACCTGTCGGCGGTCAATTCCATCAACTGGGCCCGCATCGCGGCGCAGATCCCCTATTACGTCTATGCCGCCCTGGCG
CTGGGCGCGCCGGACCGCGAGGTCTCGTTCGCCGTGCCGACCGGCAATTTCGGCAACATCCTGGCGGCGTGGGCGGCACG
GCGCATGGGCCTGCCCGTGCGCGCGCTGTGCGTGGGGTCCAACCGCAACGACATCCTGACCCGTTTCCTGCGCGACAACG
ACATGAGCGTGCAGGGCGTGGTGCCCAGCCTGTCGCCGTCGATGGACATCCAGGTCTCCTCGAATTTCGAGCGGCTGCTG
TTCGAACTGCTGAACCGCGATGCGGCGGCATGCGCGCGCATCGTCACCGAATTCCGCCAGACCGGCCACATGGCGGTGCC
CGACCCGGTGTGGCGGCAGGCATCGGGCCTGTTTCACGCCCTGGCCCTTGACGATCAGGACACGAAGACCGAAATCCGTA
ACCTGCATGCCGCCAGCCAGTATCTGGCCGACCCGCACAGCGCCATCGGGATCGCCGCCGGGCGGATGTTCCGCGAACCT
GGCATTCCGATGGTGGCGATGGCCACCGCCCATCCGGCCAAGTTCCCCGACGCCATGGAACAGGCGACCGGCATCCGCCC
GGCCCTGCCGCCGGCGCTTGCGGATCTATTCGACCGGCCGGAACGTTACGAAGTCGTGGCCGCGCGGCTGGACGTGGTCG
AGGACCGGGTTCGGGCGGCGGTGCTGAAGAACGCCTGA

Upstream 100 bases:

>100_bases
TGACGCTCTACCGCATCGATGTCCGTGCCCTGCCGCCGGCGAAATACTGACCACCGTAAGCCCCTTCGCGCGGGGCGCGC
TTGGCGATATAATCGTGGGT

Downstream 100 bases:

>100_bases
ACCGCCCTTTTCCCATCTCTTCGGACGTCCGGCCCCGCCGGCCGGACCGTCACGCAGGACCCTGATGACCGACCAGATCA
ACGTCACCCGCCTTCCCTCC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MRYLSTRGQAPVRDFSSVLLAGLAEDGGLYLPETWPVLTADDWRALRGLPYPDLAARIIAPFTAGCIAPDVLQRLCRESY
AGFDHAAIVPLTQVEDGLFVQELFHGPTLAFKDMAMQLLGRLFDHVLAERDAHVTIVGATSGDTGSAAIEACRGRERVKI
VILHPEGRTSDVQRRQMTTVLEPNVTNLAVQGTFDDCQDLVKAMFADAPFRQDMHLSAVNSINWARIAAQIPYYVYAALA
LGAPDREVSFAVPTGNFGNILAAWAARRMGLPVRALCVGSNRNDILTRFLRDNDMSVQGVVPSLSPSMDIQVSSNFERLL
FELLNRDAAACARIVTEFRQTGHMAVPDPVWRQASGLFHALALDDQDTKTEIRNLHAASQYLADPHSAIGIAAGRMFREP
GIPMVAMATAHPAKFPDAMEQATGIRPALPPALADLFDRPERYEVVAARLDVVEDRVRAAVLKNA

Sequences:

>Translated_465_residues
MRYLSTRGQAPVRDFSSVLLAGLAEDGGLYLPETWPVLTADDWRALRGLPYPDLAARIIAPFTAGCIAPDVLQRLCRESY
AGFDHAAIVPLTQVEDGLFVQELFHGPTLAFKDMAMQLLGRLFDHVLAERDAHVTIVGATSGDTGSAAIEACRGRERVKI
VILHPEGRTSDVQRRQMTTVLEPNVTNLAVQGTFDDCQDLVKAMFADAPFRQDMHLSAVNSINWARIAAQIPYYVYAALA
LGAPDREVSFAVPTGNFGNILAAWAARRMGLPVRALCVGSNRNDILTRFLRDNDMSVQGVVPSLSPSMDIQVSSNFERLL
FELLNRDAAACARIVTEFRQTGHMAVPDPVWRQASGLFHALALDDQDTKTEIRNLHAASQYLADPHSAIGIAAGRMFREP
GIPMVAMATAHPAKFPDAMEQATGIRPALPPALADLFDRPERYEVVAARLDVVEDRVRAAVLKNA
>Mature_465_residues
MRYLSTRGQAPVRDFSSVLLAGLAEDGGLYLPETWPVLTADDWRALRGLPYPDLAARIIAPFTAGCIAPDVLQRLCRESY
AGFDHAAIVPLTQVEDGLFVQELFHGPTLAFKDMAMQLLGRLFDHVLAERDAHVTIVGATSGDTGSAAIEACRGRERVKI
VILHPEGRTSDVQRRQMTTVLEPNVTNLAVQGTFDDCQDLVKAMFADAPFRQDMHLSAVNSINWARIAAQIPYYVYAALA
LGAPDREVSFAVPTGNFGNILAAWAARRMGLPVRALCVGSNRNDILTRFLRDNDMSVQGVVPSLSPSMDIQVSSNFERLL
FELLNRDAAACARIVTEFRQTGHMAVPDPVWRQASGLFHALALDDQDTKTEIRNLHAASQYLADPHSAIGIAAGRMFREP
GIPMVAMATAHPAKFPDAMEQATGIRPALPPALADLFDRPERYEVVAARLDVVEDRVRAAVLKNA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=452, Percent_Identity=34.9557522123894, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI153792148, Length=516, Percent_Identity=30.6201550387597, Blast_Score=233, Evalue=3e-61,
Organism=Escherichia coli, GI1786185, Length=441, Percent_Identity=32.6530612244898, Blast_Score=214, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6319901, Length=458, Percent_Identity=40.8296943231441, Blast_Score=332, Evalue=5e-92,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50863; Mature: 50863

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLSTRGQAPVRDFSSVLLAGLAEDGGLYLPETWPVLTADDWRALRGLPYPDLAARIIA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCEEECCCHHHHCCCCCHHHHHHHHH
PFTAGCIAPDVLQRLCRESYAGFDHAAIVPLTQVEDGLFVQELFHGPTLAFKDMAMQLLG
HHHHHCCCHHHHHHHHHHHHCCCCCEEEEEHHHCCCCHHHHHHHCCCCHHHHHHHHHHHH
RLFDHVLAERDAHVTIVGATSGDTGSAAIEACRGRERVKIVILHPEGRTSDVQRRQMTTV
HHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHH
LEPNVTNLAVQGTFDDCQDLVKAMFADAPFRQDMHLSAVNSINWARIAAQIPYYVYAALA
CCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHCHHHHHHHHH
LGAPDREVSFAVPTGNFGNILAAWAARRMGLPVRALCVGSNRNDILTRFLRDNDMSVQGV
CCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEE
VPSLSPSMDIQVSSNFERLLFELLNRDAAACARIVTEFRQTGHMAVPDPVWRQASGLFHA
CCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEE
LALDDQDTKTEIRNLHAASQYLADPHSAIGIAAGRMFREPGIPMVAMATAHPAKFPDAME
EECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHH
QATGIRPALPPALADLFDRPERYEVVAARLDVVEDRVRAAVLKNA
HHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRYLSTRGQAPVRDFSSVLLAGLAEDGGLYLPETWPVLTADDWRALRGLPYPDLAARIIA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCEEECCCHHHHCCCCCHHHHHHHHH
PFTAGCIAPDVLQRLCRESYAGFDHAAIVPLTQVEDGLFVQELFHGPTLAFKDMAMQLLG
HHHHHCCCHHHHHHHHHHHHCCCCCEEEEEHHHCCCCHHHHHHHCCCCHHHHHHHHHHHH
RLFDHVLAERDAHVTIVGATSGDTGSAAIEACRGRERVKIVILHPEGRTSDVQRRQMTTV
HHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHH
LEPNVTNLAVQGTFDDCQDLVKAMFADAPFRQDMHLSAVNSINWARIAAQIPYYVYAALA
CCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHCHHHHHHHHH
LGAPDREVSFAVPTGNFGNILAAWAARRMGLPVRALCVGSNRNDILTRFLRDNDMSVQGV
CCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEE
VPSLSPSMDIQVSSNFERLLFELLNRDAAACARIVTEFRQTGHMAVPDPVWRQASGLFHA
CCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEE
LALDDQDTKTEIRNLHAASQYLADPHSAIGIAAGRMFREPGIPMVAMATAHPAKFPDAME
EECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHH
QATGIRPALPPALADLFDRPERYEVVAARLDVVEDRVRAAVLKNA
HHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]