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The map label for this gene is metC [H]

Identifier: 162147753

GI number: 162147753

Start: 2002404

End: 2003654

Strand: Direct

Name: metC [H]

Synonym: GDI_1969

Alternate gene names: 162147753

Gene position: 2002404-2003654 (Clockwise)

Preceding gene: 162147752

Following gene: 162147757

Centisome position: 50.77

GC content: 68.82

Gene sequence:

>1251_bases
ATGACCGACCGTCAGGCCCTGCATCATGCCGTCTCCCGCGGCTGGCGCCATATGGGCACCACGCTGGTCCATCTGGCGCG
CGACCTGCCGCCGGCGGCGGAGGGCACGCTGGTCAACCCGGCCTCCACGCGCGGATCGACGGTGCTGTTCCCCACCGTCG
CGGACATGAACCGCAACGGCACGCGGCGCTATGATCACGAACTGATCTATGGTGCCATGGGCACGCCCATCCAGCACCAG
CTGGAATCCGCGATCGCGGCGCTGGAGGGTGCGCGCCATACGCAGGTGGTCTCGTCCGGCCTGGCCGCGTGCTCCACGCC
GCTGCTGGCCTTCCTGGGCAAGAATGGCCATTGCCTGATCCCGGATTCGGTCTATGGCCCGACCCGCCGCTTCGCCAATA
CCGTCCTGCGCCGCTTCGGGGTCGAGACGACCTATTACCCCCCCATGATCGACGCGGACGGGCTGCGCGCCGCCATGCGG
CCGAACACGCAGGTCGTCTTCGCCGAAAGCCCGGGCAGCCATACGTTCGAGGTCCAGGACATCCGCATGATCGCGGACAT
CGCGCACGAGCACGGCGCGCGGATGATGCTGGACAATACCTGGGGCATCGGCGTGTTCCAGCCGTTCGACCATGGGGTCG
ATATCTCGATCCAGGCGCTGACCAAATATCCGGCCGGCCATTCGGACAGCATCATCGGCGCGGTATCCGTCGCCGACGAA
CAGGACTGGCAGGCCCTGCGCGATACCAGCATCCAACTGGGGCAGGTGGCGGGCCCCGACGATTGCTGGCTGACCCTGCG
CGGGCTGCGGACCATGGGGGCGCGGCTGGAGCGGCAATCCCGCGCCGCGATCGACATCGCCCTGTGGCTGTCCGACCGGC
CCGAGGTGGCGCGCGTGCTGCATCCCGCCCTGCCGTCCTGTCCGGGACACGAGATATGGCGGCGCGATTATACCGGGGCG
TCGGCGCTGTTCGGCGTGGTCTTCCAGCCGGAATACGACGCGGCCGCGATGACGGCGATGATCGATTCCCTGGCCCTGTT
CGGAATCGGTGCCTCCTGGGGCGGATATGAAAGCCTGGTCCTGCCGACCACGGGCGGCATTACCCGGTCCTGCCCGCCCG
GCGAGGAATGCGGCCCGCAGACCGGCCCGGCCTGCCGCCTGCATATCGGACTGGAAAACCCCGAGGACCTGATCGCGGAC
CTGTCGGCCGGGCTGGAGGTGCTGGCCGGCGGGGCCGTGTACGGGGCATAG

Upstream 100 bases:

>100_bases
CCATCTGCGGGCGAACCGGCGACTCGCTTTATGACGGATCGTGGGCCGAATGGGGGTCCACCCCGGGCGCGCCGGTGGAA
ACGGGCGAGGGCACATCCCC

Downstream 100 bases:

>100_bases
GGCGAAACCGGTATCGAGGCCGCTTTTGCGCGACTGGCTGTGATGACGTTGAAGCCCAAGGACACGTTCTCTCAATATAA
AACTAAAATAAAGTATCCGA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTDRQALHHAVSRGWRHMGTTLVHLARDLPPAAEGTLVNPASTRGSTVLFPTVADMNRNGTRRYDHELIYGAMGTPIQHQ
LESAIAALEGARHTQVVSSGLAACSTPLLAFLGKNGHCLIPDSVYGPTRRFANTVLRRFGVETTYYPPMIDADGLRAAMR
PNTQVVFAESPGSHTFEVQDIRMIADIAHEHGARMMLDNTWGIGVFQPFDHGVDISIQALTKYPAGHSDSIIGAVSVADE
QDWQALRDTSIQLGQVAGPDDCWLTLRGLRTMGARLERQSRAAIDIALWLSDRPEVARVLHPALPSCPGHEIWRRDYTGA
SALFGVVFQPEYDAAAMTAMIDSLALFGIGASWGGYESLVLPTTGGITRSCPPGEECGPQTGPACRLHIGLENPEDLIAD
LSAGLEVLAGGAVYGA

Sequences:

>Translated_416_residues
MTDRQALHHAVSRGWRHMGTTLVHLARDLPPAAEGTLVNPASTRGSTVLFPTVADMNRNGTRRYDHELIYGAMGTPIQHQ
LESAIAALEGARHTQVVSSGLAACSTPLLAFLGKNGHCLIPDSVYGPTRRFANTVLRRFGVETTYYPPMIDADGLRAAMR
PNTQVVFAESPGSHTFEVQDIRMIADIAHEHGARMMLDNTWGIGVFQPFDHGVDISIQALTKYPAGHSDSIIGAVSVADE
QDWQALRDTSIQLGQVAGPDDCWLTLRGLRTMGARLERQSRAAIDIALWLSDRPEVARVLHPALPSCPGHEIWRRDYTGA
SALFGVVFQPEYDAAAMTAMIDSLALFGIGASWGGYESLVLPTTGGITRSCPPGEECGPQTGPACRLHIGLENPEDLIAD
LSAGLEVLAGGAVYGA
>Mature_415_residues
TDRQALHHAVSRGWRHMGTTLVHLARDLPPAAEGTLVNPASTRGSTVLFPTVADMNRNGTRRYDHELIYGAMGTPIQHQL
ESAIAALEGARHTQVVSSGLAACSTPLLAFLGKNGHCLIPDSVYGPTRRFANTVLRRFGVETTYYPPMIDADGLRAAMRP
NTQVVFAESPGSHTFEVQDIRMIADIAHEHGARMMLDNTWGIGVFQPFDHGVDISIQALTKYPAGHSDSIIGAVSVADEQ
DWQALRDTSIQLGQVAGPDDCWLTLRGLRTMGARLERQSRAAIDIALWLSDRPEVARVLHPALPSCPGHEIWRRDYTGAS
ALFGVVFQPEYDAAAMTAMIDSLALFGIGASWGGYESLVLPTTGGITRSCPPGEECGPQTGPACRLHIGLENPEDLIADL
SAGLEVLAGGAVYGA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=364, Percent_Identity=32.6923076923077, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI299473759, Length=364, Percent_Identity=29.6703296703297, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI25453487, Length=362, Percent_Identity=28.1767955801105, Blast_Score=135, Evalue=9e-32,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=38.9873417721519, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1790375, Length=347, Percent_Identity=31.1239193083574, Blast_Score=151, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI71980708, Length=373, Percent_Identity=32.4396782841823, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17538055, Length=366, Percent_Identity=31.9672131147541, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17560056, Length=349, Percent_Identity=32.378223495702, Blast_Score=167, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6321170, Length=328, Percent_Identity=42.9878048780488, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6319307, Length=347, Percent_Identity=29.971181556196, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323333, Length=414, Percent_Identity=25.3623188405797, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321904, Length=354, Percent_Identity=28.8135593220339, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321254, Length=379, Percent_Identity=24.5382585751979, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922554, Length=346, Percent_Identity=34.393063583815, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44720; Mature: 44589

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRQALHHAVSRGWRHMGTTLVHLARDLPPAAEGTLVNPASTRGSTVLFPTVADMNRNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEEEEHHCCCCCC
TRRYDHELIYGAMGTPIQHQLESAIAALEGARHTQVVSSGLAACSTPLLAFLGKNGHCLI
CCCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEC
PDSVYGPTRRFANTVLRRFGVETTYYPPMIDADGLRAAMRPNTQVVFAESPGSHTFEVQD
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCEEEHHH
IRMIADIAHEHGARMMLDNTWGIGVFQPFDHGVDISIQALTKYPAGHSDSIIGAVSVADE
HHHHHHHHHHCCCEEEEECCCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCC
QDWQALRDTSIQLGQVAGPDDCWLTLRGLRTMGARLERQSRAAIDIALWLSDRPEVARVL
HHHHHHHHCCEEECCCCCCCHHEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHH
HPALPSCPGHEIWRRDYTGASALFGVVFQPEYDAAAMTAMIDSLALFGIGASWGGYESLV
HHCCCCCCCHHHHHHCCCCHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEE
LPTTGGITRSCPPGEECGPQTGPACRLHIGLENPEDLIADLSAGLEVLAGGAVYGA
EECCCCCCCCCCCCHHCCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHCCCCCCCC
>Mature Secondary Structure 
TDRQALHHAVSRGWRHMGTTLVHLARDLPPAAEGTLVNPASTRGSTVLFPTVADMNRNG
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEEEEHHCCCCCC
TRRYDHELIYGAMGTPIQHQLESAIAALEGARHTQVVSSGLAACSTPLLAFLGKNGHCLI
CCCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEC
PDSVYGPTRRFANTVLRRFGVETTYYPPMIDADGLRAAMRPNTQVVFAESPGSHTFEVQD
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCEEEHHH
IRMIADIAHEHGARMMLDNTWGIGVFQPFDHGVDISIQALTKYPAGHSDSIIGAVSVADE
HHHHHHHHHHCCCEEEEECCCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCC
QDWQALRDTSIQLGQVAGPDDCWLTLRGLRTMGARLERQSRAAIDIALWLSDRPEVARVL
HHHHHHHHCCEEECCCCCCCHHEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHH
HPALPSCPGHEIWRRDYTGASALFGVVFQPEYDAAAMTAMIDSLALFGIGASWGGYESLV
HHCCCCCCCHHHHHHCCCCHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEE
LPTTGGITRSCPPGEECGPQTGPACRLHIGLENPEDLIADLSAGLEVLAGGAVYGA
EECCCCCCCCCCCCHHCCCCCCCEEEEEECCCCHHHHHHHHHHCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]