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The map label for this gene is phdA [H]

Identifier: 162147723

GI number: 162147723

Start: 1973460

End: 1974551

Strand: Direct

Name: phdA [H]

Synonym: GDI_1939

Alternate gene names: 162147723

Gene position: 1973460-1974551 (Clockwise)

Preceding gene: 162147722

Following gene: 162147724

Centisome position: 50.03

GC content: 63.19

Gene sequence:

>1092_bases
ATGACAAGGGCGATCAGACGTCCCGGGTGGGATCTGGCTTGCGATCAAAGATGTTATAACAAGAACAAGGGAGCGTTCAT
CATGGGCGAAACTCGGAAATCCGCGACAGAGGCCGGACGCAACAGTCCGTCGATGAGCAAGGAAGACCTGACGCGCGCCT
TTCATGACATGGTGCTGATCCGCCGGTTCGAGGAACGGGCCGGCCAGCTTTATGGCATGGGGCTGATCGGCGGCTTCTGC
CATCTGTATATCGGCCAGGAAGCCGTGGTCGTCGGCGTGCAGATGGAGCTGAAGCAGGGGGACAAGATCATCACCTCCTA
CCGCGACCATGGGCAGATGCTGGCCGCCGGCATGGACCCGCGCGGCGTGATGGCCGAACTGACCGGGCGCGAGGGCGGCT
ATTCCCGCGGCAAGGGCGGGTCGATGCACATGTTCTCGTCCGAGAAGCATTTCTATGGCGGGCACGGCATCGTCGGCGCC
CAGGTGTCGCTGGGTATCGGTCTGGCCTTCGCCAACAAGTATCGCGGCACGGACGAGGTCTCGATCGCCTATTTCGGCGA
GGGCGCGTCCAGCCAGGGTCAGGTCTATGAAAGCTTCAACCTGGCGGCCCTTCACAAGCTGCCCTGCGTATTCGTGCTGG
AAAACAACCATTACGGCATGGGCACCAGCGTCGAGCGGTCGTCGGCGTCCAAGGAATTGTGGCGCAATGGCGAGCCCTGG
GGCATCCCGGGCCGTCAGGTCGACGGCATGGATGTCGAGGCCGTGCGCGACGCGGCGCGCGAGGCGATCGAACATTGCCG
GCAGGGCAAGGGACCGTACCTGCTGGAGATGACGACCTATCGCTATCGCGGCCATTCGATGTCCGACCCGGCGAAGTACC
GCCCCCGCTCCGAAGTGGACGAGATGCGGAAGAATCATGACCCGATCGATCGGGTACGCAAGGAACTGCTGGCCATGGGC
GTCGGGGAAGCCGAACTGAAGACGATCGAGGACAAGGTGAAGGAAGTGGTCGTGGACGCCGCCGATTTCGCGCAGACCAG
CCCGGAGCCCGATCCGGCGGAACTGTGGACCGACGTGCTGGTGGAGGGCTGA

Upstream 100 bases:

>100_bases
CAAGACGGGCGGGCAATCCGGCTCGTACGAACGCCCCGAAGCGGGAGCGGCACCGACACCCATGGCATAACCATCCGAAC
GGCAGGCGCACGGCCTGGCC

Downstream 100 bases:

>100_bases
GCGATGACGCAGATCCTGATGCCGGCGCTTTCGCCCACCATGACCGAGGGCAAGCTGGCCCGCTGGCTGAAGACGACCGG
CGACCATGTCGCCGCCGGGG

Product: pyruvate dehydrogenase E1 component subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTRAIRRPGWDLACDQRCYNKNKGAFIMGETRKSATEAGRNSPSMSKEDLTRAFHDMVLIRRFEERAGQLYGMGLIGGFC
HLYIGQEAVVVGVQMELKQGDKIITSYRDHGQMLAAGMDPRGVMAELTGREGGYSRGKGGSMHMFSSEKHFYGGHGIVGA
QVSLGIGLAFANKYRGTDEVSIAYFGEGASSQGQVYESFNLAALHKLPCVFVLENNHYGMGTSVERSSASKELWRNGEPW
GIPGRQVDGMDVEAVRDAAREAIEHCRQGKGPYLLEMTTYRYRGHSMSDPAKYRPRSEVDEMRKNHDPIDRVRKELLAMG
VGEAELKTIEDKVKEVVVDAADFAQTSPEPDPAELWTDVLVEG

Sequences:

>Translated_363_residues
MTRAIRRPGWDLACDQRCYNKNKGAFIMGETRKSATEAGRNSPSMSKEDLTRAFHDMVLIRRFEERAGQLYGMGLIGGFC
HLYIGQEAVVVGVQMELKQGDKIITSYRDHGQMLAAGMDPRGVMAELTGREGGYSRGKGGSMHMFSSEKHFYGGHGIVGA
QVSLGIGLAFANKYRGTDEVSIAYFGEGASSQGQVYESFNLAALHKLPCVFVLENNHYGMGTSVERSSASKELWRNGEPW
GIPGRQVDGMDVEAVRDAAREAIEHCRQGKGPYLLEMTTYRYRGHSMSDPAKYRPRSEVDEMRKNHDPIDRVRKELLAMG
VGEAELKTIEDKVKEVVVDAADFAQTSPEPDPAELWTDVLVEG
>Mature_362_residues
TRAIRRPGWDLACDQRCYNKNKGAFIMGETRKSATEAGRNSPSMSKEDLTRAFHDMVLIRRFEERAGQLYGMGLIGGFCH
LYIGQEAVVVGVQMELKQGDKIITSYRDHGQMLAAGMDPRGVMAELTGREGGYSRGKGGSMHMFSSEKHFYGGHGIVGAQ
VSLGIGLAFANKYRGTDEVSIAYFGEGASSQGQVYESFNLAALHKLPCVFVLENNHYGMGTSVERSSASKELWRNGEPWG
IPGRQVDGMDVEAVRDAAREAIEHCRQGKGPYLLEMTTYRYRGHSMSDPAKYRPRSEVDEMRKNHDPIDRVRKELLAMGV
GEAELKTIEDKVKEVVVDAADFAQTSPEPDPAELWTDVLVEG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=313, Percent_Identity=51.1182108626198, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI291084742, Length=313, Percent_Identity=50.1597444089457, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI4505685, Length=313, Percent_Identity=50.1597444089457, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI291084744, Length=320, Percent_Identity=49.0625, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI291084757, Length=313, Percent_Identity=45.0479233226837, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI11386135, Length=322, Percent_Identity=30.1242236024845, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI258645172, Length=322, Percent_Identity=30.4347826086957, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=321, Percent_Identity=47.6635514018692, Blast_Score=293, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17536047, Length=321, Percent_Identity=47.6635514018692, Blast_Score=293, Evalue=9e-80,
Organism=Caenorhabditis elegans, GI86563357, Length=288, Percent_Identity=28.4722222222222, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI86563355, Length=288, Percent_Identity=28.4722222222222, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321026, Length=322, Percent_Identity=48.1366459627329, Blast_Score=293, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24639744, Length=317, Percent_Identity=47.6340694006309, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI28571106, Length=317, Percent_Identity=47.6340694006309, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24639740, Length=317, Percent_Identity=47.6340694006309, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24639748, Length=325, Percent_Identity=48.6153846153846, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=49.1803278688525, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI21355903, Length=325, Percent_Identity=28, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40214; Mature: 40083

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAIRRPGWDLACDQRCYNKNKGAFIMGETRKSATEAGRNSPSMSKEDLTRAFHDMVLI
CCCCCCCCCCCCCHHHHHHCCCCCEEEEECCHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
RRFEERAGQLYGMGLIGGFCHLYIGQEAVVVGVQMELKQGDKIITSYRDHGQMLAAGMDP
HHHHHHHCCEEEHHHHHHHHHHEECCCEEEEEEEEECCCCCHHHHHHHHCCCEEECCCCC
RGVMAELTGREGGYSRGKGGSMHMFSSEKHFYGGHGIVGAQVSLGIGLAFANKYRGTDEV
CCHHEEECCCCCCCCCCCCCCEEEECCCCCEECCCCEEECEEEHHEEEEEHHCCCCCCCE
SIAYFGEGASSQGQVYESFNLAALHKLPCVFVLENNHYGMGTSVERSSASKELWRNGEPW
EEEEECCCCCCCCCCHHCCCHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCC
GIPGRQVDGMDVEAVRDAAREAIEHCRQGKGPYLLEMTTYRYRGHSMSDPAKYRPRSEVD
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCHHCCCHHHHH
EMRKNHDPIDRVRKELLAMGVGEAELKTIEDKVKEVVVDAADFAQTSPEPDPAELWTDVL
HHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
VEG
CCC
>Mature Secondary Structure 
TRAIRRPGWDLACDQRCYNKNKGAFIMGETRKSATEAGRNSPSMSKEDLTRAFHDMVLI
CCCCCCCCCCCCHHHHHHCCCCCEEEEECCHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
RRFEERAGQLYGMGLIGGFCHLYIGQEAVVVGVQMELKQGDKIITSYRDHGQMLAAGMDP
HHHHHHHCCEEEHHHHHHHHHHEECCCEEEEEEEEECCCCCHHHHHHHHCCCEEECCCCC
RGVMAELTGREGGYSRGKGGSMHMFSSEKHFYGGHGIVGAQVSLGIGLAFANKYRGTDEV
CCHHEEECCCCCCCCCCCCCCEEEECCCCCEECCCCEEECEEEHHEEEEEHHCCCCCCCE
SIAYFGEGASSQGQVYESFNLAALHKLPCVFVLENNHYGMGTSVERSSASKELWRNGEPW
EEEEECCCCCCCCCCHHCCCHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCC
GIPGRQVDGMDVEAVRDAAREAIEHCRQGKGPYLLEMTTYRYRGHSMSDPAKYRPRSEVD
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCHHCCCHHHHH
EMRKNHDPIDRVRKELLAMGVGEAELKTIEDKVKEVVVDAADFAQTSPEPDPAELWTDVL
HHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
VEG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]