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The map label for this gene is hisS

Identifier: 162147698

GI number: 162147698

Start: 1948712

End: 1949959

Strand: Direct

Name: hisS

Synonym: GDI_1914

Alternate gene names: 162147698

Gene position: 1948712-1949959 (Clockwise)

Preceding gene: 162147697

Following gene: 162147699

Centisome position: 49.41

GC content: 70.67

Gene sequence:

>1248_bases
GTGAGCAGCTTGCAACCCGTCCGCGGCACCCATGACCTGATCGGCGAGACCCAGCTTCGTCACGCCCATGTGGTGGAGAC
CGCGCGCCGGATTGCCGGGCTTTACGGCTTCGACGAATGGGCCACCCCCATCTTCGAGGACACGCGCGTCTTCGCCCGCT
CGCTGGGCGATACGTCCGACGTCGTGTCGAAGGAGATGTATTCGTTCGAGGATCGCGGCGGTGAATCGCTGACCCTGCGG
CCCGAGGGCACGGCAGGCGTGTGCCGCGCGCTGGTGACCAACGGGCTGACCCAGTCCCTGCCGCAGAAAGTGTTCTATGC
CGGCCCGATGTTCCGCTACGAGCGGCCGCAGAAGGGACGCTACCGCCAGTTCCACCAGATCGGGGCGGAACTGATCGGCG
CGGCCGAGCCGCTGGCGGATGCCGAGGCGATCGCCATGGGCCGCGACGTGCTGAAGGCGCTGGGCATCGCGGACGAGACG
ATCCTGGACCTGAACACGCTGGGCGACACCGAAAGCCGCGCCGCGTGGCGCACGGCGCTGATCGGCTATTTCACGGAATG
CCGCGACCAGTTGTCCGACGACAGCCGCGCCCGGCTGGAGCGCAATCCGCTGCGTATCCTGGACAGCAAGGCGCCGCAGG
ATCGCGCGCTGGTGGCCGACGCGCCCCGGATCGGCGCATTCCTGACGCCCGAGGCCGTGGCCTTCTGGGATGGGCTGCGC
TCGGCGCTGGACCTGATGGGCGTGCCCTTCCGCGAAAATCCGGGCATCGTGCGCGGCCTGGATTATTACGGGCACACCGC
CTTCGAATTCGTCACCGAGCGCCTCGGCGCGCAGGGGACGGTCCTGGCCGGCGGCCGCTATGACGGGCTGGTCGCCGAAA
TGGGCGGCCCGCGCACCCCGGCCATCGGCTGGGCGGGCGGGATCGAGCGCCTGTCGATGCTGCTGGACGCGACGCCGGCG
GCCCCGCGCCCGGTCGCGGTGGTGCCGATGGGCGAGGGCGCCATGGGCGCCGCGATCCTGCTGCTGCAGGCCCTGCGCGC
GGGCGGCGTGCGGGCGGAAATCGCCTATCGCGGCAATACCAAGAAGCGGCTGGAACGGGCGAACCGGATCGGTGCCACGC
ATGCCGTGCTGATCGGCGAGGACGAGGTGGCGCGCGGCGTGGCCCAGGTCAAGGCGCTGGATGACGGGTCGCAGGCCGAA
CTGGCCCTGGACGCCGTCACGCCCTATCTGGCCGGGCTGGCCGGATAG

Upstream 100 bases:

>100_bases
CGCTGGCCCCCGCGCAATAAGGGTCCCTTCAACGCCCCCGCGGGCCGCCGAGCCGCGGCCGCCGGGGCACCTGTTCCCAT
CAACCAGGAATTTTGTCTTC

Downstream 100 bases:

>100_bases
ACCGATGGGGCTCGACGACAGGCTGGACCGGATCGTCGCCCGGTCCGAGGAATTGCAGGCCGCGCTGGCCGAAGGGCTGG
TCGGGGAGGCGTTCGCCAAG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSSLQPVRGTHDLIGETQLRHAHVVETARRIAGLYGFDEWATPIFEDTRVFARSLGDTSDVVSKEMYSFEDRGGESLTLR
PEGTAGVCRALVTNGLTQSLPQKVFYAGPMFRYERPQKGRYRQFHQIGAELIGAAEPLADAEAIAMGRDVLKALGIADET
ILDLNTLGDTESRAAWRTALIGYFTECRDQLSDDSRARLERNPLRILDSKAPQDRALVADAPRIGAFLTPEAVAFWDGLR
SALDLMGVPFRENPGIVRGLDYYGHTAFEFVTERLGAQGTVLAGGRYDGLVAEMGGPRTPAIGWAGGIERLSMLLDATPA
APRPVAVVPMGEGAMGAAILLLQALRAGGVRAEIAYRGNTKKRLERANRIGATHAVLIGEDEVARGVAQVKALDDGSQAE
LALDAVTPYLAGLAG

Sequences:

>Translated_415_residues
MSSLQPVRGTHDLIGETQLRHAHVVETARRIAGLYGFDEWATPIFEDTRVFARSLGDTSDVVSKEMYSFEDRGGESLTLR
PEGTAGVCRALVTNGLTQSLPQKVFYAGPMFRYERPQKGRYRQFHQIGAELIGAAEPLADAEAIAMGRDVLKALGIADET
ILDLNTLGDTESRAAWRTALIGYFTECRDQLSDDSRARLERNPLRILDSKAPQDRALVADAPRIGAFLTPEAVAFWDGLR
SALDLMGVPFRENPGIVRGLDYYGHTAFEFVTERLGAQGTVLAGGRYDGLVAEMGGPRTPAIGWAGGIERLSMLLDATPA
APRPVAVVPMGEGAMGAAILLLQALRAGGVRAEIAYRGNTKKRLERANRIGATHAVLIGEDEVARGVAQVKALDDGSQAE
LALDAVTPYLAGLAG
>Mature_414_residues
SSLQPVRGTHDLIGETQLRHAHVVETARRIAGLYGFDEWATPIFEDTRVFARSLGDTSDVVSKEMYSFEDRGGESLTLRP
EGTAGVCRALVTNGLTQSLPQKVFYAGPMFRYERPQKGRYRQFHQIGAELIGAAEPLADAEAIAMGRDVLKALGIADETI
LDLNTLGDTESRAAWRTALIGYFTECRDQLSDDSRARLERNPLRILDSKAPQDRALVADAPRIGAFLTPEAVAFWDGLRS
ALDLMGVPFRENPGIVRGLDYYGHTAFEFVTERLGAQGTVLAGGRYDGLVAEMGGPRTPAIGWAGGIERLSMLLDATPAA
PRPVAVVPMGEGAMGAAILLLQALRAGGVRAEIAYRGNTKKRLERANRIGATHAVLIGEDEVARGVAQVKALDDGSQAEL
ALDAVTPYLAGLAG

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Escherichia coli, GI1788861, Length=423, Percent_Identity=45.3900709219858, Blast_Score=348, Evalue=3e-97,
Organism=Drosophila melanogaster, GI24643061, Length=470, Percent_Identity=25.1063829787234, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24643059, Length=410, Percent_Identity=26.0975609756098, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_GLUDA (A9HJ49)

Other databases:

- EMBL:   AM889285
- EMBL:   CP001189
- RefSeq:   YP_001602159.1
- RefSeq:   YP_002274551.1
- ProteinModelPortal:   A9HJ49
- SMR:   A9HJ49
- GeneID:   5790168
- GeneID:   6973528
- GenomeReviews:   AM889285_GR
- GenomeReviews:   CP001189_GR
- KEGG:   gdj:Gdia_0136
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 44657; Mature: 44526

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLQPVRGTHDLIGETQLRHAHVVETARRIAGLYGFDEWATPIFEDTRVFARSLGDTSD
CCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCCHHH
VVSKEMYSFEDRGGESLTLRPEGTAGVCRALVTNGLTQSLPQKVFYAGPMFRYERPQKGR
HHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCH
YRQFHQIGAELIGAAEPLADAEAIAMGRDVLKALGIADETILDLNTLGDTESRAAWRTAL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHEEEHHCCCCCHHHHHHHHHH
IGYFTECRDQLSDDSRARLERNPLRILDSKAPQDRALVADAPRIGAFLTPEAVAFWDGLR
HHHHHHHHHHHCCCHHHHHHCCCHHHHCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
SALDLMGVPFRENPGIVRGLDYYGHTAFEFVTERLGAQGTVLAGGRYDGLVAEMGGPRTP
HHHHHHCCCCCCCCCCEECCHHHCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCC
AIGWAGGIERLSMLLDATPAAPRPVAVVPMGEGAMGAAILLLQALRAGGVRAEIAYRGNT
CCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCH
KKRLERANRIGATHAVLIGEDEVARGVAQVKALDDGSQAELALDAVTPYLAGLAG
HHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSLQPVRGTHDLIGETQLRHAHVVETARRIAGLYGFDEWATPIFEDTRVFARSLGDTSD
CCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHCCCHHH
VVSKEMYSFEDRGGESLTLRPEGTAGVCRALVTNGLTQSLPQKVFYAGPMFRYERPQKGR
HHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCH
YRQFHQIGAELIGAAEPLADAEAIAMGRDVLKALGIADETILDLNTLGDTESRAAWRTAL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHEEEHHCCCCCHHHHHHHHHH
IGYFTECRDQLSDDSRARLERNPLRILDSKAPQDRALVADAPRIGAFLTPEAVAFWDGLR
HHHHHHHHHHHCCCHHHHHHCCCHHHHCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
SALDLMGVPFRENPGIVRGLDYYGHTAFEFVTERLGAQGTVLAGGRYDGLVAEMGGPRTP
HHHHHHCCCCCCCCCCEECCHHHCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCC
AIGWAGGIERLSMLLDATPAAPRPVAVVPMGEGAMGAAILLLQALRAGGVRAEIAYRGNT
CCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCH
KKRLERANRIGATHAVLIGEDEVARGVAQVKALDDGSQAELALDAVTPYLAGLAG
HHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA