Click here to switch to the map view.

The map label for this gene is lysC [H]

Identifier: 162147693

GI number: 162147693

Start: 1943723

End: 1945048

Strand: Direct

Name: lysC [H]

Synonym: GDI_1909

Alternate gene names: 162147693

Gene position: 1943723-1945048 (Clockwise)

Preceding gene: 162147691

Following gene: 162147694

Centisome position: 49.28

GC content: 67.04

Gene sequence:

>1326_bases
ATGCCCCGTCCGGCGCCCCAGCGCGCCCGGCGGGCTGGAACGGCCGCCGCGCCGAACTGGAGAGCCCTGTCCATGCCTCG
TACCGTCCCGCGGATCGTCATGAAATTCGGTGGCACGTCTGTGGCCGACCTGGACCGAATTCGCGCGGTGGCGGAAAAAG
TGCACAAGCAGGTTGCCGCGGGATGCGAGGTCGCGGTCGTCGTCTCGGCCATGTCGGGGGTGACCAACCGCCTGGTGGGA
TACTGCCAGTCCCTGTCGCCGCTGCATGACGCGAAGGAATATGACGCCGTCGTCGCAACGGGCGAGCAGGTGACCAGCGG
CCTGCTGGCCATCGCGCTGCAGACTCTGGGGCTGGAGGCGCGGTCGTGGCTGGGGTGGCAGATTCCGCTGCGTACCGACG
GCGCGCACGGCAAGGCGCGGATCGACTCGATCGACGGCGAGGCCCTGATCACGCGGATGCGGGCCGGACAGGTTCCGGTC
ATCGCCGGCTTCCAGGGCGTGGACCCCGACGGGCGGATCACGACCCTGGGGCGGGGCGGTTCGGACACGTCCGCCGTGGC
ACTGGCGGCGGCGCTGCAGGCCGACCGGTGCGATATCTATACCGACGTCGACGGAATCTACACGACCGACCCGCGAATTG
TTGCGAGGGCGCGGAAGCTGGATAAGATCACGTACGAGGAGATGCTGGAACTGGCGTCGGTCGGGGCCAAGGTGCTCCAG
ACCCGCAGCGTCGAACTGGCGATGAAGGAGCGGGTGCGCGTACAGGTGCTGTCGAGCTTCAGCGACGGCCCCGCCCCGTC
GGAAGACAACCTGCCCGGTTCATTAGTGGTGGATGAGGACGAGATCGTGGAAAAGGAACTGGTCGCCGGCATTGCCTATT
CGCGCGACGAAGCGAAGCTGTCCGTCAGGCGCATTCCCGACCGTCCGGGCATCGCGGCGGCGATCTTCGGCCCGCTGACG
GCCGCGAACGTGAATGTGGACATGATCGTGCAGAGCACGGGGGCCGACGGCCTGACCAACATGACGTTCACCACCGGCAA
GACCGACCTGGCCCGCGCCATCCAGGCGCTGGAGGCCGCGCGGGACGTCATCCAGTATGGTGAAATGGCGACCGACGACG
ACGTGGTGAAGATCAGCGTGGTGGGCGTGGGCATGCGCTCGCACGCGGGGGTGGCCAACACGATGTTCCGCACCCTGTCG
GACCGCAACATCAATATCCAGGTCATCTCGACCAGCGAAATCAAGGTATCGGTGCTGATCGCGGCGGAATATACCGAACT
GGCGGTCCGGGCGCTGCACACCGCCTACGGCCTGGATGCGGCCTGA

Upstream 100 bases:

>100_bases
AATCGTTTACATTCATGGCTTCACCACCTTTCCGCTGACCATCTGCCGCTGGACGGCGCAGCGGTGGAAGGGTATGTGAC
GCGCCTTGCAGATAACCGCA

Downstream 100 bases:

>100_bases
ACCGATGGACACCCTCGCCATGCCCCTGTCGGATGACGCAATGTTTCGGACCGCCGCGCGCGCGCGGCTGGACCGCCTGT
GGTCCGCCGGCACGGCCTTC

Product: aspartokinase protein

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MPRPAPQRARRAGTAAAPNWRALSMPRTVPRIVMKFGGTSVADLDRIRAVAEKVHKQVAAGCEVAVVVSAMSGVTNRLVG
YCQSLSPLHDAKEYDAVVATGEQVTSGLLAIALQTLGLEARSWLGWQIPLRTDGAHGKARIDSIDGEALITRMRAGQVPV
IAGFQGVDPDGRITTLGRGGSDTSAVALAAALQADRCDIYTDVDGIYTTDPRIVARARKLDKITYEEMLELASVGAKVLQ
TRSVELAMKERVRVQVLSSFSDGPAPSEDNLPGSLVVDEDEIVEKELVAGIAYSRDEAKLSVRRIPDRPGIAAAIFGPLT
AANVNVDMIVQSTGADGLTNMTFTTGKTDLARAIQALEAARDVIQYGEMATDDDVVKISVVGVGMRSHAGVANTMFRTLS
DRNINIQVISTSEIKVSVLIAAEYTELAVRALHTAYGLDAA

Sequences:

>Translated_441_residues
MPRPAPQRARRAGTAAAPNWRALSMPRTVPRIVMKFGGTSVADLDRIRAVAEKVHKQVAAGCEVAVVVSAMSGVTNRLVG
YCQSLSPLHDAKEYDAVVATGEQVTSGLLAIALQTLGLEARSWLGWQIPLRTDGAHGKARIDSIDGEALITRMRAGQVPV
IAGFQGVDPDGRITTLGRGGSDTSAVALAAALQADRCDIYTDVDGIYTTDPRIVARARKLDKITYEEMLELASVGAKVLQ
TRSVELAMKERVRVQVLSSFSDGPAPSEDNLPGSLVVDEDEIVEKELVAGIAYSRDEAKLSVRRIPDRPGIAAAIFGPLT
AANVNVDMIVQSTGADGLTNMTFTTGKTDLARAIQALEAARDVIQYGEMATDDDVVKISVVGVGMRSHAGVANTMFRTLS
DRNINIQVISTSEIKVSVLIAAEYTELAVRALHTAYGLDAA
>Mature_440_residues
PRPAPQRARRAGTAAAPNWRALSMPRTVPRIVMKFGGTSVADLDRIRAVAEKVHKQVAAGCEVAVVVSAMSGVTNRLVGY
CQSLSPLHDAKEYDAVVATGEQVTSGLLAIALQTLGLEARSWLGWQIPLRTDGAHGKARIDSIDGEALITRMRAGQVPVI
AGFQGVDPDGRITTLGRGGSDTSAVALAAALQADRCDIYTDVDGIYTTDPRIVARARKLDKITYEEMLELASVGAKVLQT
RSVELAMKERVRVQVLSSFSDGPAPSEDNLPGSLVVDEDEIVEKELVAGIAYSRDEAKLSVRRIPDRPGIAAAIFGPLTA
ANVNVDMIVQSTGADGLTNMTFTTGKTDLARAIQALEAARDVIQYGEMATDDDVVKISVVGVGMRSHAGVANTMFRTLSD
RNINIQVISTSEIKVSVLIAAEYTELAVRALHTAYGLDAA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=474, Percent_Identity=30.168776371308, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1790455, Length=457, Percent_Identity=28.6652078774617, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790376, Length=283, Percent_Identity=26.5017667844523, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=301, Percent_Identity=28.2392026578073, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 46904; Mature: 46773

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPAPQRARRAGTAAAPNWRALSMPRTVPRIVMKFGGTSVADLDRIRAVAEKVHKQVAA
CCCCCHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
GCEVAVVVSAMSGVTNRLVGYCQSLSPLHDAKEYDAVVATGEQVTSGLLAIALQTLGLEA
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEECCHHHHHHHHHHHHHHHCCCH
RSWLGWQIPLRTDGAHGKARIDSIDGEALITRMRAGQVPVIAGFQGVDPDGRITTLGRGG
HHCCCEEEEEECCCCCCCEEEECCCCHHHHHHHHCCCCCEEECCCCCCCCCCEEEECCCC
SDTSAVALAAALQADRCDIYTDVDGIYTTDPRIVARARKLDKITYEEMLELASVGAKVLQ
CCHHHHHHHHHHHCCCCCEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRSVELAMKERVRVQVLSSFSDGPAPSEDNLPGSLVVDEDEIVEKELVAGIAYSRDEAKL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCHHE
SVRRIPDRPGIAAAIFGPLTAANVNVDMIVQSTGADGLTNMTFTTGKTDLARAIQALEAA
EEEECCCCCCEEEEECCCCEECCCCEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHH
RDVIQYGEMATDDDVVKISVVGVGMRSHAGVANTMFRTLSDRNINIQVISTSEIKVSVLI
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCEEEEEEE
AAEYTELAVRALHTAYGLDAA
EEHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PRPAPQRARRAGTAAAPNWRALSMPRTVPRIVMKFGGTSVADLDRIRAVAEKVHKQVAA
CCCCHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
GCEVAVVVSAMSGVTNRLVGYCQSLSPLHDAKEYDAVVATGEQVTSGLLAIALQTLGLEA
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEECCHHHHHHHHHHHHHHHCCCH
RSWLGWQIPLRTDGAHGKARIDSIDGEALITRMRAGQVPVIAGFQGVDPDGRITTLGRGG
HHCCCEEEEEECCCCCCCEEEECCCCHHHHHHHHCCCCCEEECCCCCCCCCCEEEECCCC
SDTSAVALAAALQADRCDIYTDVDGIYTTDPRIVARARKLDKITYEEMLELASVGAKVLQ
CCHHHHHHHHHHHCCCCCEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRSVELAMKERVRVQVLSSFSDGPAPSEDNLPGSLVVDEDEIVEKELVAGIAYSRDEAKL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCHHE
SVRRIPDRPGIAAAIFGPLTAANVNVDMIVQSTGADGLTNMTFTTGKTDLARAIQALEAA
EEEECCCCCCEEEEECCCCEECCCCEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHH
RDVIQYGEMATDDDVVKISVVGVGMRSHAGVANTMFRTLSDRNINIQVISTSEIKVSVLI
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCEEEEEEE
AAEYTELAVRALHTAYGLDAA
EEHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]